{"id":"https://openalex.org/W2284107201","doi":"https://doi.org/10.1186/s12859-016-0937-5","title":"A multiple testing procedure for multi-dimensional pairwise comparisons with application to gene expression studies","display_name":"A multiple testing procedure for multi-dimensional pairwise comparisons with application to gene expression studies","publication_year":2016,"publication_date":"2016-02-25","ids":{"openalex":"https://openalex.org/W2284107201","doi":"https://doi.org/10.1186/s12859-016-0937-5","mag":"2284107201","pmid":"https://pubmed.ncbi.nlm.nih.gov/26917217"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-016-0937-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-0937-5","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-0937-5","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-0937-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051774019","display_name":"Anjana Grandhi","orcid":"https://orcid.org/0000-0001-7339-8740"},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anjana Grandhi","raw_affiliation_strings":["BARDS, Merck Research Laboratories, RY34-A3086h, 126 E. Lincoln Avenue, Rahway, 07065, NJ, USA. ag454@njit.edu","BARDS, Merck Research Laboratories, RY34-A3086h, 126 E. Lincoln Avenue, Rahway, 07065, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BARDS, Merck Research Laboratories, RY34-A3086h, 126 E. Lincoln Avenue, Rahway, 07065, NJ, USA. ag454@njit.edu","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"BARDS, Merck Research Laboratories, RY34-A3086h, 126 E. Lincoln Avenue, Rahway, 07065, NJ, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047127505","display_name":"Wenge Guo","orcid":"https://orcid.org/0000-0003-3777-2058"},"institutions":[{"id":"https://openalex.org/I118118575","display_name":"New Jersey Institute of Technology","ror":"https://ror.org/05e74xb87","country_code":"US","type":"education","lineage":["https://openalex.org/I118118575"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenge Guo","raw_affiliation_strings":["Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, 07102, NJ, USA. wenge.guo@njit.edu","Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, 07102, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, 07102, NJ, USA. wenge.guo@njit.edu","institution_ids":["https://openalex.org/I118118575"]},{"raw_affiliation_string":"Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, 07102, NJ, USA","institution_ids":["https://openalex.org/I118118575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004718159","display_name":"Shyamal D. Peddada","orcid":"https://orcid.org/0000-0002-5014-6513"},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shyamal D. Peddada","raw_affiliation_strings":["Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, T.W.Alexander Drive, Research Triangle Park, 27709, NC, USA. peddada@niehs.nih.gov","Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, T.W.Alexander Drive, Research Triangle Park, 27709, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, T.W.Alexander Drive, Research Triangle Park, 27709, NC, USA. peddada@niehs.nih.gov","institution_ids":["https://openalex.org/I4210095140"]},{"raw_affiliation_string":"Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, T.W.Alexander Drive, Research Triangle Park, 27709, NC, USA","institution_ids":["https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004718159"],"corresponding_institution_ids":["https://openalex.org/I4210095140"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.8117,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.85527325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"17","issue":"1","first_page":"104","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.3499000072479248,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.3499000072479248,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.053300000727176666,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.043800000101327896,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.8545950651168823},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.6912093758583069},{"id":"https://openalex.org/keywords/uterine-fibroids","display_name":"Uterine fibroids","score":0.6901807188987732},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.633198082447052},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5417900085449219},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.5300245881080627},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4975025951862335},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44662150740623474},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.4243108928203583},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4197208881378174},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.41488587856292725},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4136732816696167},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.39703282713890076},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3703763782978058},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.22516992688179016},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22343796491622925},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.18856051564216614},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17220312356948853},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.15030422806739807},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.12731888890266418}],"concepts":[{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.8545950651168823},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.6912093758583069},{"id":"https://openalex.org/C2780566971","wikidata":"https://www.wikidata.org/wiki/Q556281","display_name":"Uterine fibroids","level":2,"score":0.6901807188987732},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.633198082447052},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5417900085449219},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5300245881080627},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4975025951862335},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44662150740623474},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4243108928203583},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4197208881378174},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.41488587856292725},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4136732816696167},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.39703282713890076},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3703763782978058},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.22516992688179016},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22343796491622925},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.18856051564216614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17220312356948853},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15030422806