{"id":"https://openalex.org/W2086542989","doi":"https://doi.org/10.1186/1752-0509-7-s3-s5","title":"Analysis of intercellular signal transduction in the tumor microenvironment","display_name":"Analysis of intercellular signal transduction in the tumor microenvironment","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2086542989","doi":"https://doi.org/10.1186/1752-0509-7-s3-s5","mag":"2086542989","pmid":"https://pubmed.ncbi.nlm.nih.gov/24555417"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-7-s3-s5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-s3-s5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-S3-S5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-S3-S5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030155062","display_name":"Haijun Gong","orcid":"https://orcid.org/0000-0003-1666-1674"},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Haijun Gong","raw_affiliation_strings":["Department of Mathematics and Computer Science, Saint Louis University, St. Louis, MO, 63103, USA","Dept. of Mathematics and Computer Science, Saint Louis University, St. Louis, USA"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Computer Science, Saint Louis University, St. Louis, MO, 63103, USA","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Dept. of Mathematics and Computer Science, Saint Louis University, St. Louis, USA","institution_ids":["https://openalex.org/I47838141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030155062"],"corresponding_institution_ids":["https://openalex.org/I47838141"],"apc_list":null,"apc_paid":null,"fwci":1.4949,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.82121925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"Suppl 3","first_page":"S5","last_page":"S5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatic-stellate-cell","display_name":"Hepatic stellate cell","score":0.8442922830581665},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"Pancreatic cancer","score":0.621443510055542},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.6139874458312988},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.6024337410926819},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"Angiogenesis","score":0.6015450954437256},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5684216618537903},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5410086512565613},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.5349729061126709},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.5232818722724915},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.5101059079170227},{"id":"https://openalex.org/keywords/paracrine-signalling","display_name":"Paracrine signalling","score":0.508766233921051},{"id":"https://openalex.org/keywords/protein-kinase-b","display_name":"Protein kinase B","score":0.4264986515045166},{"id":"https://openalex.org/keywords/autocrine-signalling","display_name":"Autocrine signalling","score":0.4255329668521881},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3863552510738373},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.17595648765563965},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.13577702641487122},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.08423173427581787},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.0731549859046936},{"id":"https://openalex.org/keywords/tumor-cells","display_name":"Tumor cells","score":0.07183647155761719}],"concepts":[{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.8442922830581665},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.621443510055542},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6139874458312988},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6024337410926819},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6015450954437256},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5684216618537903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5410086512565613},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5349729061126709},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5232818722724915},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5101059079170227},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.508766233921051},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4264986515045166},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.4255329668521881},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3863552510738373},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.17595648765563965},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13577702641487122},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08423173427581787},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0731549859046936},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.07183647155761719}],"mesh":[{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058954","descriptor_name":"Pancreatic Stellate Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058954","descriptor_name":"Pancreatic Stellate Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058954","descriptor_name":"Pancreatic Stellate Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-7-s3-s5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-s3-s5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-S3-S5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:24555417","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24555417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:europepmc.org:2852326","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3852214","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-7-s3-s5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-s3-s5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-S3-S5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6299999952316284,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320312021","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2086542989.pdf","grobid_xml":"https://content.openalex.org/works/W2086542989.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W339627914","https://openalex.org/W1517173520","https://openalex.org/W1563766529","https://openalex.org/W1641228030","https://openalex.org/W1886819223","https://openalex.org/W1968109047","https://openalex.org/W1977645024","https://openalex.org/W1987708512","https://openalex.org/W2002355858","https://openalex.org/W2003714139","https://openalex.org/W2011912935","https://openalex.org/W2024918098","https://openalex.org/W2025970479","https://openalex.org/W2033329729","https://openalex.org/W2064903115","https://openalex.org/W2080267935","https://openalex.org/W2080719056","https://openalex.org/W2082979850","https://openalex.org/W2086390177","https://openalex.org/W2098036848","https://openalex.org/W2101153911","https://openalex.org/W2103723044","https://openalex.org/W2122902176","https://openalex.org/W2124810679","https://openalex.org/W2138155367","https://openalex.org/W2141997480","https://openalex.org/W2144869905","https://openalex.org/W2165061154","https://openalex.org/W2165911980","https://openalex.org/W2166773454","https://openalex.org/W2316015697","https://openalex.org/W2361838659","https://openalex.org/W2913459036","https://openalex.org/W4230600927"],"related_works":["https://openalex.org/W2091727603","https://openalex.org/W2085869617","https://openalex.org/W3004047898","https://openalex.org/W2015867957","https://openalex.org/W2367035282","https://openalex.org/W1996832816","https://openalex.org/W1963652002","https://openalex.org/W1969354036","https://openalex.org/W3048253040","https://openalex.org/W2105493299"],"abstract_inverted_index":{"Our":[0,58],"studies":[1,60],"predicted":[2],"some":[3,49],"important":[4],"temporal":[5],"logic":[6],"properties":[7],"and":[8,16,34,46,69,82],"dynamic":[9],"behaviors":[10],"in":[11],"the":[12,27,63],"pancreatic":[13],"cancer":[14,67,84],"cells":[15,68,71],"stellate":[17,70],"cells.":[18],"The":[19],"verification":[20],"technique":[21],"identified":[22],"several":[23],"signaling":[24],"components,":[25],"including":[26],"RAS,":[28],"RAGE,":[29],"AKT,":[30],"IKK,":[31],"DVL,":[32],"RB":[33],"PTEN,":[35],"whose":[36],"mutation":[37],"or":[38],"loss":[39],"of":[40,50],"function":[41],"can":[42],"promote":[43,83],"cell":[44,75],"growth":[45],"inhibit":[47,77],"apoptosis,":[48,78],"which":[51],"have":[52],"been":[53],"confirmed":[54],"by":[55],"existing":[56],"experiments.":[57],"formal":[59],"demonstrated":[61],"that,":[62],"bidirectional":[64],"interaction":[65],"between":[66],"could":[72],"significantly":[73],"increase":[74],"proliferation,":[76],"induce":[79],"tumor":[80],"angiogenesis,":[81],"metastasis.":[85]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}