{"id":"https://openalex.org/W2145869919","doi":"https://doi.org/10.1186/2043-9113-1-28","title":"Role of clinical bioinformatics in the development of network-based Biomarkers","display_name":"Role of clinical bioinformatics in the development of network-based Biomarkers","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2145869919","doi":"https://doi.org/10.1186/2043-9113-1-28","mag":"2145869919","pmid":"https://pubmed.ncbi.nlm.nih.gov/22024468"},"language":"en","primary_location":{"id":"doi:10.1186/2043-9113-1-28","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-1-28","pdf_url":"https://jclinbioinformatics.biomedcentral.com/counter/pdf/10.1186/2043-9113-1-28","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jclinbioinformatics.biomedcentral.com/counter/pdf/10.1186/2043-9113-1-28","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100402348","display_name":"Xiangdong Wang","orcid":"https://orcid.org/0000-0002-8406-7928"},"institutions":[{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiangdong Wang","raw_affiliation_strings":["Biomedical Research Center, Department of Respiratory Medicine, Fudan University Zhongshan Hospital, China. xiangdong.wang@telia.com","Biomedical Research Center, Department of Respiratory Medicine, Fudan University Zhongshan Hospital, China"],"affiliations":[{"raw_affiliation_string":"Biomedical Research Center, Department of Respiratory Medicine, Fudan University Zhongshan Hospital, China. xiangdong.wang@telia.com","institution_ids":[]},{"raw_affiliation_string":"Biomedical Research Center, Department of Respiratory Medicine, Fudan University Zhongshan Hospital, China","institution_ids":["https://openalex.org/I4210127074","https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100402348"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"],"apc_list":null,"apc_paid":null,"fwci":3.7783,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.94335002,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"1","issue":"1","first_page":"28","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9611999988555908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/translational-bioinformatics","display_name":"Translational bioinformatics","score":0.6516930460929871},{"id":"https://openalex.org/keywords/informatics","display_name":"Informatics","score":0.6258932948112488},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.6123925447463989},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.6067712903022766},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.5599410533905029},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.5477707386016846},{"id":"https://openalex.org/keywords/health-informatics","display_name":"Health informatics","score":0.5462335348129272},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.528742790222168},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5268560647964478},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.47141098976135254},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3674010634422302},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3503096103668213},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.20275965332984924},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15424954891204834},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11147016286849976},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.10556134581565857}],"concepts":[{"id":"https://openalex.org/C163293594","wikidata":"https://www.wikidata.org/wiki/Q7834541","display_name":"Translational bioinformatics","level":5,"score":0.6516930460929871},{"id":"https://openalex.org/C191630685","wikidata":"https://www.wikidata.org/wiki/Q4027615","display_name":"Informatics","level":2,"score":0.6258932948112488},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6123925447463989},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6067712903022766},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.5599410533905029},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.5477707386016846},{"id":"https://openalex.org/C145642194","wikidata":"https://www.wikidata.org/wiki/Q870895","display_name":"Health informatics","level":3,"score":0.5462335348129272},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.528742790222168},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5268560647964478},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.47141098976135254},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3674010634422302},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3503096103668213},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20275965332984924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15424954891204834},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11147016286849976},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.10556134581565857},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/2043-9113-1-28","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-1-28","pdf_url":"https://jclinbioinformatics.biomedcentral.com/counter/pdf/10.1186/2043-9113-1-28","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22024468","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22024468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:2221577","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3221619","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/2043-9113-1-28","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-1-28","pdf_url":"https://jclinbioinformatics.biomedcentral.com/counter/pdf/10.1186/2043-9113-1-28","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145869919.pdf","grobid_xml":"https://content.openalex.org/works/W2145869919.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W1987070318","https://openalex.org/W2043201947","https://openalex.org/W2063171096","https://openalex.org/W2111132036","https://openalex.org/W2171064835"],"related_works":["https://openalex.org/W2044191049","https://openalex.org/W2151319628","https://openalex.org/W2273308837","https://openalex.org/W4298042893","https://openalex.org/W1577474828","https://openalex.org/W2040461874","https://openalex.org/W2121784101","https://openalex.org/W2232806625","https://openalex.org/W2415613079","https://openalex.org/W4386126675"],"abstract_inverted_index":{"Network":[0],"biomarker":[1],"as":[2],"a":[3],"new":[4],"type":[5],"of":[6,18,29,48,54,71],"biomarkers":[7,56,79],"with":[8,15,84],"protein-protein":[9],"interactions":[10],"was":[11],"initiated":[12],"and":[13,24,31,51,60,65,94,103],"investigated":[14],"the":[16,42,46,69],"integration":[17],"knowledge":[19],"on":[20],"protein":[21],"annotations,":[22],"interaction,":[23],"signaling":[25],"pathway.":[26],"A":[27],"number":[28],"methodologies":[30],"computational":[32],"programs":[33],"have":[34],"been":[35],"developed":[36],"to":[37],"integrate":[38],"selected":[39],"proteins":[40],"into":[41],"knowledge-based":[43],"networks":[44],"via":[45],"combination":[47],"genomics,":[49],"proteomics":[50],"bioinformatics.":[52],"Alterations":[53],"network":[55,75,78],"can":[57],"be":[58,81],"monitored":[59],"evaluated":[61],"at":[62],"different":[63],"stages":[64],"time":[66],"points":[67],"during":[68],"development":[70],"diseases,":[72],"named":[73],"dynamic":[74],"biomarkers.":[76],"Dynamic":[77],"should":[80],"furthermore":[82],"correlated":[83],"clinical":[85,92],"informatics,":[86],"including":[87],"patient":[88],"complaints,":[89],"history,":[90],"therapies,":[91],"symptoms":[93],"signs,":[95],"physician's":[96],"examinations,":[97],"biochemical":[98],"analyses,":[99],"imaging":[100],"profiles,":[101],"pathologies":[102],"other":[104],"measurements.":[105]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":14}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}