{"id":"https://openalex.org/W2148857874","doi":"https://doi.org/10.1186/1752-0509-8-s2-s2","title":"Use of prior knowledge for the analysis of high-throughput transcriptomics and metabolomics data","display_name":"Use of prior knowledge for the analysis of high-throughput transcriptomics and metabolomics data","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2148857874","doi":"https://doi.org/10.1186/1752-0509-8-s2-s2","mag":"2148857874","pmid":"https://pubmed.ncbi.nlm.nih.gov/25033193"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-8-s2-s2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-s2-s2","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-S2-S2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-S2-S2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050202573","display_name":"Polina Reshetova","orcid":null},"institutions":[{"id":"https://openalex.org/I2801582894","display_name":"Netherlands Bioinformatics Centre","ror":"https://ror.org/01r0k6965","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I2801582894"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Polina Reshetova","raw_affiliation_strings":["Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands","Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2801582894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083251527","display_name":"Age K. Smilde","orcid":"https://orcid.org/0000-0002-3052-4644"},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Age K Smilde","raw_affiliation_strings":["Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073421485","display_name":"Antoine H. C. van Kampen","orcid":"https://orcid.org/0000-0003-1025-7232"},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Academic Medical Center","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I2801582894","display_name":"Netherlands Bioinformatics Centre","ror":"https://ror.org/01r0k6965","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I2801582894"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Antoine HC van Kampen","raw_affiliation_strings":["Bioinformatics Laboratory, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE, Amsterdam, the Netherlands","Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands","Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Laboratory, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I887064364","https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Netherlands Bioinformatics Centre, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2801582894"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017155895","display_name":"Johan A. Westerhuis","orcid":"https://orcid.org/0000-0002-6747-9779"},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Johan A Westerhuis","raw_affiliation_strings":["Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5050202573"],"corresponding_institution_ids":["https://openalex.org/I2801582894","https://openalex.org/I887064364"],"apc_list":null,"apc_paid":null,"fwci":1.5687,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.83075052,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"8","issue":"Suppl 2","first_page":"S2","last_page":"S2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.7244240045547485},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6756147742271423},{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.5741636753082275},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.4641868472099304},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4538326561450958},{"id":"https://openalex.org/keywords/throughput","display_name":"Throughput","score":0.4523729085922241},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4253450632095337},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.41134870052337646},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3935486674308777},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3340015411376953},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2856217622756958},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25343602895736694}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.7244240045547485},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6756147742271423},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.5741636753082275},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.4641868472099304},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4538326561450958},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.4523729085922241},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4253450632095337},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.41134870052337646},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3935486674308777},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3340015411376953},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2856217622756958},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25343602895736694},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/1752-0509-8-s2-s2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-s2-s2","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-S2-S2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:25033193","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25033193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:dare.uva.nl:openaire/e4f106f5-14ce-4bfa-bb98-c8d7725a2e74","is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/use-of-prior-knowledge-for-the-analysis-of-highthroughput-transcriptomics-and-metabolomics-data(e4f106f5-14ce-4bfa-bb98-c8d7725a2e74).