{"id":"https://openalex.org/W1990859999","doi":"https://doi.org/10.1186/1758-2946-5-s1-p31","title":"Experimental validation of in silico target predictions on synergistic protein targets","display_name":"Experimental validation of in silico target predictions on synergistic protein targets","publication_year":2013,"publication_date":"2013-03-01","ids":{"openalex":"https://openalex.org/W1990859999","doi":"https://doi.org/10.1186/1758-2946-5-s1-p31","mag":"1990859999"},"language":"en","primary_location":{"id":"doi:10.1186/1758-2946-5-s1-p31","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1758-2946-5-s1-p31","pdf_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/1758-2946-5-S1-P31","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/1758-2946-5-S1-P31","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091416834","display_name":"Isidro Cort\u00e9s\u2010Ciriano","orcid":"https://orcid.org/0000-0002-2036-494X"},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Isidro Cortes-Ciriano","raw_affiliation_strings":["Institute of Biocomputation and Physics of Complex Systems (BIFI), Unidad Asociada IQFR-CSIC-BIFI, and Department of Biochemistry and Molecular and Cellular Biology, Universidad de Zaragoza, Zaragoza, Spain"],"affiliations":[{"raw_affiliation_string":"Institute of Biocomputation and Physics of Complex Systems (BIFI), Unidad Asociada IQFR-CSIC-BIFI, and Department of Biochemistry and Molecular and Cellular Biology, Universidad de Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076832707","display_name":"Alexios Koutsoukas","orcid":null},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I1342131907","display_name":"Unilever (United Kingdom)","ror":"https://ror.org/05n8ah907","country_code":"GB","type":"company","lineage":["https://openalex.org/I1342131907"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexios Koutsoukas","raw_affiliation_strings":["Unilever Centre for Molecular Science Informatics, Chemistry Department, University of Cambridge, Cambridge, CB2 1EW, UK","Unilever Centre for Molecular Science Informatics, Chemistry Department, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Unilever Centre for Molecular Science Informatics, Chemistry Department, University of Cambridge, Cambridge, CB2 1EW, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I1342131907"]},{"raw_affiliation_string":"Unilever Centre for Molecular Science Informatics, Chemistry Department, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114377861","display_name":"Olga Abi\u00e1n","orcid":"https://orcid.org/0000-0001-5664-1729"},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Olga Abian","raw_affiliation_strings":["Aragon Health Sciences Institute (I+CS), Zaragoza, Spain","Institute of Biocomputation and Physics of Complex Systems (BIFI), Unidad Asociada IQFR-CSIC-BIFI, and Department of Biochemistry and Molecular and Cellular Biology, Universidad de Zaragoza, Zaragoza, Spain","Institute of Biocomputation and Physics of Complex Systems (BIFI), Unidad Asociada IQFR-CSIC-BIFI, and Department of Biochemistry and Molecular and Cellular Biology, Universidad de Zaragoza,Zaragoza,Spain"],"affiliations":[{"raw_affiliation_string":"Aragon Health Sciences Institute (I+CS), Zaragoza, Spain","institution_ids":["https://openalex.org/I4210136512"]},{"raw_affiliation_string":"Institute of Biocomputation and Physics of Complex Systems (BIFI), Unidad Asociada IQFR-CSIC-BIFI, and Department of Biochemistry and Molecular and Cellular Biology, Universidad de Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]},{"raw_affiliation_string":"Institute of Biocomputation and Physics of Complex Systems (BIFI), Unidad Asociada IQFR-CSIC-BIFI, and Department of Biochemistry and Molecular and Cellular Biology, Universidad de Zaragoza,Zaragoza,Spain","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026643759","display_name":"Andreas Bender","orcid":"https://orcid.org/0000-0002-6683-7546"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I1342131907","display_name":"Unilever (United Kingdom)","ror":"https://ror.org/05n8ah907","country_code":"GB","type":"company","lineage":["https://openalex.org/I1342131907"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andreas Bender","raw_affiliation_strings":["Unilever Centre for Molecular Science Informatics, Chemistry Department, University of Cambridge, Cambridge, CB2 1EW, UK","Unilever Centre for Molecular Science Informatics, Chemistry Department, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Unilever Centre for Molecular Science Informatics, Chemistry Department, University of Cambridge, Cambridge, CB2 1EW, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I1342131907"]},{"raw_affiliation_string":"Unilever Centre for Molecular Science Informatics, Chemistry Department, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091692002","display_name":"Adri\u00e1n