{"id":"https://openalex.org/W2254687785","doi":"https://doi.org/10.1186/s12859-016-0918-8","title":"Design, structure prediction and molecular dynamics simulation of a fusion construct containing malaria pre-erythrocytic vaccine candidate, PfCelTOS, and human interleukin 2 as adjuvant","display_name":"Design, structure prediction and molecular dynamics simulation of a fusion construct containing malaria pre-erythrocytic vaccine candidate, PfCelTOS, and human interleukin 2 as adjuvant","publication_year":2016,"publication_date":"2016-02-06","ids":{"openalex":"https://openalex.org/W2254687785","doi":"https://doi.org/10.1186/s12859-016-0918-8","mag":"2254687785","pmid":"https://pubmed.ncbi.nlm.nih.gov/26851942"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-016-0918-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-0918-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-0918-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-0918-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024483652","display_name":"Shabnam Shamriz","orcid":null},"institutions":[{"id":"https://openalex.org/I2802500176","display_name":"Iranian Research Organization for Science and Technology","ror":"https://ror.org/017zx9g19","country_code":"IR","type":"facility","lineage":["https://openalex.org/I2802500176"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Shabnam Shamriz","raw_affiliation_strings":["Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran, Iran. Shamriz.sh@irost.ir","Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran, Iran. Shamriz.sh@irost.ir","institution_ids":[]},{"raw_affiliation_string":"Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran, Iran","institution_ids":["https://openalex.org/I2802500176"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053278381","display_name":"Hamideh Ofoghi","orcid":"https://orcid.org/0000-0003-2163-2448"},"institutions":[{"id":"https://openalex.org/I2802500176","display_name":"Iranian Research Organization for Science and Technology","ror":"https://ror.org/017zx9g19","country_code":"IR","type":"facility","lineage":["https://openalex.org/I2802500176"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hamideh Ofoghi","raw_affiliation_strings":["Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran, Iran. Ofoghi@irost.ir","Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran, Iran. Ofoghi@irost.ir","institution_ids":[]},{"raw_affiliation_string":"Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran, Iran","institution_ids":["https://openalex.org/I2802500176"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024483652"],"corresponding_institution_ids":["https://openalex.org/I2802500176"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.7408,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.84291556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"71","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.6032999753952026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.6032999753952026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.17229999601840973,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14463","display_name":"Diverse Scientific Research Studies","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6556413769721985},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5894615650177002},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"Fusion protein","score":0.542198896408081},{"id":"https://openalex.org/keywords/malaria-vaccine","display_name":"Malaria vaccine","score":0.4466472268104553},{"id":"https://openalex.org/keywords/adjuvant","display_name":"Adjuvant","score":0.4422972500324249},{"id":"https://openalex.org/keywords/malaria","display_name":"Malaria","score":0.4257677495479584},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.4198454022407532},{"id":"https://openalex.org/keywords/fusion","display_name":"Fusion","score":0.4193711280822754},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4009770452976227},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3458792567253113},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.33868587017059326},{"id":"https://openalex.org/keywords/recombinant-dna","display_name":"Recombinant DNA","score":0.27625519037246704},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.1777690052986145},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10681024193763733}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6556413769721985},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5894615650177002},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.542198896408081},{"id":"https://openalex.org/C2781034427","wikidata":"https://www.wikidata.org/wiki/Q6741353","display_name":"Malaria vaccine","level":4,"score":0.4466472268104553},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.4422972500324249},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.4257677495479584},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.4198454022407532},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.4193711280822754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4009770452976227},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3458792567253113},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33868587017059326},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.27625519037246704},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1777690052986145},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10681024193763733},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000953","descriptor_name":"Antigens, Protozoan","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000953","descriptor_name":"Antigens, Protozoan","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000953","descriptor_name":"Antigens, Protozoan","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000953","descriptor_name":"Antigens, Protozoan","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034101","descriptor_name":"Sporozoites","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D034101","descriptor_name":"Sporozoites","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D034101","descriptor_name":"Sporozoites","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D034101","descriptor_name":"Sporozoites","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12859-016-0918-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-0918-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-0918-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26851942","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26851942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4744421","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4744421","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-016-0918-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-0918-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-0918-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2254687785.pdf","grobid_xml":"https://content.openalex.org/works/W2254687785.