{"id":"https://openalex.org/W1839586932","doi":"https://doi.org/10.1186/s12859-015-0689-7","title":"Finite mixture clustering of human tissues with different levels of IGF-1 splice variants mRNA transcripts","display_name":"Finite mixture clustering of human tissues with different levels of IGF-1 splice variants mRNA transcripts","publication_year":2015,"publication_date":"2015-09-14","ids":{"openalex":"https://openalex.org/W1839586932","doi":"https://doi.org/10.1186/s12859-015-0689-7","mag":"1839586932","pmid":"https://pubmed.ncbi.nlm.nih.gov/26370240"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-015-0689-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-015-0689-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0689-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0689-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079589269","display_name":"Michele Pelosi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Michele Pelosi","raw_affiliation_strings":["Institute Pasteur Cenci-Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, IIM, Sapienza University of Rome, Via A. Scarpa 16, 00161, Rome, Italy. michi_pelo@libero.it","[Institute Pasteur-Cenci Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, IIM, Sapienza University of Rome, Rome, Italy]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute Pasteur Cenci-Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, IIM, Sapienza University of Rome, Via A. Scarpa 16, 00161, Rome, Italy. michi_pelo@libero.it","institution_ids":["https://openalex.org/I4210153523"]},{"raw_affiliation_string":"[Institute Pasteur-Cenci Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, IIM, Sapienza University of Rome, Rome, Italy]","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080632239","display_name":"Marco Alf\u00f2","orcid":"https://orcid.org/0000-0001-7651-6052"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Alf\u00f2","raw_affiliation_strings":["Dipartimento di Scienze Statistiche, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy. marco.alfo@uniroma1.it","Dipartimento di Scienze Statistiche, Sapienza University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Statistiche, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy. marco.alfo@uniroma1.it","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Dipartimento di Scienze Statistiche, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088400471","display_name":"Francesca Martella","orcid":"https://orcid.org/0000-0001-9295-8598"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Martella","raw_affiliation_strings":["Dipartimento di Scienze Statistiche, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy. francesca.martella@uniroma1.it","Dipartimento di Scienze Statistiche, Sapienza University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Statistiche, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy. francesca.martella@uniroma1.it","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Dipartimento di Scienze Statistiche, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079954720","display_name":"Elisa Pappalardo","orcid":"https://orcid.org/0000-0001-6881-9176"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elisa Pappalardo","raw_affiliation_strings":["Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RF, UK. elisa.pappalardo@path.ox.ac.uk","Sir William Dunn School of Pathology, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RF, UK. elisa.pappalardo@path.ox.ac.uk","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037361891","display_name":"Antonio Musar\u00f2","orcid":"https://orcid.org/0000-0002-2944-9739"},"institutions":[{"id":"https://openalex.org/I30771326","display_name":"Italian Institute of Technology","ror":"https://ror.org/042t93s57","country_code":"IT","type":"facility","lineage":["https://openalex.org/I30771326"]},{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Antonio Musar\u00f2","raw_affiliation_strings":["Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, Rome, 00161, Italy. antonio.musaro@uniroma1.it","Institute Pasteur Cenci-Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, IIM, Sapienza University of Rome, Via A. Scarpa 16, 00161, Rome, Italy. antonio.musaro@uniroma1.it","Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy","Institute Pasteur Cenci-Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, IIM, Sapienza University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, Rome, 00161, Italy. antonio.musaro@uniroma1.it","institution_ids":["https://openalex.org/I30771326"]},{"raw_affiliation_string":"Institute Pasteur Cenci-Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, IIM, Sapienza University of Rome, Via A. Scarpa 16, 00161, Rome, Italy. antonio.musaro@uniroma1.it","institution_ids":["https://openalex.org/I4210153523"]},{"raw_affiliation_string":"Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy","institution_ids":["https://openalex.org/I30771326"]},{"raw_affiliation_string":"Institute Pasteur