{"id":"https://openalex.org/W2140703652","doi":"https://doi.org/10.1186/1756-0381-4-4","title":"Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies","display_name":"Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W2140703652","doi":"https://doi.org/10.1186/1756-0381-4-4","mag":"2140703652","pmid":"https://pubmed.ncbi.nlm.nih.gov/21362183"},"language":"en","primary_location":{"id":"doi:10.1186/1756-0381-4-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0381-4-4","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/1756-0381-4-4","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/1756-0381-4-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080845006","display_name":"Thorsten Lehr","orcid":"https://orcid.org/0000-0002-8372-1465"},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thorsten Lehr","raw_affiliation_strings":["Boehringer Ingelheim Pharma GmbH & Co, KG, Department of Drug Metabolism and Pharmacokinetics, 88397 Biberach an der Riss, Germany. thorsten.lehr@boehringer-ingelheim.com","Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach an der Riss, Germany"],"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharma GmbH & Co, KG, Department of Drug Metabolism and Pharmacokinetics, 88397 Biberach an der Riss, Germany. thorsten.lehr@boehringer-ingelheim.com","institution_ids":[]},{"raw_affiliation_string":"Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach an der Riss, Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000421694","display_name":"Jing Yuan","orcid":"https://orcid.org/0000-0001-5345-0070"},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]},{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Jing Yuan","raw_affiliation_strings":["Boehringer Ingelheim Pharma GmbH & Co. KG, Department of Drug Metabolism and Pharmacokinetics, 88397 Biberach an der Riss, Germany","Department of Toxicology and Safety Assessment, Boehringer Ingelheim Pharma Inc, 900 Ridgebury Road, Ridgefield, CT, 06877, USA"],"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharma GmbH & Co. KG, Department of Drug Metabolism and Pharmacokinetics, 88397 Biberach an der Riss, Germany","institution_ids":["https://openalex.org/I1330995197"]},{"raw_affiliation_string":"Department of Toxicology and Safety Assessment, Boehringer Ingelheim Pharma Inc, 900 Ridgebury Road, Ridgefield, CT, 06877, USA","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091060401","display_name":"Dirk Zeumer","orcid":null},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dirk Zeumer","raw_affiliation_strings":["Boehringer Ingelheim Pharma GmbH & Co. KG, Department of Drug Metabolism and Pharmacokinetics, 88397 Biberach an der Riss, Germany","Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach an der Riss, Germany"],"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharma GmbH & Co. KG, Department of Drug Metabolism and Pharmacokinetics, 88397 Biberach an der Riss, Germany","institution_ids":["https://openalex.org/I1330995197"]},{"raw_affiliation_string":"Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach an der Riss, Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028959784","display_name":"Supriya Jayadev","orcid":null},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]},{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Supriya Jayadev","raw_affiliation_strings":["Boehringer Ingelheim Pharma GmbH & Co. KG, Department of Drug Metabolism and Pharmacokinetics, 88397 Biberach an der Riss, Germany","Department of Toxicology and Safety Assessment, Boehringer Ingelheim Pharma Inc, 900 Ridgebury Road, Ridgefield, CT, 06877, USA"],"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharma GmbH & Co. KG, Department of Drug Metabolism and Pharmacokinetics, 88397 Biberach an der Riss, Germany","institution_ids":["https://openalex.org/I1330995197"]},{"raw_affiliation_string":"Department of Toxicology and Safety Assessment, Boehringer Ingelheim Pharma Inc, 900 Ridgebury Road, Ridgefield, CT, 06877, USA","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081769614","display_name":"Marylyn D. Ritchie","orcid":"https://orcid.org/0000-0002-1208-1720"},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]},{"id":"https://openalex.org/I4210105714","display_name":"Center for Human Genetics","ror":"https://ror.org/01gcrbc43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105714"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Marylyn D Ritchie","raw_affiliation_strings":["Boehringer Ingelheim Pharma GmbH & Co. KG, Department of Drug Metabolism and Pharmacokinetics, 88397 Biberach an der Riss, Germany","Vanderbilt University Medical Center, Department of Molecular Physiology & Biophysics, Center for Human Genetics Research, 519 Light Hall, Nashville, TN, 37232, USA"],"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharma GmbH & Co. KG, Department of Drug Metabolism and Pharmacokinetics, 88397 Biberach an der Riss, Germany","institution_ids":["https://openalex.org/I1330995197"]},{"raw_affiliation_string":"Vanderbilt University Medical Center, Department of Molecular Physiology & Biophysics, Center for Human Genetics Research, 519 Light Hall, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I901861585","https://openalex.org/I4210105714"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5080845006"],"corresponding_institution_ids":["https://openalex.org/I1330995197"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.0643,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.76512227,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"4","issue":"1","first_page":"4","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9846000075340271,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.5702037215232849},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5357619524002075},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5124583840370178},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.48606565594673157},{"id":"https://openalex.org/keywords/association-rule-learning","display_name":"Association