{"id":"https://openalex.org/W2162645438","doi":"https://doi.org/10.1186/1752-0509-8-59","title":"Insight into model mechanisms through automatic parameter fitting: a new methodological framework for model development","display_name":"Insight into model mechanisms through automatic parameter fitting: a new methodological framework for model development","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2162645438","doi":"https://doi.org/10.1186/1752-0509-8-59","mag":"2162645438","pmid":"https://pubmed.ncbi.nlm.nih.gov/24886522"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-8-59","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-59","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-59","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-59","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066133441","display_name":"Kristin T\u00f8ndel","orcid":null},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Kristin T\u00f8ndel","raw_affiliation_strings":["Department of Biomedical Engineering, King's College London, St, Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK. kristin.tondel@gmail.com","Department of Biomedical Engineering, King\u2019s College London, St. Thomas\u2019 Hospital, Westminster Bridge Road, London, SE1 7EH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, King's College London, St, Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK. kristin.tondel@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Department of Biomedical Engineering, King\u2019s College London, St. Thomas\u2019 Hospital, Westminster Bridge Road, London, SE1 7EH, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000435552","display_name":"Steven Niederer","orcid":"https://orcid.org/0000-0002-4612-6982"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steven A Niederer","raw_affiliation_strings":["Department of Biomedical Engineering, King\u2019s College London, St. Thomas\u2019 Hospital, Westminster Bridge Road, London, SE1 7EH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, King\u2019s College London, St. Thomas\u2019 Hospital, Westminster Bridge Road, London, SE1 7EH, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085200850","display_name":"Sander Land","orcid":"https://orcid.org/0000-0001-8572-251X"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sander Land","raw_affiliation_strings":["Department of Biomedical Engineering, King\u2019s College London, St. Thomas\u2019 Hospital, Westminster Bridge Road, London, SE1 7EH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, King\u2019s College London, St. Thomas\u2019 Hospital, Westminster Bridge Road, London, SE1 7EH, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074257695","display_name":"Nicolas P. Smith","orcid":"https://orcid.org/0000-0002-8299-5771"},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicolas P Smith","raw_affiliation_strings":["Department of Biomedical Engineering, King\u2019s College London, St. Thomas\u2019 Hospital, Westminster Bridge Road, London, SE1 7EH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, King\u2019s College London, St. Thomas\u2019 Hospital, Westminster Bridge Road, London, SE1 7EH, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5066133441"],"corresponding_institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"],"apc_list":null,"apc_paid":{"value":1400,"currency":"EUR","value_usd":1509},"fwci":0.6051,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.74118805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"59","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.28380000591278076,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.28380000591278076,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.2750000059604645,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.251800000667572,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identifiability","display_name":"Identifiability","score":0.8211090564727783},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6496936678886414},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.5648318529129028},{"id":"https://openalex.org/keywords/experimental-data","display_name":"Experimental data","score":0.5233123302459717},{"id":"https://openalex.org/keywords/model-selection","display_name":"Model selection","score":0.49081429839134216},{"id":"https://openalex.org/keywords/estimation-theory","display_name":"Estimation theory","score":0.48292824625968933},{"id":"https://openalex.org/keywords/system-identification","display_name":"System identification","score":0.4493190050125122},{"id":"https://openalex.org/keywords/parameter-space","display_name":"Parameter space","score":0.4312349259853363},{"id":"https://openalex.org/keywords/model-parameter","display_name":"Model parameter","score":0.42734000086784363},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.4106990396976471},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3825125992298126},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3665222227573395},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3136960566043854},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.2881694734096527},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.21133571863174438},{"id":"https://openalex.org/keywords/measure","display_name":"Measure (data