Cenci-Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, IIM, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5037361891","https://openalex.org/A5079589269"],"corresponding_institution_ids":["https://openalex.org/I30771326","https://openalex.org/I4210153523","https://openalex.org/I861853513"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.689,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.68608593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"16","issue":"1","first_page":"289","last_page":"289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.30630001425743103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.30630001425743103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11901","display_name":"Bayesian Methods and Mixture Models","score":0.18389999866485596,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.053300000727176666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6739848852157593},{"id":"https://openalex.org/keywords/mixture-model","display_name":"Mixture model","score":0.6700890064239502},{"id":"https://openalex.org/keywords/splice","display_name":"splice","score":0.6475244164466858},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"Alternative splicing","score":0.5921903848648071},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5847200155258179},{"id":"https://openalex.org/keywords/estimator","display_name":"Estimator","score":0.5383819937705994},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5357638597488403},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5305699706077576},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.46808868646621704},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.44806918501853943},{"id":"https://openalex.org/keywords/gaussian","display_name":"Gaussian","score":0.4413527250289917},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.3846096396446228},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.30524736642837524},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.29736772179603577},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.287578284740448},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2344111204147339},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.15958940982818604},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.15520021319389343}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6739848852157593},{"id":"https://openalex.org/C61224824","wikidata":"https://www.wikidata.org/wiki/Q2260434","display_name":"Mixture model","level":2,"score":0.6700890064239502},{"id":"https://openalex.org/C2780989783","wikidata":"https://www.wikidata.org/wiki/Q7578557","display_name":"splice","level":3,"score":0.6475244164466858},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5921903848648071},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5847200155258179},{"id":"https://openalex.org/C185429906","wikidata":"https://www.wikidata.org/wiki/Q1130160","display_name":"Estimator","level":2,"score":0.5383819937705994},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5357638597488403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5305699706077576},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46808868646621704},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.44806918501853943},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.4413527250289917},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3846096396446228},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.30524736642837524},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29736772179603577},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.287578284740448},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2344111204147339},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.15958940982818604},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15520021319389343},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059368","descriptor_name":"RNA Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059368","descriptor_name":"RNA Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059368","descriptor_name":"RNA Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059368","descriptor_name":"RNA Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-015-0689-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-015-0689-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0689-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26370240","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26370240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:iris.uniroma1.it:11573/790124","is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/790124","pdf_url":"http://hdl.handle.net/11573/790124","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:3546252","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4570607","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-015-0689-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-015-0689-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0689-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4422207177","display_name":null,"funder_award_id":"GGP14066","funder_id":"https://openalex.org/F4320321179","funder_display_name":"Fondazione Telethon"},{"id":"https://openalex.org/G5681331125","display_name":null,"funder_award_id":"GGP13013","funder_id":"https://openalex.org/F4320321179","funder_display_name":"Fondazione Telethon"}],"funders":[{"id":"https://openalex.org/F4320321179","display_name":"Fondazione Telethon","ror":"https://ror.org/04xraxn18"},{"id":"https://openalex.org/F4320322256","display_name":"Agenzia Spaziale Italiana","ror":"https://ror.org/034zgem50"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1839586932.pdf","grobid_xml":"https://content.openalex.org/works/W1839586932.