{"id":"https://openalex.org/W2103912979","doi":"https://doi.org/10.1186/1752-0509-8-s4-s11","title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","display_name":"cytoHubba: identifying hub objects and sub-networks from complex interactome","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W2103912979","doi":"https://doi.org/10.1186/1752-0509-8-s4-s11","mag":"2103912979","pmid":"https://pubmed.ncbi.nlm.nih.gov/25521941"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-8-s4-s11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-s4-s11","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-S4-S11","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-S4-S11","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043162263","display_name":"Chia-Hao Chin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210112569","display_name":"Nanhua University","ror":"https://ror.org/01tfbz441","country_code":"TW","type":"education","lineage":["https://openalex.org/I4210112569"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Hao Chin","raw_affiliation_strings":["Department of Computer Science and Information Engineering, Nanhua University, No. 55, Sec. 1, Nanhua Rd.,, Dalin Township, Chiayi County, 62249, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Information Engineering, Nanhua University, No. 55, Sec. 1, Nanhua Rd.,, Dalin Township, Chiayi County, 62249, Taiwan","institution_ids":["https://openalex.org/I4210112569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113537934","display_name":"Shu-Hwa Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210098366","display_name":"Institute of Information Science, Academia Sinica","ror":"https://ror.org/00z83z196","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210098366","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shu-Hwa Chen","raw_affiliation_strings":["Institute of Information Science, Academia Sinica, No. 128 Academia Rd., Sec. 2, Taipei, 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Information Science, Academia Sinica, No. 128 Academia Rd., Sec. 2, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210098366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025259324","display_name":"Hsin-Hung Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210086894","display_name":"Research Center for Information Technology Innovation, Academia Sinica","ror":"https://ror.org/000zgvm20","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210086894","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Hung Wu","raw_affiliation_strings":["Research Center of Information Technology Innovation, Academia Sinica, No. 128 Academia Rd., Sec. 2, Taipei, 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center of Information Technology Innovation, Academia Sinica, No. 128 Academia Rd., Sec. 2, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210086894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109244416","display_name":"Chin-Wen Ho","orcid":null},"institutions":[{"id":"https://openalex.org/I22265921","display_name":"National Central University","ror":"https://ror.org/00944ve71","country_code":"TW","type":"education","lineage":["https://openalex.org/I22265921"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chin-Wen Ho","raw_affiliation_strings":["Department of Computer Science and Information Engineering, National Central University, No.300, Jung-da Rd Chung-li, Taoyuan 320, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Information Engineering, National Central University, No.300, Jung-da Rd Chung-li, Taoyuan 320, Taiwan","institution_ids":["https://openalex.org/I22265921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112454407","display_name":"Ming\u2010Tat Ko","orcid":null},"institutions":[{"id":"https://openalex.org/I4210098366","display_name":"Institute of Information Science, Academia Sinica","ror":"https://ror.org/00z83z196","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210098366","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210086894","display_name":"Research Center for Information Technology Innovation, Academia Sinica","ror":"https://ror.org/000zgvm20","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210086894","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Tat Ko","raw_affiliation_strings":["Institute of Information Science, Academia Sinica, No. 128 Academia Rd., Sec. 2, Taipei, 115, Taiwan","Research Center of Information Technology Innovation, Academia Sinica, No. 128 Academia Rd., Sec. 2, Taipei, 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Information Science, Academia Sinica, No. 128 Academia Rd., Sec. 2, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210098366"]},{"raw_affiliation_string":"Research Center of Information Technology Innovation, Academia Sinica, No. 128 Academia Rd., Sec. 2, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210086894"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029127365","display_name":"Chung\u2010Yen