{"id":"https://openalex.org/W2027057850","doi":"https://doi.org/10.1186/s12859-014-0402-2","title":"Improving statistical inference on pathogen densities estimated by quantitative molecular methods: malaria gametocytaemia as a case study","display_name":"Improving statistical inference on pathogen densities estimated by quantitative molecular methods: malaria gametocytaemia as a case study","publication_year":2015,"publication_date":"2015-01-15","ids":{"openalex":"https://openalex.org/W2027057850","doi":"https://doi.org/10.1186/s12859-014-0402-2","mag":"2027057850","pmid":"https://pubmed.ncbi.nlm.nih.gov/25592782"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-014-0402-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-014-0402-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-014-0402-2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-014-0402-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031563853","display_name":"Martin Walker","orcid":"https://orcid.org/0000-0001-8714-5365"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin Walker","raw_affiliation_strings":["Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St Mary's campus), Imperial College London, Norfolk Place, London, W2 1PG, UK. m.walker06@imperial.ac.uk","Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St. Mary\u2019s Campus), Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St Mary's campus), Imperial College London, Norfolk Place, London, W2 1PG, UK. m.walker06@imperial.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St. Mary\u2019s Campus), Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063396041","display_name":"Mar\u0131\u0301a-Gloria Bas\u00e1\u00f1ez","orcid":"https://orcid.org/0000-0001-5031-3361"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mar\u00eda-Gloria Bas\u00e1\u00f1ez","raw_affiliation_strings":["Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St Mary's campus), Imperial College London, Norfolk Place, London, W2 1PG, UK. m.basanez@imperial.ac.uk","Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St. Mary\u2019s Campus), Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St Mary's campus), Imperial College London, Norfolk Place, London, W2 1PG, UK. m.basanez@imperial.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St. Mary\u2019s Campus), Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035141362","display_name":"Andr\u00e9 Lin Ou\u00e9draogo","orcid":"https://orcid.org/0000-0001-5880-5512"},"institutions":[{"id":"https://openalex.org/I4210143827","display_name":"Centre National de Recherche et de Formation sur le Paludisme","ror":"https://ror.org/03y3jby41","country_code":"BF","type":"facility","lineage":["https://openalex.org/I4210143827"]}],"countries":["BF"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Lin Ou\u00e9draogo","raw_affiliation_strings":["Centre National de Recherche et de Formation sur le Paludisme, BP 2208, Ouagadougou, 01, Burkina Faso. andrelin.cnrfp@fasonet.bf","Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de Recherche et de Formation sur le Paludisme, BP 2208, Ouagadougou, 01, Burkina Faso. andrelin.cnrfp@fasonet.bf","institution_ids":["https://openalex.org/I4210143827"]},{"raw_affiliation_string":"Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso","institution_ids":["https://openalex.org/I4210143827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084292024","display_name":"Cornelus C. Hermsen","orcid":null},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Cornelus Hermsen","raw_affiliation_strings":["Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, PO Box 9101, 6500 HB, Nijmegen, Netherlands. R.Hermsen@ncmls.ru.nl","Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, PO Box 9101, 6500 HB, Nijmegen, Netherlands. R.Hermsen@ncmls.ru.nl","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036396443","display_name":"Teun Bousema","orcid":"https://orcid.org/0000-0003-2666-094X"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Teun Bousema","raw_affiliation_strings":["Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK. Teun.Bousema@lshtm.ac.uk","Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, PO Box 9101, 6500 HB, Nijmegen, Netherlands. Teun.Bousema@lshtm.ac.uk","Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK","Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK. Teun.Bousema@lshtm.ac.uk","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, PO Box 9101, 6500 HB, Nijmegen, Netherlands. Teun.Bousema@lshtm.ac.uk","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007197867","display_name":"Thomas S. Churcher","orcid":"https://orcid.org/0000-0002-8442-0525"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas S Churcher","raw_affiliation_strings":["MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St Mary's campus), Imperial College London, Norfolk Place, London, W2 1PG, UK. thomas.churcher@imperial.ac.uk","MRC Centre for Outbreak Analysis and Modelling. Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St Mary\u2019s campus), Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St Mary's campus), Imperial College London, Norfolk Place, London, W2 1PG, UK. thomas.churcher@imperial.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC Centre for Outbreak Analysis and Modelling. Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St Mary\u2019s campus), Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":4.594,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.94424575,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"16","issue":"1","first_page":"5","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9679999947547913,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9679999947547913,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.552758514881134},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.5263972282409668},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5239349007606506},{"id":"https://openalex.org/keywords/nasba","display_name":"NASBA","score":0.5097865462303162},{"id":"https://openalex.org/keywords/calibration","display_name":"Calibration","score":0.5044108629226685},{"id":"https://openalex.org/keywords/bayes-theorem","display_name":"Bayes' theorem","score":0.4875604510307312},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.4659838080406189},{"id":"https://openalex.org/keywords/bayesian-inference","display_name":"Bayesian inference","score":0.42049407958984375},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.41055387258529663},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3957182765007019},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.33449113368988037},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3202912211418152},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.27265334129333496},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.20777976512908936},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.16953971982002258},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.0920301079750061}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.552758514881134},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.5263972282409668},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5239349007606506},{"id":"https://openalex.org/C2779695955","wikidata":"https://www.wikidata.org/wiki/Q3869370","display_name":"NASBA","level":4,"score":0.5097865462303162},{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.5044108629226685},{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.4875604510307312},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4659838080406189},{"id":"https://openalex.org/C160234255","wikidata":"https://www.wikidata.org/wiki/Q812535","display_name":"Bayesian inference","level":3,"score":0.42049407958984375},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.41055387258529663},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3957182765007019},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.33449113368988037},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3202912211418152},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27265334129333496},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.20777976512908936},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16953971982002258},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0920301079750061},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C84148353","wikidata":"https://www.wikidata.org/wiki/Q863908","display_name":"Nucleic acid sequence","level":3,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016054","descriptor_name":"DNA, Protozoan","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016054","descriptor_name":"DNA, Protozoan","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016054","descriptor_name":"DNA, Protozoan","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016054","descriptor_name":"DNA, Protozoan","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D021161","descriptor_name":"Self-Sustained Sequence Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021161","descriptor_name":"Self-Sustained Sequence Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021161","descriptor_name":"Self-Sustained Sequence Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021161","descriptor_name":"Self-Sustained Sequence Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12859-014-0402-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-014-0402-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-014-0402-2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25592782","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25592782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:researchonline.lshtm.ac.uk:2124326","is_oa":false,"landing_page_url":"https://researchonline.lshtm.ac.uk/view/creators/iimmtbou.html>;","pdf_url":null,"source":{"id":"https://openalex.org/S4306402527","display_name":"LSHTM Research Online (London School of Hygiene and Tropical Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210089966","host_organization_name":"London School of Hygiene & Tropical Medicine","host_organization_lineage":["https://openalex.org/I4210089966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:researchonline.rvc.ac.uk:11594","is_oa":true,"landing_page_url":"https://researchonline.rvc.ac.uk/id/eprint/11594/1/11594.pdf","pdf_url":"https://researchonline.rvc.ac.uk/id/eprint/11594/1/11594.pdf","source":{"id":"https://openalex.org/S4306402069","display_name":"RVC Research Online (Royal Veterinary College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I133836048","host_organization_name":"Royal Veterinary College","host_organization_lineage":["https://openalex.org/I133836048"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/153121","is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/153121","pdf_url":"http://hdl.handle.net/2066/153121","source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 16","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:3282385","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4307378","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/153121","is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/153121","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1186/s12859-014-0402-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-014-0402-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-014-0402-2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1313656976","display_name":null,"funder_award_id":"MR/K010174/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2101076898","display_name":"London School of Hygiene and Tropical Medicine - to maximize and sustain the impact of existing malaria control tools and strategies over the short term; over the long term, develop and introduce ...","funder_award_id":"OPP1034789","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G5499849923","display_name":null,"funder_award_id":"OPP1034789","funder_id":"https://openalex.org/F4320338299","funder_display_name":"Armed Forces Institute of Regenerative Medicine"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320338299","display_name":"Armed Forces Institute of Regenerative Medicine","ror":"https://ror.org/0447fe631"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2027057850.pdf","grobid_xml":"https://content.openalex.org/works/W2027057850.