{"id":"https://openalex.org/W118492708","doi":"https://doi.org/10.1186/1758-2946-4-s1-p23","title":"CLOUD \u2013 CeMM library of unique drugs","display_name":"CLOUD \u2013 CeMM library of unique drugs","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W118492708","doi":"https://doi.org/10.1186/1758-2946-4-s1-p23","mag":"118492708"},"language":"en","primary_location":{"id":"doi:10.1186/1758-2946-4-s1-p23","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1758-2946-4-s1-p23","pdf_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/1758-2946-4-S1-P23","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/1758-2946-4-S1-P23","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032478852","display_name":"Patrick Markt","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Patrick Markt","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine, Lazarettgasse 14/AKH BT 25.3, 1090, Vienna, Austria","CeMM Research Center for Molecular Medicine, Vienna, Austria"],"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine, Lazarettgasse 14/AKH BT 25.3, 1090, Vienna, Austria","institution_ids":["https://openalex.org/I4210127611"]},{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine, Vienna, Austria","institution_ids":["https://openalex.org/I4210127611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008531373","display_name":"Gerhard D\u00fcrnberger","orcid":"https://orcid.org/0000-0001-5059-5362"},"institutions":[{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Gerhard D\u00fcrnberger","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine, Lazarettgasse 14/AKH BT 25.3, 1090, Vienna, Austria","CeMM Research Center for Molecular Medicine, Vienna, Austria"],"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine, Lazarettgasse 14/AKH BT 25.3, 1090, Vienna, Austria","institution_ids":["https://openalex.org/I4210127611"]},{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine, Vienna, Austria","institution_ids":["https://openalex.org/I4210127611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029758467","display_name":"Jacques Colinge","orcid":"https://orcid.org/0000-0003-2466-4824"},"institutions":[{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Jacques Colinge","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine, Lazarettgasse 14/AKH BT 25.3, 1090, Vienna, Austria","CeMM Research Center for Molecular Medicine, Vienna, Austria"],"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine, Lazarettgasse 14/AKH BT 25.3, 1090, Vienna, Austria","institution_ids":["https://openalex.org/I4210127611"]},{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine, Vienna, Austria","institution_ids":["https://openalex.org/I4210127611"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084485181","display_name":"Stefan Kubicek","orcid":"https://orcid.org/0000-0003-0855-8343"},"institutions":[{"id":"https://openalex.org/I4210127611","display_name":"CeMM Research Center for Molecular Medicine","ror":"https://ror.org/02z2dfb58","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210127611"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Stefan Kubicek","raw_affiliation_strings":["CeMM Research Center for Molecular Medicine, Lazarettgasse 14/AKH BT 25.3, 1090, Vienna, Austria","CeMM Research Center for Molecular Medicine, Vienna, Austria"],"affiliations":[{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine, Lazarettgasse 14/AKH BT 25.3, 1090, Vienna, Austria","institution_ids":["https://openalex.org/I4210127611"]},{"raw_affiliation_string":"CeMM Research Center for Molecular Medicine, Vienna, Austria","institution_ids":["https://openalex.org/I4210127611"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5032478852"],"corresponding_institution_ids":["https://openalex.org/I4210127611"],"apc_list":{"value":1290,"currency":"GBP","value_usd":1582},"apc_paid":{"value":1290,"currency":"GBP","value_usd":1582},"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0071935,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"4","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9753000140190125,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9690999984741211,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6173797249794006},{"id":"https://openalex.org/keywords/cloud-computing","display_name":"Cloud computing","score":0.58930903673172},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4947004020214081},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.4152202308177948},{"id":"https://openalex.org/keywords/operating-system","display_name":"Operating