{"id":"https://openalex.org/W2124278065","doi":"https://doi.org/10.1186/1752-0509-8-75","title":"Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines","display_name":"Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines","publication_year":2014,"publication_date":"2014-06-25","ids":{"openalex":"https://openalex.org/W2124278065","doi":"https://doi.org/10.1186/1752-0509-8-75","mag":"2124278065","pmid":"https://pubmed.ncbi.nlm.nih.gov/24970389"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-8-75","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-75","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-75","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-75","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052118312","display_name":"Silvia von der Heyde","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Silvia Von der Heyde","raw_affiliation_strings":["Statistical Bioinformatics, Department of Medical Statistics, University Medical Center G\u00f6ttingen, Humboldtallee 32, 37073 G\u00f6ttingen, Germany","Statistical Bioinformatics, Department of Medical Statistics, University Medical Center G\u00f6ttingen, 37073 G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistical Bioinformatics, Department of Medical Statistics, University Medical Center G\u00f6ttingen, Humboldtallee 32, 37073 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]},{"raw_affiliation_string":"Statistical Bioinformatics, Department of Medical Statistics, University Medical Center G\u00f6ttingen, 37073 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103449814","display_name":"Christian Bender","orcid":null},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210149035","display_name":"Translationale Onkologie an der Universit\u00e4tsmedizin der Johannes Gutenberg-Universit\u00e4t Mainz","ror":"https://ror.org/04sz26p89","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210149035"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Bender","raw_affiliation_strings":["TRON - Translational Oncology at the University Medical Center Mainz, 55131 Mainz, Germany","TRON - Translational Oncology at the University Medical Center Mainz, Langenbeckstra\u00dfe 1, 55131 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TRON - Translational Oncology at the University Medical Center Mainz, 55131 Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210149035"]},{"raw_affiliation_string":"TRON - Translational Oncology at the University Medical Center Mainz, Langenbeckstra\u00dfe 1, 55131 Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210149035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057849725","display_name":"Frauke Henjes","orcid":null},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Frauke Henjes","raw_affiliation_strings":["Science for Life Laboratory, School of Biotechnology, KTH - Royal Institute of Technology, 17121 Solna, Sweden","Science for Life Laboratory, School of Biotechnology, KTH - Royal Institute of Technology, Box 1031, 17121 Solna, Sweden","Science for Life Laboratory, School of Biotechnology, KTH \u2013 Royal Institute of Technology, 17121, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science for Life Laboratory, School of Biotechnology, KTH - Royal Institute of Technology, 17121 Solna, Sweden","institution_ids":["https://openalex.org/I86987016"]},{"raw_affiliation_string":"Science for Life Laboratory, School of Biotechnology, KTH - Royal Institute of Technology, Box 1031, 17121 Solna, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I86987016"]},{"raw_affiliation_string":"Science for Life Laboratory, School of Biotechnology, KTH \u2013 Royal Institute of Technology, 17121, Solna, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038217788","display_name":"Johanna Sonntag","orcid":"https://orcid.org/0000-0002-5066-808X"},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johanna Sonntag","raw_affiliation_strings":["Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany","Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany","Division of Molecular Genome Analysis German Cancer Research Center (DKFZ), Heidelberg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Division of Molecular Genome Analysis German Cancer Research Center (DKFZ), Heidelberg Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059498724","display_name":"Ulrike Korf","orcid":null},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrike Korf","raw_affiliation_strings":["Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany","Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany","Division of Molecular Genome Analysis German Cancer Research Center (DKFZ), Heidelberg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Division of Molecular Genome Analysis German Cancer Research Center (DKFZ), Heidelberg Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017944645","display_name":"Tim Bei\u00dfbarth","orcid":"https://orcid.org/0000-0001-6509-2143"},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tim Bei\u00dfbarth","raw_affiliation_strings":["Statistical Bioinformatics, Department of Medical Statistics, University Medical Center G\u00f6ttingen, Humboldtallee 32, 37073 G\u00f6ttingen, Germany. tim.beissbarth@ams.med.uni-goettingen.de","Statistical Bioinformatics, Department of Medical Statistics, University Medical Center G\u00f6ttingen, 37073 G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistical Bioinformatics, Department of Medical Statistics, University Medical Center G\u00f6ttingen, Humboldtallee 32, 37073 G\u00f6ttingen, Germany. tim.beissbarth@ams.med.uni-goettingen.de","institution_ids":["https://openalex.org/I74656192"]},{"raw_affiliation_string":"Statistical Bioinformatics, Department of Medical Statistics, University Medical Center G\u00f6ttingen, 37073 