{"id":"https://openalex.org/W2128959517","doi":"https://doi.org/10.1186/1752-0509-8-67","title":"Source and regulation of flux variability in Escherichia coli","display_name":"Source and regulation of flux variability in Escherichia coli","publication_year":2014,"publication_date":"2014-06-14","ids":{"openalex":"https://openalex.org/W2128959517","doi":"https://doi.org/10.1186/1752-0509-8-67","mag":"2128959517","pmid":"https://pubmed.ncbi.nlm.nih.gov/24927772"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-8-67","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-67","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-67","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-67","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077649516","display_name":"Magdalena San Rom\u00e1n","orcid":"https://orcid.org/0000-0002-2593-7727"},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":true,"raw_author_name":"Magdalena San Rom\u00e1n","raw_affiliation_strings":["Systems Biology Laboratory, Faculty of Sciences, Universidad de la Rep\u00fablica, Igu\u00e1 4225, Montevideo, 11400, Uruguay","Systems Biology Laboratory, Faculty of Sciences, Universidad de la Rep\u00fablica, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Laboratory, Faculty of Sciences, Universidad de la Rep\u00fablica, Igu\u00e1 4225, Montevideo, 11400, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Systems Biology Laboratory, Faculty of Sciences, Universidad de la Rep\u00fablica, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023945983","display_name":"H\u00e9ctor Cancela","orcid":"https://orcid.org/0000-0001-5015-0988"},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"H\u00e9ctor Cancela","raw_affiliation_strings":["Computer Science Institute, Faculty of Engineering, Universidad de la Rep\u00fablica, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Science Institute, Faculty of Engineering, Universidad de la Rep\u00fablica, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033514514","display_name":"Luis Acerenza","orcid":null},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Luis Acerenza","raw_affiliation_strings":["Systems Biology Laboratory, Faculty of Sciences, Universidad de la Rep\u00fablica, Igu\u00e1 4225, Montevideo 11400, Uruguay. aceren@fcien.edu.uy","Systems Biology Laboratory, Faculty of Sciences, Universidad de la Rep\u00fablica, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Laboratory, Faculty of Sciences, Universidad de la Rep\u00fablica, Igu\u00e1 4225, Montevideo 11400, Uruguay. aceren@fcien.edu.uy","institution_ids":[]},{"raw_affiliation_string":"Systems Biology Laboratory, Faculty of Sciences, Universidad de la Rep\u00fablica, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5077649516"],"corresponding_institution_ids":["https://openalex.org/I180910786"],"apc_list":null,"apc_paid":null,"fwci":0.8537,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.73453996,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"67","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.6440119743347168},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6289501190185547},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.5893207788467407},{"id":"https://openalex.org/keywords/escherichia-coli-proteins","display_name":"Escherichia coli Proteins","score":0.46283650398254395},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4504587650299072},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44074568152427673},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.21011504530906677},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1710716187953949},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1018500030040741}],"concepts":[{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6440119743347168},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6289501190185547},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5893207788467407},{"id":"https://openalex.org/C2908821069","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli Proteins","level":4,"score":0.46283650398254395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4504587650299072},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44074568152427673},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21011504530906677},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1710716187953949},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1018500030040741},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D064688","descriptor_name":"Metabolic Flux Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064688","descriptor_name":"Metabolic Flux Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064688","descriptor_name":"Metabolic Flux Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-8-67","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-67","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-67","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:24927772","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24927772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4074586","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4074586","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-8-67","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-67","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-67","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310753","display_name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","ror":"https://ror.org/03egaj678"},{"id":"https://openalex.org/F4320323603","display_name":"Universidad de la Rep\u00fablica Uruguay","ror":"https://ror.org/030bbe882"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2128959517.pdf","grobid_xml":"https://content.openalex.org/works/W2128959517.