{"id":"https://openalex.org/W2151484461","doi":"https://doi.org/10.1186/1752-0509-8-60","title":"Gene perturbation and intervention in context-sensitive stochastic Boolean networks","display_name":"Gene perturbation and intervention in context-sensitive stochastic Boolean networks","publication_year":2014,"publication_date":"2014-05-21","ids":{"openalex":"https://openalex.org/W2151484461","doi":"https://doi.org/10.1186/1752-0509-8-60","mag":"2151484461","pmid":"https://pubmed.ncbi.nlm.nih.gov/24886608"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-8-60","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-60","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-60","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-60","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038915198","display_name":"Peican Zhu","orcid":"https://orcid.org/0000-0002-8389-1093"},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Peican Zhu","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, Canada","Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111719252","display_name":"Jinghang Liang","orcid":null},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jinghang Liang","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, Canada","Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005550142","display_name":"Jie Han","orcid":"https://orcid.org/0000-0002-8849-4994"},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Jie Han","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, Canada. jhan8@ualberta.ca","Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, Canada. jhan8@ualberta.ca","institution_ids":[]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005550142"],"corresponding_institution_ids":["https://openalex.org/I154425047"],"apc_list":null,"apc_paid":null,"fwci":0.7114,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.70968329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"60","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6949004530906677},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5642893314361572},{"id":"https://openalex.org/keywords/perturbation","display_name":"Perturbation (astronomy)","score":0.5181789994239807},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48385918140411377},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.47421836853027344},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.470463365316391},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.46540528535842896},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.45957064628601074},{"id":"https://openalex.org/keywords/boolean-network","display_name":"Boolean network","score":0.4523041546344757},{"id":"https://openalex.org/keywords/intervention","display_name":"Intervention (counseling)","score":0.4269596338272095},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.371672123670578},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.35768935084342957},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3410895764827728},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.28000110387802124},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.23433083295822144},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2296806275844574},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.2072913646697998},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.20706778764724731},{"id":"https://openalex.org/keywords/boolean-function","display_name":"Boolean function","score":0.17595678567886353},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1365954577922821}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6949004530906677},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5642893314361572},{"id":"https://openalex.org/C177918212","wikidata":"https://www.wikidata.org/wiki/Q803623","display_name":"Perturbation (astronomy)","level":2,"score":0.5181789994239807},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48385918140411377},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.47421836853027344},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.470463365316391},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.46540528535842896},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.45957064628601074},{"id":"https://openalex.org/C134444547","wikidata":"https://www.wikidata.org/wiki/Q585230","display_name":"Boolean network","level":3,"score":0.4523041546344757},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.4269596338272095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.371672123670578},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.35768935084342957},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3410895764827728},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28000110387802124},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.23433083295822144},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2296806275844574},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.2072913646697998},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20706778764724731},{"id":"https://openalex.org/C187455244","wikidata":"https://www.wikidata.org/wiki/Q942353","display_name":"Boolean function","level":2,"score":0.17595678567886353},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1365954577922821},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-8-60","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-60","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-60","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:24886608","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24886608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:europepmc.org:3044251","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4062525","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-8-60","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-60","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-60","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319946","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2151484461.pdf","grobid_xml":"https://content.openalex.org/works/W2151484461.