{"id":"https://openalex.org/W2104896732","doi":"https://doi.org/10.1186/1752-0509-7-33","title":"A metabolite-centric view on flux distributions in genome-scale metabolic models","display_name":"A metabolite-centric view on flux distributions in genome-scale metabolic models","publication_year":2013,"publication_date":"2013-04-12","ids":{"openalex":"https://openalex.org/W2104896732","doi":"https://doi.org/10.1186/1752-0509-7-33","mag":"2104896732","pmid":"https://pubmed.ncbi.nlm.nih.gov/23587327"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-7-33","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-33","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-33","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-33","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013849061","display_name":"S. Alexander Riemer","orcid":null},"institutions":[{"id":"https://openalex.org/I94509681","display_name":"Technische Universit\u00e4t Braunschweig","ror":"https://ror.org/010nsgg66","country_code":"DE","type":"education","lineage":["https://openalex.org/I94509681"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Alexander Riemer","raw_affiliation_strings":["Department of Bioinformatics and Biochemistry, Technische Universit\u00e4t Braunschweig, Braunschweig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biochemistry, Technische Universit\u00e4t Braunschweig, Braunschweig, Germany","institution_ids":["https://openalex.org/I94509681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088785143","display_name":"Ren\u00e9 Rex","orcid":null},"institutions":[{"id":"https://openalex.org/I94509681","display_name":"Technische Universit\u00e4t Braunschweig","ror":"https://ror.org/010nsgg66","country_code":"DE","type":"education","lineage":["https://openalex.org/I94509681"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ren\u00e9 Rex","raw_affiliation_strings":["Department of Bioinformatics and Biochemistry, Technische Universit\u00e4t Braunschweig, Braunschweig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biochemistry, Technische Universit\u00e4t Braunschweig, Braunschweig, Germany","institution_ids":["https://openalex.org/I94509681"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043042218","display_name":"Dietmar Schomburg","orcid":"https://orcid.org/0000-0002-3354-822X"},"institutions":[{"id":"https://openalex.org/I94509681","display_name":"Technische Universit\u00e4t Braunschweig","ror":"https://ror.org/010nsgg66","country_code":"DE","type":"education","lineage":["https://openalex.org/I94509681"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dietmar Schomburg","raw_affiliation_strings":["Department of Bioinformatics and Biochemistry, Technische Universit\u00e4t Braunschweig, Braunschweig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biochemistry, Technische Universit\u00e4t Braunschweig, Braunschweig, Germany","institution_ids":["https://openalex.org/I94509681"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8977,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.74627248,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"7","issue":"1","first_page":"33","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12688","display_name":"Microbial metabolism and enzyme function","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"Flux balance analysis","score":0.8041769862174988},{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.7890501022338867},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6430331468582153},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6304536461830139},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.6299086809158325},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5701700448989868},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.5356179475784302},{"id":"https://openalex.org/keywords/metabolic-flux-analysis","display_name":"Metabolic flux analysis","score":0.5299050807952881},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.4823598265647888},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46285974979400635},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4465298354625702},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.4385031759738922},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3950553238391876},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.3862847089767456},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2533091902732849},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.19322821497917175},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.18891289830207825},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.18854829668998718},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12126976251602173}],"concepts":[{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.8041769862174988},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7890501022338867},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6430331468582153},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6304536461830139},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.6299086809158325},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5701700448989868},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5356179475784302},{"id":"https://openalex.org/C160941953","wikidata":"https://www.wikidata.org/wiki/Q6822342","display_name":"Metabolic