{"id":"https://openalex.org/W2066479168","doi":"https://doi.org/10.1186/s12859-015-0452-0","title":"Data-intensive analysis of HIV mutations","display_name":"Data-intensive analysis of HIV mutations","publication_year":2015,"publication_date":"2015-02-04","ids":{"openalex":"https://openalex.org/W2066479168","doi":"https://doi.org/10.1186/s12859-015-0452-0","mag":"2066479168","pmid":"https://pubmed.ncbi.nlm.nih.gov/25652056"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-015-0452-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-015-0452-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0452-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0452-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025474515","display_name":"Mina Cintho Ozahata","orcid":"https://orcid.org/0000-0002-1272-2380"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Mina Cintho Ozahata","raw_affiliation_strings":["Department of Computer Science - DCC, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010, CEP 05508-090 S\u00e3o Paulo, SP, Brazil. mina.cintho@usp.br","Department of Computer Science - DCC, University of S\u00e3o Paulo, 1010, CEP 05508-090 S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science - DCC, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010, CEP 05508-090 S\u00e3o Paulo, SP, Brazil. mina.cintho@usp.br","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Computer Science - DCC, University of S\u00e3o Paulo, 1010, CEP 05508-090 S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071061513","display_name":"\u00c9ster Cerdeira Sabino","orcid":"https://orcid.org/0000-0003-2623-5126"},"institutions":[{"id":"https://openalex.org/I34391226","display_name":"Companhia Energ\u00e9tica de S\u00e3o Paulo","ror":"https://ror.org/05pmc2b98","country_code":"BR","type":"government","lineage":["https://openalex.org/I34391226"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ester Cerdeira Sabino","raw_affiliation_strings":["Sangue Foundation, Health State Secretary, Department of Molecular Biology, Serology Division, Av Dr En\u00e9as de Carvalho Aguiar, Cerqueira Cesar, CEP 05403-000 S\u00e3o Paulo, 155, SP, Brazil. sabinoec@gmail.com","Sangue Foundation, Health State Secretary, Department of Molecular Biology, Serology Division, Cerqueira Cesar, CEP 05403-000 S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sangue Foundation, Health State Secretary, Department of Molecular Biology, Serology Division, Av Dr En\u00e9as de Carvalho Aguiar, Cerqueira Cesar, CEP 05403-000 S\u00e3o Paulo, 155, SP, Brazil. sabinoec@gmail.com","institution_ids":["https://openalex.org/I34391226"]},{"raw_affiliation_string":"Sangue Foundation, Health State Secretary, Department of Molecular Biology, Serology Division, Cerqueira Cesar, CEP 05403-000 S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079615499","display_name":"Ricardo Sobhie Diaz","orcid":"https://orcid.org/0000-0002-8395-7304"},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ricardo Sobhie Diaz","raw_affiliation_strings":["Federal University of S\u00e3o Paulo, Rua Pedro de Toledo, S\u00e3o Paulo, 669, CEP 04039-032, SP, Brazil. rsdiaz@catg.com.br","Federal University of S\u00e3o Paulo, Rua Pedro de Toledo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of S\u00e3o Paulo, Rua Pedro de Toledo, S\u00e3o Paulo, 669, CEP 04039-032, SP, Brazil. rsdiaz@catg.com.br","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Federal University of S\u00e3o Paulo, Rua Pedro de Toledo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090955523","display_name":"Roberto M. C\u00e9sar","orcid":"https://orcid.org/0000-0003-2701-4288"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I34391226","display_name":"Companhia Energ\u00e9tica de S\u00e3o Paulo","ror":"https://ror.org/05pmc2b98","country_code":"BR","type":"government","lineage":["https://openalex.org/I34391226"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Roberto M Cesar-","raw_affiliation_strings":["Department of Computer Science - DCC, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010, CEP 05508-090 S\u00e3o Paulo, SP, Brazil. cesar@ime.usp.br","Department of Computer Science - DCC, University of S\u00e3o Paulo, 1010, CEP 05508-090 S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science - DCC, University of S\u00e3o Paulo, Rua do Mat\u00e3o, 1010, CEP 05508-090 S\u00e3o Paulo, SP, Brazil. cesar@ime.usp.br","institution_ids":["https://openalex.org/I34391226"]},{"raw_affiliation_string":"Department of Computer Science - DCC, University of S\u00e3o Paulo, 1010, CEP 05508-090 S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008405795","display_name":"Jo\u00e3o Eduardo