Vel\u00e1zquez\u2010Campoy","orcid":"https://orcid.org/0000-0001-5702-4538"},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210140177","display_name":"Fundaci\u00f3n General","ror":"https://ror.org/03byqb733","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210140177"]},{"id":"https://openalex.org/I4210085944","display_name":"Fundacion Agencia Aragonesa para la Investigacion y el Desarrollo","ror":"https://ror.org/007bpwb04","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210085944"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Adrian Velazquez-Campoy","raw_affiliation_strings":["Fundacion ARAID, Diputacion General de Aragon, Spain","Institute of Biocomputation and Physics of Complex Systems (BIFI), Unidad Asociada IQFR-CSIC-BIFI, and Department of Biochemistry and Molecular and Cellular Biology, Universidad de Zaragoza, Zaragoza, Spain"],"affiliations":[{"raw_affiliation_string":"Fundacion ARAID, Diputacion General de Aragon, Spain","institution_ids":["https://openalex.org/I4210140177","https://openalex.org/I4210085944"]},{"raw_affiliation_string":"Institute of Biocomputation and Physics of Complex Systems (BIFI), Unidad Asociada IQFR-CSIC-BIFI, and Department of Biochemistry and Molecular and Cellular Biology, Universidad de Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5091416834"],"corresponding_institution_ids":["https://openalex.org/I255234318"],"apc_list":{"value":1290,"currency":"GBP","value_usd":1582},"apc_paid":{"value":1290,"currency":"GBP","value_usd":1582},"fwci":0.1497,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5581732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"5","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.7841660976409912},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6504603028297424},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4380354881286621},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4181452989578247},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2669178545475006},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13906961679458618},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09940171241760254}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7841660976409912},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6504603028297424},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4380354881286621},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4181452989578247},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2669178545475006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13906961679458618},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09940171241760254},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1758-2946-5-s1-p31","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1758-2946-5-s1-p31","pdf_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/1758-2946-5-S1-P31","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2605506","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3606266","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/244357","is_oa":true,"landing_page_url":"http://www.dspace.cam.ac.uk/handle/1810/244357","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/1758-2946-5-s1-p31","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1758-2946-5-s1-p31","pdf_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/1758-2946-5-S1-P31","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6299999952316284,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990859999.pdf","grobid_xml":"https://content.openalex.org/works/W1990859999.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2052214665","https://openalex.org/W4237095724"],"related_works":["https://openalex.org/W2003194288","https://openalex.org/W2513589746","https://openalex.org/W2213189664","https://openalex.org/W2153919606","https://openalex.org/W2113024639","https://openalex.org/W2062254828","https://openalex.org/W4237480606","https://openalex.org/W2936968863","https://openalex.org/W4378672831","https://openalex.org/W1971792277"],"abstract_inverted_index":{"RIGHTS":[0],":":[1,26],"This":[2],"article":[3],"is":[4,14],"licensed":[5],"under":[6,44],"the":[7,17,31,41,45,48,68],"BioMed":[8],"Central":[9],"licence":[10],"at":[11],"http://www.biomedcentral.com/about/license":[12],"which":[13],"similar":[15],"to":[16,65],"'Creative":[18],"Commons":[19],"Attribution":[20],"Licence'.":[21],"In":[22],"brief":[23],"you":[24],"may":[25],"copy,":[27],"distribute,":[28],"and":[29],"display":[30],"work;":[32],"make":[33,37],"derivative":[34],"works;":[35],"or":[36,58],"commercial":[38],"use":[39],"of":[40,71],"work":[42,73],"-":[43],"following":[46],"conditions:":[47],"original":[49],"author":[50],"must":[51,61],"be":[52,62],"given":[53],"credit;":[54],"for":[55],"any":[56],"reuse":[57],"distribution,":[59],"it":[60],"made":[63],"clear":[64],"others":[66],"what":[67],"license":[69],"terms":[70],"this":[72],"are.":[74]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}