{"id":"https://openalex.org/W2049944344","doi":"https://doi.org/10.1186/2043-9113-1-23","title":"Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study","display_name":"Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2049944344","doi":"https://doi.org/10.1186/2043-9113-1-23","mag":"2049944344","pmid":"https://pubmed.ncbi.nlm.nih.gov/21888658"},"language":"en","primary_location":{"id":"doi:10.1186/2043-9113-1-23","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-1-23","pdf_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-1-23","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-1-23","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100826982","display_name":"Masaharu Nomura","orcid":null},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masaharu Nomura","raw_affiliation_strings":["Dept, of Surgery I, Tokyo Medical University, Tokyo, Japan. nomuram@tokyo-med.ac.jp","Dept. of Surgery I, Tokyo Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept, of Surgery I, Tokyo Medical University, Tokyo, Japan. nomuram@tokyo-med.ac.jp","institution_ids":["https://openalex.org/I158929114"]},{"raw_affiliation_string":"Dept. of Surgery I, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052307739","display_name":"Tetsuya Fukuda","orcid":"https://orcid.org/0000-0001-7579-0674"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tetsuya Fukuda","raw_affiliation_strings":["Biosys Technologies, Inc., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosys Technologies, Inc., Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041369305","display_name":"Kiyonaga Fujii","orcid":null},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I21851649","display_name":"Hokkaido Pharmaceutical University","ror":"https://ror.org/02qh3e530","country_code":"JP","type":"education","lineage":["https://openalex.org/I21851649"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyonaga Fujii","raw_affiliation_strings":["Dept. of Structural Biology, Graduate School of Pharmaceutical Science. Hokkaido, University, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Structural Biology, Graduate School of Pharmaceutical Science. Hokkaido, University, Hokkaido, Japan","institution_ids":["https://openalex.org/I21851649","https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049043438","display_name":"Takeshi Kawamura","orcid":"https://orcid.org/0000-0003-1613-6968"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Kawamura","raw_affiliation_strings":["Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110250702","display_name":"Hiromasa Tojo","orcid":null},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromasa Tojo","raw_affiliation_strings":["Dept. of Biophysics and Biochemistry, Osaka University, Graduate School of Medicine, Suita, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biophysics and Biochemistry, Osaka University, Graduate School of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031004030","display_name":"Makoto Kihara","orcid":"https://orcid.org/0000-0002-4880-9090"},"institutions":[{"id":"https://openalex.org/I4210137957","display_name":"Machida Endoscope (Japan)","ror":"https://ror.org/03wh5v523","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210137957"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Kihara","raw_affiliation_strings":["Medical ProteoScope Co., Ltd., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical ProteoScope Co., Ltd., Tokyo, Japan","institution_ids":["https://openalex.org/I4210137957"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yasuhiko Bando","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuhiko Bando","raw_affiliation_strings":["Biosys Technologies, Inc., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosys Technologies, Inc., Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059166265","display_name":"Adi F. Gazdar","orcid":"https://orcid.org/0000-0002-5718-247X"},"institutions":[{"id":"https://openalex.org/I4388891891","display_name":"Southwestern Medical Center","ror":"https://ror.org/05d80e146","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891891"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adi F Gazdar","raw_affiliation_strings":["Hamon Center for Therapeutic Cancer Research, UT Southwestern Medical Center, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamon Center for Therapeutic Cancer Research, UT Southwestern Medical Center, Texas, USA","institution_ids":["https://openalex.org/I867280407","https://openalex.org/I4388891891"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045498137","display_name":"Masahiro Tsuboi","orcid":"https://orcid.org/0000-0003-3031-5807"},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Tsuboi","raw_affiliation_strings":["Dept. of Surgery I, Tokyo Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgery I, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023562080","display_name":"Hisashi Oshiro","orcid":"https://orcid.org/0000-0002-5036-9282"},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisashi Oshiro","raw_affiliation_strings":["Diagnostic Pathology, Division, Tokyo Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diagnostic Pathology, Division, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020199498","display_name":"Toshitaka Nagao","orcid":"https://orcid.org/0000-0003-2075-9738"},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshitaka Nagao","raw_affiliation_strings":["Diagnostic Pathology, Division, Tokyo Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diagnostic Pathology, Division, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103220668","display_name":"Tatsuo