Lin","orcid":"https://orcid.org/0000-0002-4733-9488"},"institutions":[{"id":"https://openalex.org/I4210098366","display_name":"Institute of Information Science, Academia Sinica","ror":"https://ror.org/00z83z196","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210098366","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I165441096","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I165441096"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chung-Yen Lin","raw_affiliation_strings":["Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, No. 35 Keyan Rd., Zhunan, 350, Taiwan","Institute of Fisheries Science, College of Life Science, National Taiwan University, No. 1, Roosevelt Rd. Sec 4, Taipei, 105, Taiwan","Institute of Information Science, Academia Sinica, No. 128 Academia Rd., Sec. 2, Taipei, 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, No. 35 Keyan Rd., Zhunan, 350, Taiwan","institution_ids":["https://openalex.org/I165441096"]},{"raw_affiliation_string":"Institute of Fisheries Science, College of Life Science, National Taiwan University, No. 1, Roosevelt Rd. Sec 4, Taipei, 105, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Institute of Information Science, Academia Sinica, No. 128 Academia Rd., Sec. 2, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210098366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5029127365"],"corresponding_institution_ids":["https://openalex.org/I165441096","https://openalex.org/I16733864","https://openalex.org/I4210098366"],"apc_list":null,"apc_paid":null,"fwci":4.5526,"has_fulltext":true,"cited_by_count":6695,"citation_normalized_percentile":{"value":0.95569169,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"8","issue":"S4","first_page":"S11","last_page":"S11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9828000068664551,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9828000068664551,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/betweenness-centrality","display_name":"Betweenness centrality","score":0.7132055759429932},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.7125369906425476},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6896291971206665},{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.6696298718452454},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6129752397537231},{"id":"https://openalex.org/keywords/component","display_name":"Component (thermodynamics)","score":0.5767808556556702},{"id":"https://openalex.org/keywords/plug-in","display_name":"Plug-in","score":0.5558211803436279},{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.4905197024345398},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.49021750688552856},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.4695202708244324},{"id":"https://openalex.org/keywords/clique","display_name":"Clique","score":0.4606269896030426},{"id":"https://openalex.org/keywords/bottleneck","display_name":"Bottleneck","score":0.4490073323249817},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.42411544919013977},{"id":"https://openalex.org/keywords/closeness","display_name":"Closeness","score":0.4218660295009613},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.41577354073524475},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3572976887226105},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2267751395702362},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13135048747062683},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11713862419128418}],"concepts":[{"id":"https://openalex.org/C117045392","wikidata":"https://www.wikidata.org/wiki/Q4899215","display_name":"Betweenness centrality","level":3,"score":0.7132055759429932},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.7125369906425476},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6896291971206665},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.6696298718452454},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6129752397537231},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.5767808556556702},{"id":"https://openalex.org/C4924752","wikidata":"https://www.wikidata.org/wiki/Q184148","display_name":"Plug-in","level":2,"score":0.5558211803436279},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.4905197024345398},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.49021750688552856},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.4695202708244324},{"id":"https://openalex.org/C2777035058","wikidata":"https://www.wikidata.org/wiki/Q1662634","display_name":"Clique","level":2,"score":0.4606269896030426},{"id":"https://openalex.org/C2780513914","wikidata":"https://www.wikidata.org/wiki/Q18210350","display_name":"Bottleneck","level":2,"score":0.4490073323249817},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.42411544919013977},{"id":"https://openalex.org/C2779545769","wikidata":"https://www.wikidata.org/wiki/Q5135364","display_name":"Closeness","level":2,"score":0.4218660295009613},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