warehouse)","score":0.13714951276779175},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.10933816432952881}],"concepts":[{"id":"https://openalex.org/C122770356","wikidata":"https://www.wikidata.org/wiki/Q1656753","display_name":"Identifiability","level":2,"score":0.8211090564727783},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6496936678886414},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.5648318529129028},{"id":"https://openalex.org/C55037315","wikidata":"https://www.wikidata.org/wiki/Q5421151","display_name":"Experimental data","level":2,"score":0.5233123302459717},{"id":"https://openalex.org/C93959086","wikidata":"https://www.wikidata.org/wiki/Q6888345","display_name":"Model selection","level":2,"score":0.49081429839134216},{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.48292824625968933},{"id":"https://openalex.org/C119247159","wikidata":"https://www.wikidata.org/wiki/Q1366192","display_name":"System identification","level":3,"score":0.4493190050125122},{"id":"https://openalex.org/C73586568","wikidata":"https://www.wikidata.org/wiki/Q2600211","display_name":"Parameter space","level":2,"score":0.4312349259853363},{"id":"https://openalex.org/C2983447341","wikidata":"https://www.wikidata.org/wiki/Q1413083","display_name":"Model parameter","level":2,"score":0.42734000086784363},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.4106990396976471},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3825125992298126},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3665222227573395},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3136960566043854},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2881694734096527},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21133571863174438},{"id":"https://openalex.org/C2780009758","wikidata":"https://www.wikidata.org/wiki/Q6804172","display_name":"Measure (data warehouse)","level":2,"score":0.13714951276779175},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.10933816432952881},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-8-59","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-59","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-59","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:24886522","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24886522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/26714d0d-dc95-4efd-9d61-ab759a21bdaf","is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/26714d0d-dc95-4efd-9d61-ab759a21bdaf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"T\u00f8ndel, K, Niederer, S A, Land, S & Smith, N P 2014, 'Insight into model mechanisms through automatic parameter fitting : a new methodological framework for model development', Bmc Systems Biology, vol. 8, 59. https://doi.org/10.1186/1752-0509-8-59","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:europepmc.org:3058250","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4078362","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-8-59","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-59","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-59","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2073892509","display_name":null,"funder_award_id":"WT 088641/Z/09/Z","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G250786833","display_name":"Computer to Clinic: Personalised Fluid-Mechanical Models Applied to Heart Failure","funder_award_id":"EP/G007527/2","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2526812106","display_name":null,"funder_award_id":"WT 088641/Z/09/Z","funder_id":"https://openalex.org/F4320312400","funder_display_name":"King's College Hospital NHS Foundation Trust"},{"id":"https://openalex.org/G3087759835","display_name":null,"funder_award_id":"EP/G007527/2","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4419744298","display_name":null,"funder_award_id":"BB/J017272/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5144266031","display_name":"Modelling the human heart: an integrated experimental and computational study","funder_award_id":"BB/J017272/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6019431264","display_name":null,"funder_award_id":"WT 088641/Z/09/Z","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G8377015798","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G8786097091","display_name":null,"funder_award_id":"EP/F043929/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8946277657","display_name":null,"funder_award_id":"EP/F043929/2","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320312400","display_name":"King's College Hospital NHS Foundation Trust","ror":"https://ror.org/01n0k5m85"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320285","display_name":"King's College London","ror":"https://ror.org/0220mzb33"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2162645438.pdf","grobid_xml":"https://content.openalex.org/works/W2162645438.