Ferreira","orcid":"https://orcid.org/0000-0001-9607-2014"},"institutions":[{"id":"https://openalex.org/I4210122617","display_name":"Health Foundation","ror":"https://ror.org/02bzj4420","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210122617"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Eduardo Ferreira","raw_affiliation_strings":["Sangue Foundation, Health State Secretary, Department of Molecular Biology, Serology Division, Av Dr En\u00e9as de Carvalho Aguiar, Cerqueira Cesar, CEP 05403-000 S\u00e3o Paulo, 155, SP, Brazil. jef@ime.usp.br","Sangue Foundation, Health State Secretary, Department of Molecular Biology, Serology Division, Cerqueira Cesar, CEP 05403-000 S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sangue Foundation, Health State Secretary, Department of Molecular Biology, Serology Division, Av Dr En\u00e9as de Carvalho Aguiar, Cerqueira Cesar, CEP 05403-000 S\u00e3o Paulo, 155, SP, Brazil. jef@ime.usp.br","institution_ids":["https://openalex.org/I4210122617"]},{"raw_affiliation_string":"Sangue Foundation, Health State Secretary, Department of Molecular Biology, Serology Division, Cerqueira Cesar, CEP 05403-000 S\u00e3o Paulo, Brazil","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025474515"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.1564,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.50804477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"16","issue":"1","first_page":"35","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.1818999946117401,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.1818999946117401,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.14239999651908875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14065","display_name":"Biological Research and Disease Studies","score":0.09449999779462814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reverse-transcriptase","display_name":"Reverse transcriptase","score":0.5523595809936523},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5423499345779419},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5216569900512695},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5209149718284607},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.5160691142082214},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.49055641889572144},{"id":"https://openalex.org/keywords/bitmap","display_name":"Bitmap","score":0.45602482557296753},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4453170597553253},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.39548206329345703},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.31930047273635864},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2645108699798584},{"id":"https://openalex.org/keywords/polymerase-chain-reaction","display_name":"Polymerase chain reaction","score":0.1464070975780487},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.13543039560317993}],"concepts":[{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.5523595809936523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5423499345779419},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5216569900512695},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5209149718284607},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5160691142082214},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49055641889572144},{"id":"https://openalex.org/C3115412","wikidata":"https://www.wikidata.org/wiki/Q1194708","display_name":"Bitmap","level":2,"score":0.45602482557296753},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4453170597553253},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39548206329345703},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.31930047273635864},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2645108699798584},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.1464070975780487},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13543039560317993}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12859-015-0452-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-015-0452-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0452-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25652056","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25652056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:www.producao.usp.br:BDPI/48418","is_oa":false,"landing_page_url":"http://doi.org/10.1186/s12859-015-0452-0","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da USP","raw_type":"publishedVersion"},{"id":"pmh:oai:www.producao.usp.br:BDPI/51124","is_oa":false,"landing_page_url":"http://www.producao.usp.br/handle/BDPI/51124","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da