rule learning","score":0.46987611055374146},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.44665783643722534},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4219260513782501},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3999429941177368},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.35603266954421997},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3321170508861542},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24913957715034485},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.18106374144554138},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.15046429634094238},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.13452377915382385}],"concepts":[{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.5702037215232849},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5357619524002075},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5124583840370178},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.48606565594673157},{"id":"https://openalex.org/C193524817","wikidata":"https://www.wikidata.org/wiki/Q386780","display_name":"Association rule learning","level":2,"score":0.46987611055374146},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.44665783643722534},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4219260513782501},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3999429941177368},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35603266954421997},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3321170508861542},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24913957715034485},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.18106374144554138},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.15046429634094238},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.13452377915382385},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/1756-0381-4-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0381-4-4","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/1756-0381-4-4","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},{"id":"pmid:21362183","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21362183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData mining","raw_type":null},{"id":"pmh:oai:doaj.org/article:aa72845de4e64dab8e3c6316d28c13ca","is_oa":true,"landing_page_url":"https://doaj.org/article/aa72845de4e64dab8e3c6316d28c13ca","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Mining, Vol 4, Iss 1, p 4 (2011)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3060133","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3060133","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Min","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1756-0381-4-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0381-4-4","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/1756-0381-4-4","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.699999988079071,"display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2140703652.pdf","grobid_xml":"https://content.openalex.org/works/W2140703652.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1504694836","https://openalex.org/W1528113134","https://openalex.org/W1565377632","https://openalex.org/W1570448133","https://openalex.org/W1591552413","https://openalex.org/W1598808289","https://openalex.org/W1670263352","https://openalex.org/W1975600922","https://openalex.org/W1976634586","https://openalex.org/W2009969871","https://openalex.org/W2036144540","https://openalex.org/W2037768235","https://openalex.org/W2040369616","https://openalex.org/W2073527744","https://openalex.org/W2076354996","https://openalex.org/W2111762864","https://openalex.org/W2122732537","https://openalex.org/W2125055259","https://openalex.org/W2125779167","https://openalex.org/W2127405401","https://openalex.org/W2129586493","https://openalex.org/W2131878646","https://openalex.org/W2143249342","https://openalex.org/W2159391661","https://openalex.org/W2482589566"],"related_works":["https://openalex.org/W2392697706","https://openalex.org/W366033468","https://openalex.org/W128746893","https://openalex.org/W2367573304","https://openalex.org/W2537030075","https://openalex.org/W2006971496","https://openalex.org/W4310720718","https://openalex.org/W2065998343","https://openalex.org/W2369717039","https://openalex.org/W2384676159"],"abstract_inverted_index":{"The":[0,44],"current":[1],"analyses":[2,66,133],"substantiate":[3],"the":[4,17,38,62,65,71,85,127],"utility":[5],"of":[6,19,40,64,98,129,134],"rule":[7,72,119],"based":[8,73,120],"classifiers":[9,27,121],"such":[10],"as":[11,93],"RIPPER,":[12],"RIDOR":[13],"and":[14,56],"PART":[15],"for":[16,81,96,132],"detection":[18],"gene-gene/gene-environment":[20],"interactions":[21],"in":[22,37,49,103,111,114],"genetic":[23,41,136],"association":[24,42,137],"studies.":[25,43,138],"These":[26],"could":[28,76],"provide":[29,46],"a":[30],"valuable":[31,94],"new":[32],"method,":[33],"complementing":[34],"existing":[35],"approaches,":[36],"analysis":[39],"methods":[45],"an":[47,123],"advantage":[48],"being":[50],"able":[51],"to":[52,69,100,126],"handle":[53],"both":[54],"categorical":[55],"continuous":[57],"variable":[58],"types.":[59],"Further,":[60],"because":[61],"outputs":[63],"are":[67,87,122],"easy":[68],"interpret,":[70],"classifier":[74],"approach":[75],"quickly":[77],"generate":[78],"testable":[79],"hypotheses":[80],"additional":[82],"evaluation.":[83],"Since":[84],"algorithms":[86],"computationally":[88,106],"inexpensive,":[89],"they":[90],"may":[91],"serve":[92],"tools":[95,130],"preselection":[97],"attributes":[99],"be":[101],"used":[102,110],"more":[104],"complex,":[105],"intensive":[107],"approaches.":[108],"Whether":[109],"isolation":[112],"or":[113],"conjunction":[115],"with":[116],"other":[117],"tools,":[118],"important":[124],"addition":[125],"armamentarium":[128],"available":[131],"complex":[135]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
