{"id":"https://openalex.org/W1853932644","doi":"https://doi.org/10.1186/1758-2946-5-s1-p15","title":"Annotating targets with pathways: extending approaches to mode of action analysis","display_name":"Annotating targets with pathways: extending approaches to mode of action analysis","publication_year":2013,"publication_date":"2013-03-01","ids":{"openalex":"https://openalex.org/W1853932644","doi":"https://doi.org/10.1186/1758-2946-5-s1-p15","mag":"1853932644"},"language":"en","primary_location":{"id":"doi:10.1186/1758-2946-5-s1-p15","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1758-2946-5-s1-p15","pdf_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/1758-2946-5-S1-P15","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/1758-2946-5-S1-P15","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002397695","display_name":"Sonia Liggi","orcid":"https://orcid.org/0000-0003-1802-357X"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I1342131907","display_name":"Unilever (United Kingdom)","ror":"https://ror.org/05n8ah907","country_code":"GB","type":"company","lineage":["https://openalex.org/I1342131907"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sonia Liggi","raw_affiliation_strings":["Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK","Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I1342131907"]},{"raw_affiliation_string":"Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I1342131907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076832707","display_name":"Alexios Koutsoukas","orcid":null},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I1342131907","display_name":"Unilever (United Kingdom)","ror":"https://ror.org/05n8ah907","country_code":"GB","type":"company","lineage":["https://openalex.org/I1342131907"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexios Koutsoukas","raw_affiliation_strings":["Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK","Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I1342131907"]},{"raw_affiliation_string":"Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I1342131907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036977624","display_name":"Yasaman Kalantar Motamedi","orcid":null},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I1342131907","display_name":"Unilever (United Kingdom)","ror":"https://ror.org/05n8ah907","country_code":"GB","type":"company","lineage":["https://openalex.org/I1342131907"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yasaman Kalantar Motamedi","raw_affiliation_strings":["Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK","Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I1342131907"]},{"raw_affiliation_string":"Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I1342131907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014283781","display_name":"Robert C. Glen","orcid":"https://orcid.org/0000-0003-1759-2914"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I1342131907","display_name":"Unilever (United Kingdom)","ror":"https://ror.org/05n8ah907","country_code":"GB","type":"company","lineage":["https://openalex.org/I1342131907"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert C Glen","raw_affiliation_strings":["Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK","Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I1342131907"]},{"raw_affiliation_string":"Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I1342131907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026643759","display_name":"Andreas Bender","orcid":"https://orcid.org/0000-0002-6683-7546"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I1342131907","display_name":"Unilever (United Kingdom)","ror":"https://ror.org/05n8ah907","country_code":"GB","type":"company","lineage":["https://openalex.org/I1342131907"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andreas Bender","raw_affiliation_strings":["Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK","Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I1342131907"]},{"raw_affiliation_string":"Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I1342131907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5002397695"],"corresponding_institution_ids":["https://openalex.org/I1342131907","https://openalex.org/I241749"],"apc_list":{"value":1290,"currency":"GBP","value_usd":1582},"apc_paid":{"value":1290,"currency":"GBP","value_usd":1582},"fwci":0.3702,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.61758846,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"5","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cheminformatics","display_name":"Cheminformatics","score":0.7470957636833191},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.7118141055107117},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6482177972793579},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6259225606918335},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6137310862541199},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5747003555297852},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.560234546661377},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.539662778377533},{"id":"https://openalex.org/keywords/pathway-analysis","display_name":"Pathway analysis","score":0.4177263081073761},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3902280330657959},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3266344368457794},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14068603515625},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1231050193309784},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.10422006249427795}],"concepts":[{"id":"https://openalex.org/C68762167","wikidata":"https://www.wikidata.org/wiki/Q910164","display_name":"Cheminformatics","level":2,"score":0.7470957636833191},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.7118141055107117},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6482177972793579},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6259225606918335},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6137310862541199},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5747003555297852},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.560234546661377},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.539662778377533},{"id":"https://openalex.org/C2779230013","wikidata":"https://www.wikidata.org/wiki/Q25303877","display_name":"Pathway analysis","level":4,"score":0.4177263081073761},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3902280330657959},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3266344368457794},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14068603515625},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1231050193309784},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10422006249427795},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1758-2946-5-s1-p15","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1758-2946-5-s1-p15","pdf_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/1758-2946-5-S1-P15","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2605504","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3606261","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/244361","is_oa":true,"landing_page_url":"http://www.dspace.cam.ac.uk/handle/1810/244361","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference Object"}],"best_oa_location":{"id":"doi:10.1186/1758-2946-5-s1-p15","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1758-2946-5-s1-p15","pdf_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/1758-2946-5-S1-P15","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1853932644.pdf","grobid_xml":"https://content.openalex.org/works/W1853932644.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2044542784","https://openalex.org/W2074192927","https://openalex.org/W2085827128","https://openalex.org/W2092053124","https://openalex.org/W2165209834"],"related_works":["https://openalex.org/W2803206732","https://openalex.org/W1964657534","https://openalex.org/W2070692310","https://openalex.org/W4200184670","https://openalex.org/W2402340532","https://openalex.org/W2751692355","https://openalex.org/W2048384644","https://openalex.org/W1596975594","https://openalex.org/W3104918602","https://openalex.org/W2154972152"],"abstract_inverted_index":{"RIGHTS":[0],":":[1,26],"This":[2],"article":[3],"is":[4,14],"licensed":[5],"under":[6,44],"the":[7,17,31,41,45,48,68],"BioMed":[8],"Central":[9],"licence":[10],"at":[11],"http://www.biomedcentral.com/about/license":[12],"which":[13],"similar":[15],"to":[16,65],"'Creative":[18],"Commons":[19],"Attribution":[20],"Licence'.":[21],"In":[22],"brief":[23],"you":[24],"may":[25],"copy,":[27],"distribute,":[28],"and":[29],"display":[30],"work;":[32],"make":[33,37],"derivative":[34],"works;":[35],"or":[36,58],"commercial":[38],"use":[39],"of":[40,71],"work":[42,73],"-":[43],"following":[46],"conditions:":[47],"original":[49],"author":[50],"must":[51,61],"be":[52,62],"given":[53],"credit;":[54],"for":[55],"any":[56],"reuse":[57],"distribution,":[59],"it":[60],"made":[63],"clear":[64],"others":[66],"what":[67],"license":[69],"terms":[70],"this":[72],"are.":[74]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}