{"id":"https://openalex.org/W2126964466","doi":"https://doi.org/10.1186/1756-0381-5-16","title":"GAMETES: a fast, direct algorithm for generating pure, strict, epistatic models with random architectures","display_name":"GAMETES: a fast, direct algorithm for generating pure, strict, epistatic models with random architectures","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2126964466","doi":"https://doi.org/10.1186/1756-0381-5-16","mag":"2126964466","pmid":"https://pubmed.ncbi.nlm.nih.gov/23025260"},"language":"en","primary_location":{"id":"doi:10.1186/1756-0381-5-16","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0381-5-16","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/1756-0381-5-16","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/1756-0381-5-16","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023718023","display_name":"Ryan J. Urbanowicz","orcid":"https://orcid.org/0000-0002-0487-5555"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I126688049","display_name":"Dartmouth Institute for Health Policy and Clinical Practice","ror":"https://ror.org/0511yej17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126688049"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan J Urbanowicz","raw_affiliation_strings":["Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, NH, USA. jason.h.moore@dartmouth.edu","Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, NH, USA. jason.h.moore@dartmouth.edu","institution_ids":["https://openalex.org/I126688049","https://openalex.org/I107672454"]},{"raw_affiliation_string":"Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070068281","display_name":"Jeff Kiralis","orcid":null},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff Kiralis","raw_affiliation_strings":["Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, NH, USA","Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, NH, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111941876","display_name":"Nicholas A. Sinnott\u2010Armstrong","orcid":null},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas A Sinnott-Armstrong","raw_affiliation_strings":["Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, NH, USA","Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, NH, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013609227","display_name":"Heberling Tamra","orcid":null},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamra Heberling","raw_affiliation_strings":["Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, NH, USA","Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, NH, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025883825","display_name":"Jonathan Fisher","orcid":"https://orcid.org/0009-0000-5858-9936"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan M Fisher","raw_affiliation_strings":["Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, NH, USA","Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, NH, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032971510","display_name":"Jason H. Moore","orcid":"https://orcid.org/0000-0002-5015-1099"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason H Moore","raw_affiliation_strings":["Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, NH, USA","Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, NH, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Genetics, Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, USA","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5032971510"],"corresponding_institution_ids":["https://openalex.org/I107672454"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":6.7462,"has_fulltext":true,"cited_by_count":227,"citation_normalized_percentile":{"value":0.9733491,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"5","issue":"1","first_page":"16","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.830592930316925},{"id":"https://openalex.org/keywords/locus","display_name":"Locus (genetics)","score":0.6202101707458496},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5492852926254272},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.45160165429115295},{"id":"https://openalex.org/keywords/genetic-model","display_name":"Genetic model","score":0.43893831968307495},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3359086513519287},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31819069385528564},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3075416088104248},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.18239068984985352},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11178675293922424}],"concepts":[{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.830592930316925},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6202101707458496},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5492852926254272},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.45160165429115295},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.43893831968307495},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3359086513519287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31819069385528564},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3075416088104248},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.18239068984985352},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11178675293922424}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1756-0381-5-16","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0381-5-16","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/1756-0381-5-16","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},{"id":"pmid:23025260","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23025260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData mining","raw_type":null},{"id":"pmh:oai:europepmc.org:2604236","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3605108","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1756-0381-5-16","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0381-5-16","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/1756-0381-5-16","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","score":0.4399999976158142,"display_name":"Partnerships