{"id":"https://openalex.org/W1969894243","doi":"https://doi.org/10.1186/s12859-014-0439-2","title":"Nonparametric Bayesian clustering to detect bipolar methylated genomic loci","display_name":"Nonparametric Bayesian clustering to detect bipolar methylated genomic loci","publication_year":2015,"publication_date":"2015-01-15","ids":{"openalex":"https://openalex.org/W1969894243","doi":"https://doi.org/10.1186/s12859-014-0439-2","mag":"1969894243","pmid":"https://pubmed.ncbi.nlm.nih.gov/25592753"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-014-0439-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-014-0439-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-014-0439-2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-014-0439-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055039090","display_name":"Xiaowei Wu","orcid":"https://orcid.org/0000-0001-9916-3624"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaowei Wu","raw_affiliation_strings":["Department of Statistics, Virginia Tech, 250 Drillfield Drive, Blacksburg, 24061, VA, USA. xwwu@vt.edu","Department of Statistics, Virginia Tech, Blacksburg, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Virginia Tech, 250 Drillfield Drive, Blacksburg, 24061, VA, USA. xwwu@vt.edu","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Statistics, Virginia Tech, Blacksburg, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115604209","display_name":"Ming-an Sun","orcid":"https://orcid.org/0000-0002-4661-3027"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming-an Sun","raw_affiliation_strings":["Virginia Bioinformatics Institute, Virginia Tech, 1015 Life Science Circle, Blacksburg, 24061, VA, USA. masun@vt.edu","Virginia Bioinformatics Institute, Virginia Tech., Blacksburg, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Bioinformatics Institute, Virginia Tech, 1015 Life Science Circle, Blacksburg, 24061, VA, USA. masun@vt.edu","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Virginia Bioinformatics Institute, Virginia Tech., Blacksburg, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023737066","display_name":"Hongxiao Zhu","orcid":"https://orcid.org/0000-0001-5674-6483"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongxiao Zhu","raw_affiliation_strings":["Department of Statistics, Virginia Tech, 250 Drillfield Drive, Blacksburg, 24061, VA, USA. hongxiao@vt.edu","Department of Statistics, Virginia Tech, Blacksburg, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Virginia Tech, 250 Drillfield Drive, Blacksburg, 24061, VA, USA. hongxiao@vt.edu","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Statistics, Virginia Tech, Blacksburg, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070711045","display_name":"Hehuang Xie","orcid":"https://orcid.org/0000-0001-5739-1653"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hehuang Xie","raw_affiliation_strings":["Department of Biological Sciences, Virginia Tech, 1405 Perry Street, Blacksburg, 24061, VA, USA. davidxie@vt.edu","Virginia Bioinformatics Institute, Virginia Tech, 1015 Life Science Circle, Blacksburg, 24061, VA, USA. davidxie@vt.edu","Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, USA","Department of Biological Sciences, Virginia Tech, Blacksburg, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Virginia Tech, 1405 Perry Street, Blacksburg, 24061, VA, USA. davidxie@vt.edu","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Virginia Bioinformatics Institute, Virginia Tech, 1015 Life Science Circle, Blacksburg, 24061, VA, USA. davidxie@vt.edu","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, USA","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Biological Sciences, Virginia Tech, Blacksburg, USA","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070711045"],"corresponding_institution_ids":["https://openalex.org/I859038795"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1487,"currency":"EUR","value_usd":1603},"fwci":0.5912,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.68089554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"16","issue":"1","first_page":"11","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8953999876976013,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8953999876976013,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.706540584564209},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7060897350311279},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.6445410847663879},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.5889627933502197},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5839607119560242},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5556029081344604},{"id":"https://openalex.org/keywords/bisulfite-sequencing","display_name":"Bisulfite sequencing","score":0.529839038848877},{"id":"https://openalex.org/keywords/methylated-dna-immunoprecipitation","display_name":"Methylated DNA immunoprecipitation","score":0.4748166799545288},{"id":"https://openalex.org/keywords/illumina-methylation-assay","display_name":"Illumina Methylation Assay","score":0.47345229983329773},{"id":"https://openalex.org/keywords/epigenomics","display_name":"Epigenomics","score":0.42149555683135986},{"id":"https://openalex.org/keywords/differentially-methylated-regions","display_name":"Differentially methylated regions","score":0.41087770462036133},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.34050875902175903},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1658586859703064}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.706540584564209},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7060897350311279},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6445410847663879},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5889627933502197},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5839607119560242},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5556029081344604},{"id":"https://openalex.org/C189235521","wikidata":"https://www.wikidata.org/wiki/Q4087270","display_name":"Bisulfite sequencing","level":5,"score":0.529839038848877},{"id":"https://openalex.org/C116114238","wikidata":"https://www.wikidata.org/wiki/Q6823960","display_name":"Methylated