{"id":"https://openalex.org/W2172235175","doi":"https://doi.org/10.1186/2043-9113-1-36","title":"Elucidating the identity of resistance mechanisms to prednisolone exposure in acute lymphoblastic leukemia cells through transcriptomic analysis: A computational approach","display_name":"Elucidating the identity of resistance mechanisms to prednisolone exposure in acute lymphoblastic leukemia cells through transcriptomic analysis: A computational approach","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2172235175","doi":"https://doi.org/10.1186/2043-9113-1-36","mag":"2172235175","pmid":"https://pubmed.ncbi.nlm.nih.gov/22185641"},"language":"en","primary_location":{"id":"doi:10.1186/2043-9113-1-36","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-1-36","pdf_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-1-36","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-1-36","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009958595","display_name":"Emmanouil G. Sifakis","orcid":"https://orcid.org/0000-0001-9919-4471"},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Emmanouil G Sifakis","raw_affiliation_strings":["School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I174458059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072379918","display_name":"George \u0399. Lambrou","orcid":"https://orcid.org/0000-0001-8389-1360"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"George I Lambrou","raw_affiliation_strings":["First Department of Pediatrics, University of Athens, Choremeio Research Laboratory, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pediatrics, University of Athens, Choremeio Research Laboratory, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060597716","display_name":"Andriana Prentza","orcid":"https://orcid.org/0000-0001-6904-7534"},"institutions":[{"id":"https://openalex.org/I154757721","display_name":"University of Piraeus","ror":"https://ror.org/02qs84g94","country_code":"GR","type":"education","lineage":["https://openalex.org/I154757721"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Andriana Prentza","raw_affiliation_strings":["Department of Digital Systems, University of Piraeus, Piraeus, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Digital Systems, University of Piraeus, Piraeus, Greece","institution_ids":["https://openalex.org/I154757721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071471828","display_name":"Spiros Vlahopoulos","orcid":"https://orcid.org/0000-0001-6245-3863"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Spiros Vlahopoulos","raw_affiliation_strings":["First Department of Pediatrics, University of Athens, Choremeio Research Laboratory, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pediatrics, University of Athens, Choremeio Research Laboratory, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016776217","display_name":"Dimitris Koutsouris","orcid":"https://orcid.org/0000-0003-1205-9918"},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitris Koutsouris","raw_affiliation_strings":["School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I174458059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069420342","display_name":"Fotini Tzortzatou\u2010Stathopoulou","orcid":null},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Fotini Tzortzatou-Stathopoulou","raw_affiliation_strings":["University Research Institute for Genetic and Malignant Diseases of Childhood, University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Research Institute for Genetic and Malignant Diseases of Childhood, University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067189264","display_name":"Aristotelis Chatziioannou","orcid":"https://orcid.org/0000-0003-2078-0844"},"institutions":[{"id":"https://openalex.org/I4210127711","display_name":"National Hellenic Research Foundation","ror":"https://ror.org/033m02g29","country_code":"GR","type":"funder","lineage":["https://openalex.org/I4210127711"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Aristotelis A Chatziioannou","raw_affiliation_strings":["Institute of Biological Research & Biotechnology, National Hellenic Research Foundation, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Research & Biotechnology, National Hellenic Research Foundation, Athens, Greece","institution_ids":["https://openalex.org/I4210127711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5067189264"],"corresponding_institution_ids":["https://openalex.org/I4210127711"],"apc_list":null,"apc_paid":null,"fwci":0.309,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.63995859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"1","issue":"1","first_page":"36","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.24809999763965607,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.24809999763965607,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.23270000517368317,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.07280000299215317,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prednisolone","display_name":"Prednisolone","score":0.8095609545707703},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.7341302633285522},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.5576691031455994},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.4882242977619171},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.44804489612579346},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.44678959250450134},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.44075721502304077},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4320058226585388},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4264141917228699},{"id":"https://openalex.org/keywords/cytotoxic-t-cell","display_name":"Cytotoxic