{"id":"https://openalex.org/W2079616103","doi":"https://doi.org/10.1186/s12859-015-0494-3","title":"Impact of missing data imputation methods on gene expression clustering and classification","display_name":"Impact of missing data imputation methods on gene expression clustering and classification","publication_year":2015,"publication_date":"2015-02-25","ids":{"openalex":"https://openalex.org/W2079616103","doi":"https://doi.org/10.1186/s12859-015-0494-3","mag":"2079616103","pmid":"https://pubmed.ncbi.nlm.nih.gov/25888091"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-015-0494-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-015-0494-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0494-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0494-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107521585","display_name":"Marcilio CP de Souto","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143826","display_name":"Institut National des Sciences Appliqu\u00e9es Centre Val de Loire","ror":"https://ror.org/03y0qc033","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210143826"]},{"id":"https://openalex.org/I4210129154","display_name":"Centre Val de Loire","ror":"https://ror.org/03ntmtb29","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210129154"]},{"id":"https://openalex.org/I12449238","display_name":"Universit\u00e9 d'Orl\u00e9ans","ror":"https://ror.org/014zrew76","country_code":"FR","type":"education","lineage":["https://openalex.org/I12449238"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Marcilio CP de Souto","raw_affiliation_strings":["Univ. Orleans, INSA Centre Val de Loire, LIFO EA 4022, Orleans, France. marcilio.desouto@univ-orleans.fr","Univ. Orl\u00e9ans, INSA Centre Val de Loire, Orl\u00e9ans, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Orleans, INSA Centre Val de Loire, LIFO EA 4022, Orleans, France. marcilio.desouto@univ-orleans.fr","institution_ids":[]},{"raw_affiliation_string":"Univ. Orl\u00e9ans, INSA Centre Val de Loire, Orl\u00e9ans, France","institution_ids":["https://openalex.org/I4210129154","https://openalex.org/I4210143826","https://openalex.org/I12449238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040915584","display_name":"Pablo Andretta Jaskowiak","orcid":"https://orcid.org/0000-0002-6377-3372"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pablo A Jaskowiak","raw_affiliation_strings":["Institute of Mathematics and Computer Sciences, University of S\u00e3o Paulo, S\u00e3o Carlos - SP, Brazil. pablo@icmc.usp.br","Institute of Mathematics and Computer Sciences, University of S\u00e3o Paulo, S\u00e3o Carlos - SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Mathematics and Computer Sciences, University of S\u00e3o Paulo, S\u00e3o Carlos - SP, Brazil. pablo@icmc.usp.br","institution_ids":[]},{"raw_affiliation_string":"Institute of Mathematics and Computer Sciences, University of S\u00e3o Paulo, S\u00e3o Carlos - SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057250270","display_name":"Ivan G. Costa","orcid":"https://orcid.org/0000-0003-2890-8697"},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["BR","DE"],"is_corresponding":false,"raw_author_name":"Ivan G Costa","raw_affiliation_strings":["Center of Informatics, Federal University of Pernambuco, Recife - PE, Brazil. ivan.costa@rwth-aachen.de","IZKF Computational Biology Research Group, Institute for Biomedical Engineering, RWTH Aachen University Medical School, Aachen, Germany. ivan.costa@rwth-aachen.de","IZKF Computational Biology Research Group, Institute for Biomedical Engineering, RWTH Aachen University Medical School, Aachen, Germany","Center of Informatics, Federal University of Pernambuco, Recife - PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Informatics, Federal University of Pernambuco, Recife - PE, Brazil. ivan.costa@rwth-aachen.de","institution_ids":[]},{"raw_affiliation_string":"IZKF Computational Biology Research Group, Institute for Biomedical Engineering, RWTH Aachen University Medical School, Aachen, Germany. ivan.costa@rwth-aachen.de","institution_ids":[]},{"raw_affiliation_string":"IZKF Computational Biology Research Group, Institute for Biomedical Engineering, RWTH Aachen University Medical School, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Center of Informatics, Federal University of Pernambuco, Recife - PE, Brazil","institution_ids":["https://openalex.org/I25112270"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5107521585"],"corresponding_institution_ids":["https://openalex.org/I12449238","https://openalex.org/I4210129154","https://openalex.org/I4210143826"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":4.216,"has_fulltext":true,"cited_by_count":112,"citation_normalized_percentile":{"value":0.9478322,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"16","issue":"1","first_page":"64","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8324000239372253,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8324000239372253,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.04450000077486038,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imputation","display_name":"Imputation (statistics)","score":0.8323198556900024},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.7498441338539124},{"id":"https://openalex.org/keywords/missing-data","display_name":"Missing data","score":0.6311521530151367},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.619606614112854},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.6092367768287659},{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.5001184940338135},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3889765739440918},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.34162840247154236},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3021630048751831},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18500521779060364}],"concepts":[{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.8323198556900024},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.7498441338539124},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.6311521530151367},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.619606614112854},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.6092367768287659},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.5001184940338135},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3889765739440918},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.34162840247154236},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3021630048751831},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18500521779060364}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12859-015-0494-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-015-0494-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0494-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25888091","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25888091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:HAL:hal-01121344v1","is_oa":false,"landing_page_url":"https://hal.science/hal-01121344","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 