USP","raw_type":"publishedVersion"},{"id":"pmh:002677789","is_oa":true,"landing_page_url":"http://www.dx.doi.org/10.1186/s12859-015-0452-0","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da USP (Biblioteca Digital da Produ\u00e7\u00e3o Intelectual)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:americanae.aecid.es:3200099","is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/38751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:4344997","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4344997","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-015-0452-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-015-0452-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-015-0452-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.7099999785423279,"display_name":"Reduced inequalities"}],"awards":[{"id":"https://openalex.org/G4965097422","display_name":"Models and methods of e-Science for life and agricultural sciences","funder_award_id":"11/50761-2","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2066479168.pdf","grobid_xml":"https://content.openalex.org/works/W2066479168.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W5383056","https://openalex.org/W49232095","https://openalex.org/W192016177","https://openalex.org/W1533957288","https://openalex.org/W1548031241","https://openalex.org/W1981651833","https://openalex.org/W1992419399","https://openalex.org/W1994344457","https://openalex.org/W2004800530","https://openalex.org/W2011430131","https://openalex.org/W2021791924","https://openalex.org/W2064309578","https://openalex.org/W2065248159","https://openalex.org/W2069388608","https://openalex.org/W2079361215","https://openalex.org/W2087182348","https://openalex.org/W2087478505","https://openalex.org/W2093081715","https://openalex.org/W2097126893","https://openalex.org/W2102218736","https://openalex.org/W2103855842","https://openalex.org/W2110300768","https://openalex.org/W2120338717","https://openalex.org/W2125038904","https://openalex.org/W2133149215","https://openalex.org/W2136431383","https://openalex.org/W2143666977","https://openalex.org/W2150215096","https://openalex.org/W2151238491","https://openalex.org/W2155676461","https://openalex.org/W2158238436","https://openalex.org/W2160877552","https://openalex.org/W2161771770","https://openalex.org/W2164032557","https://openalex.org/W2164169368","https://openalex.org/W2167892704","https://openalex.org/W2170218446","https://openalex.org/W2170987946","https://openalex.org/W2171236519","https://openalex.org/W2400580124","https://openalex.org/W2475645889","https://openalex.org/W4297914773"],"related_works":["https://openalex.org/W2350456333","https://openalex.org/W2101993108","https://openalex.org/W2356608866","https://openalex.org/W2355840328","https://openalex.org/W1975966184","https://openalex.org/W2364393392","https://openalex.org/W2137246017","https://openalex.org/W2377096008","https://openalex.org/W3126935378","https://openalex.org/W2809136181"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1],"this":[2],"study,":[3],"clustering":[4],"was":[5,74],"performed":[6],"using":[7,76,144],"a":[8,133,140],"bitmap":[9],"representation":[10,73],"of":[11,23,32,51,105,112,139,150],"HIV":[12,24,41],"reverse":[13,48],"transcriptase":[14,49],"and":[15,37,47,55,98,122],"protease":[16,46],"sequences,":[17],"to":[18,126,147],"produce":[19],"an":[20,62,77,127],"unsupervised":[21],"classification":[22,27],"sequences.":[25],"The":[26],"will":[28],"aid":[29],"our":[30],"understanding":[31],"the":[33,45,52,85,88,91,95,99,113,137],"interactions":[34],"between":[35],"mutations":[36,59,106,118,151],"drug":[38],"resistance.":[39],"10,229":[40],"genomic":[42],"sequences":[43,93],"from":[44,94],"regions":[50],"pol":[53],"gene":[54],"antiretroviral":[56],"resistant":[57],"related":[58,125],"represented":[60,90,101],"in":[61,87,107],"82-dimensional":[63],"binary":[64,145],"vector":[65],"space":[66],"were":[67],"analyzed.":[68],"RESULTS:":[69],"A":[70],"new":[71],"cluster":[72,158],"proposed":[75],"image":[78,89],"inspired":[79],"by":[80,157],"microarray":[81],"data,":[82],"such":[83],"that":[84,116,152],"rows":[86],"protein":[92,109],"genotype":[96],"data":[97,146],"columns":[100],"presence":[102],"or":[103],"absence":[104],"each":[108],"position.The":[110],"visualization":[111],"clusters":[114,149],"showed":[115],"some":[117],"frequently":[119],"occur":[120],"together":[121],"are":[123],"probably":[124],"epistatic":[128],"phenomenon.":[129],"CONCLUSION:":[130],"We":[131],"described":[132],"methodology":[134],"based":[135],"on":[136],"application":[138],"pattern":[141],"recognition":[142],"algorithm":[143],"suggest":[148],"can":[153],"easily":[154],"be":[155],"discriminated":[156],"viewing":[159],"schemes.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}