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W234963275","https://openalex.org/W1480307447","https://openalex.org/W1597762351","https://openalex.org/W1640253646","https://openalex.org/W1878240447","https://openalex.org/W1968467027","https://openalex.org/W1972670688","https://openalex.org/W1983153145","https://openalex.org/W1996460711","https://openalex.org/W2001624473","https://openalex.org/W2003153311","https://openalex.org/W2012980277","https://openalex.org/W2018041072","https://openalex.org/W2025663053","https://openalex.org/W2037248648","https://openalex.org/W2053460598","https://openalex.org/W2054719673","https://openalex.org/W2056756011","https://openalex.org/W2061334781","https://openalex.org/W2063810972","https://openalex.org/W2070020713","https://openalex.org/W2076262841","https://openalex.org/W2077055700","https://openalex.org/W2078351015","https://openalex.org/W2078355959","https://openalex.org/W2084161922","https://openalex.org/W2094399313","https://openalex.org/W2096245011","https://openalex.org/W2102164505","https://openalex.org/W2103041540","https://openalex.org/W2105028012","https://openalex.org/W2111421616","https://openalex.org/W2120289437","https://openalex.org/W2124737787","https://openalex.org/W2142836135","https://openalex.org/W2153373497","https://openalex.org/W2157197665","https://openalex.org/W2161827792","https://openalex.org/W2163459094","https://openalex.org/W2165011536","https://openalex.org/W2170427655","https://openalex.org/W2469522767","https://openalex.org/W4299328967"],"related_works":["https://openalex.org/W2360987025","https://openalex.org/W5284979","https://openalex.org/W2135850184","https://openalex.org/W2252376317","https://openalex.org/W2022891666","https://openalex.org/W2727878429","https://openalex.org/W2469250300","https://openalex.org/W3208158820","https://openalex.org/W4245853730","https://openalex.org/W174748315"],"abstract_inverted_index":{"BACKGROUND:":[0],"Metabolic":[1],"responses":[2,18],"are":[3,297],"essential":[4],"for":[5,75,180,242,269],"the":[6,20,49,56,59,76,103,111,181,206,214,217,221,235,270,286,294,306],"adaptation":[7],"of":[8,16,51,107,114,157,167,205,213,216,239,288,293,305],"microorganisms":[9],"to":[10,36,45,58,73,134,144,171,190,253,276,300],"changing":[11],"environmental":[12,191,277],"conditions.":[13],"The":[14,193,256,279],"repertoire":[15],"flux":[17,33,52,108,152,240,248],"that":[19,148],"metabolic":[21,38,63,126,186],"network":[22],"can":[23,88,160],"display":[24],"in":[25,65,110,125,154,185,260],"different":[26],"external":[27,95],"conditions":[28,245],"may":[29],"be":[30,89,161],"quantified":[31],"applying":[32],"variability":[34,87,101,109,153,233,241,249],"analysis":[35],"genome-scale":[37],"reconstructions.":[39],"RESULTS:":[40],"A":[41],"procedure":[42,57],"is":[43,102,234],"developed":[44],"classify":[46],"and":[47,80,96,117,201,262,265,290,296],"quantify":[48],"sources":[50],"variability.":[53,98],"We":[54],"apply":[55],"latest":[60,218],"Escherichia":[61],"coli":[62,129,159,228],"reconstruction,":[64,219],"glucose":[66],"minimal":[67],"medium,":[68],"with":[69,197],"an":[70,178,202,267],"additional":[71],"constraint":[72],"account":[74],"mechanism":[77],"coordinating":[78],"carbon":[79],"nitrogen":[81],"utilization":[82],"mediated":[83],"by":[84],"\u03b1-ketoglutarate.":[85],"Flux":[86],"decomposed":[90],"into":[91],"three":[92],"components:":[93],"internal,":[94],"growth":[97,100,132,232,252],"Unexpectedly,":[99],"only":[104,236],"significant":[105,237],"component":[106,238],"physiological":[112,244,261],"ranges":[113],"glucose,":[115,231],"oxygen":[116],"ammonia":[118],"uptake":[119],"rates.":[120],"To":[121],"obtain":[122],"substantial":[123],"increases":[124],"flexibility,":[127],"E.":[128,158,227],"must":[130],"decrease":[131],"rate":[133],"suboptimal":[135,254],"values.":[136,255],"This":[137],"growth-flexibility":[138,257],"trade-off":[139,258],"gives":[140],"a":[141,155,164,198],"straightforward":[142],"interpretation":[143],"recent":[145],"work":[146],"showing":[147],"most":[149,169],"overall":[150],"cell-to-cell":[151],"population":[156],"attained":[162],"sampling":[163],"small":[165],"number":[166],"enzymes":[168],"likely":[170],"constrain":[172],"cell":[173],"growth.":[174],"Importantly,":[175],"it":[176],"provides":[177,266],"explanation":[179,268],"global":[182,271],"reorganization":[183,272],"occurring":[184,273],"networks":[187],"during":[188,274],"adaptations":[189,275],"challenges.":[192,278],"calculations":[194],"were":[195],"repeated":[196],"pathogenic":[199],"strain":[200],"old":[203],"reconstruction":[204],"commensal":[207],"strain,":[208],"having":[209],"less":[210],"than":[211],"50%":[212],"reactions":[215],"obtaining":[220],"same":[222],"general":[223],"conclusions.":[224],"CONCLUSIONS:":[225],"In":[226],"growing":[229],"on":[230,285],"all":[243],"explored.":[246],"Increasing":[247],"requires":[250],"reducing":[251],"operates":[259],"evolutionary":[263],"adaptations,":[264],"results":[280],"obtained":[281],"do":[282],"not":[283],"rely":[284],"knowledge":[287,304],"kinetic":[289],"regulatory":[291],"details":[292],"system":[295],"highly":[298],"robust":[299],"incomplete":[301],"or":[302],"incorrect":[303],"reaction":[307],"network.":[308]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}
