{"id":"https://openalex.org/W2148535591","doi":"https://doi.org/10.1186/1752-0509-7-67","title":"Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate","display_name":"Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate","publication_year":2013,"publication_date":"2013-07-24","ids":{"openalex":"https://openalex.org/W2148535591","doi":"https://doi.org/10.1186/1752-0509-7-67","mag":"2148535591","pmid":"https://pubmed.ncbi.nlm.nih.gov/23883471"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-7-67","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-67","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-67","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-67","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068402419","display_name":"Marta N. Bogda\u0142","orcid":null},"institutions":[{"id":"https://openalex.org/I4210119410","display_name":"Institute of Fundamental Technological Research","ror":"https://ror.org/03fs4aq04","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marta N Bogda\u0142","raw_affiliation_strings":["Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw 02-106, Poland","Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw 02-106, Poland","institution_ids":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]},{"raw_affiliation_string":"Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland","institution_ids":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085228117","display_name":"Beata Hat","orcid":"https://orcid.org/0000-0002-7049-5729"},"institutions":[{"id":"https://openalex.org/I4210119410","display_name":"Institute of Fundamental Technological Research","ror":"https://ror.org/03fs4aq04","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Beata Hat","raw_affiliation_strings":["Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland","institution_ids":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041747421","display_name":"Marek Kocha\u0144czyk","orcid":"https://orcid.org/0000-0003-1215-3920"},"institutions":[{"id":"https://openalex.org/I4210119410","display_name":"Institute of Fundamental Technological Research","ror":"https://ror.org/03fs4aq04","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marek Kocha\u0144czyk","raw_affiliation_strings":["Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland","institution_ids":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024103451","display_name":"Tomasz Lipniacki","orcid":"https://orcid.org/0000-0002-3488-2561"},"institutions":[{"id":"https://openalex.org/I4210119410","display_name":"Institute of Fundamental Technological Research","ror":"https://ror.org/03fs4aq04","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL","US"],"is_corresponding":true,"raw_author_name":"Tomasz Lipniacki","raw_affiliation_strings":["Department of Statistics, Rice University, Houston, TX, 77025, USA","Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Rice University, Houston, TX, 77025, USA","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland","institution_ids":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024103451"],"corresponding_institution_ids":["https://openalex.org/I4210119410","https://openalex.org/I74775410","https://openalex.org/I99542240"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":1.5133,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.82453113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"1","first_page":"67","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.6831146478652954},{"id":"https://openalex.org/keywords/regulator","display_name":"Regulator","score":0.6635181903839111},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.46564731001853943},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.44015809893608093},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3673168420791626},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.36334285140037537},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13157609105110168}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6831146478652954},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.6635181903839111},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46564731001853943},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.44015809893608093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3673168420791626},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36334285140037537},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13157609105110168},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D008128","descriptor_name":"Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008128","descriptor_name":"Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008128","descriptor_name":"Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D039301","descriptor_name":"Computers, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D039301","descriptor_name":"Computers, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D039301","descriptor_name":"Computers, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051025","descriptor_name":"bcl-Associated Death Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051025","descriptor_name":"bcl-Associated Death Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051025","descriptor_name":"bcl-Associated Death Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-7-67","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-67","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-67","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:23883471","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23883471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:europepmc.org:2744185","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3750306","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3750306","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3750306","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-7-67","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-67","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-67","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6600000262260437,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148535591.pdf","grobid_xml":"https://content.openalex.org/works/W2148535591.