{"id":"https://openalex.org/W2145729768","doi":"https://doi.org/10.1186/1752-0509-7-40","title":"Modeling mutant phenotypes and oscillatory dynamics in the Saccharomyces cerevisiae cAMP-PKA pathway","display_name":"Modeling mutant phenotypes and oscillatory dynamics in the Saccharomyces cerevisiae cAMP-PKA pathway","publication_year":2013,"publication_date":"2013-05-17","ids":{"openalex":"https://openalex.org/W2145729768","doi":"https://doi.org/10.1186/1752-0509-7-40","mag":"2145729768","pmid":"https://pubmed.ncbi.nlm.nih.gov/23680078"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-7-40","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-40","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-40","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-40","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110249515","display_name":"Kevin Edmond Gonzales","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kevin Gonzales","raw_affiliation_strings":["Department of Mathematics, Duke University, Durham, NC 27708, USA"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007883474","display_name":"\u00d6m\u00fcr Kay\u0131k\u00e7\u0131","orcid":"https://orcid.org/0009-0001-6438-6227"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"\u00d6m\u00fcr Kay\u0131k\u00e7\u0131","raw_affiliation_strings":["Department of Biology, Duke University, Durham, NC 27708, USA","IGSP Center for Systems Biology, Duke University, Durham, NC 27708, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biology, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"IGSP Center for Systems Biology, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105935537","display_name":"David G. Schaeffer","orcid":null},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G Schaeffer","raw_affiliation_strings":["Department of Mathematics, Duke University, Durham, NC 27708, USA","IGSP Center for Systems Biology, Duke University, Durham, NC 27708, USA"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"IGSP Center for Systems Biology, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033538586","display_name":"Paul M. Magwene","orcid":"https://orcid.org/0000-0002-7659-2589"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M Magwene","raw_affiliation_strings":["Department of Biology, Duke University, Durham, NC 27708, USA","IGSP Center for Systems Biology, Duke University, Durham, NC 27708, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biology, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"IGSP Center for Systems Biology, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5110249515"],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":null,"apc_paid":null,"fwci":0.4492,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.66723614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"7","issue":"1","first_page":"40","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.7984602451324463},{"id":"https://openalex.org/keywords/phosphodiesterase","display_name":"Phosphodiesterase","score":0.7697392702102661},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.6646029949188232},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.663094162940979},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"Protein kinase A","score":0.6189896464347839},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6022464036941528},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5855518579483032},{"id":"https://openalex.org/keywords/camp-dependent-pathway","display_name":"cAMP-dependent pathway","score":0.5198826789855957},{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.5031020045280457},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4932700991630554},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.4899548590183258},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.4427988529205322},{"id":"https://openalex.org/keywords/second-messenger-system","display_name":"Second messenger system","score":0.4411766231060028},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.3468877971172333},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2841736674308777},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.26343297958374023},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.17564091086387634},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15491554141044617}],"concepts":[{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.7984602451324463},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.7697392702102661},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6646029949188232},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.663094162940979},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.6189896464347839},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6022464036941528},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5855518579483032},{"id":"https://openalex.org/C115466790","wikidata":"https://www.wikidata.org/wiki/Q5008667","display_name":"cAMP-dependent pathway","level":4,"score":0.5198826789855957},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5031020045280457},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4932700991630554},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4899548590183258},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4427988529205322},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.4411766231060028},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3468877971172333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2841736674308777},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26343297958374023},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17564091086387634},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15491554141044617}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-7-40","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-40","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-40","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:23680078","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23680078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:europepmc.org:2685161","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3679983","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-7-40","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-40","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-40","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4399999976158142,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G350993928","display_name":null,"funder_award_id":"P50GM081883-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6504685700","display_name":null,"funder_award_id":"P50GM081883","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145729768.pdf","grobid_xml":"https://content.openalex.org/works/W2145729768.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W617023439","https://openalex.org/W1511208409","https://openalex.org/W1525055187","https://openalex.org/W1576399086","https://openalex.org/W1594189146","https://openalex.org/W1607658564","https://openalex.org/W1897167776","https://openalex.org/W1902685772","https://openalex.org/W1938497882","https://openalex.org/W1960379494","https://openalex.org/W1964967925","https://openalex.org/W1965829421","https://openalex.org/W1978862801","https://openalex.org/W1981592350","https://openalex.org/W1985464808","https://openalex.org/W1991174482","https://openalex.org/W1991445188","https://openalex.org/W1992887398","https://openalex.org/W1995324166","https://openalex.org/W1998871484","https://openalex.org/W2003992236","https://openalex.org/W2008014792","https://openalex.org/W2009770052","https://openalex.org/W2012665233","https://openalex.org/W2019075805","https://openalex.org/W2019471411","https://openalex.org/W2019850520","https://openalex.org/W2024656972","https://openalex.org/W2026059959","https://openalex.org/W2028403255","https://openalex.org/W2035119251","https://openalex.org/W2036973943","https://openalex.org/W2039187918","https://openalex.org/W2041730675","https://openalex.org/W2042937027","https://openalex.org/W2049917443","https://openalex.org/W2050416286","https://openalex.org/W2056406543","https://openalex.org/W2064314968","https://openalex.org/W2074883812","https://openalex.org/W2088127501","https://openalex.org/W2090286898","https://openalex.org/W2093434319","https://openalex.org/W2100403768","https://openalex.org/W2100597606","https://openalex.org/W2104479866","https://openalex.org/W2112247858","https://openalex.org/W2123482247","https://openalex.org/W2125141239","https://openalex.org/W2127735616","https://openalex.org/W2132416603","https://openalex.org/W2135744551","https://openalex.org/W2136140489","https://openalex.org/W2141524439","https://openalex.org/W2142130012","https://openalex.org/W2149128987","https://openalex.org/W2161057669","https://openalex.org/W2161430054","https://openalex.org/W2165130891","https://openalex.org/W2167348821","https://openalex.org/W2168797545","https://openalex.org/W2171761685","https://openalex.org/W2325148341","https://openalex.org/W2416823561","https://openalex.org/W4253710897"],"related_works":["https://openalex.org/W2417347919","https://openalex.org/W2072731694","https://openalex.org/W1541261816","https://openalex.org/W3120238434","https://openalex.org/W2169979796","https://openalex.org/W2092264183","https://openalex.org/W2038991205","https://openalex.org/W3089092446","https://openalex.org/W2145729768","https://openalex.org/W1983496075"],"abstract_inverted_index":{"Our":[0],"model":[1,21],"of":[2,40],"the":[3,20],"cAMP-PKA":[4],"pathway":[5],"provides":[6],"new":[7],"insights":[8],"into":[9],"how":[10],"yeast":[11],"respond":[12],"to":[13],"alterations":[14],"in":[15],"their":[16],"nutrient":[17],"environment.":[18],"Because":[19],"has":[22],"both":[23],"predictive":[24],"and":[25,37],"explanatory":[26],"power":[27],"it":[28],"will":[29],"serve":[30],"as":[31],"a":[32],"foundation":[33],"for":[34],"future":[35],"mathematical":[36],"experimental":[38],"studies":[39],"this":[41],"important":[42],"signaling":[43],"network.":[44]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}