Ohira","orcid":"https://orcid.org/0000-0002-7927-6987"},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuo Ohira","raw_affiliation_strings":["Dept. of Surgery I, Tokyo Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgery I, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108560622","display_name":"Norihiko Ikeda","orcid":"https://orcid.org/0000-0002-5141-8808"},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norihiko Ikeda","raw_affiliation_strings":["Dept. of Surgery I, Tokyo Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgery I, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085007436","display_name":"Noriko Gotoh","orcid":"https://orcid.org/0000-0003-3733-260X"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriko Gotoh","raw_affiliation_strings":["Division of Systems Biomedical Technology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Systems Biomedical Technology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109083536","display_name":"Harubumi Kato","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harubumi Kato","raw_affiliation_strings":["Niizashiki Central General Hospital, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Niizashiki Central General Hospital, Saitama, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025688013","display_name":"Gy\u00f6rgy Marko\u2010Varga","orcid":"https://orcid.org/0000-0001-7140-8925"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gyorgy Marko-Varga","raw_affiliation_strings":["Clinical Protein Science & Imaging, Dept. of Measurement Technology and Industrial Electrical Engineering, Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Protein Science & Imaging, Dept. of Measurement Technology and Industrial Electrical Engineering, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033393526","display_name":"Toshihide Nishimura","orcid":"https://orcid.org/0000-0003-4136-5535"},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]},{"id":"https://openalex.org/I4210137957","display_name":"Machida Endoscope (Japan)","ror":"https://ror.org/03wh5v523","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210137957"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihide Nishimura","raw_affiliation_strings":["Biosys Technologies, Inc., Tokyo, Japan","Dept. of Surgery I, Tokyo Medical University, Tokyo, Japan","Medical ProteoScope Co., Ltd., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosys Technologies, Inc., Tokyo, Japan","institution_ids":[]},{"raw_affiliation_string":"Dept. of Surgery I, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]},{"raw_affiliation_string":"Medical ProteoScope Co., Ltd., Tokyo, Japan","institution_ids":["https://openalex.org/I4210137957"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5100826982"],"corresponding_institution_ids":["https://openalex.org/I158929114"],"apc_list":null,"apc_paid":null,"fwci":2.4128,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.89618025,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"1","issue":"1","first_page":"23","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.32600000500679016,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.32600000500679016,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.15919999778270721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.1193000003695488,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6145164370536804},{"id":"https://openalex.org/keywords/cancer-stem-cell","display_name":"Cancer stem cell","score":0.5689821243286133},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.5675137042999268},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.5513861775398254},{"id":"https://openalex.org/keywords/carcinoma","display_name":"Carcinoma","score":0.443459689617157},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4370863437652588},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.43215325474739075},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4144863486289978},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3865804672241211},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3597840666770935},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35942697525024414},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2366580367088318},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.13061001896858215}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6145164370536804},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5689821243286133},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5675137042999268},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5513861775398254},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.443459689617157},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4370863437652588},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43215325474739075},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4144863486289978},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3865804672241211},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3597840666770935},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35942697525024414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2366580367088318},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13061001896858215}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/2043-9113-1-23","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-1-23","pdf_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-1-23","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21888658","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21888658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3178477","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3178477","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Clin Bioinforma","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/2043-9113-1-23","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2043-9113-1-23","pdf_url":"https://jclinbioinformatics.biomedcentral.com/track/pdf/10.1186/2043-9113-1-23","source":{"id":"https://openalex.org/S141199735","display_name":"Journal of Clinical Bioinformatics","issn_l":"2043-9113","issn":["2043-9113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6800000071525574}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2049944344.pdf","grobid_xml":"https://content.openalex.org/works/W2049944344.