{"id":"https://openalex.org/W2117737711","doi":"https://doi.org/10.1186/1752-0509-8-48","title":"Historical contingency and the gradual evolution of metabolic properties in central carbon and genome-scale metabolisms","display_name":"Historical contingency and the gradual evolution of metabolic properties in central carbon and genome-scale metabolisms","publication_year":2014,"publication_date":"2014-04-23","ids":{"openalex":"https://openalex.org/W2117737711","doi":"https://doi.org/10.1186/1752-0509-8-48","mag":"2117737711","pmid":"https://pubmed.ncbi.nlm.nih.gov/24758311"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-8-48","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-48","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-48","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-48","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085687962","display_name":"Aditya Barve","orcid":"https://orcid.org/0000-0001-5441-2236"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"funder","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Aditya Barve","raw_affiliation_strings":["Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, Bldg. Y27, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland","The Swiss Institute of Bioinformatics, Bioinformatics, Quartier Sorge, Batiment Genopode, 1015, Lausanne, Switzerland","The Swiss Institute of Bioinformatics, Bioinformatics, Quartier Sorge, Batiment Genopode, Lausanne, Switzerland","Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, Bldg. Y27, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"The Swiss Institute of Bioinformatics, Bioinformatics, Quartier Sorge, Batiment Genopode, 1015, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"The Swiss Institute of Bioinformatics, Bioinformatics, Quartier Sorge, Batiment Genopode, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081323352","display_name":"Sayed\u2010Rzgar Hosseini","orcid":"https://orcid.org/0000-0002-2308-6754"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"funder","lineage":["https://openalex.org/I12708293"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sayed-Rzgar Hosseini","raw_affiliation_strings":["Computational Biology and Bioinformatics Master\u2019s Program, Department of Computer Science, ETH Zurich, Universit\u00e4tsstrasse 6, CH-8092, Zurich, Switzerland","Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, Bldg. Y27, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland","The Swiss Institute of Bioinformatics, Bioinformatics, Quartier Sorge, Batiment Genopode, 1015, Lausanne, Switzerland","Computational Biology and Bioinformatics Master\u2019s Program, Department of Computer Science, ETH Zurich, Universit\u00e4tsstrasse 6, Zurich, Switzerland","Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, Zurich, Switzerland","The Swiss Institute of Bioinformatics, Bioinformatics, Quartier Sorge, Batiment Genopode, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology and Bioinformatics Master\u2019s Program, Department of Computer Science, ETH Zurich, Universit\u00e4tsstrasse 6, CH-8092, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I202697423"]},{"raw_affiliation_string":"Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, Bldg. Y27, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"The Swiss Institute of Bioinformatics, Bioinformatics, Quartier Sorge, Batiment Genopode, 1015, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"Computational Biology and Bioinformatics Master\u2019s Program, Department of Computer Science, ETH Zurich, Universit\u00e4tsstrasse 6, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"The Swiss Institute of Bioinformatics, Bioinformatics, Quartier Sorge, Batiment Genopode, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005002059","display_name":"Olivier Martin","orcid":"https://orcid.org/0000-0002-5295-5963"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olivier C Martin","raw_affiliation_strings":["INRA, UMR 0320/UMR 8120 G\u00e9n\u00e9tique V\u00e9g\u00e9tale, Univ Paris-Sud, F-91190, Gif-sur-Yvette, France","INRA, UMR 0320/UMR 8120 G\u00e9n\u00e9tique V\u00e9g\u00e9tale, Univ Paris-Sud, Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRA, UMR 0320/UMR 8120 G\u00e9n\u00e9tique V\u00e9g\u00e9tale, Univ Paris-Sud, F-91190, Gif-sur-Yvette, France","institution_ids":[]},{"raw_affiliation_string":"INRA, UMR 0320/UMR 8120 G\u00e9n\u00e9tique V\u00e9g\u00e9tale, Univ Paris-Sud, Gif-sur-Yvette, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079730045","display_name":"Andreas Wagner","orcid":"https://orcid.org/0000-0003-4299-3840"},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"funder","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"funder","lineage":["https://openalex.org/I1308548392"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Andreas Wagner","raw_affiliation_strings":["Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, Bldg, Y27, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. andreas.wagner@ieu.uzh.ch","The Santa Fe Institute, Santa Fe, USA","Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, Zurich, Switzerland","The Swiss Institute of Bioinformatics, Bioinformatics, Quartier Sorge, Batiment Genopode, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, Bldg, Y27, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. andreas.wagner@ieu.uzh.ch","institution_ids":[]},{"raw_affiliation_string":"The