{"id":"https://openalex.org/W2141021005","doi":"https://doi.org/10.1186/1752-0509-7-s1-s3","title":"Effects of multimerization on the temporal variability of protein complex abundance","display_name":"Effects of multimerization on the temporal variability of protein complex abundance","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W2141021005","doi":"https://doi.org/10.1186/1752-0509-7-s1-s3","mag":"2141021005","pmid":"https://pubmed.ncbi.nlm.nih.gov/24267954"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-7-s1-s3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-s1-s3","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-S1-S3","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-S1-S3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033673376","display_name":"Antti H\u00e4kkinen","orcid":"https://orcid.org/0000-0002-8081-1588"},"institutions":[{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Antti H\u00e4kkinen","raw_affiliation_strings":["Department of Signal Processing, Tampere University of Technology, P.O. box 553, 33101, Tampere, Finland","[Department of Signal Processing, Tampere University of Technology, Tampere, FINLAND]"],"affiliations":[{"raw_affiliation_string":"Department of Signal Processing, Tampere University of Technology, P.O. box 553, 33101, Tampere, Finland","institution_ids":["https://openalex.org/I4210133110"]},{"raw_affiliation_string":"[Department of Signal Processing, Tampere University of Technology, Tampere, FINLAND]","institution_ids":["https://openalex.org/I4210133110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055011838","display_name":"Huy Tran","orcid":"https://orcid.org/0000-0002-9057-060X"},"institutions":[{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Huy Tran","raw_affiliation_strings":["Department of Signal Processing, Tampere University of Technology, P.O. box 553, 33101, Tampere, Finland","[Department of Signal Processing, Tampere University of Technology, Tampere, FINLAND]"],"affiliations":[{"raw_affiliation_string":"Department of Signal Processing, Tampere University of Technology, P.O. box 553, 33101, Tampere, Finland","institution_ids":["https://openalex.org/I4210133110"]},{"raw_affiliation_string":"[Department of Signal Processing, Tampere University of Technology, Tampere, FINLAND]","institution_ids":["https://openalex.org/I4210133110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026230936","display_name":"Olli Yli\u2010Harja","orcid":"https://orcid.org/0000-0001-8581-4414"},"institutions":[{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]},{"id":"https://openalex.org/I58610484","display_name":"Seattle University","ror":"https://ror.org/02jqc0m91","country_code":"US","type":"education","lineage":["https://openalex.org/I58610484"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Olli Yli-Harja","raw_affiliation_strings":["Department of Signal Processing, Tampere University of Technology, P.O. box 553, 33101, Tampere, Finland","Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington, 98103-8904, USA","Institute for Systems Biology, Seattle, USA","Department of Signal Processing, Tampere University of Technology, Tampere, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Signal Processing, Tampere University of Technology, P.O. box 553, 33101, Tampere, Finland","institution_ids":["https://openalex.org/I4210133110"]},{"raw_affiliation_string":"Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington, 98103-8904, USA","institution_ids":["https://openalex.org/I3148997608"]},{"raw_affiliation_string":"Institute for Systems Biology, Seattle, USA","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I58610484"]},{"raw_affiliation_string":"Department of Signal Processing, Tampere University of Technology, Tampere, Finland","institution_ids":["https://openalex.org/I166825849","https://openalex.org/I4210133110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014787617","display_name":"Brian Ingalls","orcid":"https://orcid.org/0000-0003-2118-3881"},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Brian Ingalls","raw_affiliation_strings":["Department of Applied Mathematics, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada","Department of Applied Mathematics University of Waterloo Waterloo Canada"],"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]},{"raw_affiliation_string":"Department of Applied Mathematics University of Waterloo Waterloo Canada","institution_ids":["https://openalex.org/I151746483"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040628945","display_name":"Andr\u00e9 S. Ribeiro","orcid":"https://orcid.org/0000-0002-7255-5211"},"institutions":[{"id":"https://openalex.org/I4210133110","display_name":"Tampere University","ror":null,"country_code":"FI","type":null,"lineage":["https://openalex.org/I4210133110"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Andre S Ribeiro","raw_affiliation_strings":["Department of Signal Processing, Tampere University of Technology, P.O. box 553, 33101, Tampere, Finland","[Department of Signal Processing, Tampere University of Technology, Tampere, FINLAND]"],"affiliations":[{"raw_affiliation_string":"Department of Signal Processing, Tampere University of Technology, P.O. box 553, 33101, Tampere, Finland","institution_ids":["https://openalex.org/I4210133110"]},{"raw_affiliation_string":"[Department of Signal Processing, Tampere University of