system","score":0.07967892289161682}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6173797249794006},{"id":"https://openalex.org/C79974875","wikidata":"https://www.wikidata.org/wiki/Q483639","display_name":"Cloud computing","level":2,"score":0.58930903673172},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4947004020214081},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.4152202308177948},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.07967892289161682}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/1758-2946-4-s1-p23","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1758-2946-4-s1-p23","pdf_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/1758-2946-4-S1-P23","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3341249","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3341249","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Cheminform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1758-2946-4-s1-p23","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1758-2946-4-s1-p23","pdf_url":"https://jcheminf.biomedcentral.com/track/pdf/10.1186/1758-2946-4-S1-P23","source":{"id":"https://openalex.org/S180838163","display_name":"Journal of Cheminformatics","issn_l":"1758-2946","issn":["1758-2946"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cheminformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W118492708.pdf","grobid_xml":"https://content.openalex.org/works/W118492708.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2008731781","https://openalex.org/W2108492672"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W4244478748","https://openalex.org/W4223488648","https://openalex.org/W2134969820","https://openalex.org/W2251605416","https://openalex.org/W4389340727","https://openalex.org/W4205786897","https://openalex.org/W3150465815","https://openalex.org/W2802581102","https://openalex.org/W1997222214"],"abstract_inverted_index":{"Approved":[0],"drugs":[1,118,129,169,202],"serve":[2],"as":[3,54,222,224],"functional":[4],"probes":[5],"for":[6,82,193],"analyzing":[7],"disease-relevant":[8],"biochemical":[9,195],"pathways":[10],"or":[11],"are":[12,69,203],"screened":[13],"against":[14],"proteins":[15],"to":[16,38,130,155,213,218],"identify":[17],"novel":[18],"medical":[19],"applications":[20],"resulting":[21],"in":[22,150,205,210],"a":[23,41,102,131,206],"repurposing":[24],"of":[25,31,49,94,98,105,127,133,159,164,184,190],"known":[26],"drugs.":[27,50,111],"Despite":[28],"these":[29],"benefits":[30],"approved":[32,128],"drugs,":[33,165],"it":[34],"is":[35,86,174],"almost":[36],"impossible":[37],"physically":[39],"obtain":[40],"complete":[42],"collection.":[43],"Commercial":[44],"vendors":[45],"cover":[46],"about":[47],"50-65%":[48],"Academic":[51],"efforts":[52],"such":[53],"the":[55,64,92,95,171,181,188,191],"Johns":[56],"Hopkins":[57],"Clinical":[58],"Compound":[59],"Library":[60,97],"(JHCCL)":[61],"[1]":[62],"and":[63,122,138,161,196],"NCGC":[65],"Pharmaceutical":[66],"collection":[67,104],"[2]":[68],"only":[70],"accessible":[71],"via":[72],"collaboration":[73],"agreements.":[74],"Thus,":[75],"an":[76],"affordable":[77],"reference":[78],"drug":[79],"library":[80,113,192],"obtainable":[81],"all":[83,200],"screening":[84,221],"centers":[85],"still":[87,175],"missing.":[88],"Here":[89],"we":[90],"report":[91],"generation":[93],"CeMM":[96],"Unique":[99],"Drugs":[100],"(CLOUD),":[101],"focused":[103],"314":[106],"systemically":[107,134],"bioavailable":[108],"small":[109,136],"molecule":[110],"The":[112],"was":[114],"derived":[115],"from":[116],"FDA-approved":[117],"applying":[119],"data":[120],"mining":[121],"structural":[123,160],"clustering":[124,139],"techniques.":[125],"Reduction":[126],"set":[132,158],"available":[135],"molecules":[137,179],"based":[140],"on":[141],"their":[142,214],"activity":[143],"classes":[144],"(e.g.":[145],"dopamine":[146],"receptor":[147],"agonist)":[148],"resulted":[149],"244":[151],"compounds.":[152],"In":[153],"addition":[154],"this":[156],"representative":[157],"biological":[162,172],"space":[163],"CLOUD":[166,185,201],"contains":[167],"35":[168,178],"where":[170],"target":[173],"unknown.":[176],"Another":[177],"representing":[180],"active":[182],"forms":[183],"prodrugs":[186],"ensure":[187],"usability":[189],"both":[194],"cell-based":[197],"assays.":[198],"Finally,":[199],"delivered":[204],"single":[207],"384-well":[208],"plate":[209],"concentrations":[211],"related":[212],"therapeutic":[215],"plasma":[216],"levels":[217],"make":[219],"high-throughput":[220],"comfortable":[223],"possible.":[225]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