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":1475,"currency":"EUR","value_usd":1590},"fwci":1.9322,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.87302463,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"75","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erbb","display_name":"ErbB","score":0.8873286247253418},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"Trastuzumab","score":0.7178945541381836},{"id":"https://openalex.org/keywords/pertuzumab","display_name":"Pertuzumab","score":0.6440985202789307},{"id":"https://openalex.org/keywords/skbr3","display_name":"SKBR3","score":0.5654194355010986},{"id":"https://openalex.org/keywords/mapk/erk-pathway","display_name":"MAPK/ERK pathway","score":0.5528730750083923},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.5458396673202515},{"id":"https://openalex.org/keywords/erlotinib","display_name":"Erlotinib","score":0.5375551581382751},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5218285918235779},{"id":"https://openalex.org/keywords/pi3k/akt/mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.4836074411869049},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.47241368889808655},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.4518139958381653},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"Epidermal growth factor receptor","score":0.3929556608200073},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.37630143761634827},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.3697301149368286},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.32706499099731445},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.25760966539382935},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.2209700644016266},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1507149040699005}],"concepts":[{"id":"https://openalex.org/C2779251935","wikidata":"https://www.wikidata.org/wiki/Q5385089","display_name":"ErbB","level":3,"score":0.8873286247253418},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.7178945541381836},{"id":"https://openalex.org/C2781164504","wikidata":"https://www.wikidata.org/wiki/Q1998021","display_name":"Pertuzumab","level":5,"score":0.6440985202789307},{"id":"https://openalex.org/C191560914","wikidata":"https://www.wikidata.org/wiki/Q7390592","display_name":"SKBR3","level":5,"score":0.5654194355010986},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5528730750083923},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5458396673202515},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.5375551581382751},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5218285918235779},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4836074411869049},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47241368889808655},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4518139958381653},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.3929556608200073},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37630143761634827},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3697301149368286},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.32706499099731445},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.25760966539382935},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2209700644016266},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1507149040699005},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000069347","descriptor_name":"Erlotinib Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069347","descriptor_name":"Erlotinib Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069347","descriptor_name":"Erlotinib Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-8-75","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-75","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-75","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:24970389","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24970389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:europepmc.org:3077046","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4087127","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/33140","is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/33140","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal_article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-8-75","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-75","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-75","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124278065.pdf","grobid_xml":"https://content.openalex.org/works/W2124278065.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W620245629","https://openalex.org/W1556540926","https://openalex.org/W1840642725","https://openalex.org/W1911421926","https://openalex.org/W1970439470","https://openalex.org/W1972371039","https://openalex.org/W1981989535","https://openalex.org/W1992708996","https://openalex.org/W1994056101","https://openalex.org/W1997056190","https://openalex.org/W1999025555","https://openalex.org/W2001447115","https://openalex.org/W2005557370","https://openalex.org/W2007393641","https://openalex.org/W2008633581","https://openalex.org/W2010601523","https://openalex.org/W2026558596","https://openalex.org/W2029735288","https://openalex.org/W2033795441","https://openalex.org/W2034091339","https://openalex.org/W2035848150","https://openalex.org/W2036348300","https://openalex.org/W2036960789","https://openalex.org/W2042459594","https://openalex.org/W2066469176","https://openalex.org/W2069233518","https://openalex.org/W2071344383","https://openalex.org/W2072009200","https://openalex.org/W2073903631","https://openalex.org/W2075161553","https://openalex.org/W2075669011","https://openalex.org/W2077550665","https://openalex.org/W2080973679","https://openalex.org/W2081034667","https://openalex.org/W2084448164","https://openalex.org/W2086