{"id":"https://openalex.org/W2136853577","doi":"https://doi.org/10.1186/2043-9113-3-6","title":"MicroRNAs: an emerging science in cancer epigenetics","display_name":"MicroRNAs: an emerging science in cancer epigenetics","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2136853577","doi":"https://doi.org/10.1186/2043-9113-3-6","mag":"2136853577","pmid":"https://pubmed.ncbi.nlm.nih.gov/23497588"},"language":"en","primary_location":{"id":"doi:10.1186/2043-9113-3-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-3-6","pdf_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-3-6","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-3-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033874608","display_name":"Rishabh Kala","orcid":"https://orcid.org/0000-0002-7364-5745"},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rishabh Kala","raw_affiliation_strings":["Department of Biology, University of Alabama Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA. trygve@uab.edu","Department of Biology, University of Alabama Birmingham, 1300 University Boulevard, Birmingham, AL, 35294, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Alabama Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA. trygve@uab.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Biology, University of Alabama Birmingham, 1300 University Boulevard, Birmingham, AL, 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063016605","display_name":"Gregory W. Peek","orcid":null},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory W Peek","raw_affiliation_strings":["Department of Biology, University of Alabama Birmingham, 1300 University Boulevard, Birmingham, AL, 35294, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Alabama Birmingham, 1300 University Boulevard, Birmingham, AL, 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006998070","display_name":"Tabitha M. Hardy","orcid":null},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tabitha M Hardy","raw_affiliation_strings":["Department of Biology, University of Alabama Birmingham, 1300 University Boulevard, Birmingham, AL, 35294, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Alabama Birmingham, 1300 University Boulevard, Birmingham, AL, 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001695890","display_name":"Trygve O. Tollefsbol","orcid":"https://orcid.org/0000-0002-0284-1511"},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Trygve O Tollefsbol","raw_affiliation_strings":["Center for Aging, University of Alabama Birmingham, 1530 3rd Avenue South, Birmingham, AL, 35294, USA","Comprehensive Cancer Center, University of Alabama Birmingham, 1802 6th Avenue South, Birmingham, AL, 35294, USA","Comprehensive Diabetes Center, University of Alabama Birmingham, 1825 University Boulevard, Birmingham, AL, 35294, USA","Department of Biology, University of Alabama Birmingham, 1300 University Boulevard, Birmingham, AL, 35294, USA","Nutrition Obesity Research Center, University ofs Alabama Birmingham, 1675 University Boulevard, Birmingham, AL, 35294, USA"],"affiliations":[{"raw_affiliation_string":"Center for Aging, University of Alabama Birmingham, 1530 3rd Avenue South, Birmingham, AL, 35294, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Comprehensive Cancer Center, University of Alabama Birmingham, 1802 6th Avenue South, Birmingham, AL, 35294, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Comprehensive Diabetes Center, University of Alabama Birmingham, 1825 University Boulevard, Birmingham, AL, 35294, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Biology, University of Alabama Birmingham, 1300 University Boulevard, Birmingham, AL, 35294, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Nutrition Obesity Research Center, University ofs Alabama Birmingham, 1675 University Boulevard, Birmingham, AL, 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001695890"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":null,"apc_paid":null,"fwci":4.6658,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.95350407,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"6","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8786876201629639},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.7254247069358826},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6202268004417419},{"id":"https://openalex.org/keywords/translation","display_name":"Translation (biology)","score":0.5827438235282898},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5223183035850525},{"id":"https://openalex.org/keywords/biogenesis","display_name":"Biogenesis","score":0.47641098499298096},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4641757011413574},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.424822062253952},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"Non-coding RNA","score":0.4114851951599121},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3492776155471802},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3308046758174896},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3076059818267822}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8786876201629639},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7254247069358826},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6202268004417419},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.5827438235282898},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5223183035850525},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.47641098499298096},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4641757011413574},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.424822062253952},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.4114851951599121},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3492776155471802},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3308046758174896},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3076059818267822}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/2043-9113-3-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