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W51833465","https://openalex.org/W1480692184","https://openalex.org/W1496218110","https://openalex.org/W1532781952","https://openalex.org/W1650797637","https://openalex.org/W1966789782","https://openalex.org/W1970557025","https://openalex.org/W1971224531","https://openalex.org/W1975766849","https://openalex.org/W1979634817","https://openalex.org/W1980570931","https://openalex.org/W1982349563","https://openalex.org/W1985331876","https://openalex.org/W1987862415","https://openalex.org/W1990514789","https://openalex.org/W2006811029","https://openalex.org/W2011628627","https://openalex.org/W2015722366","https://openalex.org/W2042321087","https://openalex.org/W2051591256","https://openalex.org/W2058794142","https://openalex.org/W2071310017","https://openalex.org/W2074297949","https://openalex.org/W2077350721","https://openalex.org/W2084052553","https://openalex.org/W2086150890","https://openalex.org/W2096813836","https://openalex.org/W2097651998","https://openalex.org/W2098470668","https://openalex.org/W2101792624","https://openalex.org/W2104842841","https://openalex.org/W2106034845","https://openalex.org/W2107342968","https://openalex.org/W2115782725","https://openalex.org/W2118467699","https://openalex.org/W2125408642","https://openalex.org/W2130721915","https://openalex.org/W2131754626","https://openalex.org/W2132810680","https://openalex.org/W2134978629","https://openalex.org/W2136559804","https://openalex.org/W2146009166","https://openalex.org/W2146764432","https://openalex.org/W2155418451","https://openalex.org/W2156768230","https://openalex.org/W2160904474","https://openalex.org/W2165284694","https://openalex.org/W2165350808","https://openalex.org/W2168399023","https://openalex.org/W2171280873","https://openalex.org/W2530014580","https://openalex.org/W4238726034","https://openalex.org/W4245662196","https://openalex.org/W4404810058"],"related_works":["https://openalex.org/W1422717320","https://openalex.org/W2402814600","https://openalex.org/W2794960257","https://openalex.org/W2330768201","https://openalex.org/W2108120899","https://openalex.org/W2158714033","https://openalex.org/W2349909726","https://openalex.org/W2128085946","https://openalex.org/W2063978705","https://openalex.org/W2156091616"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,65],"a":[2,36,40,44,66,75,113,157,169,178,181,194,206,221,226,291,302,314,332],"gene":[3,7,63,267,272,299,336],"regulatory":[4,273],"network":[5,41,289,315,334],"(GRN),":[6],"expressions":[8],"are":[9,25,256],"affected":[10],"by":[11],"noise,":[12],"and":[13,55,71,223,231,243,269,344],"stochastic":[14,23,122,141,252],"fluctuations":[15],"exist":[16],"in":[17,35,39,58,168,202,271,290],"the":[18,59,91,97,148,166,187,198,217,264,283,287,306,310,327],"interactions":[19,24],"among":[20],"genes.":[21],"These":[22],"context":[26,61,318],"dependent,":[27],"thus":[28],"it":[29],"becomes":[30],"important":[31],"to":[32,197,262,317],"consider":[33],"noise":[34,57],"context-sensitive":[37,47,161],"manner":[38],"model.":[42],"As":[43],"logical":[45],"model,":[46],"probabilistic":[48],"Boolean":[49,123,142,253],"networks":[50,124,143,254],"(CSPBNs)":[51],"account":[52],"for":[53,84,147,164,185,204,225],"molecular":[54],"genetic":[56],"temporal":[60],"of":[62,78,90,96,112,133,140,151,160,177,183,220,266,286,309,313,331],"functions.":[64],"CSPBN":[67,179,222],"with":[68,180],"n":[69],"genes":[70],"k":[72],"contexts,":[73],"however,":[74],"computational":[76],"complexity":[77,182],"O(nk222n)":[79],"(or":[80,87,106],"O(nk2n))":[81],"is":[82,118,145,193,236,295],"required":[83,199],"an":[85,130,134,174,240,247,259],"accurate":[86,245],"approximate)":[88],"computation":[89],"state":[92,115,188,312,329],"transition":[93,189],"matrix":[94],"(STM)":[95],"size":[98],"(2n":[99,103],"\u2219":[100,104],"k)":[101,105],"\u00d7":[102,108],"2n":[107],"2n).":[109],"The":[110,138,233,321],"evaluation":[111],"steady":[114,311,328],"distribution":[116,308,330],"(SSD)":[117],"more":[119,237,244],"challenging.":[120],"Recently,":[121],"(SBNs)":[125,144],"have":[126],"been":[127],"proposed":[128,257],"as":[129,258],"efficient":[131,175,238,260],"implementation":[132],"instantaneous":[135],"PBN.":[136],"RESULTS:":[137],"notion":[139],"extended":[146],"general":[149],"model":[150],"PBNs,":[152],"i.e.,":[153],"CSPBNs.":[154],"This":[155],"yields":[156],"novel":[158],"structure":[159],"SBNs":[162],"(CSSBNs)":[163,255],"modeling":[165,263],"stochasticity":[167],"GRN.":[170],"A":[171,209,275],"CSSBN":[172,203,212,234,276,322],"enables":[173],"simulation":[176],"O(nLk2n)":[184],"computing":[186],"matrix,":[190],"where":[191],"L":[192],"factor":[195],"related":[196],"sequence":[200],"length":[201],"achieving":[205],"desired":[207],"accuracy.":[208],"time-frame":[210],"expanded":[211],"can":[213,324],"further":[214,325],"efficiently":[215],"simulate":[216],"stationary":[218],"behavior":[219],"allow":[224],"tunable":[227],"tradeoff":[228],"between":[229],"accuracy":[230],"efficiency.":[232],"approach":[235,261,323],"than":[239,246],"analytical":[241],"method":[242],"approximate":[248],"analysis.":[249],"CONCLUSIONS:":[250],"Context-sensitive":[251],"effects":[265],"perturbation":[268,300],"intervention":[270,348],"networks.":[274],"analysis":[277],"provides":[278],"biologically":[279],"meaningful":[280],"insights":[281],"into":[282],"oscillatory":[284],"dynamics":[285],"p53-Mdm2":[288],"context-switching":[292],"environment.":[293],"It":[294],"shown":[296],"that":[297],"random":[298],"has":[301],"greater":[303],"effect":[304],"on":[305],"final":[307],"compared":[316],"switching":[319],"activities.":[320],"predict":[326],"glioma":[333],"under":[335],"intervention.":[337],"Ultimately,":[338],"this":[339],"will":[340],"help":[341],"drug":[342,347],"discovery":[343],"develop":[345],"effective":[346],"strategies.":[349]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}