080480","https://openalex.org/W2090020814","https://openalex.org/W2092022003","https://openalex.org/W2092537625","https://openalex.org/W2093223772","https://openalex.org/W2096595244","https://openalex.org/W2098073308","https://openalex.org/W2099724117","https://openalex.org/W2103097715","https://openalex.org/W2103454055","https://openalex.org/W2103723044","https://openalex.org/W2105118244","https://openalex.org/W2106844031","https://openalex.org/W2110065044","https://openalex.org/W2115620023","https://openalex.org/W2116466534","https://openalex.org/W2123125245","https://openalex.org/W2123206362","https://openalex.org/W2124082948","https://openalex.org/W2130284297","https://openalex.org/W2140217512","https://openalex.org/W2140349867","https://openalex.org/W2141425188","https://openalex.org/W2142384443","https://openalex.org/W2145436165","https://openalex.org/W2145899141","https://openalex.org/W2149106642","https://openalex.org/W2151950281","https://openalex.org/W2153316724","https://openalex.org/W2155087336","https://openalex.org/W2157208434","https://openalex.org/W2157658519","https://openalex.org/W2158134441","https://openalex.org/W2160496362","https://openalex.org/W2161682775","https://openalex.org/W2167437179","https://openalex.org/W2171572477","https://openalex.org/W2172081236","https://openalex.org/W2413892098","https://openalex.org/W2582743722","https://openalex.org/W2617635878"],"related_works":["https://openalex.org/W3001641205","https://openalex.org/W4237763823","https://openalex.org/W2330582602","https://openalex.org/W3139229505","https://openalex.org/W1601510090","https://openalex.org/W2891579961","https://openalex.org/W2769397950","https://openalex.org/W2901986589","https://openalex.org/W2019769353","https://openalex.org/W2914195240"],"abstract_inverted_index":{"BACKGROUND:":[0],"Despite":[1],"promising":[2],"progress":[3],"in":[4,51,89,131,184,208,293],"targeted":[5],"breast":[6,93,305],"cancer":[7,94,306],"therapy,":[8],"drug":[9,239,322,345],"resistance":[10,76,214,323],"remains":[11],"challenging.":[12],"The":[13,44,160,233],"monoclonal":[14],"antibody":[15],"drugs":[16],"trastuzumab":[17,104,213,258],"and":[18,33,86,99,114,135,172,231,265,275,291,320,338,347],"pertuzumab":[19],"as":[20,22,342],"well":[21],"the":[23,71,90,170,177,193,211,220,224,243,263,294,312,331],"small":[24],"molecule":[25],"inhibitor":[26,150],"erlotinib":[27],"were":[28,125,328],"designed":[29],"to":[30,41,62,69,74,111,149,152,163,257,278,311],"prevent":[31],"ErbB-2":[32,91],"ErbB-1":[34],"receptor":[35],"induced":[36],"deregulated":[37],"protein":[38,300],"signalling,":[39,207],"contributing":[40,256],"tumour":[42],"progression.":[43],"oncogenic":[45],"potential":[46,321],"of":[47,53,83,169,215,245,254,326],"ErbB":[48,72,84],"receptors":[49,60,85],"unfolds":[50],"case":[52],"overexpression":[54],"or":[55,105,108,284],"mutations.":[56],"Dimerisation":[57],"with":[58,102,210,330],"other":[59],"allows":[61],"bypass":[63],"pathway":[64,237],"blockades.":[65],"Our":[66],"intention":[67],"is":[68,269],"reconstruct":[70],"network":[73,147,315],"reveal":[75],"mechanisms.":[77,324],"We":[78,298],"used":[79],"longitudinal":[80],"proteomic":[81],"data":[82,130],"downstream":[87],"targets":[88],"amplified":[92],"cell":[95,133,164,217,282,307],"lines":[96],"BT474,":[97,176],"SKBR3":[98],"HCC1954":[100,249],"treated":[101],"erlotinib,":[103],"pertuzumab,":[106],"alone":[107],"combined,":[109],"up":[110],"60":[112],"minutes":[113],"30":[115],"hours,":[116],"respectively.":[117],"In":[118,175,191,219],"a":[119,132,236],"Boolean":[120],"modelling":[121],"approach,":[122],"signalling":[123,154,267],"networks":[124,161],"reconstructed":[126],"based":[127],"on":[128,223,262,273],"these":[129],"line":[134,165,209],"time":[136],"course":[137],"specific":[138,166,238],"manner,":[139],"including":[140],"prior":[141],"literature":[142],"knowledge.":[143],"Finally,":[144],"we":[145,201,227,287],"simulated":[146],"response":[148],"combinations":[151],"detect":[153],"nodes":[155],"reflecting":[156],"growth":[157,246,283],"inhibition.":[158],"RESULTS:":[159],"pointed":[162],"activation":[167],"patterns":[168],"MAPK":[171,189],"PI3K":[173,178,206],"pathway.":[174],"signal":[179],"route":[180],"was":[181],"favoured,":[182],"while":[183],"SKBR3,":[185],"novel":[186],"edges":[187,195],"highlighted":[188],"signalling.":[190],"HCC1954,":[192],"inferred":[194],"stimulated":[196],"both":[197],"pathways.":[198],"For":[199],"example,":[200],"uncovered":[202],"feedback":[203],"loops":[204],"amplifying":[205],"known":[212],"this":[216],"line.":[218],"perturbation":[221],"simulations":[222],"short-term":[225],"networks,":[226],"analysed":[228,289],"ERK1/2,":[229],"AKT":[230,264],"p70S6K.":[232],"results":[234],"indicated":[235],"response,":[240],"driven":[241],"by":[242,271],"type":[244,253],"factor":[247],"stimulus.":[248],"revealed":[250],"an":[251],"edgetic":[252],"PIK3CA-mutation,":[255],"inefficacy.":[259],"Drug":[260],"impact":[261],"ERK1/2":[266],"axes":[268],"mirrored":[270],"effects":[272],"RB":[274,290],"RPS6,":[276],"relating":[277],"phenotypic":[279],"events":[280],"like":[281],"proliferation.":[285],"Therefore,":[286],"additionally":[288],"RPS6":[292],"long-term":[295],"networks.":[296],"CONCLUSIONS:":[297],"derived":[299],"interaction":[301],"models":[302],"for":[303,344],"three":[304],"lines.":[308],"Changes":[309],"compared":[310],"common":[313],"reference":[314],"hint":[316],"towards":[317],"individual":[318],"characteristics":[319],"Simulation":[325],"perturbations":[327],"consistent":[329],"experimental":[332],"data,":[333],"confirming":[334],"our":[335],"combined":[336],"reverse":[337],"forward":[339],"engineering":[340],"approach":[341],"valuable":[343],"discovery":[346],"personalised":[348],"medicine.":[349]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