Santa Fe Institute, Santa Fe, USA","institution_ids":["https://openalex.org/I1308548392"]},{"raw_affiliation_string":"Institute of Evolutionary Biology and Environmental Sciences, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"The Swiss Institute of Bioinformatics, Bioinformatics, Quartier Sorge, Batiment Genopode, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5085687962"],"corresponding_institution_ids":["https://openalex.org/I12708293","https://openalex.org/I202697423"],"apc_list":null,"apc_paid":null,"fwci":1.1383,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.77798409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"48","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.8946999907493591,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.8946999907493591,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.07500000298023224,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.7157652378082275},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.5760820508003235},{"id":"https://openalex.org/keywords/contingency","display_name":"Contingency","score":0.5652869939804077},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5251143574714661},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5131848454475403},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5079274773597717},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.48185718059539795},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2773011326789856},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.22972044348716736},{"id":"https://openalex.org/keywords/geography","display_name":"Geography","score":0.16220977902412415},{"id":"https://openalex.org/keywords/philosophy","display_name":"Philosophy","score":0.10097965598106384},{"id":"https://openalex.org/keywords/epistemology","display_name":"Epistemology","score":0.09000787138938904}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.7157652378082275},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.5760820508003235},{"id":"https://openalex.org/C97508593","wikidata":"https://www.wikidata.org/wiki/Q1359069","display_name":"Contingency","level":2,"score":0.5652869939804077},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5251143574714661},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5131848454475403},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5079274773597717},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.48185718059539795},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2773011326789856},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22972044348716736},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.16220977902412415},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.10097965598106384},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.09000787138938904},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/1752-0509-8-48","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-48","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-48","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:24758311","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24758311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:doi:10.5167/uzh-107386","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4406922384","display_name":"Open MIND","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:HAL:hal-02639978v1","is_oa":true,"landing_page_url":"https://hal.inrae.fr/hal-02639978","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, 2014, 8, &#x27E8;10.1186/1752-0509-8-48&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:europepmc.org:3008590","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4022055","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/83846","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/83846","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, 8","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"doi:10.3929/ethz-b-000083846","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000083846","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-8-48","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-48","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-48","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5099999904632568,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G4966013024","display_name":null,"funder_award_id":"315230","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G8000199768","display_name":"Metabolic network analysis, design, and optimization through Metropolis sampling of network space.","funder_award_id":"129708","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320323874","display_name":"Universit\u00e4t Z\u00fcrich","ror":"https://ror.org/02crff812"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2117737711.pdf","grobid_xml":"https://content.openalex.org/works/W2117737711.