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W68436435","https://openalex.org/W1517555081","https://openalex.org/W1565240145","https://openalex.org/W1913431666","https://openalex.org/W1969565647","https://openalex.org/W1987680111","https://openalex.org/W1988223348","https://openalex.org/W1988452752","https://openalex.org/W1995480192","https://openalex.org/W2005881305","https://openalex.org/W2008183439","https://openalex.org/W2008662004","https://openalex.org/W2030003382","https://openalex.org/W2037765904","https://openalex.org/W2045656233","https://openalex.org/W2054354571","https://openalex.org/W2057392561","https://openalex.org/W2057518951","https://openalex.org/W2057765075","https://openalex.org/W2058665460","https://openalex.org/W2070649137","https://openalex.org/W2073857965","https://openalex.org/W2093947668","https://openalex.org/W2098920479","https://openalex.org/W2099114511","https://openalex.org/W2102326013","https://openalex.org/W2107932739","https://openalex.org/W2111166381","https://openalex.org/W2112253754","https://openalex.org/W2114570899","https://openalex.org/W2118219703","https://openalex.org/W2121562097","https://openalex.org/W2124263521","https://openalex.org/W2124312641","https://openalex.org/W2127014145","https://openalex.org/W2127848106","https://openalex.org/W2129938023","https://openalex.org/W2131240051","https://openalex.org/W2134012062","https://openalex.org/W2134343377","https://openalex.org/W2136309995","https://openalex.org/W2143146123","https://openalex.org/W2145320240","https://openalex.org/W2149251475","https://openalex.org/W2156537900","https://openalex.org/W2165178639","https://openalex.org/W2168420558","https://openalex.org/W2322163093","https://openalex.org/W2507058334","https://openalex.org/W2527882685","https://openalex.org/W2898950502","https://openalex.org/W2953607564","https://openalex.org/W3137970571","https://openalex.org/W4232383088","https://openalex.org/W4247425722","https://openalex.org/W6634015478","https://openalex.org/W6662203318"],"related_works":["https://openalex.org/W2117545158","https://openalex.org/W1919985504","https://openalex.org/W3013612038","https://openalex.org/W2407375987","https://openalex.org/W2032094637","https://openalex.org/W2950975704","https://openalex.org/W2010643158","https://openalex.org/W2505726097","https://openalex.org/W2106867672","https://openalex.org/W4310268968"],"abstract_inverted_index":{"BACKGROUND:":[0],"Quantitative":[1],"molecular":[2],"methods":[3,39],"(QMMs)":[4],"such":[5],"as":[6,43],"quantitative":[7,17,198],"real-time":[8],"polymerase":[9],"chain":[10],"reaction":[11],"(q-PCR),":[12],"reverse-transcriptase":[13],"PCR":[14],"(qRT-PCR)":[15],"and":[16,35,71,96,113,133,158,172,190,199,228,232],"nucleic":[18],"acid":[19],"sequence-based":[20],"amplification":[21],"(QT-NASBA)":[22],"are":[23,40,51,108,168],"increasingly":[24],"used":[25],"to":[26,142,223],"estimate":[27],"pathogen":[28,66,92,145,162,218],"density":[29,163],"in":[30,211],"a":[31,55,110,114,236],"variety":[32,238],"of":[33,47,65,82,91,125,137,161,197,214,217,230,239],"clinical":[34,231],"epidemiological":[36,233],"contexts.":[37],"These":[38],"often":[41],"classified":[42],"semi-quantitative,":[44],"yet":[45],"estimates":[46,160,216],"reliability":[48,63,90,189],"or":[49],"sensitivity":[50],"seldom":[52],"reported.":[53],"Here,":[54],"statistical":[56,105,123,206],"framework":[57],"is":[58,78],"developed":[59],"for":[60,122,151,235],"assessing":[61],"the":[62,72,97,212,221,226],"(uncertainty)":[64],"densities":[67],"estimated":[68,101],"using":[69],"QMMs":[70,157],"associated":[73],"diagnostic":[74,99,175,200],"sensitivity.":[75,176],"The":[76,89,119,177],"method":[77,112],"illustrated":[79],"with":[80,144],"quantification":[81],"Plasmodium":[83],"falciparum":[84],"gametocytaemia":[85],"by":[86,102],"QT-NASBA.":[87],"RESULTS:":[88],"(e.g.":[93],"gametocyte)":[94],"densities,":[95],"accompanying":[98],"sensitivity,":[100],"two":[103],"contrasting":[104],"calibration":[106,148,207],"techniques,":[107],"compared;":[109],"traditional":[111,209],"mixed":[115,179,204],"model":[116,180,205],"Bayesian":[117,178,203],"approach.":[118],"latter":[120],"accounts":[121],"dependence":[124],"QMM":[126,186],"assays":[127,171],"run":[128],"under":[129],"identical":[130],"laboratory":[131],"protocols":[132],"permits":[134],"structural":[135],"modelling":[136],"experimental":[138],"measurements,":[139],"allowing":[140],"precision":[141],"vary":[143],"density.":[146],"Traditional":[147],"cannot":[149],"account":[150],"inter-assay":[152,191],"variability":[153],"arising":[154],"from":[155,184],"imperfect":[156],"generates":[159],"that":[164],"have":[165],"poor":[166],"reliability,":[167],"variable":[169],"among":[170],"inaccurately":[173],"reflect":[174],"approach":[181],"assimilates":[182],"information":[183],"replica":[185],"assays,":[187],"improving":[188],"homogeneity,":[192],"providing":[193],"an":[194],"accurate":[195],"appraisal":[196],"performance.":[201],"CONCLUSIONS:":[202],"supersedes":[208],"techniques":[210],"context":[213],"QMM-derived":[215],"density,":[219],"offering":[220],"potential":[222],"improve":[224],"substantially":[225],"depth":[227],"quality":[229],"inference":[234],"wide":[237],"pathogens.":[240]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}