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1502527850","https://openalex.org/W1582645007","https://openalex.org/W1901823973","https://openalex.org/W1956520347","https://openalex.org/W1974228449","https://openalex.org/W1980498000","https://openalex.org/W1990146258","https://openalex.org/W1992154841","https://openalex.org/W1997526378","https://openalex.org/W2005930077","https://openalex.org/W2009091194","https://openalex.org/W2014084531","https://openalex.org/W2015249754","https://openalex.org/W2015335852","https://openalex.org/W2019201408","https://openalex.org/W2024060531","https://openalex.org/W2028952104","https://openalex.org/W2038669746","https://openalex.org/W2047480488","https://openalex.org/W2052279177","https://openalex.org/W2061783166","https://openalex.org/W2063386545","https://openalex.org/W2075114163","https://openalex.org/W2075402097","https://openalex.org/W2075665712","https://openalex.org/W2084421529","https://openalex.org/W2084593711","https://openalex.org/W2087070363","https://openalex.org/W2101589741","https://openalex.org/W2106465633","https://openalex.org/W2113076747","https://openalex.org/W2115591470","https://openalex.org/W2125643834","https://openalex.org/W2141136982","https://openalex.org/W2161023180","https://openalex.org/W2161304688","https://openalex.org/W2171074980","https://openalex.org/W2294798173","https://openalex.org/W2740586183","https://openalex.org/W2989457786","https://openalex.org/W4213138763","https://openalex.org/W4243838184","https://openalex.org/W4247072014","https://openalex.org/W4252057248"],"related_works":["https://openalex.org/W58409073","https://openalex.org/W3006948849","https://openalex.org/W2080540637","https://openalex.org/W3200883601","https://openalex.org/W1998523300","https://openalex.org/W2949789807","https://openalex.org/W3089616691","https://openalex.org/W2000610039","https://openalex.org/W4386557042","https://openalex.org/W2962585917"],"abstract_inverted_index":{"BACKGROUND:":[0],"Striking":[1],"a":[2,22,90,113,128,207,215,272],"balance":[3],"between":[4,60,191],"the":[5,68,121,136,151,154,189,194,204,228,240,256,259,280,284,293,306],"degree":[6],"of":[7,32,45,70,98,103,115,120,124,135,142,148,153,168,206,210,217,227,247,275,279,327,331],"model":[8,33,46,61,95,99,104,178,184,195,209,226,248,266,300,329],"complexity":[9,308],"and":[10,43,53,62,101,127,146,166,220,302,335],"parameter":[11,38,137,158,169,286],"identifiability,":[12,170],"while":[13],"still":[14],"producing":[15],"biologically":[16,132],"feasible":[17,133],"simulations":[18,149],"using":[19,214],"modelling":[20],"is":[21,110,200,296],"major":[23],"challenge":[24],"in":[25,150],"computational":[26,71],"biology.":[27],"While":[28],"these":[29],"two":[30],"elements":[31],"development":[34],"are":[35,196],"closely":[36],"coupled,":[37],"fitting":[39,159],"from":[40,223],"measured":[41,155,218,310],"data":[42,63,219,222],"analysis":[44,102,165,167,263],"mechanisms":[47],"have":[48],"traditionally":[49],"been":[50],"performed":[51],"separately":[52],"sequentially.":[54],"This":[55],"process":[56],"produces":[57],"potential":[58,320],"mismatches":[59],"complexities":[64],"that":[65,250,265,292,315],"can":[66,251],"compromise":[67],"ability":[69],"frameworks":[72],"to":[73,258,271,305,336],"reveal":[74],"mechanistic":[75],"insights":[76],"or":[77],"predict":[78],"new":[79,143],"behaviour.":[80],"In":[81],"this":[82,86,181,232,316],"study":[83],"we":[84],"address":[85],"issue":[87],"by":[88,139,202,245],"presenting":[89],"generic":[91],"framework":[92],"for":[93,174,177,239,298,321,325],"combined":[94],"parameterisation,":[96],"comparison":[97],"alternatives":[100,301],"mechanisms.":[105],"RESULTS:":[106],"The":[107,157,198],"presented":[108,294],"methodology":[109,199],"based":[111],"on":[112,276],"combination":[114,216],"multivariate":[116],"metamodelling":[117],"(statistical":[118],"approximation":[119],"input-output":[122],"relationships":[123],"deterministic":[125],"models)":[126],"systematic":[129],"zooming":[130],"into":[131],"regions":[134],"space":[138],"iterative":[140],"generation":[141],"experimental":[144],"designs":[145],"look-up":[147],"proximity":[152],"data.":[156,261,311],"pipeline":[160],"includes":[161],"an":[162,224],"implicit":[163],"sensitivity":[164],"making":[171],"it":[172],"suitable":[173],"testing":[175],"hypotheses":[176],"reduction.":[179],"Using":[180,231],"approach,":[182,233],"under-constrained":[183],"parameters,":[185],"as":[186,188],"well":[187],"coupling":[190],"parameters":[192,205,267],"within":[193],"identified.":[197],"demonstrated":[201],"refitting":[203],"published":[208],"cardiac":[211],"cellular":[212],"mechanics":[213],"synthetic":[221],"alternative":[225],"same":[229],"system.":[230],"reduced":[234],"models":[235,304,334],"with":[236],"simplified":[237],"expressions":[238],"tropomyosin/crossbridge":[241],"kinetics":[242],"were":[243],"found":[244],"identification":[246,326],"components":[249,330],"be":[252,269],"omitted":[253],"without":[254],"affecting":[255],"fit":[257],"parameterising":[260],"Our":[262,289],"revealed":[264],"could":[268],"constrained":[270],"standard":[273],"deviation":[274],"average":[277],"15%":[278],"mean":[281],"values":[282],"over":[283],"succeeding":[285],"sets.":[287],"CONCLUSIONS:":[288],"results":[290],"indicate":[291],"approach":[295,317],"effective":[297],"comparing":[299],"reducing":[303],"minimum":[307],"replicating":[309],"We":[312],"therefore":[313],"believe":[314],"has":[318],"significant":[319],"reparameterising":[322],"existing":[323],"frameworks,":[324],"redundant":[328],"large":[332],"biophysical":[333],"increase":[337],"their":[338],"predictive":[339],"capacity.":[340]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}