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W99575393","https://openalex.org/W118179289","https://openalex.org/W255996521","https://openalex.org/W605552760","https://openalex.org/W1031578623","https://openalex.org/W1506213102","https://openalex.org/W1508418323","https://openalex.org/W1536886974","https://openalex.org/W1584891551","https://openalex.org/W1749257195","https://openalex.org/W1803102843","https://openalex.org/W1863266496","https://openalex.org/W1901003958","https://openalex.org/W1905994259","https://openalex.org/W1916481354","https://openalex.org/W1966823964","https://openalex.org/W1975304761","https://openalex.org/W1977743896","https://openalex.org/W1977799036","https://openalex.org/W1987134040","https://openalex.org/W2011349326","https://openalex.org/W2017023595","https://openalex.org/W2031298775","https://openalex.org/W2033930149","https://openalex.org/W2049502419","https://openalex.org/W2050888432","https://openalex.org/W2053599146","https://openalex.org/W2054621277","https://openalex.org/W2057021995","https://openalex.org/W2074986801","https://openalex.org/W2077877646","https://openalex.org/W2085576068","https://openalex.org/W2116379079","https://openalex.org/W2119351286","https://openalex.org/W2120031158","https://openalex.org/W2127703127","https://openalex.org/W2130541969","https://openalex.org/W2140625289","https://openalex.org/W2153722729","https://openalex.org/W2159768764","https://openalex.org/W2502905247","https://openalex.org/W4210996251","https://openalex.org/W4244736178","https://openalex.org/W4247395585"],"related_works":["https://openalex.org/W4393023263","https://openalex.org/W4394290853","https://openalex.org/W2792976722","https://openalex.org/W1966221413","https://openalex.org/W2157889559","https://openalex.org/W2119076403","https://openalex.org/W2015243764","https://openalex.org/W2062216916","https://openalex.org/W2048038600","https://openalex.org/W3022065910"],"abstract_inverted_index":{"BACKGROUND:":[0],"Malaria":[1],"infection":[2],"is":[3,112],"still":[4],"widespread":[5],"in":[6,31,53,115,126,149,160,249,279],"some":[7],"parts":[8],"of":[9,16,18,35,66,71,110,129,135,157,196,232,288],"the":[10,14,33,105,127,131,154,161,166,174,189,210,227,266,274,283],"world":[11],"and":[12,38,63,78,86,124,133,147,182,203,234,238,265],"threatens":[13],"lives":[15],"millions":[17],"people":[19],"every":[20],"year.":[21],"Vaccines,":[22],"especially":[23],"oral":[24,45,55,290],"vaccines":[25],"are":[26,224,269],"considered":[27],"to":[28,82,141,152,173,187,272],"be":[29],"effective":[30],"reducing":[32],"burden":[34],"malaria":[36,294],"morbidity":[37],"mortality.":[39],"By":[40],"using":[41,178],"recombinant":[42],"technology,":[43],"suitable":[44],"hosts":[46],"could":[47],"serve":[48],"as":[49,92],"antigen":[50],"delivering":[51],"vehicles":[52],"developing":[54,96,287],"vaccines.":[56],"This":[57],"study":[58,255],"was":[59,171,185,206],"aimed":[60],"towards":[61],"designing":[62],"computational":[64,122,183],"analysis":[65,151,184,219,231],"a":[67,93,97,144,179,262],"fusion":[68,163,176,191,204,235],"protein":[69,75,116],"consisting":[70],"Plasmodium":[72],"falciparum":[73],"cell-traversal":[74],"for":[76,201,213],"ookinetes":[77],"sporozoites":[79],"(PfCelTOS)":[80],"fused":[81,139],"human":[83],"interleukin-2":[84],"(IL-2)":[85],"M":[87],"cell-specific":[88],"peptide":[89],"ligand":[90,170],"(Co1),":[91],"step":[94,285],"toward":[95,286],"vaccine":[98,291],"candidate.":[99],"RESULTS:":[100],"To":[101],"our":[102],"best":[103],"knowledge,":[104],"three":[106],"dimensional":[107],"(3D)":[108],"structure":[109,134,177,194,264],"CelTOS":[111],"not":[113],"reported":[114,278],"database.":[117],"Therefore,":[118,276],"we":[119,138],"carried":[120],"out":[121,195],"modeling":[123],"simulation":[125,218,241],"hope":[128],"understanding":[130],"properties":[132],"PfCelTOS.":[136],"Then":[137],"IL-2":[140],"PfCelTOS":[142,202,233],"by":[143,199],"flexible":[145],"linker":[146,181],"did":[148],"silico":[150,254],"confirm":[153],"proper":[155],"folding":[156],"each":[158],"domain":[159],"designed":[162],"protein.":[164],"In":[165,253],"last":[167],"step,":[168],"Co1":[169],"added":[172],"confirmed":[175],"rigid":[180],"performed":[186],"evaluate":[188],"final":[190],"construct.":[192],"One":[193],"five":[197],"predicted":[198,222],"I-TASSER":[200],"constructs":[205,236],"selected":[207,267],"based":[208],"on":[209],"highest":[211],"value":[212],"C-score.":[214],"Molecular":[215],"dynamics":[216],"(MD)":[217],"indicated":[220],"that":[221,244,257],"structures":[223],"stable":[225],"during":[226],"simulation.":[228],"Ramchandran":[229],"Plot":[230],"before":[237],"after":[239],"MD":[240],"also":[242],"represented":[243],"most":[245],"residues":[246],"were":[247],"fallen":[248],"favorable":[250],"regions.":[251],"CONCLUSION:":[252],"showed":[256],"Co1-(AEEEK)3-":[258],"IL-2-(GGGGS)3-PfCelTOS":[259],"construct":[260],"has":[261],"constant":[263],"linkers":[268],"effectively":[270],"able":[271],"separate":[273],"domains.":[275],"data":[277],"this":[280],"paper":[281],"represents":[282],"first":[284],"an":[289],"candidate":[292],"against":[293],"infection.":[295]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}