{"id":"https://openalex.org/W2059410845","doi":"https://doi.org/10.1186/1752-0509-8-74","title":"Prediction of kinase inhibitor response using activity profiling, in vitro screening, and elastic net regression","display_name":"Prediction of kinase inhibitor response using activity profiling, in vitro screening, and elastic net regression","publication_year":2014,"publication_date":"2014-06-25","ids":{"openalex":"https://openalex.org/W2059410845","doi":"https://doi.org/10.1186/1752-0509-8-74","mag":"2059410845","pmid":"https://pubmed.ncbi.nlm.nih.gov/24961498"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-8-74","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-74","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-74","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-74","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103491517","display_name":"Trish P Tran","orcid":null},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Trish P Tran","raw_affiliation_strings":["Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA","Sanford-Burnham Medical Research Institute, La Jolla, USA,"],"affiliations":[{"raw_affiliation_string":"Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Sanford-Burnham Medical Research Institute, La Jolla, USA,","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007063951","display_name":"Edison Ong","orcid":"https://orcid.org/0000-0002-5159-414X"},"institutions":[{"id":"https://openalex.org/I4210157378","display_name":"Salgomed (United States)","ror":"https://ror.org/045s0p143","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157378"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edison Ong","raw_affiliation_strings":["Salgomed Inc., Del Mar, CA 92014, USA","Salgomed Inc., Del Mar, USA"],"affiliations":[{"raw_affiliation_string":"Salgomed Inc., Del Mar, CA 92014, USA","institution_ids":["https://openalex.org/I4210157378"]},{"raw_affiliation_string":"Salgomed Inc., Del Mar, USA","institution_ids":["https://openalex.org/I4210157378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035450253","display_name":"Andrew P. Hodges","orcid":"https://orcid.org/0000-0002-5100-8673"},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew P Hodges","raw_affiliation_strings":["Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA","Sanford-Burnham Medical Research Institute, La Jolla, USA,"],"affiliations":[{"raw_affiliation_string":"Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Sanford-Burnham Medical Research Institute, La Jolla, USA,","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004265401","display_name":"Giovanni Paternostro","orcid":"https://orcid.org/0000-0003-4029-5467"},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I4210157378","display_name":"Salgomed (United States)","ror":"https://ror.org/045s0p143","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157378"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giovanni Paternostro","raw_affiliation_strings":["Salgomed Inc., Del Mar, CA 92014, USA","Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA","Sanford-Burnham Medical Research Institute, La Jolla, USA"],"affiliations":[{"raw_affiliation_string":"Salgomed Inc., Del Mar, CA 92014, USA","institution_ids":["https://openalex.org/I4210157378"]},{"raw_affiliation_string":"Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Sanford-Burnham Medical Research Institute, La Jolla, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053987245","display_name":"Carlo Piermarocchi","orcid":"https://orcid.org/0000-0003-2762-8562"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlo Piermarocchi","raw_affiliation_strings":["Salgomed Inc,, Del Mar, CA 92014, USA. carlo@pa.msu.edu","Department of Physics and Astronomy, Michigan State University, East Lansing, USA"],"affiliations":[{"raw_affiliation_string":"Salgomed Inc,, Del Mar, CA 92014, USA. carlo@pa.msu.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Physics and Astronomy, Michigan State University, East Lansing, USA","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5103491517"],"corresponding_institution_ids":["https://openalex.org/I188891513"],"apc_list":null,"apc_paid":null,"fwci":4.3868,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.94695968,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"74","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9876000285148621,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.6993910074234009},{"id":"https://openalex.org/keywords/elastic-net-regularization","display_name":"Elastic net regularization","score":0.6817100048065186},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6005972623825073},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5357654690742493},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.43419349193573},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4064551591873169},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3861730396747589},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.31704291701316833},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.27033308148384094},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.19355466961860657},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.18863454461097717},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.15069976449012756}],"concepts":[{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6993910074234009},{"id":"https://openalex.org/C203868755","wikidata":"https://www.wikidata.org/wiki/Q5353562","display_name":"Elastic net regularization","level":3,"score":0.6817100048065186},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6005972623825073},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5357654690742493},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.43419349193573},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4064551591873169},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3861730396747589},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31704291701316833},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27033308148384094},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.19355466961860657},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.18863454461097717},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15069976449012756}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-8-74","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-74","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-74","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:24961498","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24961498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:arXiv.org:1307.4802","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1307.4802","pdf_url":"https://arxiv.org/pdf/1307.4802","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:europepmc.org:3076074","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4094402","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-8-74","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-74","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-74","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7799999713897705}],"awards":[{"id":"https://openalex.org/G2451222952","display_name":"The control landscape of selective cell death","funder_award_id":"0829891","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320338273","display_name":"Congressionally Directed Medical Research Programs","ror":"https://ror.org/03g2zjp07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2059410845.pdf","grobid_xml":"https://content.openalex.org/works/W2059410845.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1680392829","https://openalex.org/W1842491185","https://openalex.org/W1977863938","https://openalex.org/W1999895438","https://openalex.org/W2006686722","https://openalex.org/W2013734711","https://openalex.org/W2014582878","https://openalex.org/W2030900222","https://openalex.org/W2031350461","https://openalex.org/W2042111453","https://openalex.org/W2043398720","https://openalex.org/W2053126761","https://openalex.org/W2098480759","https://openalex.org/W2100772783","https://openalex.org/W2101234009","https://openalex.org/W2105129830","https://openalex.org/W2108523633","https://openalex.org/W2109384743","https://openalex.org/W2110065044","https://openalex.org/W2117379303","https://openalex.org/W2119816457","https://openalex.org/W2119862467","https://openalex.org/W2122825543","https://openalex.org/W2125789330","https://openalex.org/W2129860849","https://openalex.org/W2135046866","https://openalex.org/W2138778824","https://openalex.org/W2152265294","https://openalex.org/W2161732139","https://openalex.org/W2161922735","https://openalex.org/W2531563875","https://openalex.org/W3101756747"],"related_works":["https://openalex.org/W4213314600","https://openalex.org/W3211319599","https://openalex.org/W2122825543","https://openalex.org/W4292248859","https://openalex.org/W4388594321","https://openalex.org/W4221147225","https://openalex.org/W2148172612","https://openalex.org/W4392841950","https://openalex.org/W2771997889","https://openalex.org/W2954774635"],"abstract_inverted_index":{"We":[0],"have":[1],"proposed":[2],"an":[3],"integrated":[4],"experimental":[5],"and":[6,37],"computational":[7],"methodology,":[8],"called":[9],"KIEN,":[10],"that":[11],"identifies":[12],"the":[13,19,31,38],"role":[14],"of":[15,22,33,40,45],"specific":[16],"kinases":[17],"in":[18],"drug":[20],"response":[21],"a":[23],"given":[24],"cell":[25],"line.":[26],"The":[27],"method":[28],"will":[29],"facilitate":[30],"design":[32],"new":[34],"kinase":[35],"inhibitors":[36],"development":[39],"therapeutic":[41],"interventions":[42],"with":[43],"combinations":[44],"many":[46],"inhibitors.":[47]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