flux analysis","level":3,"score":0.5299050807952881},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.4823598265647888},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46285974979400635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4465298354625702},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4385031759738922},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3950553238391876},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3862847089767456},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2533091902732849},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19322821497917175},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18891289830207825},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.18854829668998718},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12126976251602173},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005634","descriptor_name":"Fructose-Bisphosphate Aldolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005634","descriptor_name":"Fructose-Bisphosphate Aldolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005634","descriptor_name":"Fructose-Bisphosphate Aldolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010728","descriptor_name":"Phosphoenolpyruvate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010728","descriptor_name":"Phosphoenolpyruvate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010728","descriptor_name":"Phosphoenolpyruvate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013403","descriptor_name":"Sugar Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013403","descriptor_name":"Sugar Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013403","descriptor_name":"Sugar Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-7-33","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-33","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-33","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:23587327","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23587327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:europepmc.org:2647930","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3644240","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-7-33","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-33","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-33","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.44999998807907104,"display_name":"Affordable and clean energy"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104896732.pdf","grobid_xml":"https://content.openalex.org/works/W2104896732.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W241117969","https://openalex.org/W261856527","https://openalex.org/W1504385853","https://openalex.org/W1780750897","https://openalex.org/W1912527875","https://openalex.org/W1963489914","https://openalex.org/W1965399445","https://openalex.org/W1970136377","https://openalex.org/W1972689835","https://openalex.org/W1973851828","https://openalex.org/W1977675219","https://openalex.org/W1978408474","https://openalex.org/W1982346730","https://openalex.org/W1982403564","https://openalex.org/W1984843095","https://openalex.org/W1986733749","https://openalex.org/W1987607959","https://openalex.org/W1989488173","https://openalex.org/W1990566373","https://openalex.org/W1996791690","https://openalex.org/W2003835605","https://openalex.org/W2010727789","https://openalex.org/W2013310483","https://openalex.org/W2026089579","https://openalex.org/W2048073138","https://openalex.org/W2049196570","https://openalex.org/W2049759143","https://openalex.org/W2066327397","https://openalex.org/W2076262841","https://openalex.org/W2078355959","https://openalex.org/W2082382448","https://openalex.org/W2083011190","https://openalex.org/W2084074441","https://openalex.org/W2086554780","https://openalex.org/W2090863753","https://openalex.org/W2093057648","https://openalex.org/W2094315987","https://openalex.org/W2096056489","https://openalex.org/W2096245011","https://openalex.org/W2098824895","https://openalex.org/W2104485225","https://openalex.org/W2107792766","https://openalex.org/W2111421616","https://openalex.org/W2112463359","https://openalex.org/W2117509624","