.41577354073524475},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3572976887226105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2267751395702362},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13135048747062683},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11713862419128418},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-8-s4-s11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-s4-s11","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-S4-S11","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:25521941","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25521941","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4290687","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4290687","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-8-s4-s11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-s4-s11","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-S4-S11","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103912979.pdf","grobid_xml":"https://content.openalex.org/works/W2103912979.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1967570846","https://openalex.org/W1971937094","https://openalex.org/W1974444469","https://openalex.org/W1985241583","https://openalex.org/W1998674591","https://openalex.org/W2002418817","https://openalex.org/W2019150902","https://openalex.org/W2061627113","https://openalex.org/W2112513984","https://openalex.org/W2118446779","https://openalex.org/W2129617194","https://openalex.org/W2130687290","https://openalex.org/W2130790725","https://openalex.org/W2144656637","https://openalex.org/W2149690808","https://openalex.org/W2155019453","https://openalex.org/W2159675211","https://openalex.org/W2170432219"],"related_works":["https://openalex.org/W4292634579","https://openalex.org/W2356738361","https://openalex.org/W1516497519","https://openalex.org/W2964314049","https://openalex.org/W2012724202","https://openalex.org/W2141346699","https://openalex.org/W2043924719","https://openalex.org/W2103730437","https://openalex.org/W2083975137","https://openalex.org/W2010661649"],"abstract_inverted_index":{"BACKGROUND:":[0],"Network":[1],"is":[2,204],"a":[3,52,61,113,131,163],"useful":[4],"way":[5],"for":[6,57,190],"presenting":[7],"many":[8],"types":[9],"of":[10,46,82,119,202],"biological":[11,47,139],"data":[12],"including":[13,73],"protein-protein":[14],"interactions,":[15],"gene":[16],"regulations,":[17],"cellular":[18],"pathways,":[19],"and":[20,38,89,97,159,169,186],"signal":[21],"transductions.":[22],"We":[23,50],"can":[24,40],"measure":[25],"nodes":[26,59,137],"by":[27,63,172],"their":[28,33,64],"network":[29,62,65,168],"features":[30],"to":[31,134,155,179,194],"infer":[32],"importance":[34],"in":[35,60,138,146],"the":[36,104,107,117,124,199],"network,":[37],"it":[39],"help":[41],"us":[42],"identify":[43],"central":[44],"elements":[45],"networks.":[48,140],"RESULTS:":[49],"introduce":[51],"novel":[53,164],"Cytoscape":[54],"plugin":[55,196],"cytoHubba":[56,157,203],"ranking":[58],"features.":[66],"CytoHubba":[67,129],"provides":[68],"11":[69],"topological":[70,174],"analysis":[71,165,175],"methods":[72,145],"Degree,":[74],"Edge":[75],"Percolated":[76],"Component,":[77,80,85],"Maximum":[78,83],"Neighborhood":[79,84],"Density":[81],"Maximal":[86],"Clique":[87],"Centrality":[88],"six":[90],"centralities":[91],"(Bottleneck,":[92],"EcCentricity,":[93],"Closeness,":[94],"Radiality,":[95],"Betweenness,":[96],"Stress)":[98],"based":[99],"on":[100,116,182],"shortest":[101],"paths.":[102],"Among":[103],"eleven":[105,144],"methods,":[106],"new":[108,180],"proposed":[109],"method,":[110],"MCC,":[111],"has":[112],"better":[114],"performance":[115],"precision":[118],"predicting":[120],"essential":[121,183],"proteins":[122],"from":[123],"yeast":[125],"PPI":[126],"network.":[127],"CONCLUSIONS:":[128],"provide":[130],"user-friendly":[132],"interface":[133],"explore":[135],"important":[136],"It":[141],"computes":[142],"all":[143],"one":[147],"stop":[148],"shopping":[149],"way.":[150],"Besides,":[151],"researchers":[152],"are":[153],"able":[154],"combine":[156],"with":[158],"other":[160],"plugins":[161],"into":[162],"scheme.":[166],"The":[167],"sub-networks":[170],"caught":[171],"this":[173],"strategy":[176],"will":[177],"lead":[178],"insights":[181],"regulatory":[184],"networks":[185],"protein":[187],"drug":[188],"targets":[189],"experimental":[191],"biologists.":[192],"According":[193],"cytoscape":[195],"download":[197],"statistics,":[198],"accumulated":[200],"number":[201],"around":[205],"6,700":[206],"times":[207],"since":[208],"2010.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":307},{"year":2025,"cited_by_count":1051},{"year":2024,"cited_by_count":1369},{"year":2023,"cited_by_count":1093},{"year":2022,"cited_by_count":1207},{"year":2021,"cited_by_count":844},{"year":2020,"cited_by_count":552},{"year":2019,"cited_by_count":161},{"year":2018,"cited_by_count":76},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}