-3-6","pdf_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-3-6","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},{"id":"pmid:23497588","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23497588","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:2605107","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3608239","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/2043-9113-3-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-3-6","pdf_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-3-6","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G4359693134","display_name":null,"funder_award_id":"NIGMS","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4411373967","display_name":null,"funder_award_id":"K12GM088010","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5610507649","display_name":null,"funder_award_id":"5K12GM088010","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6286612688","display_name":null,"funder_award_id":"5K12GM088010","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8473772396","display_name":null,"funder_award_id":"K12GM088010","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G935210731","display_name":null,"funder_award_id":"GM088010","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306231","display_name":"American Institute for Cancer Research","ror":"https://ror.org/03b3akj74"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136853577.pdf","grobid_xml":"https://content.openalex.org/works/W2136853577.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1046070","https://openalex.org/W144423133","https://openalex.org/W1982535740","https://openalex.org/W1988525462","https://openalex.org/W2000496185","https://openalex.org/W2006173503","https://openalex.org/W2008471043","https://openalex.org/W2017199818","https://openalex.org/W2017426710","https://openalex.org/W2017905687","https://openalex.org/W2026508704","https://openalex.org/W2027873015","https://openalex.org/W2029860792","https://openalex.org/W2039275665","https://openalex.org/W2040191060","https://openalex.org/W2041509376","https://openalex.org/W2044832480","https://openalex.org/W2048270152","https://openalex.org/W2052041317","https://openalex.org/W2053835153","https://openalex.org/W2059036341","https://openalex.org/W2059073003","https://openalex.org/W2065566217","https://openalex.org/W2069588389","https://openalex.org/W2070571588","https://openalex.org/W2074803927","https://openalex.org/W2079927449","https://openalex.org/W2080137338","https://openalex.org/W2083381199","https://openalex.org/W2085342498","https://openalex.org/W2087846605","https://openalex.org/W2094532696","https://openalex.org/W2100257850","https://openalex.org/W2102242260","https://openalex.org/W2103177465","https://openalex.org/W2107961632","https://openalex.org/W2112192177","https://openalex.org/W2117551340","https://openalex.org/W2117692326","https://openalex.org/W2123356446","https://openalex.org/W2123603746","https://openalex.org/W2128768066","https://openalex.org/W2133968430","https://openalex.org/W2136816004","https://openalex.org/W2138015614","https://openalex.org/W2144093986","https://openalex.org/W2144154026","https://openalex.org/W2146126066","https://openalex.org/W2146656223","https://openalex.org/W2146974679","https://openalex.org/W2157403368","https://openalex.org/W2159888101","https://openalex.org/W2160998038","https://openalex.org/W2162674813","https://openalex.org/W2168166472","https://openalex.org/W2168230240","https://openalex.org/W4210430020"],"related_works":["https://openalex.org/W4366603091","https://openalex.org/W2748993459","https://openalex.org/W2073251235","https://openalex.org/W2049521543","https://openalex.org/W2485141070","https://openalex.org/W2411374999","https://openalex.org/W2083798468","https://openalex.org/W1511329766","https://openalex.org/W2372977766","https://openalex.org/W2764188251"],"abstract_inverted_index":{"MicroRNAs":[0],"(miRNAs)":[1],"are":[2,41],"remarkable":[3],"molecules":[4,26],"that":[5],"appear":[6],"to":[7,177],"have":[8,28,125],"a":[9,20,93,101,113,119,126],"fundamental":[10],"role":[11],"in":[12,34,47,129,162],"the":[13,16,36,51,75,88,108,135,144,152],"biology":[14],"of":[15,22,38,53,67,80,90,96,104,110,121,138,140,146,154,181],"cell.":[17],"They":[18],"constitute":[19],"class":[21,95,103],"non-protein":[23],"encoding":[24],"RNA":[25],"which":[27,49,173],"now":[29],"emerged":[30],"as":[31,71,92,100],"key":[32],"players":[33],"regulating":[35],"activity":[37,52],"mRNA.":[39],"miRNAs":[40,68,91,116,155],"small":[42],"RNAmolecules":[43],"around":[44],"22":[45],"nucleotides":[46],"length,":[48],"affect":[50],"specific":[54],"mRNA,":[55],"directly":[56],"degrading":[57],"it":[58],"and/or":[59],"preventing":[60],"its":[61],"translation":[62],"into":[63],"protein.":[64],"The":[65],"science":[66],"holds":[69],"them":[70],"candidate":[72],"biomarkers":[73],"for":[74,87,107],"early":[76],"detection":[77],"and":[78,99,123,151,159],"management":[79],"cancer.":[81],"There":[82],"is":[83],"also":[84,167],"considerable":[85],"excitement":[86],"use":[89],"novel":[94],"therapeutic":[97,105],"targets":[98,180],"new":[102],"agents":[106],"treatment":[109],"cancers.":[111,164],"From":[112],"clinical":[114],"perspective,":[115],"can":[117,174],"induce":[118],"number":[120],"effects":[122],"may":[124],"diverse":[127],"application":[128],"biomedical":[130],"research.":[131],"This":[132],"review":[133],"highlights":[134],"general":[136],"mode":[137],"action":[139],"miRNAs,":[141],"their":[142],"biogenesis,":[143],"effect":[145],"diet":[147],"on":[148,156,170],"miRNA":[149],"expression":[150],"impact":[153],"cancer":[157],"epigenetics":[158],"drug":[160],"resistance":[161],"various":[163],"Further":[165],"we":[166],"provide":[168],"emphasis":[169],"bioinformatics":[171],"software":[172],"be":[175],"used":[176],"determine":[178],"potential":[179],"miRNAs.":[182]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":7}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