2015, 16, pp.64. &#x27E8;10.1186/s12859-015-0494-3&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:europepmc.org:3317372","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4350881","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:publications.rwth-aachen.de:479797","is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/record/479797","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC bioinformatics 16(1), 64 (2015). doi:10.1186/s12859-015-0494-3","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"doi:10.18154/rwth-2015-03299","is_oa":true,"landing_page_url":"https://doi.org/10.18154/rwth-2015-03299","pdf_url":null,"source":{"id":"https://openalex.org/S4306401033","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s12859-015-0494-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-015-0494-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0494-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.7099999785423279,"id":"https://metadata.un.org/sdg/10"}],"awards":[{"id":"https://openalex.org/G1615501055","display_name":null,"funder_award_id":"GSC 111","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1707149129","display_name":null,"funder_award_id":"2011/04247-5","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320324232","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2079616103.pdf","grobid_xml":"https://content.openalex.org/works/W2079616103.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1556472699","https://openalex.org/W1565746575","https://openalex.org/W1663973292","https://openalex.org/W1966701961","https://openalex.org/W1971784203","https://openalex.org/W2003984511","https://openalex.org/W2015439533","https://openalex.org/W2044758663","https://openalex.org/W2046143776","https://openalex.org/W2096863518","https://openalex.org/W2102168143","https://openalex.org/W2109204369","https://openalex.org/W2111104102","https://openalex.org/W2114933215","https://openalex.org/W2119047401","https://openalex.org/W2121536973","https://openalex.org/W2128215982","https://openalex.org/W2129065148","https://openalex.org/W2133990480","https://openalex.org/W2147246240","https://openalex.org/W2152491277","https://openalex.org/W2154952425","https://openalex.org/W2160264790","https://openalex.org/W2162210260","https://openalex.org/W2164672347","https://openalex.org/W2166111585","https://openalex.org/W2168470985","https://openalex.org/W2170584976","https://openalex.org/W2171118759","https://openalex.org/W2319660501","https://openalex.org/W2480680997","https://openalex.org/W4235169531","https://openalex.org/W4238235198","https://openalex.org/W6770641979"],"related_works":["https://openalex.org/W2181530120","https://openalex.org/W4211215373","https://openalex.org/W2024529227","https://openalex.org/W1574575415","https://openalex.org/W3144172081","https://openalex.org/W3179858851","https://openalex.org/W3028371478","https://openalex.org/W2081476516","https://openalex.org/W2581984549","https://openalex.org/W3123177881"],"abstract_inverted_index":{"BACKGROUND:":[0],"Several":[1],"missing":[2,125,195],"value":[3,76,126],"imputation":[4,37,127,161,175],"methods":[5,128,162,176,190],"for":[6,89,108,150],"gene":[7,142],"expression":[8,75,143],"data":[9],"have":[10,22,178],"been":[11,23],"proposed":[12],"in":[13,80,101,136,154,213],"the":[14,17,35,48,51,57,68,71,74,91,94,98,102,120,137,151,164,167,174,183,194,200],"literature.":[15],"In":[16],"past":[18],"few":[19],"years,":[20],"researchers":[21],"putting":[24],"a":[25,116,147,179],"great":[26],"deal":[27],"of":[28,34,50,70,73,93,119,122,139,166],"effort":[29],"into":[30],"presenting":[31],"systematic":[32],"evaluations":[33],"different":[36,160],"algorithms.":[38],"Initially,":[39],"most":[40],"algorithms":[41],"were":[42],"assessed":[43],"with":[44],"an":[45],"emphasis":[46],"on":[47,129,182],"accuracy":[49],"imputation,":[52],"using":[53],"metrics":[54],"such":[55,191],"as":[56,84,192,204,206],"root":[58],"mean":[59,198],"squared":[60],"error.":[61],"However,":[62],"it":[63],"has":[64],"become":[65],"clear":[66],"that":[67,173],"success":[69],"estimation":[72],"should":[77],"be":[78],"evaluated":[79,177],"more":[81,207],"practical":[82],"terms":[83],"well.":[85],"One":[86],"can":[87],"consider,":[88],"example,":[90],"ability":[92],"method":[95],"to":[96,157],"preserve":[97],"significant":[99],"genes":[100],"dataset,":[103],"or":[104,199],"its":[105],"discriminative/predictive":[106],"power":[107],"classification/clustering":[109],"purposes.":[110],"RESULTS":[111],"AND":[112],"CONCLUSIONS:":[113],"We":[114,145],"performed":[115,203],"broad":[117],"analysis":[118],"impact":[121,181],"five":[123],"well-known":[124],"three":[130],"clustering":[131,187],"and":[132,185],"four":[133],"classification":[134,184],"methods,":[135],"context":[138],"12":[140],"cancer":[141],"datasets.":[144],"employed":[146],"statistical":[148],"framework,":[149],"first":[152],"time":[153],"this":[155,214],"field,":[156],"assess":[158],"whether":[159],"improve":[163],"performance":[165],"clustering/classification":[168],"methods.":[169],"Our":[170],"results":[171],"suggest":[172],"minor":[180],"downstream":[186],"analyses.":[188],"Simple":[189],"replacing":[193],"values":[196,202],"by":[197],"median":[201],"well":[205],"complex":[208],"strategies.":[209],"The":[210],"datasets":[211],"analyzed":[212],"study":[215],"are":[216],"available":[217],"at":[218],"http://costalab.org/Imputation/":[219],".":[220]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3}],"updated_date":"2026-05-12T08:28:47.272897","created_date":"2016-06-24T00:00:00"}
