{"id":"https://openalex.org/W2143836431","doi":"https://doi.org/10.1186/1752-0509-8-65","title":"A systems biology investigation of neurodegenerative dementia reveals a pivotal role of autophagy","display_name":"A systems biology investigation of neurodegenerative dementia reveals a pivotal role of autophagy","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2143836431","doi":"https://doi.org/10.1186/1752-0509-8-65","mag":"2143836431","pmid":"https://pubmed.ncbi.nlm.nih.gov/24908109"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-8-65","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-65","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-65","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-65","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090761378","display_name":"Laura Caberlotto","orcid":"https://orcid.org/0000-0002-2122-851X"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I2802934434","display_name":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology","ror":"https://ror.org/04kcgyj43","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1290206253","https://openalex.org/I193223587","https://openalex.org/I2802934434","https://openalex.org/I4210164937"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Laura Caberlotto","raw_affiliation_strings":["The Microsoft Research, University of Trento Centre for Computational Systems Biology (COSBI), Piazza Manifattura 1, 38068 Rovereto, Italy. caberlotto@cosbi.eu","The Microsoft Research, University of Trento Centre for Computational Systems Biology (COSBI), Rovereto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Microsoft Research, University of Trento Centre for Computational Systems Biology (COSBI), Piazza Manifattura 1, 38068 Rovereto, Italy. caberlotto@cosbi.eu","institution_ids":[]},{"raw_affiliation_string":"The Microsoft Research, University of Trento Centre for Computational Systems Biology (COSBI), Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101655330","display_name":"Thanh-Phuong Nguyen","orcid":"https://orcid.org/0000-0003-3817-5183"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I2802934434","display_name":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology","ror":"https://ror.org/04kcgyj43","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1290206253","https://openalex.org/I193223587","https://openalex.org/I2802934434","https://openalex.org/I4210164937"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Thanh-Phuong Nguyen","raw_affiliation_strings":["The Microsoft Research, University of Trento Centre for Computational Systems Biology (COSBI), Piazza Manifattura 1, 38068, Rovereto, Italy","The Microsoft Research, University of Trento Centre for Computational Systems Biology (COSBI), Rovereto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Microsoft Research, University of Trento Centre for Computational Systems Biology (COSBI), Piazza Manifattura 1, 38068, Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]},{"raw_affiliation_string":"The Microsoft Research, University of Trento Centre for Computational Systems Biology (COSBI), Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090761378"],"corresponding_institution_ids":["https://openalex.org/I193223587","https://openalex.org/I2802934434"],"apc_list":null,"apc_paid":null,"fwci":2.8067,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.90650298,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"65","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6388999819755554,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6388999819755554,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0851999968290329,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.058400001376867294,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.7476775050163269},{"id":"https://openalex.org/keywords/autophagy","display_name":"Autophagy","score":0.7172136306762695},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5661553144454956},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5497567653656006},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5253219604492188},{"id":"https://openalex.org/keywords/dementia","display_name":"Dementia","score":0.4562167227268219},{"id":"https://openalex.org/keywords/cognitive-science","display_name":"Cognitive science","score":0.3471892476081848},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3224322199821472},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2202291190624237},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.1804024577140808},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16754284501075745},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.1522887647151947},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.08464959263801575}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.7476775050163269},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7172136306762695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5661553144454956},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5497567653656006},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5253219604492188},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4562167227268219},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.3471892476081848},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3224322199821472},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2202291190624237},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1804024577140808},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16754284501075745},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1522887647151947},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08464959263801575},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-8-65","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-65","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-65","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:24908109","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24908109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:orbilu.uni.lu:10993/21655","is_oa":true,"landing_page_url":"https://orbilu.uni.lu/handle/10993/21655","pdf_url":null,"source":{"id":"https://openalex.org/S4306401815","display_name":"Open Repository and Bibliography (University of Luxembourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I186903577","host_organization_name":"University of Luxembourg","host_organization_lineage":["https://openalex.org/I186903577"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4077228","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4077228","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-8-65","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-65","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-65","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6200000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2143836431.pdf","grobid_xml":"https://content.openalex.org/works/W2143836431.