{"id":"https://openalex.org/W1994212310","doi":"https://doi.org/10.1186/1752-0509-8-s1-s5","title":"Detection of type 2 diabetes related modules and genes based on epigenetic networks","display_name":"Detection of type 2 diabetes related modules and genes based on epigenetic networks","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1994212310","doi":"https://doi.org/10.1186/1752-0509-8-s1-s5","mag":"1994212310","pmid":"https://pubmed.ncbi.nlm.nih.gov/24565181"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-8-s1-s5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-s1-s5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-S1-S5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-S1-S5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101912980","display_name":"Hui Liu","orcid":"https://orcid.org/0000-0001-9549-2615"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]},{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hui Liu","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin, 150001, China","College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin, 150001, China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100687967","display_name":"Tongtong Wang","orcid":"https://orcid.org/0000-0002-8807-2441"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210132813","display_name":"Second Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/03s8txj32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tongtong Wang","raw_affiliation_strings":["The second Affiliated Hospital at Harbin Medical University, Harbin, 150081, China","The second Affiliated Hospital at Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The second Affiliated Hospital at Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"]},{"raw_affiliation_string":"The second Affiliated Hospital at Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045576282","display_name":"Hongbo Liu","orcid":"https://orcid.org/0000-0002-0733-8616"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]},{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongbo Liu","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin, 150001, China","College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin, 150001, China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056869329","display_name":"Yanjun Wei","orcid":"https://orcid.org/0000-0003-4200-2859"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanjun Wei","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071556628","display_name":"Guofeng Zhao","orcid":"https://orcid.org/0000-0002-5765-2232"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guofeng Zhao","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083159278","display_name":"Jianzhong Su","orcid":"https://orcid.org/0000-0002-1172-7411"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianzhong Su","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100638546","display_name":"Qiong Wu","orcid":"https://orcid.org/0000-0003-3305-6652"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiong Wu","raw_affiliation_strings":["School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin, 150001, China","School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin, 150001, China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024814634","display_name":"Hong Qiao","orcid":"https://orcid.org/0000-0003-3359-1962"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210132813","display_name":"Second Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/03s8txj32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Qiao","raw_affiliation_strings":["The second Affiliated Hospital at Harbin Medical University, Harbin, 150081, China","The second Affiliated Hospital at Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The second Affiliated Hospital at Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"]},{"raw_affiliation_string":"The second Affiliated Hospital at Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100456299","display_name":"Yan Zhang","orcid":"https://orcid.org/0000-0002-7111-7164"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5101912980"],"corresponding_institution_ids":["https://openalex.org/I156144747","https://openalex.org/I204983213"],"apc_list":null,"apc_paid":null,"fwci":1.4228,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.80477417,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"S1","first_page":"S5","last_page":"S5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7462999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7462999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.05429999902844429,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0364999994635582,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.7868751287460327},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6855957508087158},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6442528963088989},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5388571619987488},{"id":"https://openalex.org/keywords/type","display_name":"Type (biology)","score":0.5194630026817322},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5085121393203735},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"Type 2 diabetes","score":0.4856370985507965},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.48080459237098694},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.4206126034259796},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4158342480659485},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.40420472621917725},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3455032706260681},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.25684109330177307},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20515543222427368},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.07136040925979614},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.06598389148712158}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7868751287460327},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6855957508087158},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6442528963088989},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5388571619987488},{"id":"https://openalex.org/C2777299769","wikidata":"https://www.wikidata.org/wiki/Q3707858","display_name":"Type (biology)","level":2,"score":0.5194630026817322},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5085121393203735},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4856370985507965},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48080459237098694},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.4206126034259796},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4158342480659485},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40420472621917725},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3455032706260681},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.25684109330177307},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20515543222427368},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07136040925979614},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.06598389148712158}],"mesh":[{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-8-s1-s5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-s1-s5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-S1-S5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:24565181","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24565181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4080446","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4080446","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-8-s1-s5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-s1-s5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-S1-S5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6200000047683716}],"awards":[{"id":"https://openalex.org/G2043796661","display_name":null,"funder_award_id":"31171383","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6713399096","display_name":null,"funder_award_id":"31371478","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320312270","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321940","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994212310.pdf","grobid_xml":"https://content.openalex.org/works/W1994212310.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1969709265","https://openalex.org/W1978215768","https://openalex.org/W1987840126","https://openalex.org/W1989396582","https://openalex.org/W1999127582","https://openalex.org/W2003516452","https://openalex.org/W2026194398","https://openalex.org/W2028133290","https://openalex.org/W2037618070","https://openalex.org/W2039057389","https://openalex.org/W2045788154","https://openalex.org/W2047014433","https://openalex.org/W2062533676","https://openalex.org/W2069435157","https://openalex.org/W2082122713","https://openalex.org/W2083045667","https://openalex.org/W2095365870","https://openalex.org/W2095867585","https://openalex.org/W2096766502","https://openalex.org/W2097498614","https://openalex.org/W2097698606","https://openalex.org/W2100271953","https://openalex.org/W2101668231","https://openalex.org/W2115977666","https://openalex.org/W2120453034","https://openalex.org/W2122220050","https://openalex.org/W2122863289","https://openalex.org/W2130597092","https://openalex.org/W2130687290","https://openalex.org/W2134394193","https://openalex.org/W2135902632","https://openalex.org/W2136850043","https://openalex.org/W2144656637","https://openalex.org/W2146107508","https://openalex.org/W2147000452","https://openalex.org/W2149952464","https://openalex.org/W2151681456","https://openalex.org/W2152653671","https://openalex.org/W2156737316","https://openalex.org/W2157795344","https://openalex.org/W2159422401","https://openalex.org/W2163323666","https://openalex.org/W2163480486","https://openalex.org/W2166884670","https://openalex.org/W2171874894","https://openalex.org/W2414618010","https://openalex.org/W2468012934","https://openalex.org/W2520432709","https://openalex.org/W4241151929","https://openalex.org/W4250120438","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W78967844","https://openalex.org/W3213185671","https://openalex.org/W4210989272","https://openalex.org/W4386628104","https://openalex.org/W4206945140","https://openalex.org/W2130939068","https://openalex.org/W3163717165","https://openalex.org/W2509687359","https://openalex.org/W2114466827"],"abstract_inverted_index":{"BACKGROUND:":[0],"Type":[1],"2":[2],"diabetes":[3],"(T2D)":[4],"is":[5,98,200],"one":[6],"of":[7,21,30,33,45,123,167,180,191,228,239,249,262],"the":[8,19,31,42,46,51,54,58,65,76,118,129,147,173,189,207,213,226,235,259],"most":[9],"common":[10],"chronic":[11],"metabolic":[12,110],"diseases":[13],"characterized":[14],"by":[15,69,146,212,265],"insulin":[16,22],"resistance":[17],"and":[18,57,68,85,120,137,161,183,217,224,242],"decrease":[20],"secretion.":[23],"Genetic":[24],"variation":[25],"can":[26],"only":[27],"explain":[28],"part":[29],"heritability":[32],"T2D,":[34],"so":[35],"there":[36,203],"need":[37],"new":[38,255],"methods":[39],"to":[40],"detect":[41],"susceptibility":[43],"genes":[44,113,205],"disease.":[47],"Epigenetics":[48],"could":[49,163],"establish":[50],"interface":[52],"between":[53],"environmental":[55],"factor":[56],"T2D":[59,104,196,250,263],"Pathological":[60],"mechanism.":[61],"RESULTS:":[62],"Based":[63],"on":[64],"network":[66,81,106,133,156],"theory":[67],"combining":[70],"epigenetic":[71,169,251,266],"characteristics":[72],"with":[73,126,206],"human":[74,78,195],"interactome,":[75],"weighted":[77,130],"DNA":[79,181,215,240],"methylation":[80,182,216,241],"(WMPN)":[82],"was":[83,90,135,144],"constructed,":[84],"a":[86,103,138,153,165,254],"T2D-related":[87,93,139,168],"subnetwork":[88,143],"(TMSN)":[89],"obtained":[91,145],"through":[92],"differentially":[94],"methylated":[95],"genes.":[96],"It":[97],"found":[99,201],"that":[100,108,159,202],"TMSN":[101,148,160],"had":[102,152],"specific":[105],"structure":[107],"non-fatal":[109],"disease":[111],"causing":[112],"were":[114,186],"often":[115],"located":[116],"in":[117,194],"topological":[119],"functional":[121],"periphery":[122],"network.":[124],"Combined":[125],"chromatin":[127,131,140,184,219,243],"modifications,":[128,220],"modification":[132,141],"(WCPN)":[134],"built,":[136],"pattern":[142],"gene":[149,192],"set.":[150],"TCSN":[151,162],"densely":[154],"connected":[155],"community,":[157],"indicating":[158],"represent":[164],"collection":[166],"dysregulated":[170],"sub-pathways.":[171],"Using":[172],"cumulative":[174],"hypergeometric":[175],"test,":[176],"24":[177],"interplay":[178,237],"modules":[179,238],"modifications":[185,244],"identified.":[187],"By":[188],"analysis":[190],"expression":[193,209],"islet":[197],"tissue,":[198],"it":[199],"existed":[204],"variant":[208],"level":[210],"caused":[211,264],"aberrant":[214],"(or)":[218],"which":[221],"might":[222],"affect":[223],"promote":[225],"development":[227],"T2D.":[229,246],"CONCLUSIONS:":[230],"Here":[231],"we":[232],"have":[233],"detected":[234],"potential":[236],"for":[245,257],"The":[247],"study":[248],"networks":[252],"provides":[253],"way":[256],"understanding":[258],"pathogenic":[260],"mechanism":[261],"disorders.":[267]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}