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W49766303","https://openalex.org/W229097380","https://openalex.org/W1493392084","https://openalex.org/W1499996884","https://openalex.org/W1512810258","https://openalex.org/W1570688784","https://openalex.org/W1875112053","https://openalex.org/W1968763100","https://openalex.org/W1971013467","https://openalex.org/W1971403296","https://openalex.org/W1972517047","https://openalex.org/W1972740086","https://openalex.org/W1973220360","https://openalex.org/W1974183989","https://openalex.org/W1977940795","https://openalex.org/W1980207389","https://openalex.org/W1980965251","https://openalex.org/W1981673913","https://openalex.org/W1982583288","https://openalex.org/W1982799855","https://openalex.org/W1990507322","https://openalex.org/W1996529795","https://openalex.org/W2002055996","https://openalex.org/W2018643684","https://openalex.org/W2025663053","https://openalex.org/W2026089579","https://openalex.org/W2029338813","https://openalex.org/W2029838687","https://openalex.org/W2031681107","https://openalex.org/W2033830649","https://openalex.org/W2035612098","https://openalex.org/W2041303239","https://openalex.org/W2041652393","https://openalex.org/W2047200742","https://openalex.org/W2049130716","https://openalex.org/W2059557910","https://openalex.org/W2064306419","https://openalex.org/W2067229758","https://openalex.org/W2068855150","https://openalex.org/W2073912275","https://openalex.org/W2078236617","https://openalex.org/W2081050097","https://openalex.org/W2081943059","https://openalex.org/W2082195055","https://openalex.org/W2083034544","https://openalex.org/W2084516445","https://openalex.org/W2086150549","https://openalex.org/W2102164505","https://openalex.org/W2105557836","https://openalex.org/W2109253882","https://openalex.org/W2109449871","https://openalex.org/W2111075099","https://openalex.org/W2111967267","https://openalex.org/W2113221321","https://openalex.org/W2113350312","https://openalex.org/W2122883138","https://openalex.org/W2125859860","https://openalex.org/W2125910575","https://openalex.org/W2126074998","https://openalex.org/W2126214820","https://openalex.org/W2129020329","https://openalex.org/W2132496668","https://openalex.org/W2136331515","https://openalex.org/W2137266088","https://openalex.org/W2139553051","https://openalex.org/W2152612505","https://openalex.org/W2153333215","https://openalex.org/W2157657843","https://openalex.org/W2170427655","https://openalex.org/W2171437346","https://openalex.org/W2951404033","https://openalex.org/W3025652231","https://openalex.org/W3124837637","https://openalex.org/W4238452917","https://openalex.org/W4254626188","https://openalex.org/W4254837461","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1999445737","https://openalex.org/W2064614962","https://openalex.org/W2981368688","https://openalex.org/W2371399368","https://openalex.org/W2362572632","https://openalex.org/W2383984957","https://openalex.org/W4306403143","https://openalex.org/W1078495752","https://openalex.org/W2107885303","https://openalex.org/W2357598074"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"metabolism":[2],"can":[3,37,61,77,100,182],"evolve":[4],"through":[5,106],"changes":[6,26,112],"in":[7,33,64,86,150,221],"its":[8,34,51,225],"biochemical":[9],"reactions":[10,206],"that":[11,76,95,113,172,224],"are":[12,84,168,207,212],"caused":[13],"by":[14,188,230],"processes":[15],"such":[16,25,42,59,210],"as":[17,43,140,142],"horizontal":[18],"gene":[19,22],"transfer":[20],"and":[21,50,55,125,133],"deletion.":[23],"While":[24],"need":[27],"to":[28,53,163],"preserve":[29],"an":[30],"organism's":[31],"viability":[32,115],"environment,":[35],"they":[36],"modify":[38],"other":[39],"important":[40,132],"properties,":[41,139],"a":[44,87,107],"metabolism's":[45],"maximal":[46],"biomass":[47,81],"synthesis":[48],"rate":[49],"robustness":[52],"genetic":[54],"environmental":[56],"change.":[57],"Whether":[58],"properties":[60,226],"be":[62,101,183,228],"modulated":[63],"evolution":[65],"depends":[66],"on":[67],"whether":[68,165],"all":[69,79,90,174],"or":[70],"most":[71,179],"viable":[72,98,121,166,180],"metabolisms":[73,99,122,162,167,181],"-":[74,83],"those":[75],"synthesize":[78],"essential":[80,200],"precursors":[82],"connected":[85],"space":[88],"of":[89,109,120,137,145,160,204,243],"possible":[91,161],"metabolisms.":[92],"Connectedness":[93],"means":[94],"any":[96],"two":[97,157],"converted":[102],"into":[103,185],"one":[104,186],"another":[105,187],"sequence":[108],"single":[110,189],"reaction":[111,191],"leave":[114],"intact.":[116],"If":[117],"the":[118,135,143,176,197,222,241],"set":[119],"is":[123,195,217],"disconnected":[124],"highly":[126,219],"fragmented,":[127],"then":[128],"historical":[129],"contingency":[130,236],"becomes":[131],"restricts":[134],"alteration":[136],"metabolic":[138,147,201,245],"well":[141],"number":[144],"novel":[146,244],"phenotypes":[148],"accessible":[149],"evolution.":[151],"RESULTS:":[152],"We":[153,170],"here":[154],"computationally":[155],"explore":[156],"vast":[158],"spaces":[159],"ask":[164],"connected.":[169],"find":[171],"for":[173],"but":[175,209],"simplest":[177],"metabolisms,":[178],"transformed":[184],"viability-preserving":[190],"changes.":[192],"Where":[193],"this":[194],"not":[196,213,238],"case,":[198],"alternative":[199],"pathways":[202,211],"consisting":[203],"multiple":[205],"responsible,":[208],"common.":[214],"CONCLUSIONS:":[215],"Metabolism":[216],"thus":[218],"evolvable,":[220],"sense":[223],"could":[227],"fine-tuned":[229],"successively":[231],"altering":[232],"individual":[233],"reactions.":[234],"Historical":[235],"does":[237],"strongly":[239],"restrict":[240],"origin":[242],"phenotypes.":[246]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}