T cell","score":0.41822558641433716},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"Mechanism of action","score":0.41711798310279846},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.38473355770111084},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3637682795524597},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.36158156394958496},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3287316560745239},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.32208436727523804},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19101107120513916},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.17608293890953064},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.16734462976455688}],"concepts":[{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.8095609545707703},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7341302633285522},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5576691031455994},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4882242977619171},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.44804489612579346},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.44678959250450134},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44075721502304077},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4320058226585388},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4264141917228699},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.41822558641433716},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.41711798310279846},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38473355770111084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3637682795524597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36158156394958496},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3287316560745239},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.32208436727523804},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19101107120513916},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17608293890953064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16734462976455688},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/2043-9113-1-36","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-1-36","pdf_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-1-36","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22185641","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22185641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:2326896","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3313905","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:http://helios-eie.ekt.gr:10442/13186","is_oa":true,"landing_page_url":"http://hdl.handle.net/10442/13186","pdf_url":null,"source":{"id":"https://openalex.org/S4306402248","display_name":"National Hellenic Research Foundation Helios Repository (National Hellenic Research Foundation)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210127711","host_organization_name":"National Hellenic Research Foundation","host_organization_lineage":["https://openalex.org/I4210127711"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"doi:10.1186/2043-9113-1-36","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-1-36","pdf_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-1-36","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6899999976158142,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2172235175.pdf","grobid_xml":"https://content.openalex.org/works/W2172235175.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W178153478","https://openalex.org/W370143576","https://openalex.org/W563832787","https://openalex.org/W1484116911","https://openalex.org/W1489608363","https://openalex.org/W1493454437","https://openalex.org/W1521652389","https://openalex.org/W1523843467","https://openalex.org/W1530061350","https://openalex.org/W1537397007","https://openalex.org/W1571259701","https://openalex.org/W1578104218","https://openalex.org/W1592837410","https://openalex.org/W1602614022","https://openalex.org/W1916592475","https://openalex.org/W1968657808","https://openalex.org/W1969429198","https://openalex.org/W1972647537","https://openalex.org/W1980439394","https://openalex.org/W1980665688","https://openalex.org/W1986943079","https://openalex.org/W1988393300","https://openalex.org/W1997069623","https://openalex.org/W2000153135","https://openalex.org/W2000436912","https://openalex.org/W2001814784","https://openalex.org/W2008552722","https://openalex.org/W2017606565","https://openalex.org/W2017936125","https://openalex.org/W2017977879","https://openalex.org/W2021701623","https://openalex.org/W2024081693","https://openalex.org/W2030352564","https://openalex.org/W2032005651","https://openalex.org/W2032510252","https://openalex.org/W2039740528","https://openalex.org/W2049427447","https://openalex.org/W2057625331","https://openalex.org/W2059010948","https://openalex.org/W2061767013","https://openalex.org/W2063615390","https://openalex.org/W2064923609","https://openalex.org/W2071326040","https://openalex.org/W2075728723","https://openalex.org/W2087194126","https://openalex.org/W2096525273","https://openalex.org/W2096758922","https://openalex.org/W2099373309","https://openalex.org/W2100956382","https://openalex.org/W2103017472","https://openalex.org/W2104143846","https://openalex.org/W2106538287","https://openalex.org/W2111566545","https://openalex.org/W2114049512","https://openalex.org/W2116211027","https://openalex.org/W2127789926","https://openalex.org/W2128396288","https://openalex.org/W2129066856","https://openalex.org/W2129249398","https://openalex.org/W2130675837","https://openalex.org/W2133111499","https://openalex.org/W2134060756","https://openalex.org/W2134905274","https://openalex.org/W2135230352","https://openalex.org/W2136418557","https://openalex.org/W2138179857","https://openalex.org/W2138247507","https://openalex.org/W2140558141","https://openalex.org/W2141407136","https://openalex.org/W2142913541","https://openalex.org/W2143287609","https://openalex.org/W2144821964","https://openalex.org/W2144907278","https://openalex.org/W2150036465","https://openalex.org/W2150593711","https://openalex.org/W2152584857","https://openalex.org/W2153034562","https://openalex.org/W2154174652","https://openalex.org/W2154981570","https://openalex.org/W2159482845","https://openalex.org/W2162169788","https://openalex.org/W2168113705","https://openalex.org/W2168425992","https://openalex.org/W2170040895","https://openalex.org/W2320257314","https://openalex.org/W2498631646","https://openalex.org/W2752128027","https://openalex.org/W2999729612","https://openalex.org/W4237737483","https://openalex.org/W4246395620","https://openalex.org/W4253016408","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2796636403","https://openalex.org/W2015700328","https://openalex.org/W2364565895","https://openalex.org/W2767847608","https://openalex.org/W2911678823","https://openalex.org/W2152648570","https://openalex.org/W2037892364","https://openalex.org/W2319154570","https://openalex.org/W3152114242","https://openalex.org/W3028764459"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1],"has":[2],"been":[3],"shown":[4],"previously":[5],"that":[6,149,273],"glucocorticoids":[7,254],"exert":[8],"a":[9,26,40,63,154,163,280,292],"dual":[10,42],"mechanism":[11,43,86,156,169,213],"of":[12,44,46,57,87,94,105,118,132,136,157,170,207,214,220,238,242,249,261,265,284,300,304],"action,":[13],"entailing":[14],"cytotoxic,":[15],"mitogenic":[16],"as":[17,19],"well":[18],"cell":[20,52,201],"proliferative":[21,202],"and":[22,89,121,125,184,193,224,286],"anti-apoptotic":[23],"responses,":[24],"in":[25,72,195,276],"dose-dependent":[27,41],"manner":[28],"on":[29,51],"CCRF-CEM":[30,79,150,274],"cells":[31,80,138,151,275],"at":[32,139,173],"72":[33,55,130],"h.":[34],"Early":[35],"gene":[36],"expression":[37],"response":[38,135,158],"implies":[39,210],"action":[45],"prednisolone":[47,97,176,186],"too,":[48],"something":[49],"reflected":[50],"state":[53],"upon":[54,96],"h":[56,256],"treatment.":[58,98],"METHODS:":[59],"In":[60,144,204],"this":[61,145,277],"work,":[62,146],"generic,":[64],"computational":[65],"microarray":[66],"data":[67],"analysis":[68,228],"framework":[69,229],"is":[70],"proposed,":[71],"order":[73],"to":[74,159,178,191,253,289],"examine":[75],"the":[76,91,103,107,122,133,137,140,217,245,250,259,266],"hypothesis,":[77],"whether":[78],"exhibit":[81,279],"an":[82,167,211],"intrinsic":[83,168,285],"or":[84],"acquired":[85,287],"resistance":[88,215,288],"investigate":[90],"molecular":[92,134,302],"imprint":[93],"this,":[95],"The":[99,227],"experimental":[100],"design":[101],"enables":[102],"examination":[104],"both":[106,196],"dose":[108],"(0":[109],"nM,":[110,112],"10":[111],"22":[113],"uM,":[114],"700":[115],"uM)":[116],"effect":[117,260],"glucocorticoid":[119],"exposure":[120,252],"dynamics":[123],"(early":[124],"late,":[126],"namely":[127],"4":[128,174],"h,":[129,175],"h)":[131],"transcriptomic":[141],"layer.":[142],"RESULTS:":[143],"we":[147],"demonstrated":[148],"may":[152],"attain":[153],"mixed":[155],"glucocorticoids,":[160],"however,":[161],"with":[162,291],"clear":[164],"preference":[165],"towards":[166,294],"resistance.":[171,226],"Specifically,":[172],"appeared":[177],"down-regulate":[179],"apoptotic":[180],"genes.":[181,243],"Also,":[182],"low":[183],"high":[185],"concentrations":[187],"up-regulates":[188],"genes":[189,209],"related":[190],"metabolism":[192],"signal-transduction":[194],"time":[197],"points,":[198],"thus":[199],"favoring":[200],"actions.":[203],"addition,":[205],"regulation":[206],"NF-\u03baB-related":[208],"inherent":[212,295],"through":[216,236,298],"established":[218],"link":[219],"NF-\u03baB":[221],"inflammatory":[222],"role":[223],"GC-induced":[225],"applied":[230],"here":[231],"highlights":[232,258],"prednisolone-activated":[233],"regulatory":[234],"mechanisms":[235,264],"identification":[237],"early":[239],"responding":[240],"sets":[241],"On":[244],"other":[246],"hand,":[247],"study":[248,278],"prolonged":[251],"(72":[255],"exposure)":[257],"homeostatic":[262],"feedback":[263],"treated":[267],"cells.":[268],"CONCLUSIONS:":[269],"Overall,":[270],"it":[271],"appears":[272],"diversified,":[281],"combined":[282],"pattern":[283],"prednisolone,":[290],"tendency":[293],"resistant":[296],"characteristics,":[297],"activation":[299],"different":[301],"courses":[303],"action.":[305]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-07-31T08:31:51.225901","created_date":"2025-10-10T00:00:00"}