DNA immunoprecipitation","level":5,"score":0.4748166799545288},{"id":"https://openalex.org/C136953436","wikidata":"https://www.wikidata.org/wiki/Q6000286","display_name":"Illumina Methylation Assay","level":5,"score":0.47345229983329773},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.42149555683135986},{"id":"https://openalex.org/C154253233","wikidata":"https://www.wikidata.org/wiki/Q14862240","display_name":"Differentially methylated regions","level":5,"score":0.41087770462036133},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34050875902175903},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1658586859703064}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-014-0439-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-014-0439-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-014-0439-2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25592753","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25592753","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:3282268","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4302125","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/55021","is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/55021","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article - Refereed"},{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/74908","is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/74908","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article - Refereed"}],"best_oa_location":{"id":"doi:10.1186/s12859-014-0439-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-014-0439-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-014-0439-2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1969894243.pdf","grobid_xml":"https://content.openalex.org/works/W1969894243.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1564090547","https://openalex.org/W1666941160","https://openalex.org/W1971284773","https://openalex.org/W1975364471","https://openalex.org/W1976787939","https://openalex.org/W1979273476","https://openalex.org/W1979892065","https://openalex.org/W1981978912","https://openalex.org/W1990021188","https://openalex.org/W1991959431","https://openalex.org/W1993846148","https://openalex.org/W1994583863","https://openalex.org/W1997366055","https://openalex.org/W2004729058","https://openalex.org/W2010123584","https://openalex.org/W2011593699","https://openalex.org/W2019172365","https://openalex.org/W2030181113","https://openalex.org/W2045960652","https://openalex.org/W2051568429","https://openalex.org/W2053856108","https://openalex.org/W2060967135","https://openalex.org/W2067130606","https://openalex.org/W2076792376","https://openalex.org/W2096600620","https://openalex.org/W2106446870","https://openalex.org/W2106889224","https://openalex.org/W2107724814","https://openalex.org/W2109281377","https://openalex.org/W2113611401","https://openalex.org/W2115637687","https://openalex.org/W2121417064","https://openalex.org/W2127408708","https://openalex.org/W2131374955","https://openalex.org/W2132522861","https://openalex.org/W2133208588","https://openalex.org/W2141737525","https://openalex.org/W2149784730","https://openalex.org/W2150847421","https://openalex.org/W2152642144","https://openalex.org/W2158217645","https://openalex.org/W2164214190","https://openalex.org/W2168810759","https://openalex.org/W2169556367","https://openalex.org/W2596405656"],"related_works":["https://openalex.org/W2124748744","https://openalex.org/W2589930442","https://openalex.org/W2745907774","https://openalex.org/W4381851513","https://openalex.org/W1858190415","https://openalex.org/W2758690282","https://openalex.org/W252553679","https://openalex.org/W2094827321","https://openalex.org/W3038469736","https://openalex.org/W2099688182"],"abstract_inverted_index":{"BACKGROUND:":[0],"With":[1,162],"recent":[2],"development":[3],"in":[4,42,95,109,187],"sequencing":[5,21,97],"technology,":[6],"a":[7,85,188],"large":[8],"number":[9],"of":[10,19,25,111,180],"genome-wide":[11],"DNA":[12,26,43,151],"methylation":[13,27,37,47,51,55,67,71,152],"studies":[14,100],"have":[15,83],"generated":[16],"massive":[17],"amounts":[18],"bisulfite":[20,96],"data.":[22,98],"The":[23,129],"analysis":[24],"patterns":[28,38,48,58],"helps":[29],"researchers":[30],"understand":[31],"epigenetic":[32,155,185],"regulatory":[33],"mechanisms.":[34],"Highly":[35],"variable":[36],"reflect":[39],"stochastic":[40],"fluctuations":[41],"methylation,":[44],"whereas":[45],"well-structured":[46],"imply":[49],"deterministic":[50],"events.":[52],"Among":[53],"these":[54],"patterns,":[56],"bipolar":[57,91,130],"are":[59,134],"important":[60],"as":[61],"they":[62],"may":[63],"originate":[64],"from":[65,122],"allele-specific":[66,163],"(ASM)":[68],"or":[69,160,167],"cell-specific":[70,181],"(CSM).":[72],"RESULTS:":[73],"Utilizing":[74],"nonparametric":[75],"Bayesian":[76],"clustering":[77],"followed":[78],"by":[79,144,158],"hypothesis":[80],"testing,":[81],"we":[82],"developed":[84],"novel":[86],"statistical":[87],"approach":[88,174],"to":[89,119],"identify":[90],"methylated":[92,131,141],"genomic":[93],"regions":[94,142],"Simulation":[99],"demonstrate":[101],"that":[102],"the":[103,117,139,178],"proposed":[104,173],"method":[105,118],"achieves":[106],"good":[107],"performance":[108],"terms":[110],"specificity":[112],"and":[113,125],"sensitivity.":[114],"We":[115],"used":[116],"analyze":[120],"data":[121],"mouse":[123],"brain":[124],"human":[126],"blood":[127],"methylomes.":[128],"segments":[132],"detected":[133],"found":[135],"highly":[136],"consistent":[137],"with":[138],"differentially":[140],"identified":[143],"using":[145],"purified":[146],"cell":[147,190],"subsets.":[148],"CONCLUSIONS:":[149],"Bipolar":[150],"often":[153],"indicates":[154],"heterogeneity":[156],"caused":[157],"ASM":[159],"CSM.":[161],"events":[164],"filtered":[165],"out":[166],"appropriately":[168],"taken":[169],"into":[170],"account,":[171],"our":[172],"sheds":[175],"light":[176],"on":[177],"identification":[179],"genes/pathways":[182],"under":[183],"strong":[184],"control":[186],"heterogeneous":[189],"population.":[191]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}
