{"id":"https://openalex.org/W2112633311","doi":"https://doi.org/10.1186/2043-9113-4-11","title":"Meta-analyses of 4 CFTR variants associated with the risk of the congenital bilateral absence of the vas deferens","display_name":"Meta-analyses of 4 CFTR variants associated with the risk of the congenital bilateral absence of the vas deferens","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2112633311","doi":"https://doi.org/10.1186/2043-9113-4-11","mag":"2112633311","pmid":"https://pubmed.ncbi.nlm.nih.gov/25170420"},"language":"en","primary_location":{"id":"doi:10.1186/2043-9113-4-11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-4-11","pdf_url":"https://jclinbioinformatics.biomedcentral.com/counter/pdf/10.1186/2043-9113-4-11","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jclinbioinformatics.biomedcentral.com/counter/pdf/10.1186/2043-9113-4-11","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036880568","display_name":"Xuting Xu","orcid":"https://orcid.org/0000-0003-0425-8239"},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuting Xu","raw_affiliation_strings":["Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100550551","display_name":"Jufen Zheng","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127634","display_name":"Shanghai Institute of Planned Parenthood Research","ror":"https://ror.org/03awxj939","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127634"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jufen Zheng","raw_affiliation_strings":["China National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices, SIPPR, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices, SIPPR, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I4210127634","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102004890","display_name":"Qi Liao","orcid":"https://orcid.org/0000-0001-8769-9325"},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Liao","raw_affiliation_strings":["Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068701913","display_name":"Huiqing Zhu","orcid":"https://orcid.org/0000-0002-8543-3192"},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiqing Zhu","raw_affiliation_strings":["Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110378302","display_name":"Hongyan Xie","orcid":null},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyan Xie","raw_affiliation_strings":["Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101886878","display_name":"Huijuan Shi","orcid":"https://orcid.org/0000-0003-0324-2470"},"institutions":[{"id":"https://openalex.org/I4210127634","display_name":"Shanghai Institute of Planned Parenthood Research","ror":"https://ror.org/03awxj939","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huijuan Shi","raw_affiliation_strings":["China National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices, Shanghai Institute of Planned Parenthood Research (SIPPR), Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices, Shanghai Institute of Planned Parenthood Research (SIPPR), Shanghai 200032, China","institution_ids":["https://openalex.org/I4210127634"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021249077","display_name":"Shiwei Duan","orcid":"https://orcid.org/0000-0001-7682-2877"},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiwei Duan","raw_affiliation_strings":["Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China","institution_ids":["https://openalex.org/I109935558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5036880568"],"corresponding_institution_ids":["https://openalex.org/I109935558"],"apc_list":null,"apc_paid":null,"fwci":1.6966,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.85103789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"4","issue":"1","first_page":"11","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.7657999992370605,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.7657999992370605,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.02800000086426735,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6012414693832397},{"id":"https://openalex.org/keywords/vas-deferens","display_name":"Vas deferens","score":0.5313644409179688},{"id":"https://openalex.org/keywords/risk-factor","display_name":"Risk factor","score":0.5285241603851318},{"id":"https://openalex.org/keywords/meta-analysis","display_name":"Meta-analysis","score":0.43109646439552307},{"id":"https://openalex.org/keywords/gynecology","display_name":"Gynecology","score":0.3905705213546753},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3770531117916107},{"id":"https://openalex.org/keywords/demography","display_name":"Demography","score":0.3234351873397827}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6012414693832397},{"id":"https://openalex.org/C2778210472","wikidata":"https://www.wikidata.org/wiki/Q735505","display_name":"Vas deferens","level":2,"score":0.5313644409179688},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.5285241603851318},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.43109646439552307},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3905705213546753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3770531117916107},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3234351873397827},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/2043-9113-4-11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-4-11","pdf_url":"https://jclinbioinformatics.biomedcentral.com/counter/pdf/10.1186/2043-9113-4-11","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25170420","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25170420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:3112713","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4147875","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/2043-9113-4-11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-4-11","pdf_url":"https://jclinbioinformatics.biomedcentral.com/counter/pdf/10.1186/2043-9113-4-11","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G138284973","display_name":null,"funder_award_id":"LR13H020003","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G1539336174","display_name":null,"funder_award_id":"81371469","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1713255739","display_name":null,"funder_award_id":"2012C50032","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G1828425977","display_name":null,"funder_award_id":"973 