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W65521289","https://openalex.org/W1535426243","https://openalex.org/W1607777232","https://openalex.org/W1644794975","https://openalex.org/W1870720170","https://openalex.org/W1942214720","https://openalex.org/W1965071591","https://openalex.org/W1966861384","https://openalex.org/W1971411560","https://openalex.org/W1972146095","https://openalex.org/W1976720365","https://openalex.org/W1978518304","https://openalex.org/W1979012323","https://openalex.org/W1979634817","https://openalex.org/W1984547206","https://openalex.org/W1988756673","https://openalex.org/W1989095713","https://openalex.org/W1991865867","https://openalex.org/W1995117660","https://openalex.org/W1995354282","https://openalex.org/W1995773170","https://openalex.org/W1999014427","https://openalex.org/W1999163644","https://openalex.org/W2000011855","https://openalex.org/W2002010679","https://openalex.org/W2006652614","https://openalex.org/W2008715871","https://openalex.org/W2008757142","https://openalex.org/W2008841394","https://openalex.org/W2009347496","https://openalex.org/W2009966959","https://openalex.org/W2010134143","https://openalex.org/W2013075289","https://openalex.org/W2018116689","https://openalex.org/W2024334150","https://openalex.org/W2024996523","https://openalex.org/W2025277638","https://openalex.org/W2026057304","https://openalex.org/W2027217537","https://openalex.org/W2027395744","https://openalex.org/W2035188342","https://openalex.org/W2037960329","https://openalex.org/W2042316019","https://openalex.org/W2045086385","https://openalex.org/W2050981751","https://openalex.org/W2051258629","https://openalex.org/W2053864637","https://openalex.org/W2054208935","https://openalex.org/W2056891806","https://openalex.org/W2057713336","https://openalex.org/W2058631780","https://openalex.org/W2061497413","https://openalex.org/W2065855687","https://openalex.org/W2067751798","https://openalex.org/W2068382906","https://openalex.org/W2073571990","https://openalex.org/W2075334136","https://openalex.org/W2075941967","https://openalex.org/W2077319000","https://openalex.org/W2079541630","https://openalex.org/W2082979850","https://openalex.org/W2087877138","https://openalex.org/W2089574530","https://openalex.org/W2090326380","https://openalex.org/W2091545748","https://openalex.org/W2093628776","https://openalex.org/W2094052642","https://openalex.org/W2094068658","https://openalex.org/W2097007474","https://openalex.org/W2097767970","https://openalex.org/W2098276373","https://openalex.org/W2099000660","https://openalex.org/W2102369096","https://openalex.org/W2103616303","https://openalex.org/W2109183374","https://openalex.org/W2113126782","https://openalex.org/W2119683782","https://openalex.org/W2125886217","https://openalex.org/W2130361718","https://openalex.org/W2130698963","https://openalex.org/W2131532199","https://openalex.org/W2138892400","https://openalex.org/W2141997480","https://openalex.org/W2142713529","https://openalex.org/W2142911981","https://openalex.org/W2143067729","https://openalex.org/W2145915855","https://openalex.org/W2150048195","https://openalex.org/W2150097377","https://openalex.org/W2152247516","https://openalex.org/W2160340008","https://openalex.org/W2161641464","https://openalex.org/W2166467949","https://openalex.org/W2166601968","https://openalex.org/W2166625995","https://openalex.org/W2167921512","https://openalex.org/W2170743452","https://openalex.org/W2318612270"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W2151865869","https://openalex.org/W2117258802","https://openalex.org/W4234157524"],"abstract_inverted_index":{"BACKGROUND:":[0],"Apoptosis":[1],"is":[2,105],"a":[3,33,58,122,150,188,194,225,272],"tightly":[4],"regulated":[5],"process:":[6],"cellular":[7],"survive-or-die":[8,274],"decisions":[9,77],"cannot":[10],"be":[11,15,22,39],"accidental":[12],"and":[13,72,96,138,181,223,233,258],"must":[14],"unambiguous.":[16],"Since":[17],"the":[18,50,62,87,103,115,127,162,174,177,238,246,263],"suicide":[19],"program":[20],"may":[21,266],"initiated":[23],"in":[24,221,254],"response":[25,255],"to":[26,38,45,121,256],"numerous":[27],"stress":[28,169],"stimuli,":[29],"signals":[30,71,257],"transmitted":[31],"through":[32],"number":[34],"of":[35,49,52,61,86,126,132,146,153,164,176,183,191,197,205,248,251],"checkpoints":[36],"have":[37],"eventually":[40],"integrated.":[41],"RESULTS:":[42],"In":[43,186,237],"order":[44],"analyze":[46],"possible":[47,217],"mechanisms":[48,220],"integration":[51,219],"multiple":[53],"pro-apoptotic":[54,90,97,147],"signals,":[55],"we":[56],"constructed":[57],"simple":[59],"model":[60,104],"Bcl-2":[63,88,116],"family":[64,117],"regulatory":[65,264],"module.":[66],"The":[67],"module":[68,118],"collects":[69],"upstream":[70],"processes":[73],"them":[74],"into":[75,271],"life-or-death":[76],"by":[78,136,141],"employing":[79],"interactions":[80],"between":[81,227],"proteins":[82,134,253],"from":[83,245],"three":[84],"subgroups":[85],"family:":[89],"multidomain":[91,94],"effectors,":[92],"pro-survival":[93,154],"restrainers,":[95],"single":[98],"domain":[99],"BH3-only":[100,133],"proteins.":[101],"Although":[102],"based":[106,230],"on":[107,130,216,231,234],"ordinary":[108],"differential":[109],"equations":[110],"(ODEs),":[111],"it":[112],"demonstrates":[113],"that":[114],"behaves":[119],"akin":[120],"Boolean":[123,235],"logic":[124,241],"gate":[125,157,200],"type":[128],"dependent":[129],"levels":[131],"(represented":[135,140],"Bad)":[137],"restrainers":[139],"Bcl-xL).":[142],"A":[143],"low":[144,195],"level":[145,152,180,190,196],"Bad":[148,192],"or":[149,193],"high":[151,189],"Bcl-xL":[155,198],"implies":[156,199],"AND,":[158],"which":[159,203],"allows":[160],"for":[161,202,209],"initiation":[163],"apoptosis":[165],"only":[166],"when":[167],"two":[168,268],"stimuli":[170,207],"are":[171],"simultaneously":[172],"present:":[173],"rise":[175],"p53":[178],"killer":[179],"dephosphorylation":[182],"kinase":[184],"Akt.":[185],"turn,":[187],"OR,":[201],"any":[204],"these":[206],"suffices":[208],"apoptosis.":[210],"CONCLUSIONS:":[211],"Our":[212],"study":[213],"sheds":[214],"light":[215],"signal":[218],"cells,":[222],"spans":[224],"bridge":[226],"modeling":[228],"approaches":[229],"ODEs":[232],"logic.":[236],"proposed":[239],"scheme,":[240],"gates":[242],"switching":[243],"results":[244],"change":[247],"relative":[249],"abundances":[250],"interacting":[252],"involves":[259],"system":[260,265],"bistability.":[261],"Consequently,":[262],"process":[267],"analogous":[269],"inputs":[270],"digital":[273],"decision.":[275]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