Technology, Tampere, FINLAND]","institution_ids":["https://openalex.org/I4210133110"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5033673376"],"corresponding_institution_ids":["https://openalex.org/I4210133110"],"apc_list":null,"apc_paid":null,"fwci":0.2995,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.63121515,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"7","issue":"S1","first_page":"S3","last_page":"S3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5318446159362793},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5293693542480469},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.5137625932693481},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.43357765674591064},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41462406516075134},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4012104868888855},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.36041033267974854},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30781543254852295}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5318446159362793},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5293693542480469},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5137625932693481},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.43357765674591064},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41462406516075134},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4012104868888855},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36041033267974854},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30781543254852295}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-7-s1-s3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-s1-s3","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-S1-S3","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:24267954","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24267954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:europepmc.org:2744217","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3750523","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3750523","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3750523","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-7-s1-s3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-s1-s3","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-S1-S3","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2141021005.pdf","grobid_xml":"https://content.openalex.org/works/W2141021005.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1552342234","https://openalex.org/W1588939728","https://openalex.org/W1970013640","https://openalex.org/W1970950317","https://openalex.org/W1971577678","https://openalex.org/W1980279189","https://openalex.org/W1984916226","https://openalex.org/W2000945933","https://openalex.org/W2011097028","https://openalex.org/W2023524368","https://openalex.org/W2026888821","https://openalex.org/W2031720568","https://openalex.org/W2035767053","https://openalex.org/W2049492969","https://openalex.org/W2053460598","https://openalex.org/W2058740724","https://openalex.org/W2066641338","https://openalex.org/W2075251971","https://openalex.org/W2078097311","https://openalex.org/W2078771267","https://openalex.org/W2091198609","https://openalex.org/W2091489806","https://openalex.org/W2105466636","https://openalex.org/W2117956780","https://openalex.org/W2118274513","https://openalex.org/W2134440848","https://openalex.org/W2134759932","https://openalex.org/W2135054636","https://openalex.org/W2140158396","https://openalex.org/W2142706774","https://openalex.org/W2147136931","https://openalex.org/W2155418451","https://openalex.org/W2167244112"],"related_works":["https://openalex.org/W2360987025","https://openalex.org/W2387178301","https://openalex.org/W3144733943","https://openalex.org/W2785993273","https://openalex.org/W2382269147","https://openalex.org/W3184323118","https://openalex.org/W2799462113","https://openalex.org/W36834100","https://openalex.org/W2376819606","https://openalex.org/W2034625591"],"abstract_inverted_index":{"We":[0,56],"explore":[1],"whether":[2],"the":[3,17,30,46,53,65,83,100,111,119,134,162,169],"process":[4,28],"of":[5,19,33,39,48,52,68,82,99,123,143,150,164,171],"multimerization":[6,60,108,151,165],"can":[7,72],"be":[8],"used":[9],"as":[10],"a":[11,40,78],"means":[12],"to":[13,114],"regulate":[14],"noise":[15,62,74,91],"in":[16,75,90,137,146,152,157],"abundance":[18,81],"functional":[20,35,54,69,84,124],"protein":[21,101,127,147],"complexes.":[22],"Additionally,":[23],"we":[24,105,131],"analyze":[25],"how":[26],"this":[27],"affects":[29],"mean":[31,66],"level":[32,170],"these":[34],"units,":[36],"response":[37,112],"time":[38,113],"gene,":[41],"and":[42,51,96,126,149,154,160],"temporal":[43],"correlation":[44,120],"between":[45,121],"numbers":[47,148],"expressed":[49],"proteins":[50,85],"multimers.":[55],"show":[57,132],"that,":[58],"although":[59],"increases":[61,110],"by":[63],"reducing":[64],"number":[67,122],"complexes":[70,125],"it":[71],"reduce":[73],"comparison":[76],"with":[77,139],"monomer,":[79],"when":[80],"are":[86,102,136,166],"comparable.":[87],"Alternatively,":[88],"reduction":[89],"occurs":[92],"if":[93],"both":[94],"monomeric":[95],"multimeric":[97],"forms":[98],"functional.":[103],"Moreover,":[104],"find":[106],"that":[107,133,161],"either":[109],"external":[115],"signals":[116],"or":[117],"decreases":[118],"production":[128],"kinetics.":[129],"Finally,":[130],"results":[135],"agreement":[138],"recent":[140],"genome-wide":[141],"assessments":[142],"cell-to-cell":[144],"variability":[145],"essential":[153],"non-essential":[155],"genes":[156],"Escherichia":[158],"coli,":[159],"effects":[163],"tangible":[167],"at":[168],"genetic":[172],"circuits.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