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W204885769","https://openalex.org/W1489950266","https://openalex.org/W1519718418","https://openalex.org/W1520396509","https://openalex.org/W1528177290","https://openalex.org/W1536842040","https://openalex.org/W1538224811","https://openalex.org/W1562705858","https://openalex.org/W1579271636","https://openalex.org/W1966129222","https://openalex.org/W1979125524","https://openalex.org/W1998378660","https://openalex.org/W2011832962","https://openalex.org/W2011920499","https://openalex.org/W2019314643","https://openalex.org/W2063530272","https://openalex.org/W2071447906","https://openalex.org/W2092740654","https://openalex.org/W2104808399","https://openalex.org/W2112797272","https://openalex.org/W2124482801","https://openalex.org/W2129905273","https://openalex.org/W2143508593","https://openalex.org/W2154528735","https://openalex.org/W2156148379","https://openalex.org/W2163288162","https://openalex.org/W2165841486","https://openalex.org/W2168175751","https://openalex.org/W2275579348","https://openalex.org/W2343272106","https://openalex.org/W2488678869","https://openalex.org/W2598891571","https://openalex.org/W4233014035","https://openalex.org/W4252979015"],"related_works":["https://openalex.org/W2001319824","https://openalex.org/W2067501355","https://openalex.org/W2008389025","https://openalex.org/W1943031701","https://openalex.org/W2136950317","https://openalex.org/W2321791250","https://openalex.org/W4213427798","https://openalex.org/W2023199111","https://openalex.org/W2564462691","https://openalex.org/W2155793948"],"abstract_inverted_index":{"BACKGROUND:":[0],"This":[1],"study":[2],"addresses":[3],"a":[4,12,17,45,51,76,183,189,255,261],"recurrent":[5],"biological":[6],"problem,":[7],"that":[8,153],"is":[9,197],"to":[10,100,200,239,293],"define":[11],"formal":[13,184,258],"clustering":[14,47,185,263,314],"structure":[15],"for":[16,69,133,260,279],"set":[18],"of":[19,24,28,54,79,90,105,118,126,129,143,173,203,215,232,245,264,274,276,296,313],"tissues":[20,92,144,267,297],"on":[21,50,188,317],"the":[22,25,36,66,102,119,127,130,134,141,154,171,201,207,216,222,229,252,265,277,305,311],"basis":[23],"relative":[26,103],"abundance":[27],"multiple":[29,282],"alternatively":[30,300],"spliced":[31,301],"isoforms":[32],"mRNAs":[33,278,302],"generated":[34,303],"by":[35,145,162,211,271,304],"same":[37,67,217,223,306],"gene.":[38],"To":[39],"this":[40,181,243],"aim,":[41],"we":[42,60,73,122,225],"have":[43,226],"used":[44],"model-based":[46,262],"approach,":[48],"based":[49,187,316],"finite":[52,77,190,230],"mixture":[53,78,191,231],"multivariate":[55],"Gaussian":[56,195],"densities.":[57],"However,":[58],"given":[59],"had":[61],"more":[62],"technical":[63,208],"replicates":[64,209],"from":[65],"tissue":[68,178],"each":[70],"quantitative":[71,96,120,213],"measurement,":[72],"also":[74,227],"employed":[75,228],"linear":[80,233],"mixed":[81,234],"models,":[82],"with":[83,194],"tissue-specific":[84],"random":[85],"effects.":[86],"RESULTS:":[87],"A":[88],"panel":[89],"human":[91,266],"was":[93],"analysed":[94,155],"through":[95],"real-time":[97],"PCR":[98],"methods,":[99],"quantify":[101],"amount":[104],"mRNA":[106,137,157,218],"encoding":[107],"different":[108,135],"IGF-1":[109,136,156,283],"alternative":[110,284],"splicing":[111,285],"variants.":[112],"After":[113],"an":[114,124],"appropriate,":[115],"preliminary,":[116],"equalization":[117],"data,":[121],"provided":[123,254],"estimate":[125],"distribution":[128],"observed":[131,152],"concentrations":[132,275],"splice":[138,158,219,321],"variants":[139,159],"in":[140,221,268],"cohort":[142,295],"employing":[146],"suitable":[147],"kernel":[148],"density":[149],"estimators.":[150],"We":[151],"were":[160],"characterized":[161,270],"multimodal":[163],"distributions,":[164],"which":[165,237],"could":[166],"be":[167,291],"interpreted":[168],"as":[169],"describing":[170],"presence":[172,202],"several":[174,299],"sub-population,":[175],"i.e.":[176],"potential":[177,204],"clusters.":[179],"In":[180],"context,":[182],"approach":[186],"model":[192],"(FMM)":[193],"components":[196],"proposed.":[198],"Due":[199],"dependence":[205],"between":[206,320],"(originated":[210],"repeated":[212],"measurements":[214],"isoform":[220,322],"tissue)":[224],"models":[235],"(FMLMM),":[236],"allowed":[238],"take":[240],"into":[241],"account":[242],"kind":[244],"within-tissue":[246],"dependence.":[247],"CONCLUSIONS:":[248],"The":[249,287],"FMM":[250],"and":[251,308],"FMLMM":[253],"convenient":[256],"yet":[257],"setting":[259],"sub-populations,":[269],"homogeneous":[272],"values":[273],"one":[280],"or":[281],"isoforms.":[286],"proposed":[288],"approaches":[289],"can":[290,309],"applied":[292],"any":[294],"expressing":[298],"gene,":[307],"overcome":[310],"limitations":[312],"methods":[315],"simple":[318],"comparisons":[319],"expression":[323],"levels.":[324]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2}],"updated_date":"2026-08-04T08:18:43.703281","created_date":"2025-10-10T00:00:00"}