for the goals"}],"awards":[{"id":"https://openalex.org/G2916098388","display_name":null,"funder_award_id":"R01 AI059694","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G299099718","display_name":null,"funder_award_id":"LM009012","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5614804429","display_name":null,"funder_award_id":"AI59694","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5668804095","display_name":null,"funder_award_id":"P20 GM103534","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G582462499","display_name":null,"funder_award_id":"R01 LM009012","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G6682602594","display_name":null,"funder_award_id":"LM010098","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310400","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2126964466.pdf","grobid_xml":"https://content.openalex.org/works/W2126964466.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1492992226","https://openalex.org/W1519864894","https://openalex.org/W1554403518","https://openalex.org/W1560801430","https://openalex.org/W1566107011","https://openalex.org/W1567107174","https://openalex.org/W1820420379","https://openalex.org/W1966315117","https://openalex.org/W1967668456","https://openalex.org/W1976632102","https://openalex.org/W1986450144","https://openalex.org/W1993449345","https://openalex.org/W1994050986","https://openalex.org/W1995997000","https://openalex.org/W1997744129","https://openalex.org/W2004159986","https://openalex.org/W2004897641","https://openalex.org/W2023615944","https://openalex.org/W2040709122","https://openalex.org/W2062885451","https://openalex.org/W2063389953","https://openalex.org/W2063575312","https://openalex.org/W2125779167","https://openalex.org/W2125858955","https://openalex.org/W2128584751","https://openalex.org/W2148981095","https://openalex.org/W2152905639","https://openalex.org/W2154572047","https://openalex.org/W2167638767","https://openalex.org/W2303043072","https://openalex.org/W2492353954","https://openalex.org/W3104824402","https://openalex.org/W4205232216"],"related_works":["https://openalex.org/W2115675860","https://openalex.org/W2133790197","https://openalex.org/W2124724808","https://openalex.org/W2589149327","https://openalex.org/W2182810250","https://openalex.org/W2147212144","https://openalex.org/W2056064843","https://openalex.org/W2052173596","https://openalex.org/W1886625688","https://openalex.org/W2028554823"],"abstract_inverted_index":{"BACKGROUND:":[0],"Geneticists":[1],"who":[2],"look":[3],"beyond":[4],"single":[5,156],"locus":[6],"disease":[7,48,110,126,160],"associations":[8,114],"require":[9],"additional":[10],"strategies":[11],"for":[12,42,57,135,162,212,246],"the":[13,31,54,104,125,187,218,271,285],"detection":[14],"of":[15,33,38,88,108,186,209,222,309],"complex":[16,139,154,248],"multi-locus":[17,21,60,140],"effects.":[18,141],"Epistasis,":[19],"a":[20,25,85,146,195,240,257],"masking":[22],"effect,":[23],"presents":[24],"particular":[26],"challenge,":[27],"and":[28,79,96,99,150,167,189,220,243,312],"has":[29,256],"been":[30],"target":[32],"bioinformatic":[34],"development.":[35],"Thorough":[36],"evaluation":[37],"new":[39,281],"algorithms":[40],"calls":[41],"simulation":[43,136,163,198,227,278,296],"studies":[44,137,279],"in":[45,106,124,277],"which":[46,90,152,200],"known":[47],"models":[49,62,83,102,161,174,250,262,274,311],"are":[50,70,122],"sought.":[51],"To":[52],"date,":[53],"best":[55],"methods":[56,69],"generating":[58,247,270],"simulated":[59,210],"epistatic":[61,101],"rely":[63],"on":[64],"genetic":[65,177,214,310],"algorithms.":[66,282],"However,":[67],"such":[68,113],"computationally":[71],"expensive,":[72],"difficult":[73],"to":[74,76,81,93,204,234,260,305],"adapt":[75],"multiple":[77],"objectives,":[78],"unlikely":[80],"yield":[82],"with":[84,175,224,251,263,293],"precise":[86,244],"form":[87],"epistasis":[89],"we":[91],"refer":[92],"as":[94],"pure":[95],"strict.":[97],"Purely":[98],"strictly":[100],"constitute":[103],"worst-case":[105],"terms":[107],"detecting":[109],"associations,":[111],"since":[112],"may":[115,201,289],"only":[116],"be":[117,202,290,303],"observed":[118],"if":[119],"all":[120],"n-loci":[121],"included":[123],"model.":[127],"This":[128],"makes":[129],"them":[130],"an":[131,207,225,231],"attractive":[132],"gold":[133],"standard":[134],"considering":[138],"RESULTS:":[142],"We":[143,216],"introduce":[144],"GAMETES,":[145],"user-friendly":[147],"software":[148],"package":[149],"algorithm":[151,232],"generates":[153,169],"biallelic":[155],"nucleotide":[157],"polymorphism":[158],"(SNP)":[159],"studies.":[164],"GAMETES":[165,192,223,238,255,286,301],"rapidly":[166,205],"precisely":[168],"random,":[170],"pure,":[171],"strict":[172],"n-locus":[173,249],"specified":[176],"constraints.":[178],"These":[179],"constraints":[180],"include":[181],"heritability,":[182],"minor":[183],"allele":[184],"frequencies":[185],"SNPs,":[188],"population":[190],"prevalence.":[191],"also":[193],"includes":[194],"simple":[196],"dataset":[197,295,299],"strategy":[199,288],"utilized":[203],"generate":[206,261],"archive":[208],"datasets":[211],"given":[213],"models.":[215],"highlight":[217],"utility":[219],"limitations":[221],"example":[226],"study":[228],"using":[229],"MDR,":[230],"designed":[233],"detect":[235],"epistasis.":[236,313],"CONCLUSIONS:":[237],"is":[239,267],"fast,":[241],"flexible,":[242],"tool":[245],"random":[252],"architectures.":[253],"While":[254],"limited":[258],"ability":[259],"higher":[264],"heritabilities,":[265],"it":[266],"proficient":[268],"at":[269],"lower":[272],"heritability":[273],"typically":[275],"used":[276],"evaluating":[280],"In":[283],"addition,":[284],"modeling":[287],"flexibly":[291],"combined":[292],"any":[294],"strategy.":[297],"Beyond":[298],"simulation,":[300],"could":[302],"employed":[304],"pursue":[306],"theoretical":[307],"characterization":[308]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}