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3807587789","display_name":null,"funder_award_id":"81371469","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G4738266212","display_name":null,"funder_award_id":"31100919","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G4964988780","display_name":null,"funder_award_id":"2012C50032","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5706985488","display_name":null,"funder_award_id":"973 Program","funder_id":"https://openalex.org/F4320327563","funder_display_name":"Major State Basic Research Development Program of China"},{"id":"https://openalex.org/G6024264494","display_name":null,"funder_award_id":"31100919","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6641875606","display_name":null,"funder_award_id":"LR13H020003","funder_id":"https://openalex.org/F4320322605","funder_display_name":"Ningbo University"},{"id":"https://openalex.org/G6875554279","display_name":null,"funder_award_id":"LR13H020003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7660317513","display_name":null,"funder_award_id":"2012C50032","funder_id":"https://openalex.org/F4320322605","funder_display_name":"Ningbo University"},{"id":"https://openalex.org/G7689846578","display_name":null,"funder_award_id":"81371469","funder_id":"https://openalex.org/F4320322605","funder_display_name":"Ningbo University"},{"id":"https://openalex.org/G7760664725","display_name":null,"funder_award_id":"31100919","funder_id":"https://openalex.org/F4320322605","funder_display_name":"Ningbo University"},{"id":"https://openalex.org/G8691334274","display_name":null,"funder_award_id":"81270744","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322605","display_name":"Ningbo University","ror":"https://ror.org/03et85d35"},{"id":"https://openalex.org/F4320327563","display_name":"Major State Basic Research Development Program of China","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2112633311.pdf","grobid_xml":"https://content.openalex.org/works/W2112633311.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1497758300","https://openalex.org/W1626567511","https://openalex.org/W1967063520","https://openalex.org/W2000163923","https://openalex.org/W2000873849","https://openalex.org/W2003540897","https://openalex.org/W2023243075","https://openalex.org/W2024025918","https://openalex.org/W2039599894","https://openalex.org/W2045694196","https://openalex.org/W2057382056","https://openalex.org/W2058169488","https://openalex.org/W2067670010","https://openalex.org/W2075322208","https://openalex.org/W2086313593","https://openalex.org/W2093681651","https://openalex.org/W2107328434","https://openalex.org/W2116941855","https://openalex.org/W2122576100","https://openalex.org/W2123949450","https://openalex.org/W2124639812","https://openalex.org/W2125435699","https://openalex.org/W2126609769","https://openalex.org/W2130234574","https://openalex.org/W2137181767","https://openalex.org/W2140460198","https://openalex.org/W2323217275","https://openalex.org/W2399234860","https://openalex.org/W2611983443","https://openalex.org/W3106798016","https://openalex.org/W3142841951","https://openalex.org/W4210996550"],"related_works":["https://openalex.org/W2425009132","https://openalex.org/W2368196183","https://openalex.org/W189596413","https://openalex.org/W2017675185","https://openalex.org/W2372597604","https://openalex.org/W2081078100","https://openalex.org/W2154744234","https://openalex.org/W1971907185","https://openalex.org/W1996277250","https://openalex.org/W1981603691"],"abstract_inverted_index":{"AIMS:":[0],"The":[1],"aim":[2],"of":[3,20,39,45,49,64,149],"our":[4],"study":[5],"was":[6,29,145,164,180],"to":[7],"evaluate":[8],"the":[9,16,21,32,36,43,62,85,125,142],"relationship":[10],"between":[11,81,133],"four":[12],"CFTR":[13,40,134,162],"variations":[14,41,68,135],"and":[15,55,71,83,111,136,159,175,188],"congenital":[17],"bilateral":[18],"absence":[19],"vas":[22],"deferens":[23],"(CBAVD).":[24],"METHODS:":[25],"A":[26,47],"systematic":[27],"search":[28],"performed":[30],"in":[31,151,169],"literature":[33],"databases":[34],"for":[35,61],"case-control":[37],"studies":[38,51],"with":[42,73],"risk":[44,147,167],"CBAVD.":[46,74,137],"total":[48],"29":[50],"among":[52,184],"1139":[53],"controls":[54],"1562":[56],"CBAVD":[57,82,150],"patients":[58],"were":[59],"gathered":[60],"meta-analyses":[63,77],"three":[65,86],"commonly":[66],"tecsted":[67],"(5T,":[69],"\u0394F508":[70,112,163],"M470V)":[72],"RESULTS:":[75],"Our":[76,138],"observed":[78],"significant":[79,131],"associations":[80],"all":[84],"variations,":[87],"including":[88,171],"5T":[89,143],"(P":[90,101,113],"<":[91,114],"0.001,":[92,115],"OR":[93,104,116],"=":[94,98,102,105,109,117,121],"8.35,":[95],"95%":[96,107,119],"CI":[97,108,120],"6.68-10.43),":[99],"M470V":[100,179],"0.027,":[103],"0.74,":[106],"0.60-0.91)":[110],"22.20,":[118],"7.49-65.79).":[122],"CONCLUSION:":[123],"In":[124,177],"current":[126],"study,":[127],"we":[128],"demonstrated":[129],"a":[130,146,181],"association":[132],"results":[139],"showed":[140],"that":[141],"variation":[144],"factor":[148,168,183],"French,":[152,185],"Spanish,":[153],"Japanese,":[154],"Chinese,":[155,186],"Iranian,":[156],"Indian,":[157],"Mexican":[158],"Egyptian":[160],"populations.":[161,190],"another":[165],"important":[166],"Caucasians,":[170],"Slovenians,":[172],"Canadians,":[173],"Iranians,":[174],"Egyptians.":[176],"addition,":[178],"protective":[182],"Italian":[187],"Iranian":[189]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-05-12T08:28:47.272897","created_date":"2025-10-10T00:00:00"}
