{"id":"https://openalex.org/W1984865885","doi":"https://doi.org/10.1186/1756-0381-4-26","title":"Improved Bevirimat resistance prediction by combination of structural and sequence-based classifiers","display_name":"Improved Bevirimat resistance prediction by combination of structural and sequence-based classifiers","publication_year":2011,"publication_date":"2011-11-14","ids":{"openalex":"https://openalex.org/W1984865885","doi":"https://doi.org/10.1186/1756-0381-4-26","mag":"1984865885","pmid":"https://pubmed.ncbi.nlm.nih.gov/22082002"},"language":"en","primary_location":{"id":"doi:10.1186/1756-0381-4-26","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0381-4-26","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/1756-0381-4-26","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/1756-0381-4-26","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110433181","display_name":"J. Nikolaj Dybowski","orcid":null},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"J Nikolaj Dybowski","raw_affiliation_strings":["Department of Bioinformatics, Center of Medical Biotechnology, University of Duisburg-Essen, Universitaetsstr, 2, 45117 Essen, Germany. Dominik.heider@uni-due.de","Department of Bioinformatics, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Center of Medical Biotechnology, University of Duisburg-Essen, Universitaetsstr, 2, 45117 Essen, Germany. Dominik.heider@uni-due.de","institution_ids":["https://openalex.org/I62318514"]},{"raw_affiliation_string":"Department of Bioinformatics, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103405558","display_name":"Mona Riemenschneider","orcid":null},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mona Riemenschneider","raw_affiliation_strings":["Leibniz Institute for Arteriosclerosis Research, University of M\u00fcnster, Domagkstr. 3, 48149, M\u00fcnster, Germany","Leibniz Institute for Arteriosclerosis Research, University of M\u00fcnster, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leibniz Institute for Arteriosclerosis Research, University of M\u00fcnster, Domagkstr. 3, 48149, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"Leibniz Institute for Arteriosclerosis Research, University of M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019564672","display_name":"Sascha Hauke","orcid":"https://orcid.org/0000-0001-7822-0191"},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technische Universit\u00e4t Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sascha Hauke","raw_affiliation_strings":["CASED, Technische Universit\u00e4t Darmstadt, Mornewegstr. 32, 64293, Darmstadt, Germany","CASED, Technische Universit\u00e4t Darmstadt, Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CASED, Technische Universit\u00e4t Darmstadt, Mornewegstr. 32, 64293, Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]},{"raw_affiliation_string":"CASED, Technische Universit\u00e4t Darmstadt, Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029628252","display_name":"Martin Pyka","orcid":null},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Pyka","raw_affiliation_strings":["Department of Psychiatry, University of Marburg, Rudolf-Bultmann-Str. 8, 35039, Marburg, Germany","Dept of Psychiatry, University of Marburg, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Marburg, Rudolf-Bultmann-Str. 8, 35039, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]},{"raw_affiliation_string":"Dept of Psychiatry, University of Marburg, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021429161","display_name":"Jens Verheyen","orcid":"https://orcid.org/0000-0001-7463-3714"},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jens Verheyen","raw_affiliation_strings":["Institute of Virology, University of Cologne, Fuerst-Pueckler-Str. 56, 50935, Cologne, Germany","Institute of Virology, University of Cologne; Cologne Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, University of Cologne, Fuerst-Pueckler-Str. 56, 50935, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Institute of Virology, University of Cologne; Cologne Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074555350","display_name":"Daniel Hoffmann","orcid":"https://orcid.org/0000-0003-2973-7869"},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Hoffmann","raw_affiliation_strings":["Department of Bioinformatics, Center of Medical Biotechnology, University of Duisburg-Essen, Universitaetsstr. 2, 45117, Essen, Germany","Department of Bioinformatics, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Center of Medical Biotechnology, University of Duisburg-Essen, Universitaetsstr. 2, 45117, Essen, Germany","institution_ids":["https://openalex.org/I62318514"]},{"raw_affiliation_string":"Department of Bioinformatics, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060650201","display_name":"Dominik Heider","orcid":"https://orcid.org/0000-0002-3108-8311"},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominik Heider","raw_affiliation_strings":["Department of Bioinformatics, Center of Medical Biotechnology, University of Duisburg-Essen, Universitaetsstr. 2, 45117, Essen, Germany","Department of Bioinformatics, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Center of Medical Biotechnology, University of Duisburg-Essen, Universitaetsstr. 2, 45117, Essen, Germany","institution_ids":["https://openalex.org/I62318514"]},{"raw_affiliation_string":"Department of Bioinformatics, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5110433181"],"corresponding_institution_ids":["https://openalex.org/I62318514"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.9515,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.72362743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":"1","first_page":"26","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7332000136375427,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7332000136375427,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.20509999990463257,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5702287554740906},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.5650725960731506},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.5321874618530273},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5141003727912903},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4829482436180115},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48211216926574707},{"id":"https://openalex.org/keywords/protease","display_name":"Protease","score":0.48115599155426025},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3560711145401001},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3130459785461426},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.21244752407073975},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.0867244303226471},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.07217985391616821}],"concepts":[{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5