{"id":"https://openalex.org/W1967822274","doi":"https://doi.org/10.1186/1752-0509-8-82","title":"Integrative analysis of differential miRNA and functional study of miR-21 by seed-targeting inhibition in multiple myeloma cells in response to berberine","display_name":"Integrative analysis of differential miRNA and functional study of miR-21 by seed-targeting inhibition in multiple myeloma cells in response to berberine","publication_year":2014,"publication_date":"2014-07-07","ids":{"openalex":"https://openalex.org/W1967822274","doi":"https://doi.org/10.1186/1752-0509-8-82","mag":"1967822274","pmid":"https://pubmed.ncbi.nlm.nih.gov/25000828"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-8-82","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-82","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-82","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-82","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030143926","display_name":"Xiaochuang Luo","orcid":null},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaochuang Luo","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China","Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075970986","display_name":"Jingyi Gu","orcid":null},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Gu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China","Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023320325","display_name":"Rongxuan Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongxuan Zhu","raw_affiliation_strings":["Department of Clinical Medicine, Medical College of Jinan University, Guangzhou, 510632, China","Department of Clinical Medicine, Medical College of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Medical College of Jinan University, Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Department of Clinical Medicine, Medical College of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020966873","display_name":"Maoxiao Feng","orcid":"https://orcid.org/0000-0002-3612-9792"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Maoxiao Feng","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China","Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101392934","display_name":"Xuejiao Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuejiao Zhu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China","Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100630384","display_name":"Yumin Li","orcid":"https://orcid.org/0000-0002-9267-1412"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yumin Li","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China","Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100608689","display_name":"Jia Fei","orcid":"https://orcid.org/0000-0002-6650-7870"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Fei","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China. efeijia@163.com","Department of Biochemistry and Molecular Biology,Medical College of Jinan University,Guangzhou 510632,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China. efeijia@163.com","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology,Medical College of Jinan University,Guangzhou 510632,China","institution_ids":["https://openalex.org/I159948400"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5030143926"],"corresponding_institution_ids":["https://openalex.org/I159948400"],"apc_list":null,"apc_paid":null,"fwci":2.9055,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.8898826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"82","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.9211999773979187,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.9211999773979187,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/berberine","display_name":"Berberine","score":0.9042662382125854},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7630915641784668},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.7591261863708496},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6260833144187927},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.5537084341049194},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.5004351139068604},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.48773154616355896},{"id":"https://openalex.org/keywords/stat-protein","display_name":"STAT protein","score":0.4377307891845703},{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.4313993752002716},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.43104875087738037},{"id":"https://openalex.org/keywords/cell-cycle-checkpoint","display_name":"Cell cycle checkpoint","score":0.4253702461719513},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.41852378845214844},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.4150528013706207},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4036637544631958},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.23852455615997314},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.17873108386993408},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14301368594169617},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12305131554603577}],"concepts":[{"id":"https://openalex.org/C2780116568","wikidata":"https://www.wikidata.org/wiki/Q176525","display_name":"Berberine","level":2,"score":0.9042662382125854},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7630915641784668},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.7591261863708496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6260833144187927},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5537084341049194},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5004351139068604},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.48773154616355896},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.4377307891845703},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4313993752002716},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43104875087738037},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4253702461719513},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41852378845214844},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4150528013706207},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4036637544631958},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23852455615997314},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17873108386993408},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14301368594169617},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12305131554603577}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001599","descriptor_name":"Berberine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001599","descriptor_name":"Berberine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001599","descriptor_name":"Berberine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059565","descriptor_name":"G2 