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W18034176","https://openalex.org/W62275226","https://openalex.org/W1492229294","https://openalex.org/W1554596985","https://openalex.org/W1560623477","https://openalex.org/W1589164005","https://openalex.org/W1601336661","https://openalex.org/W1641175229","https://openalex.org/W1966919503","https://openalex.org/W1969353942","https://openalex.org/W1970095814","https://openalex.org/W1972336737","https://openalex.org/W1974900059","https://openalex.org/W1987721502","https://openalex.org/W1988602805","https://openalex.org/W1994823455","https://openalex.org/W1994922654","https://openalex.org/W1999292282","https://openalex.org/W2003380425","https://openalex.org/W2005264361","https://openalex.org/W2008864875","https://openalex.org/W2009295603","https://openalex.org/W2009405916","https://openalex.org/W2013656566","https://openalex.org/W2018961056","https://openalex.org/W2020301095","https://openalex.org/W2028642327","https://openalex.org/W2028808454","https://openalex.org/W2030089671","https://openalex.org/W2031418848","https://openalex.org/W2031864556","https://openalex.org/W2035521611","https://openalex.org/W2038963685","https://openalex.org/W2040639372","https://openalex.org/W2044002635","https://openalex.org/W2045373134","https://openalex.org/W2047693963","https://openalex.org/W2051244976","https://openalex.org/W2051279608","https://openalex.org/W2054125361","https://openalex.org/W2062214806","https://openalex.org/W2062533676","https://openalex.org/W2063043143","https://openalex.org/W2063252164","https://openalex.org/W2064746187","https://openalex.org/W2067841476","https://openalex.org/W2070754796","https://openalex.org/W2075412264","https://openalex.org/W2081431643","https://openalex.org/W2091334591","https://openalex.org/W2097219059","https://openalex.org/W2097574897","https://openalex.org/W2097962551","https://openalex.org/W2098656855","https://openalex.org/W2103545941","https://openalex.org/W2108086395","https://openalex.org/W2110684048","https://openalex.org/W2112282100","https://openalex.org/W2112329697","https://openalex.org/W2113951828","https://openalex.org/W2119412782","https://openalex.org/W2125722904","https://openalex.org/W2125726293","https://openalex.org/W2128428892","https://openalex.org/W2134121616","https://openalex.org/W2136832436","https://openalex.org/W2144014661","https://openalex.org/W2145206598","https://openalex.org/W2148502410","https://openalex.org/W2152285853","https://openalex.org/W2155581408","https://openalex.org/W2155699197","https://openalex.org/W2164837103","https://openalex.org/W2165126337","https://openalex.org/W2232572728","https://openalex.org/W4231446368","https://openalex.org/W4237360036","https://openalex.org/W4248234957","https://openalex.org/W4249201383"],"related_works":["https://openalex.org/W3150996080","https://openalex.org/W2498134948","https://openalex.org/W3151903987","https://openalex.org/W2005626592","https://openalex.org/W3149538430","https://openalex.org/W2382353027","https://openalex.org/W2324929766","https://openalex.org/W3141893332","https://openalex.org/W5284979","https://openalex.org/W4245853730"],"abstract_inverted_index":{"BACKGROUND:":[0],"Neurodegenerative":[1],"dementia":[2,35,112,147,233],"comprises":[3],"chronic":[4],"and":[5,15,20,27,49,61,132,168,189,244],"progressive":[6,14],"illnesses":[7],"with":[8,106,234],"major":[9,137],"clinical":[10,109],"features":[11],"represented":[12],"by":[13,42,241],"permanent":[16],"loss":[17],"of":[18,25,33,44,47,51,65,71,111,129,139,143,154,186,190,213],"cognitive":[19],"mental":[21],"performance,":[22],"including":[23],"impairment":[24],"memory":[26],"brain":[28],"functions.":[29],"Many":[30],"different":[31,69],"forms":[32],"neurodegenerative":[34,84,232],"exist,":[36],"but":[37],"they":[38],"are":[39],"all":[40],"characterized":[41,240],"death":[43],"specific":[45,169],"subpopulation":[46],"neurons":[48],"accumulation":[50],"proteins":[52,131,196],"in":[53,67,83,146,150,163,184,197,231,238,249],"the":[54,68,72,87,98,107,155,164,191,198,211,223,246,250],"brain.":[55],"We":[56],"incorporated":[57],"data":[58],"from":[59],"OMIM":[60],"primary":[62],"molecular":[63,99,157,208],"targets":[64,171],"drugs":[66],"phases":[70,153],"drug":[73,133,170],"discovery":[74],"process":[75,145,230],"to":[76,78,96,124,160,173,194],"try":[77],"reveal":[79],"possible":[80],"hidden":[81],"mechanism":[82],"dementia.":[85],"In":[86,182],"present":[88,218],"study,":[89],"a":[90,136,206,227,235],"systems":[91,219],"biology":[92,220],"approach":[93],"was":[94,122],"used":[95],"investigate":[97],"connections":[100],"among":[101],"seemingly":[102],"distinct":[103],"complex":[104],"diseases":[105,239],"shared":[108],"symptoms":[110],"that":[113,252],"could":[114,176,202,253],"suggest":[115],"related":[116],"disease":[117,130,166],"mechanisms.":[118],"RESULTS:":[119],"Network":[120],"analysis":[121],"applied":[123],"characterize":[125],"an":[126],"interaction":[127],"network":[128],"targets,":[134],"revealing":[135],"role":[138],"metabolism":[140],"and,":[141,148],"predominantly,":[142],"autophagy":[144,156,174,195,224],"particularly,":[149],"tauopathies.":[151],"Different":[152],"pathway":[158,225,251],"appear":[159],"be":[161,177,203,254],"implicated":[162],"individual":[165],"pathophysiology":[167],"associated":[172],"modulation":[175],"considered":[178,255],"for":[179,210,256],"pharmacological":[180],"intervention.":[181],"particular,":[183],"view":[185],"their":[187],"centrality":[188],"direct":[192],"association":[193],"network,":[199],"PP2A":[200],"subunits":[201],"suggested":[204],"as":[205,226],"suitable":[207],"target":[209],"development":[212],"novel":[214],"drugs.":[215],"CONCLUSION:":[216],"The":[217],"investigation":[221],"identifies":[222],"central":[228],"dis-regulated":[229],"prevalent":[236],"involvement":[237],"tau":[242],"inclusion":[243],"indicates":[245],"disease-specific":[247],"molecules":[248],"therapy.":[257]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}