702287554740906},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5650725960731506},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.5321874618530273},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5141003727912903},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4829482436180115},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48211216926574707},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.48115599155426025},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3560711145401001},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3130459785461426},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.21244752407073975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0867244303226471},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07217985391616821}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/1756-0381-4-26","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0381-4-26","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/1756-0381-4-26","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},{"id":"pmid:22082002","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22082002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData mining","raw_type":null},{"id":"pmh:oai:duepublico2.uni-due.de:duepublico_mods_00047106","is_oa":true,"landing_page_url":"https://duepublico2.uni-due.de/receive/duepublico_mods_00047106","pdf_url":"https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00046271/Dybowski_et_al_Improved_Bevirimat.pdf","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doc-type:article"},{"id":"pmh:oai:doaj.org/article:26d494233dd745a2b68e8c8a95535891","is_oa":true,"landing_page_url":"https://doaj.org/article/26d494233dd745a2b68e8c8a95535891","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioData Mining, Vol 4, Iss 1, p 26 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2252490","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3248369","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1756-0381-4-26","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0381-4-26","pdf_url":"https://biodatamining.biomedcentral.com/counter/pdf/10.1186/1756-0381-4-26","source":{"id":"https://openalex.org/S84409260","display_name":"BioData Mining","issn_l":"1756-0381","issn":["1756-0381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioData Mining","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1544361802","display_name":null,"funder_award_id":"SFB/Transregio 60","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1818345779","display_name":null,"funder_award_id":"Transregio 60","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1984865885.pdf","grobid_xml":"https://content.openalex.org/works/W1984865885.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W8503389","https://openalex.org/W28412257","https://openalex.org/W273955616","https://openalex.org/W1565746575","https://openalex.org/W1969482724","https://openalex.org/W1975304761","https://openalex.org/W1988195734","https://openalex.org/W1988848004","https://openalex.org/W1997107638","https://openalex.org/W1999766624","https://openalex.org/W2022328970","https://openalex.org/W2023294425","https://openalex.org/W2035210758","https://openalex.org/W2042636471","https://openalex.org/W2043338013","https://openalex.org/W2045497270","https://openalex.org/W2053088580","https://openalex.org/W2053337262","https://openalex.org/W2053956845","https://openalex.org/W2054688372","https://openalex.org/W2062340962","https://openalex.org/W2065283382","https://openalex.org/W2084387914","https://openalex.org/W2092013007","https://openalex.org/W2093463359","https://openalex.org/W2097364929","https://openalex.org/W2101550580","https://openalex.org/W2116844530","https://openalex.org/W2117519369","https://openalex.org/W2119423166","https://openalex.org/W2122102984","https://openalex.org/W2124005542","https://openalex.org/W2125520180","https://openalex.org/W2128685318","https://openalex.org/W2128936065","https://openalex.org/W2136362180","https://openalex.org/W2145126338","https://openalex.org/W2155921043","https://openalex.org/W2157963336","https://openalex.org/W2158698691","https://openalex.org/W2159504933","https://openalex.org/W2159628402","https://openalex.org/W2160176988","https://openalex.org/W2161631032","https://openalex.org/W2582743722","https://openalex.org/W2911964244","https://openalex.org/W4252684946","https://openalex.org/W4256361765"],"related_works":["https://openalex.org/W2379938146","https://openalex.org/W314815708","https://openalex.org/W2361364942","https://openalex.org/W2355642964","https://openalex.org/W1969181144","https://openalex.org/W1983970916","https://openalex.org/W2391339579","https://openalex.org/W2381515630","https://openalex.org/W2350506131","https://openalex.org/W2358847771"],"abstract_inverted_index":{"BACKGROUND:":[0],"Maturation":[1],"inhibitors":[2,65,151,157],"such":[3,152],"as":[4,153],"Bevirimat":[5,88,122],"are":[6,126,158,177],"a":[7,182],"new":[8,79],"class":[9],"of":[10,17,77,141,167],"antiretroviral":[11,168],"drugs":[12,169],"that":[13,96],"hamper":[14],"the":[15,35,75,117,139,165,171],"cleavage":[16,33],"HIV-1":[18,36,147],"proteins":[19],"into":[20],"their":[21,32],"functional":[22],"active":[23],"forms.":[24],"They":[25],"bind":[26],"to":[27,51,60,63,68,86,106,115,145,180],"these":[28,78],"preproteins":[29],"and":[30,57,99,108,162],"inhibit":[31],"by":[34],"protease,":[37],"resulting":[38],"in":[39,47,91,102,127,170],"non-functional":[40],"virus":[41],"particles.":[42],"Nevertheless,":[43],"there":[44],"exist":[45],"mutations":[46],"this":[48],"region":[49],"leading":[50],"resistance":[52,62,89,123,148],"against":[53,149],"Bevirimat.":[54,154],"Highly":[55],"specific":[56],"accurate":[58,107,174],"tools":[59,176],"predict":[61,146],"maturation":[64,150,156],"can":[66],"help":[67],"identify":[69,116],"patients,":[70],"who":[71],"might":[72,163],"benefit":[73],"from":[74,132],"usage":[76],"drugs.":[80],"RESULTS:":[81],"We":[82],"tested":[83],"several":[84],"methods":[85],"improve":[87],"prediction":[90,175],"HIV-1.":[92],"It":[93],"turned":[94],"out":[95],"combining":[97],"structural":[98],"sequence-based":[100],"information":[101],"classifier":[103],"ensembles":[104],"led":[105],"reliable":[109],"predictions.":[110],"Moreover,":[111],"we":[112],"were":[113],"able":[114],"most":[118],"crucial":[119],"regions":[120],"for":[121],"computationally,":[124],"which":[125],"line":[128],"with":[129],"experimental":[130],"results":[131],"other":[133],"studies.":[134],"CONCLUSIONS:":[135],"Our":[136],"analysis":[137],"demonstrated":[138],"use":[140],"machine":[142],"learning":[143],"techniques":[144],"New":[155],"already":[159],"under":[160],"development":[161],"enlarge":[164],"arsenal":[166],"future.":[172],"Thus,":[173],"very":[178],"useful":[179],"enable":[181],"personalized":[183],"therapy.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