Phase Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059565","descriptor_name":"G2 Phase Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059565","descriptor_name":"G2 Phase Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-8-82","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-82","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-82","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:25000828","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25000828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:europepmc.org:3067986","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4096730","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-8-82","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-82","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-82","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2190045764","display_name":null,"funder_award_id":"81170496","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3495901708","display_name":null,"funder_award_id":"21609406","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322292","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1967822274.pdf","grobid_xml":"https://content.openalex.org/works/W1967822274.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1536110039","https://openalex.org/W1648301895","https://openalex.org/W1808827347","https://openalex.org/W1966852194","https://openalex.org/W1973921593","https://openalex.org/W1998639716","https://openalex.org/W1999360191","https://openalex.org/W1999746960","https://openalex.org/W2010180766","https://openalex.org/W2016266035","https://openalex.org/W2023858596","https://openalex.org/W2028164074","https://openalex.org/W2031242141","https://openalex.org/W2031252637","https://openalex.org/W2038623184","https://openalex.org/W2042748226","https://openalex.org/W2049437653","https://openalex.org/W2050079849","https://openalex.org/W2067915426","https://openalex.org/W2070172183","https://openalex.org/W2075258024","https://openalex.org/W2081476178","https://openalex.org/W2087294802","https://openalex.org/W2090688567","https://openalex.org/W2090759673","https://openalex.org/W2094636384","https://openalex.org/W2098318517","https://openalex.org/W2099617191","https://openalex.org/W2102144501","https://openalex.org/W2102842031","https://openalex.org/W2103211592","https://openalex.org/W2108089802","https://openalex.org/W2117391818","https://openalex.org/W2122655172","https://openalex.org/W2123716127","https://openalex.org/W2124230718","https://openalex.org/W2126803500","https://openalex.org/W2133814931","https://openalex.org/W2152091242","https://openalex.org/W2157026647","https://openalex.org/W2161491961","https://openalex.org/W2165371985","https://openalex.org/W2166508172","https://openalex.org/W2171918265","https://openalex.org/W2331935945","https://openalex.org/W3140743036","https://openalex.org/W3195431600","https://openalex.org/W4211135634","https://openalex.org/W6600922481"],"related_works":["https://openalex.org/W2001536256","https://openalex.org/W2358789216","https://openalex.org/W2370523994","https://openalex.org/W2619745062","https://openalex.org/W2350294409","https://openalex.org/W2379033026","https://openalex.org/W2071534171","https://openalex.org/W2147266699","https://openalex.org/W4283782187","https://openalex.org/W2374592133"],"abstract_inverted_index":{"BACKGROUND:":[0],"Berberine":[1],"is":[2,14,27,39,81,88,242],"a":[3,8,123],"natural":[4],"alkaloid":[5],"derived":[6],"from":[7],"traditional":[9,269],"Chinese":[10,270],"herbal":[11,271],"medicine.":[12],"It":[13],"known":[15],"to":[16,95,166,237,244],"modulate":[17],"microRNA":[18],"(miRNA)":[19],"levels,":[20],"although":[21],"the":[22,34,66,91,115,142,249,262],"mechanism":[23],"for":[24],"this":[25],"action":[26],"unknown.":[28],"Here,":[29],"we":[30],"previously":[31],"demonstrate":[32],"that":[33,51,63,107,131,141,217],"expression":[35,111,116],"of":[36,65,90,117,153,158,168,199,248,265],"87":[37],"miRNAs":[38,50,68],"differentially":[40],"affected":[41,97],"by":[42,98,136,148,162,201,228],"berberine":[43,99,108,163,179,218],"in":[44,70,83,100,174,193,209,226,246,268],"multiple":[45,101,175,194,210,220],"myeloma":[46,102,195,211,221],"cells.":[47,103,212],"Among":[48],"49":[49],"are":[52],"down-regulated,":[53],"nine":[54],"act":[55],"as":[56],"oncomirs,":[57],"including":[58],"miR-21.":[59,137],"Integrative":[60],"analysis":[61,139],"showed":[62],"28":[64],"down-regulated":[67,109],"participate":[69],"tumor":[71],"protein":[72],"p53":[73,250],"(TP53)":[74],"signaling":[75,251],"and":[76,87,112,151,180,190],"other":[77],"cancer":[78],"pathways.":[79],"miR-21":[80,125,143,169,230],"involved":[82],"all":[84],"these":[85],"pathways,":[86],"one":[89],"most":[92],"important":[93],"oncomirs":[94],"be":[96,146],"RESULTS:":[104],"We":[105],"confirmed":[106,130],"miRNA-21":[110],"significantly":[113],"up-regulated":[114],"programmed":[118],"cell":[119,187,196,222],"death":[120],"4":[121],"(PDCD4),":[122],"predicted":[124],"target.":[126],"Luciferase":[127],"reporter":[128],"assays":[129],"PDCD4":[132,200,239],"was":[133],"directly":[134],"regulated":[135],"Bioinformatic":[138],"revealed":[140],"promoter":[144],"can":[145],"targeted":[147],"signal":[149],"transducer":[150],"activator":[152],"transcription":[154,170],"3":[155],"(STAT3).":[156],"Down-regulation":[157],"interleukin":[159],"6":[160],"(IL6)":[161],"might":[164],"lead":[165],"inhibition":[167,192],"through":[171,233],"STAT3":[172],"down-regulation":[173],"myeloma.":[176],"Furthermore,":[177],"both":[178],"seed-targeting":[181],"anti-miR-21":[182],"oligonucleotide":[183],"induced":[184],"apoptosis,":[185],"G2-phase":[186],"cycle":[188],"arrest":[189],"colony":[191],"lines.":[197],"Depletion":[198],"short":[202],"interfering":[203],"RNA":[204],"could":[205],"rescue":[206],"berberine-induced":[207],"cytotoxicity":[208],"CONCLUSIONS:":[213],"Our":[214],"results":[215],"suggest":[216],"suppresses":[219],"growth,":[223],"at":[224],"least":[225],"part,":[227],"down-regulating":[229],"levels":[231],"possibly":[232],"IL6/STAT3.":[234],"This":[235],"led":[236],"increased":[238],"expression,":[240],"which":[241],"likely":[243],"result":[245],"suppression":[247],"pathway.":[252],"These":[253],"findings":[254],"may":[255],"also":[256],"provide":[257],"new":[258],"mechanistic":[259],"insight":[260],"into":[261],"anti-cancer":[263],"effects":[264],"certain":[266],"compounds":[267],"medicines.":[272]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}