739807},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12731888890266418},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007889","descriptor_name":"Leiomyoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007889","descriptor_name":"Leiomyoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007889","descriptor_name":"Leiomyoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007889","descriptor_name":"Leiomyoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12859-016-0937-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-0937-5","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-0937-5","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26917217","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26917217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:3738234","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4768411","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-016-0937-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-0937-5","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-0937-5","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6100000143051147,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2561058100","display_name":"Collaborative Research: Constructing New Multiple Testing Methods","funder_award_id":"1006021","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2915613352","display_name":null,"funder_award_id":"DMS-1309162","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3781504350","display_name":"Collaborative Research:   New Directions for Research on Some Large-Scale Multiple Testing Problems","funder_award_id":"1309162","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5887795977","display_name":null,"funder_award_id":"DMS-1006021","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1543230487","https://openalex.org/W1583913308","https://openalex.org/W1598616201","https://openalex.org/W1815550493","https://openalex.org/W1965138864","https://openalex.org/W1967805052","https://openalex.org/W1989797779","https://openalex.org/W2003605385","https://openalex.org/W2011170801","https://openalex.org/W2012757283","https://openalex.org/W2015447652","https://openalex.org/W2021880490","https://openalex.org/W2023767567","https://openalex.org/W2043610361","https://openalex.org/W2044204905","https://openalex.org/W2054714441","https://openalex.org/W2068568853","https://openalex.org/W2074089196","https://openalex.org/W2076014057","https://openalex.org/W2079260025","https://openalex.org/W2091841926","https://openalex.org/W2096374131","https://openalex.org/W2097993004","https://openalex.org/W2099984528","https://openalex.org/W2104620926","https://openalex.org/W2105517232","https://openalex.org/W2110065044","https://openalex.org/W2115012618","https://openalex.org/W2116101489","https://openalex.org/W2121044470","https://openalex.org/W2142869689","https://openalex.org/W2146638566","https://openalex.org/W2152678181","https://openalex.org/W2157785358","https://openalex.org/W2170353148","https://openalex.org/W2474303154"],"related_works":["https://openalex.org/W2467227750","https://openalex.org/W4293336298","https://openalex.org/W4300887971","https://openalex.org/W2178204436","https://openalex.org/W2143079975","https://openalex.org/W2032708737","https://openalex.org/W2026085942","https://openalex.org/W2333750400","https://openalex.org/W2055598935","https://openalex.org/W2509093327"],"abstract_inverted_index":{"BACKGROUND:":[0],"Often":[1],"researchers":[2,295],"are":[3,46,133,176,241],"interested":[4],"in":[5,41,243,252],"comparing":[6],"multiple":[7,55,183],"experimental":[8],"groups":[9],"(e.g.":[10,17,27],"tumor":[11,275,290],"size)":[12],"with":[13,204,233],"a":[14,32,42,68,101,141,178,201],"reference":[15],"group":[16],"normal":[18],"tissue)":[19],"on":[20],"the":[21,62,85,91,110,138,171,189,217,244,263,284,305],"basis":[22],"of":[23,25,49,140,170,188,200,220,246,280,301],"thousands":[24],"features":[26],"genes)":[28],"and":[29,61,108,130,235,270,283,304],"determine":[30],"if":[31],"differentially":[33,126],"expressed":[34,127],"feature":[35,69],"is":[36,78,89,248,272,292],"up":[37,72],"or":[38],"down":[39],"regulated":[40,75],"pairwise":[43,59,184],"comparison.":[44],"There":[45],"two":[47],"sources":[48],"false":[50,94],"discoveries,":[51],"one":[52],"due":[53,64],"to":[54,65,70,137,211,237,289,296],"testing":[56,106,165],"involving":[57],"several":[58,125,213],"comparisons":[60],"second":[63],"falsely":[66],"declaring":[67],"be":[71,156],"(or":[73],"down)":[74],"when":[76],"it":[77],"not":[79],"(known":[80],"as":[81],"directional":[82,93],"error).":[83],"Together,":[84],"total":[86],"error":[87],"rate":[88,96],"called":[90],"mixed":[92],"discovery":[95],"(mdFDR).":[97],"RESULTS:":[98],"We":[99,123],"develop":[100],"general":[102,147,160,172,179],"powerful":[103,207],"mdFDR":[104],"controlling":[105],"procedure":[107,148],"illustrate":[109],"methodology":[111,161,208],"by":[112,162],"analyzing":[113],"uterine":[114,142,190,221],"fibroid":[115,191,202,268],"gene":[116,193],"expression":[117,194],"data":[118,195],"(PLoS":[119],"ONE":[120],"8:63909,":[121],"2013).":[122],"identify":[124],"genes":[128],"(DEGs)":[129],"pathways":[131,287,306],"that":[132,197,240,262],"specifically":[134],"enriched":[135,250,286],"according":[136,288],"size":[139,291],"fibroid.":[143],"CONCLUSIONS:":[144],"The":[145],"proposed":[146],"strongly":[149],"controls":[150],"mdFDR.":[151],"Several":[152],"specific":[153],"methodologies":[154],"can":[155],"derived":[157],"from":[158],"this":[159],"using":[163],"appropriate":[164],"procedures":[166],"at":[167],"different":[168],"steps":[169],"procedure.":[173],"Thus":[174],"we":[175],"providing":[177],"framework":[180],"for":[181,267,294],"making":[182],"comparisons.":[185],"Our":[186,206],"analysis":[187],"growth":[192,269],"suggests":[196],"molecular":[198,218,264],"characteristics":[199,219],"changes":[203],"size.":[205],"allowed":[209],"us":[210],"draw":[212],"interesting":[214],"conclusions":[215],"regarding":[216],"fibroids.":[222],"For":[223],"example,":[224],"IL-1":[225],"signaling":[226],"pathway":[227],"(Sci":[228],"STKE":[229],"2003:3,":[230],"2003),":[231],"associated":[232],"inflammation":[234],"known":[236],"activate":[238],"prostaglandins":[239],"implicated":[242],"progression":[245],"fibroids,":[247],"significantly":[249],"only":[251],"small":[253],"tumors":[254],"(volume":[255],"<":[256],"5.7":[257],"cm":[258],"(3)).":[259],"It":[260],"appears":[261],"apparatus":[265],"necessary":[266],"development":[271],"established":[273],"during":[274],"development.":[276],"A":[277],"complete":[278],"list":[279],"all":[281],"DEGs":[282,303],"corresponding":[285],"provided":[293],"mine":[297],"these":[298,302],"data.":[299],"Identification":[300],"may":[307],"potentially":[308],"have":[309],"clinical":[310],"implications.":[311]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}