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reshetova, P, Smilde, A K, van Kampen, A H C & Westerhuis, J A 2014, 'Use of prior knowledge for the analysis of high-throughput transcriptomics and metabolomics data', BMC Systems Biology, vol. 8, no. suppl 2, pp. S2. https://doi.org/10.1186/1752-0509-8-S2-S2","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:dare.uva.nl:openaire_cris_publications/e4f106f5-14ce-4bfa-bb98-c8d7725a2e74","is_oa":true,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/use-of-prior-knowledge-for-the-analysis-of-highthroughput-transcriptomics-and-metabolomics-data(e4f106f5-14ce-4bfa-bb98-c8d7725a2e74).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reshetova, P, Smilde, A K, van Kampen, A H C & Westerhuis, J A 2014, 'Use of prior knowledge for the analysis of high-throughput transcriptomics and metabolomics data', BMC Systems Biology, vol. 8, no. suppl 2, pp. S2. https://doi.org/10.1186/1752-0509-8-S2-S2","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pure.amsterdamumc.nl:publications/635f6846-ed19-4838-b793-8c0b72dc59a2","is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/635f6846-ed19-4838-b793-8c0b72dc59a2","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reshetova, P, Smilde, A K, van Kampen, A H C & Westerhuis, J A 2014, 'Use of prior knowledge for the analysis of high-throughput transcriptomics and metabolomics data', BMC systems biology, vol. 8, no. Suppl. 2, pp. S2. https://doi.org/10.1186/1752-0509-8-S2-S2","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/89552fac-dd09-4bc9-add4-709a4728eed3","is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/use-of-prior-knowledge-for-the-analysis-of-highthroughput-transcriptomics-and-metabolomics-data(89552fac-dd09-4bc9-add4-709a4728eed3).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC systems biology, 8(Suppl. 2). BioMed Central","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dare.uva.nl:publications/e4f106f5-14ce-4bfa-bb98-c8d7725a2e74","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:europepmc.org:3072286","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4101693","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-8-s2-s2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-s2-s2","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-S2-S2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","score":0.4099999964237213,"display_name":"Industry, innovation and infrastructure"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148857874.pdf","grobid_xml":"https://content.openalex.org/works/W2148857874.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1906461790","https://openalex.org/W1983463159","https://openalex.org/W1990512452","https://openalex.org/W1998767819","https://openalex.org/W2014349355","https://openalex.org/W2025429156","https://openalex.org/W2039140169","https://openalex.org/W2055867223","https://openalex.org/W2061674320","https://openalex.org/W2069645361","https://openalex.org/W2079269074","https://openalex.org/W2081879778","https://openalex.org/W2095368623","https://openalex.org/W2108901799","https://openalex.org/W2109014721","https://openalex.org/W2109948920","https://openalex.org/W2116063398","https://openalex.org/W2116298046","https://openalex.org/W2118069309","https://openalex.org/W2120413242","https://openalex.org/W2122825543","https://openalex.org/W2127952499","https://openalex.org/W2130410032","https://openalex.org/W2133465414","https://openalex.org/W2138040987","https://openalex.org/W2142433578","https://openalex.org/W2144317357","https://openalex.org/W2145265944","https://openalex.org/W2146405127","https://openalex.org/W2154947819","https://openalex.org/W2157911533","https://openalex.org/W2160514535","https://openalex.org/W2164011577","https://openalex.org/W2167310130","https://openalex.org/W2170746618","https://openalex.org/W2604823638"],"related_works":["https://openalex.org/W2162899405","https://openalex.org/W3113091479","https://openalex.org/W941090075","https://openalex.org/W2044987316","https://openalex.org/W3134374554","https://openalex.org/W2237480245","https://openalex.org/W2075065631","https://openalex.org/W2166430819","https://openalex.org/W78967844","https://openalex.org/W3202802607"],"abstract_inverted_index":{"BACKGROUND:":[0],"High-throughput":[1],"omics":[2],"technologies":[3],"have":[4],"enabled":[5],"the":[6,44,47,54,62,68,91,99,110,129,133],"measurement":[7],"of":[8,36,49,81,109,132],"many":[9],"genes":[10],"or":[11],"metabolites":[12],"simultaneously.":[13],"The":[14],"resulting":[15],"high":[16],"dimensional":[17],"experimental":[18],"data":[19,27],"poses":[20],"significant":[21],"challenges":[22],"to":[23,33,42,60,66],"transcriptomics":[24,86],"and":[25,87,107,125],"metabolomics":[26],"analysis":[28,69],"methods,":[29,104],"which":[30,115],"may":[31],"lead":[32],"spurious":[34],"instead":[35],"biologically":[37],"relevant":[38],"results.":[39],"One":[40],"strategy":[41,57],"improve":[43],"results":[45],"is":[46,58,123],"incorporation":[48],"prior":[50,116],"biological":[51,71],"knowledge":[52,117],"in":[53,85,94],"analysis.":[55],"This":[56],"used":[59,84],"reduce":[61],"solution":[63],"space":[64],"and/or":[65],"focus":[67],"on":[70,98],"meaningful":[72],"regions.":[73],"In":[74],"this":[75],"article,":[76],"we":[77],"review":[78],"a":[79],"selection":[80],"these":[82],"methods":[83,93,106],"metabolomics.":[88],"We":[89,113],"combine":[90],"reviewed":[92],"three":[95],"groups":[96],"based":[97],"underlying":[100,134],"mathematical":[101,130],"model:":[102],"exploratory":[103],"supervised":[105],"estimation":[108],"covariance":[111],"matrix.":[112],"discuss":[114],"has":[118],"been":[119],"used,":[120],"how":[121,126],"it":[122,127],"incorporated":[124],"modifies":[128],"properties":[131],"methods.":[135]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2025-10-10T00:00:00"}