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W36128392","https://openalex.org/W60650206","https://openalex.org/W1967123204","https://openalex.org/W1969812965","https://openalex.org/W1972990592","https://openalex.org/W1986883916","https://openalex.org/W1994747339","https://openalex.org/W2002873037","https://openalex.org/W2004462647","https://openalex.org/W2007252845","https://openalex.org/W2008549209","https://openalex.org/W2008618763","https://openalex.org/W2016957415","https://openalex.org/W2030659753","https://openalex.org/W2037088166","https://openalex.org/W2038873665","https://openalex.org/W2063543381","https://openalex.org/W2071167287","https://openalex.org/W2072631602","https://openalex.org/W2077160928","https://openalex.org/W2088720324","https://openalex.org/W2090867350","https://openalex.org/W2091217195","https://openalex.org/W2101995865","https://openalex.org/W2104098330","https://openalex.org/W2116394959","https://openalex.org/W2121076737","https://openalex.org/W2151879335","https://openalex.org/W2152539487"],"related_works":["https://openalex.org/W2064573700","https://openalex.org/W2967366602","https://openalex.org/W2376385980","https://openalex.org/W2075817938","https://openalex.org/W1496498748","https://openalex.org/W2129774558","https://openalex.org/W1997032381","https://openalex.org/W2063254961","https://openalex.org/W1979593122","https://openalex.org/W2287922696"],"abstract_inverted_index":{"BACKGROUND:":[0],"Large":[1],"cell":[2,13,23,264],"neuroendocrine":[3,19],"carcinoma":[4,14,25],"(LCNEC)":[5],"of":[6,11,53,85,140,153,173,277],"the":[7,107,158,186],"lung,":[8],"a":[9,47,56,138,174,182],"subtype":[10],"large":[12],"(LCC),":[15],"is":[16],"characterized":[17],"by":[18,76,118,123,129,250],"differentiation":[20],"that":[21,274],"small":[22],"lung":[24],"(SCLC)":[26],"shares.":[27],"Pre-therapeutic":[28],"histological":[29,101],"distinction":[30],"between":[31],"LCNEC":[32,54,86,178,204,278],"and":[33,94,111,126,171,234,240,285],"SCLC":[34,90,207],"has":[35],"so":[36],"far":[37],"been":[38],"problematic,":[39],"leading":[40],"to":[41,113,146,164,177,261,281,294],"adverse":[42],"clinical":[43],"outcome.":[44],"We":[45,196],"started":[46],"project":[48],"establishing":[49],"protein":[50,199],"targets":[51],"characteristic":[52],"with":[55,99,185,206,208],"proteomic":[57,148,268,287],"method":[58],"using":[59,137,181],"formalin":[60],"fixed":[61],"paraffin-embedded":[62],"(FFPE)":[63],"tissues,":[64],"which":[65],"will":[66],"help":[67],"make":[68],"diagnosis":[69],"convincing.":[70],"METHODS:":[71],"Cancer":[72],"cells":[73,284],"were":[74,104,121,134,162,248,279],"collected":[75],"laser":[77],"microdissection":[78],"from":[79,106,157],"cancer":[80,160,262,282],"foci":[81],"in":[82,203],"FFPE":[83,290],"tissues":[84],"(n":[87,91,96],"=":[88,92,97,220,232,238,244],"4),":[89],"5),":[93],"LCC":[95],"5)":[98],"definite":[100],"diagnosis.":[102],"Proteins":[103,116],"extracted":[105],"harvested":[108],"sections,":[109],"trypsin-digested,":[110],"subjected":[112,163],"HPLC/mass":[114],"spectrometry.":[115],"identified":[117,156,197],"database":[119],"search":[120],"semi-quantified":[122],"spectral":[124],"counting":[125],"statistically":[127],"sorted":[128],"pair-wise":[130,165],"G-statistics.":[131],"The":[132],"results":[133,272],"immunohistochemically":[135],"verified":[136],"total":[139,152],"10":[141],"cases":[142],"for":[143,191],"each":[144],"group":[145,194],"confirm":[147],"results.":[149,269],"RESULTS:":[150],"A":[151],"1981":[154],"proteins":[155],"three":[159],"groups":[161],"G-test":[166],"under":[167],"p":[168],"<":[169],"0.05":[170],"specificity":[172],"protein's":[175],"expression":[176],"was":[179,292],"checked":[180],"3D":[183],"plot":[184],"coordinates":[187],"comprising":[188],"G-statistic":[189],"values":[190],"every":[192],"two":[193],"comparisons.":[195],"four":[198],"candidates":[200,258],"preferentially":[201],"expressed":[202],"compared":[205],"convincingly":[209],"low":[210],"p-values:":[211],"aldehyde":[212],"dehydrogenase":[213],"1":[214,227],"family":[215,226],"member":[216],"A1":[217],"(AL1A1)":[218],"(p":[219,231,237,243],"6.1":[221],"\u00d7":[222],"10-4),":[223],"aldo-keto":[224],"reductase":[225],"members":[228],"C1":[229],"(AK1C1)":[230],"9.6x10-10)":[233],"C3":[235],"(AK1C3)":[236],"3.9x10-10)":[239],"CD44":[241],"antigen":[242],"0.021).":[245],"These":[246,271],"p-values":[247],"confirmed":[249],"non-parametric":[251],"exact":[252],"inference":[253],"tests.":[254],"Interestingly,":[255],"all":[256],"these":[257],"would":[259],"belong":[260],"stem":[263,283],"markers.":[265],"Immunohistochmistry":[266],"supported":[267],"CONCLUSIONS:":[270],"suggest":[273],"candidate":[275],"biomarkers":[276],"related":[280],"this":[286],"approach":[288],"via":[289],"samples":[291],"effective":[293],"detect":[295],"them.":[296]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}