{"id":"https://openalex.org/W2141420868","doi":"https://doi.org/10.1186/1752-0509-8-43","title":"Classification of transient behaviours in a time-dependent toggle switch model","display_name":"Classification of transient behaviours in a time-dependent toggle switch model","publication_year":2014,"publication_date":"2014-04-04","ids":{"openalex":"https://openalex.org/W2141420868","doi":"https://doi.org/10.1186/1752-0509-8-43","mag":"2141420868"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-8-43","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-43","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-43","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-43","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077821023","display_name":"Berta Verd","orcid":"https://orcid.org/0000-0001-9835-009X"},"institutions":[{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"funder","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I170486558","display_name":"Pompeu Fabra University","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Berta Verd","raw_affiliation_strings":["EMBL/CRG Research Unit in Systems Biology, Centre for Genomic Regulation (CRG), Barcelona, Spain","Universitat Pompeu Fabra (UPF), Barcelona, Spain","Universitat Pompeu Fabra (UPF); Barcelona Spain"],"affiliations":[{"raw_affiliation_string":"EMBL/CRG Research Unit in Systems Biology, Centre for Genomic Regulation (CRG), Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF); Barcelona Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012212547","display_name":"Anton Crombach","orcid":"https://orcid.org/0000-0002-2889-5120"},"institutions":[{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"funder","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I170486558","display_name":"Pompeu Fabra University","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Anton Crombach","raw_affiliation_strings":["EMBL/CRG Research Unit in Systems Biology, Centre for Genomic Regulation (CRG), Barcelona, Spain","Universitat Pompeu Fabra (UPF), Barcelona, Spain","Universitat Pompeu Fabra (UPF); Barcelona Spain"],"affiliations":[{"raw_affiliation_string":"EMBL/CRG Research Unit in Systems Biology, Centre for Genomic Regulation (CRG), Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF); Barcelona Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008115010","display_name":"Johannes Jaeger","orcid":"https://orcid.org/0000-0002-2568-2103"},"institutions":[{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"funder","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I170486558","display_name":"Pompeu Fabra University","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Johannes Jaeger","raw_affiliation_strings":["EMBL/CRG Research Unit in Systems Biology, Centre for Genomic Regulation (CRG), Barcelona, Spain","Universitat Pompeu Fabra (UPF), Barcelona, Spain","Universitat Pompeu Fabra (UPF); Barcelona Spain"],"affiliations":[{"raw_affiliation_string":"EMBL/CRG Research Unit in Systems Biology, Centre for Genomic Regulation (CRG), Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF); Barcelona Spain","institution_ids":["https://openalex.org/I170486558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5077821023"],"corresponding_institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210137962"],"apc_list":null,"apc_paid":null,"fwci":3.2801,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.92846987,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"8","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9801999926567078,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transient","display_name":"Transient (computer programming)","score":0.7134095430374146},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6016412973403931},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4638391137123108},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24631446599960327},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.1998506784439087},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.1232559084892273}],"concepts":[{"id":"https://openalex.org/C2780799671","wikidata":"https://www.wikidata.org/wiki/Q17087362","display_name":"Transient (computer