{"id":"https://openalex.org/W1577582622","doi":"https://doi.org/10.1186/s12859-015-0650-9","title":"Deciding when to stop: efficient experimentation to learn to predict drug-target interactions","display_name":"Deciding when to stop: efficient experimentation to learn to predict drug-target interactions","publication_year":2015,"publication_date":"2015-07-07","ids":{"openalex":"https://openalex.org/W1577582622","doi":"https://doi.org/10.1186/s12859-015-0650-9","mag":"1577582622","pmid":"https://pubmed.ncbi.nlm.nih.gov/26153434"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-015-0650-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-015-0650-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0650-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0650-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052979679","display_name":"Maja Temerinac-Ott","orcid":"https://orcid.org/0009-0001-8588-7151"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maja Temerinac-Ott","raw_affiliation_strings":["Freiburg Institute for Advanced Studies, University of Freiburg, Freiburg, Germany. temerina@frias.uni-freiburg.de","Freiburg Institute for Advanced Studies, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Freiburg Institute for Advanced Studies, University of Freiburg, Freiburg, Germany. temerina@frias.uni-freiburg.de","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Freiburg Institute for Advanced Studies, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029328053","display_name":"Armaghan W. Naik","orcid":"https://orcid.org/0000-0002-7844-2832"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Armaghan W Naik","raw_affiliation_strings":["Computational Biology Department, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA. rumi@cmu.edu","Computational Biology Department, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Department, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA. rumi@cmu.edu","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Computational Biology Department, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061773929","display_name":"Robert F. Murphy","orcid":"https://orcid.org/0000-0003-0358-901X"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Robert F Murphy","raw_affiliation_strings":["Computational Biology Department, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA. murphy@cmu.edu","Departments of Biological Sciences, Biomedical Engineering and Machine Learning, Carnegie Mellon University, 5000 Forbes Ave15213, Pittsburgh, PA, USA. murphy@cmu.edu","Freiburg Institute for Advanced Studies, University of Freiburg, Freiburg, Germany. murphy@cmu.edu","Computational Biology Department, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Department, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA. murphy@cmu.edu","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Departments of Biological Sciences, Biomedical Engineering and Machine Learning, Carnegie Mellon University, 5000 Forbes Ave15213, Pittsburgh, PA, USA. murphy@cmu.edu","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Freiburg Institute for Advanced Studies, University of Freiburg, Freiburg, Germany. murphy@cmu.edu","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Computational Biology Department, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, 15213, PA, USA","institution_ids":["https://openalex.org/I74973139"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061773929"],"corresponding_institution_ids":["https://openalex.org/I161046081","https://openalex.org/I74973139"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1594,"currency":"EUR","value_usd":1719},"fwci":1.0587,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.77918342,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"16","issue":"1","first_page":"213","last_page":"213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5311999917030334,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5311999917030334,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12072","display_name":"Machine Learning and Algorithms","score":0.37220001220703125,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11948","display_name":"Machine Learning in Materials Science","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7569727897644043},{"id":"https://openalex.org/keywords/active-learning","display_name":"Active learning (machine learning)","score":0.6610994338989258},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.6281735301017761},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.5888106226921082},{"id":"https://openalex.org/keywords/drug-target","display_name":"Drug target","score":0.575681209564209},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5301476716995239},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.4870803654193878},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.39842426776885986},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1344285011291504},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10776674747467041}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7569727897644043},{"id":"https://openalex.org/C77967617","wikidata":"https://www.wikidata.org/wiki/Q4677561","display_name":"Active learning (machine learning)","level":2,"score":0.6610994338989258},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.6281735301017761},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5888106226921082},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.575681209564209},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5301476716995239},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.4870803654193878},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.39842426776885986},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1344285011291504},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10776674747467041},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1186/s12859-015-0650-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-015-0650-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0650-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26153434","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26153434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:repository.cmu.edu:cbd-1027","is_oa":true,"landing_page_url":"http://repository.cmu.edu/cgi/viewcontent.cgi?article=1027&context=cbd","pdf_url":null,"source":{"id":"https://openalex.org/S4306400668","display_name":"Research Showcase @ Carnegie Mellon University (Carnegie Mellon University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I74973139","host_organization_name":"Carnegie Mellon University","host_organization_lineage":["https://openalex.org/I74973139"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational Biology Department","raw_type":"text"},{"id":"pmh:doi:10.1184/r1/6702071","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4406922384","display_name":"Open MIND","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal contribution"},{"id":"pmh:oai:figshare.com:article/6702071","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Deciding_when_to_stop_efficient_experimentation_to_learn_to_predict_drug-target_interactions_/6702071","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:freidok.uni-freiburg.de:12532","is_oa":false,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bsz:25-freidok-125322","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics. 16 (2015), 213, DOI 10.1186/s12859-015-0650-9, issn: 1471-2105","raw_type":"article"},{"id":"pmh:oai:opus4.hsfu:12007","is_oa":true,"landing_page_url":"https://opus.hs-furtwangen.de/frontdoor/index/index/docId/12007","pdf_url":null,"source":{"id":"https://openalex.org/S4377196512","display_name":"Repository of Futwangen University of Applied Sciences (Furtwangen University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I882953328","host_organization_name":"Furtwangen University","host_organization_lineage":["https://openalex.org/I882953328"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4495685","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4495685","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"doi:10.1184/r1/6702071.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1184/r1/6702071.v1","pdf_url":null,"source":{"id":"https://openalex.org/S7407050927","display_name":"KiltHub Repository","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1186/s12859-015-0650-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-015-0650-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0650-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.47999998927116394,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2242462635","display_name":null,"funder_award_id":"FKZ0316185","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1577582622.pdf","grobid_xml":"https://content.openalex.org/works/W1577582622.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W29665","https://openalex.org/W1482422241","https://openalex.org/W1536886974","https://openalex.org/W1807800941","https://openalex.org/W1971731086","https://openalex.org/W1972821149","https://openalex.org/W1984084871","https://openalex.org/W2006348601","https://openalex.org/W2009313526","https://openalex.org/W2010865240","https://openalex.org/W2021367230","https://openalex.org/W2029348196","https://openalex.org/W2034475831","https://openalex.org/W2039643849","https://openalex.org/W2048435239","https://openalex.org/W2065383075","https://openalex.org/W2085989833","https://openalex.org/W2087007556","https://openalex.org/W2087064593","https://openalex.org/W2092527471","https://openalex.org/W2098009642","https://openalex.org/W2108069034","https://openalex.org/W2125079066","https://openalex.org/W2135007932","https://openalex.org/W2135046866","https://openalex.org/W2137084389","https://openalex.org/W2138512826","https://openalex.org/W2139516171","https://openalex.org/W2139736926","https://openalex.org/W2143894320","https://openalex.org/W2144000913","https://openalex.org/W2147084679","https://openalex.org/W2153838454","https://openalex.org/W2154718035","https://openalex.org/W2154896031","https://openalex.org/W2161782568","https://openalex.org/W2165618135","https://openalex.org/W2165674132","https://openalex.org/W2166311977","https://openalex.org/W2169678694","https://openalex.org/W2170711872","https://openalex.org/W2237440835","https://openalex.org/W2560674852","https://openalex.org/W2608018571","https://openalex.org/W2912376836","https://openalex.org/W4242186041"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4224009465","https://openalex.org/W4306674287","https://openalex.org/W4286629047","https://openalex.org/W2914897824","https://openalex.org/W2759744443","https://openalex.org/W4224256816","https://openalex.org/W2183624479","https://openalex.org/W2076360034","https://openalex.org/W4206195464"],"abstract_inverted_index":{"BACKGROUND:":[0],"Active":[1],"learning":[2,23,48,97,113,188],"is":[3,67],"a":[4,19,71,123],"powerful":[5],"tool":[6],"for":[7,42,126,148,179],"guiding":[8],"an":[9],"experimentation":[10,87],"process.":[11,88],"Instead":[12],"of":[13,56,77,129,137,175,204],"doing":[14],"all":[15],"possible":[16],"experiments":[17,30,57,178,205],"in":[18,64,102,119,170,198,201],"given":[20],"domain,":[21],"active":[22,47,96,112,131,187],"can":[24,98,168,190],"be":[25,107,191],"used":[26],"to":[27,37,52,59,69,73,84,95,121,207],"pick":[28],"the":[29,34,38,54,75,78,86,103,127,130,135,138,165,176,202],"that":[31,163,186],"will":[32],"add":[33],"most":[35],"knowledge":[36],"current":[39,79],"model.":[40],"Especially,":[41],"drug":[43,159],"discovery":[44],"and":[45,81,100,196],"development,":[46],"has":[49],"been":[50],"shown":[51],"reduce":[53],"number":[55,203],"needed":[58],"obtain":[60],"high-confidence":[61],"predictions.":[62,182,211],"However,":[63],"practice,":[65],"it":[66],"crucial":[68],"have":[70],"method":[72],"evaluate":[74],"quality":[76],"predictions":[80],"decide":[82],"when":[83],"stop":[85],"Only":[89],"by":[90],"applying":[91,164],"reliable":[92],"stopping":[93,146,166],"criteria":[94,147,167],"time":[99],"costs":[101],"experimental":[104,151],"process":[105],"actually":[106],"saved.":[108],"RESULTS:":[109],"We":[110,153,184],"compute":[111],"traces":[114],"on":[115,141,155],"simulated":[116,142,194],"drug-target":[117,210],"matrices":[118],"order":[120],"determine":[122],"regression":[124,139],"model":[125,140],"accuracy":[128,189],"learner.":[132],"By":[133],"analyzing":[134],"performance":[136],"data,":[143],"we":[144],"design":[145],"previously":[149,157],"unseen":[150],"matrices.":[152],"demonstrate":[154],"four":[156],"characterized":[158],"effect":[160],"data":[161,195],"sets":[162],"result":[169],"upto":[171],"40":[172],"%":[173],"savings":[174,200],"total":[177],"highly":[180],"accurate":[181,209],"CONCLUSIONS:":[183],"show":[185],"predicted":[192],"using":[193],"results":[197],"substantial":[199],"required":[206],"make":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}