https://openalex.org/W2123698848","https://openalex.org/W2124737787","https://openalex.org/W2132022337","https://openalex.org/W2132056336","https://openalex.org/W2134026900","https://openalex.org/W2135476401","https://openalex.org/W2141360045","https://openalex.org/W2144621559","https://openalex.org/W2146126338","https://openalex.org/W2150908245","https://openalex.org/W2151023149","https://openalex.org/W2152428375","https://openalex.org/W2154061034","https://openalex.org/W2160079005","https://openalex.org/W2162237022","https://openalex.org/W2163219351","https://openalex.org/W2169641851","https://openalex.org/W2170427655","https://openalex.org/W2171560951","https://openalex.org/W2415732307","https://openalex.org/W2419380513","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2129022886","https://openalex.org/W1566184819","https://openalex.org/W2163219351","https://openalex.org/W2164290927","https://openalex.org/W2070388085","https://openalex.org/W1865302071","https://openalex.org/W2013685063","https://openalex.org/W1983785665","https://openalex.org/W2042444504","https://openalex.org/W2335648240"],"abstract_inverted_index":{"BACKGROUND:":[0],"Genome-scale":[1],"metabolic":[2,30,79,93,227,254,267,296,322],"models":[3,31],"are":[4,178,278,290],"important":[5],"tools":[6],"in":[7,36,61,132,140,142,174,184,252,307],"systems":[8,274],"biology.":[9],"They":[10],"permit":[11],"the":[12,54,75,84,90,100,116,122,160,175,205,226,237,247,259,271,291,294,302,319],"in-silico":[13],"prediction":[14],"of":[15,50,58,77,95,103,107,154,195,207,214,249,288,293,298,321],"cellular":[16],"phenotypes":[17],"via":[18],"mathematical":[19],"optimisation":[20],"procedures,":[21],"most":[22,91],"importantly":[23],"flux":[24,59,250,315],"balance":[25,101],"analysis.":[26],"Current":[27],"studies":[28],"on":[29,39,314],"mostly":[32],"consider":[33],"reaction":[34,283],"fluxes":[35,173,264],"isolation.":[37],"Based":[38],"a":[40,48,104,127,147,187,221,311],"recently":[41],"proposed":[42],"metabolite-centric":[43,64,85,148,235,244,312],"approach,":[44,236],"we":[45,110],"here":[46,88,240],"describe":[47],"set":[49],"methods":[51,238],"that":[52,169,256,277],"enable":[53],"analysis":[55,213],"and":[56,124,159,193,217,265,301],"interpretation":[57,248],"distributions":[60,251,316],"an":[62,233,242],"integrated":[63,243],"view.":[65],"We":[66,82],"demonstrate":[67,145],"how":[68,146],"this":[69,289,308],"framework":[70,245],"can":[71,170,257,317],"be":[72,199],"used":[73],"for":[74,129,204,246,324],"refinement":[76,131,320],"genome-scale":[78,253],"models.":[80],"RESULTS:":[81],"applied":[83],"view":[86,149,313],"developed":[87],"to":[89,113,125,144,180,273],"recent":[92],"reconstruction":[94],"Escherichia":[96],"coli.":[97],"By":[98],"compiling":[99],"sheets":[102],"small":[105],"number":[106],"currency":[108],"metabolites,":[109],"were":[111,138,164],"able":[112],"fully":[114],"characterise":[115],"energy":[117,299],"metabolism":[118,300],"as":[119,166,201],"predicted":[120],"by":[121],"model":[123,130,176,208],"identify":[126],"possibility":[128],"NADPH":[133],"metabolism.":[134],"Selected":[135],"branch":[136,218],"points":[137,219],"examined":[139],"detail":[141],"order":[143],"allows":[150,220],"identifying":[151],"functional":[152],"roles":[153],"metabolites.":[155],"Fructose":[156],"6-phosphate":[157],"aldolase":[158],"sedoheptulose":[161],"bisphosphate":[162],"bypass":[163],"identified":[165,200],"enzymatic":[167],"reactions":[168],"carry":[171],"high":[172],"but":[177],"unlikely":[179],"exhibit":[181],"significant":[182],"activity":[183],"vivo.":[185],"Performing":[186],"metabolite":[188],"essentiality":[189],"analysis,":[190],"unconstrained":[191],"import":[192],"export":[194],"iron":[196],"ions":[197],"could":[198],"potentially":[202],"problematic":[203],"quality":[206],"predictions.":[209],"CONCLUSIONS:":[210],"The":[211],"system-wide":[212],"split":[215],"ratios":[216],"much":[222],"deeper":[223],"insight":[224],"into":[225],"network":[228],"than":[229],"reaction-centric":[230,261],"analyses.":[231],"Extending":[232],"earlier":[234],"introduced":[239],"establish":[241],"networks":[255],"complement":[258],"classical":[260],"framework.":[262],"Analysing":[263],"their":[266],"context":[268],"simultaneously":[269],"opens":[270],"door":[272],"biological":[275],"interpretations":[276],"not":[279],"apparent":[280],"from":[281],"isolated":[282],"fluxes.":[284],"Particularly":[285],"powerful":[286],"demonstrations":[287],"analyses":[292],"complete":[295],"contexts":[297],"folate-dependent":[303],"one-carbon":[304],"pool":[305],"presented":[306],"work.":[309],"Finally,":[310],"guide":[318],"reconstructions":[323],"specific":[325],"growth":[326],"scenarios.":[327]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