programming)","level":2,"score":0.7134095430374146},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6016412973403931},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4638391137123108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24631446599960327},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.1998506784439087},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.1232559084892273}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-8-43","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-43","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-43","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmh:oai:repositori-api.upf.edu:10230/23226","is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/23226","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:europepmc.org:3089644","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4109741","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-8-43","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-8-43","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-8-43","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.5}],"awards":[{"id":"https://openalex.org/G1556249486","display_name":null,"funder_award_id":"FP7-KBBE-2011-5/289434","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3157282430","display_name":null,"funder_award_id":"FP7-KBBE-2011-5","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3394992377","display_name":null,"funder_award_id":"KBBE-2011-5","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5609784543","display_name":null,"funder_award_id":"BFU2012-33775","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G6099923277","display_name":null,"funder_award_id":"BFU2009-10184","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G6528990353","display_name":null,"funder_award_id":"BFU2009-10184","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G6926309754","display_name":null,"funder_award_id":"BFU2012-33775","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G7216406532","display_name":"From Data to Models: New Bioinformatics Methods and Tools for Data-Driven Predictive Dynamic Modelling in Biotechnological Applications","funder_award_id":"289434","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7433645226","display_name":null,"funder_award_id":"SGR Grant 406","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G7582053920","display_name":null,"funder_award_id":"FP7-KBBE","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320334830","display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","ror":"https://ror.org/01n4pqe45"},{"id":"https://openalex.org/F4320338366","display_name":"FP7 Food, Agriculture and Fisheries, Biotechnology","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2141420868.pdf","grobid_xml":"https://content.openalex.org/works/W2141420868.grobid-xml"},"referenced_works_count":102,"referenced_works":["https://openalex.org/W56792789","https://openalex.org/W91588129","https://openalex.org/W143074851","https://openalex.org/W190049560","https://openalex.org/W225301010","https://openalex.org/W234963275","https://openalex.org/W330247109","https://openalex.org/W581861726","https://openalex.org/W594264775","https://openalex.org/W605074410","https://openalex.org/W650948262","https://openalex.org/W1487547526","https://openalex.org/W1487920553","https://openalex.org/W1511656840","https://openalex.org/W1558736232","https://openalex.org/W1596321532","https://openalex.org/W1623155147","https://openalex.org/W1876456565","https://openalex.org/W1965698498","https://openalex.org/W1967142676","https://openalex.org/W1969547738","https://openalex.org/W1970283086","https://openalex.org/W1970779075","https://openalex.org/W1971445167","https://openalex.org/W1973081915","https://openalex.org/W1973734174","https://openalex.org/W1975380397","https://openalex.org/W1977242824","https://openalex.org/W1978217382","https://openalex.org/W1992428669","https://openalex.org/W1997882261","https://openalex.org/W2000163865","https://openalex.org/W2005481656","https://openalex.org/W2006874219","https://openalex.org/W2007497552","https://openalex.org/W2010795839","https://openalex.org/W2016180314","https://openalex.org/W2018745056","https://openalex.org/W2026211608","https://openalex.org/W2027139969","https://openalex.org/W2027703497","https://openalex.org/W2029669415","https://openalex.org/W2029991507","https://openalex.org/W2032619610","https://openalex.org/W2035824523","https://openalex.org/W2044013267","https://openalex.org/W2044775606","https://openalex.org/W2046537766","https://openalex.org/W2047919241","https://openalex.org/W2048438929","https://openalex.org/W2049168941","https://openalex.org/W2050953282","https://openalex.org/W2056556558","https://openalex.org/W2056784874","https://openalex.org/W2056827131","https://openalex.org/W2058564254","https://openalex.org/W2061425021","https://openalex.org/W2063854986","https://openalex.org/W2067284166","https://openalex.org/W2069386222","https://openalex.org/W2072319015","https://openalex.org/W2076373434","https://openalex.org/W2078201066","https://openalex.org/W2081848717","https://openalex.org/W2083249373","https://openalex.org/W2090359786","https://openalex.org/W2093047307","https://openalex.org/W2094520873","https://openalex.org/W2094902224","https://openalex.org/W2102216585","https://openalex.org/W2102910500","https://openalex.org/W2108020239","https://openalex.org/W2108350807","https://openalex.org/W2114518254","https://openalex.org/W2123634285","https://openalex.org/W2124869224","https://openalex.org/W2126606094","https://openalex.org/W2130172508","https://openalex.org/W2130907138","https://openalex.org/W2132278571","https://openalex.org/W2132770070","https://openalex.org/W2135264057","https://openalex.org/W2137057693","https://openalex.org/W2137416773","https://openalex.org/W2141545875","https://openalex.org/W2147615881","https://openalex.org/W2150918587","https://openalex.org/W2153268540","https://openalex.org/W2157103346","https://openalex.org/W2168221215","https://openalex.org/W2319502789","https://openalex.org/W2324145849","https://openalex.org/W2331030820","https://openalex.org/W2936242773","https://openalex.org/W3122143681","https://openalex.org/W3148645581","https://openalex.org/W4231888453","https://openalex.org/W4246704063","https://openalex.org/W4254837461","https://openalex.org/W4255040207","https://openalex.org/W4299870202","https://openalex.org/W4388252848"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Waddington\u2019s":[0],"epigenetic":[1],"landscape":[2,28,57],"is":[3,256,281],"an":[4],"intuitive":[5],"metaphor":[6],"for":[7,117,130],"the":[8,51,55,64,93,138,162,218,243,259,270],"developmental":[9],"and":[10,20,39,80,156,177,206,216,267],"evolutionary":[11],"potential":[12,43,48,78,163],"of":[13,54,69,97,133,140,175,188,202,209,220,228,245,251,261,273,287],"biological":[14,70,104,288],"regulatory":[15,33],"processes.":[16,289],"It":[17],"emphasises":[18],"time-dependence":[19],"transient":[21,67,120,167,264],"behaviour.":[22],"Nowadays,":[23],"we":[24,72,153],"can":[25,154,234],"derive":[26],"this":[27,46,150],"by":[29,224],"modelling":[30],"a":[31,36,110,115,127,141,173,226,284],"specific":[32,239],"network":[34],"as":[35],"dynamical":[37,99],"system":[38],"calculating":[40],"its":[41],"so-called":[42],"surface.":[44],"In":[45,59],"sense,":[47],"surfaces":[49],"are":[50,106],"mathematical":[52,89],"equivalent":[53],"Waddingtonian":[56],"metaphor.":[58],"order":[60],"to":[61,76,161,196,237,257,268,283],"fully":[62],"capture":[63],"time-dependent":[65,263],"(non-autonomous)":[66],"behaviour":[68,96,265],"processes,":[71],"must":[73],"be":[74,183,235],"able":[75],"characterise":[77],"landscapes":[79],"how":[81,103,232],"they":[82],"change":[83],"over":[84],"time.":[85],"However,":[86],"currently":[87],"available":[88],"tools":[90],"focus":[91],"on":[92,137,166],"asymptotic":[94],"(steady-state)":[95],"autonomous":[98,189],"systems,":[100],"which":[101],"restricts":[102],"systems":[105,171,277],"studied.":[107],"We":[108,125,211],"present":[109],"pragmatic":[111],"first":[112],"step":[113],"towards":[114],"methodology":[116],"dealing":[118],"with":[119,146],"behaviours":[121,180],"in":[122,169,185,214,276],"non-autonomous":[123,170,274],"systems.":[124,190],"propose":[126],"classification":[128,222,254],"scheme":[129,223,255],"different":[131,200],"kinds":[132,201,208],"such":[134],"dynamics":[135,168,244],"based":[136],"simulation":[139],"simple":[142],"genetic":[143],"toggle-switch":[144],"model":[145],"time-variable":[147],"parameters.":[148],"For":[149],"low-dimensional":[151],"system,":[152],"calculate":[155],"explicitly":[157,262],"visualise":[158],"numerical":[159],"approximations":[160],"landscape.":[164],"Focussing":[165],"reveals":[172],"range":[174],"interesting":[176],"biologically":[178],"relevant":[179],"that":[181,230],"would":[182],"missed":[184],"steady-state":[186],"analyses":[187],"Our":[191,279],"simulation-based":[192],"approach":[193],"allows":[194],"us":[195],"identify":[197],"four":[198],"qualitatively":[199],"dynamics:":[203],"transitions,":[204],"pursuits,":[205],"two":[207],"captures.":[210],"describe":[212],"these":[213],"detail,":[215],"illustrate":[217],"usefulness":[219],"our":[221,252],"providing":[225],"number":[227],"examples":[229],"demonstrate":[231],"it":[233],"employed":[236],"gain":[238],"mechanistic":[240],"insights":[241],"into":[242],"gene":[246],"regulation.":[247],"The":[248],"practical":[249],"aim":[250],"proposed":[253],"make":[258],"analysis":[260],"tractable,":[266],"encourage":[269],"wider":[271],"use":[272],"models":[275],"biology.":[278],"method":[280],"applicable":[282],"large":[285],"class":[286]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
