{"id":"https://openalex.org/W2118953105","doi":"https://doi.org/10.1186/2043-9113-2-1","title":"A network flow approach to predict drug targets from microarray data, disease genes and interactome network - case study on prostate cancer","display_name":"A network flow approach to predict drug targets from microarray data, disease genes and interactome network - case study on prostate cancer","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2118953105","doi":"https://doi.org/10.1186/2043-9113-2-1","mag":"2118953105","pmid":"https://pubmed.ncbi.nlm.nih.gov/22239822"},"language":"en","primary_location":{"id":"doi:10.1186/2043-9113-2-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-2-1","pdf_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-2-1","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-2-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060803167","display_name":"Shih-Heng Yeh","orcid":null},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shih-Heng Yeh","raw_affiliation_strings":["Institute of Information Systems and Applications, National Tsing Hua University, HsinChu 300, Taiwan","Institute of Information Systems and Applications, National Tsing Hua University, HsinChu, 300, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Information Systems and Applications, National Tsing Hua University, HsinChu 300, Taiwan","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Institute of Information Systems and Applications, National Tsing Hua University, HsinChu, 300, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048127662","display_name":"Hsiang\u2010Yuan Yeh","orcid":"https://orcid.org/0000-0002-6267-9958"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsiang-Yuan Yeh","raw_affiliation_strings":["Department of Computer Science, National Tsing Hua University, HsinChu 300, Taiwan","Department of Computer Science, National Tsing Hua University, HsinChu, 300, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, National Tsing Hua University, HsinChu 300, Taiwan","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Department of Computer Science, National Tsing Hua University, HsinChu, 300, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080558475","display_name":"Von\u2010Wun Soo","orcid":"https://orcid.org/0000-0002-4810-1244"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Von-Wun Soo","raw_affiliation_strings":["Department of Computer Science, National Tsing Hua University, HsinChu 300, Taiwan","Institute of Information Systems and Applications, National Tsing Hua University, HsinChu 300, Taiwan","Institute of Information Systems and Applications, National Tsing Hua University, HsinChu, 300, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, National Tsing Hua University, HsinChu 300, Taiwan","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Institute of Information Systems and Applications, National Tsing Hua University, HsinChu 300, Taiwan","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Institute of Information Systems and Applications, National Tsing Hua University, HsinChu, 300, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060803167"],"corresponding_institution_ids":["https://openalex.org/I25846049"],"apc_list":null,"apc_paid":null,"fwci":6.9594,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.97509912,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"2","issue":"1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.7212428450584412},{"id":"https://openalex.org/keywords/drugbank","display_name":"DrugBank","score":0.684833824634552},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.6046287417411804},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"Prostate cancer","score":0.5471018552780151},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5352272391319275},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.513372540473938},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.48125502467155457},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4402008652687073},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4323503375053406},{"id":"https://openalex.org/keywords/toxicogenomics","display_name":"Toxicogenomics","score":0.42014509439468384},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.41532766819000244},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4102061092853546},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3668096661567688},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2527748942375183},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22546693682670593},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1577560007572174},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.14685314893722534},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10325184464454651},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.09788903594017029},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.07483437657356262}],"concepts":[{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.7212428450584412},{"id":"https://openalex.org/C155261790","wikidata":"https://www.wikidata.org/wiki/Q1122544","display_name":"DrugBank","level":3,"score":0.684833824634552},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6046287417411804},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5471018552780151},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5352272391319275},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.513372540473938},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.48125502467155457},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4402008652687073},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4323503375053406},{"id":"https://openalex.org/C93231420","wikidata":"https://www.wikidata.org/wiki/Q841450","display_name":"Toxicogenomics","level":4,"score":0.42014509439468384},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41532766819000244},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4102061092853546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3668096661567688},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2527748942375183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22546693682670593},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1577560007572174},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.14685314893722534},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10325184464454651},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09788903594017029},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07483437657356262}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/2043-9113-2-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-2-1","pdf_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-2-1","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22239822","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22239822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3285036","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3285036","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Clin Bioinforma","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/2043-9113-2-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-2-1","pdf_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-2-1","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7799999713897705,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322767","display_name":"Chang Gung Medical Foundation","ror":"https://ror.org/02verss31"},{"id":"https://openalex.org/F4320323092","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118953105.pdf","grobid_xml":"https://content.openalex.org/works/W2118953105.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1517267863","https://openalex.org/W1581171480","https://openalex.org/W1685122025","https://openalex.org/W1880178588","https://openalex.org/W1967385589","https://openalex.org/W1969779540","https://openalex.org/W1976526581","https://openalex.org/W1977431865","https://openalex.org/W1984307736","https://openalex.org/W1995089537","https://openalex.org/W2007572995","https://openalex.org/W2009313526","https://openalex.org/W2011912935","https://openalex.org/W2013296244","https://openalex.org/W2018408116","https://openalex.org/W2050474043","https://openalex.org/W2053126761","https://openalex.org/W2060672363","https://openalex.org/W2062776683","https://openalex.org/W2070120800","https://openalex.org/W2081146141","https://openalex.org/W2081562576","https://openalex.org/W2086121836","https://openalex.org/W2090359754","https://openalex.org/W2096863518","https://openalex.org/W2097508612","https://openalex.org/W2098979213","https://openalex.org/W2105657168","https://openalex.org/W2106202847","https://openalex.org/W2107277505","https://openalex.org/W2113962581","https://openalex.org/W2118128448","https://openalex.org/W2121604817","https://openalex.org/W2122144032","https://openalex.org/W2129916980","https://openalex.org/W2137518425","https://openalex.org/W2138512826","https://openalex.org/W2139736926","https://openalex.org/W2142237411","https://openalex.org/W2143738293","https://openalex.org/W2144209831","https://openalex.org/W2149047666","https://openalex.org/W2149951991","https://openalex.org/W2152216760","https://openalex.org/W2152227081","https://openalex.org/W2152772600","https://openalex.org/W2153838454","https://openalex.org/W2154896031","https://openalex.org/W2154897810","https://openalex.org/W2155037464","https://openalex.org/W2160475600","https://openalex.org/W2163480486","https://openalex.org/W2165867280","https://openalex.org/W2171088586","https://openalex.org/W2171429997","https://openalex.org/W2999129308"],"related_works":["https://openalex.org/W3114988578","https://openalex.org/W4390649784","https://openalex.org/W4387767168","https://openalex.org/W4390539447","https://openalex.org/W4385514295","https://openalex.org/W2797260394","https://openalex.org/W3035455406","https://openalex.org/W4387572939","https://openalex.org/W4285394780","https://openalex.org/W2998254619"],"abstract_inverted_index":{"Our":[0],"method":[1],"does":[2],"not":[3],"know":[4],"the":[5,10,18,27,36],"real":[6],"ideal":[7],"routes":[8],"in":[9,55],"disease":[11,28],"network":[12],"but":[13],"it":[14],"tries":[15],"to":[16,21,26],"find":[17],"feasible":[19],"flow":[20,45],"give":[22],"a":[23,43],"strong":[24],"influence":[25],"genes":[29],"through":[30],"possible":[31],"paths.":[32],"We":[33],"successfully":[34],"formulate":[35],"identification":[37],"of":[38],"drug":[39,53],"target":[40],"prediction":[41],"as":[42],"maximum":[44],"problem":[46],"on":[47],"biological":[48],"networks":[49],"and":[50],"discover":[51],"potential":[52],"targets":[54],"an":[56],"accurate":[57],"manner.":[58]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-03-03T08:47:05.690250","created_date":"2025-10-10T00:00:00"}
