{"id":"https://openalex.org/W1991363773","doi":"https://doi.org/10.1186/1752-0509-7-23","title":"Modelling the widespread effects of TOC1 signalling on the plant circadian clock and its outputs","display_name":"Modelling the widespread effects of TOC1 signalling on the plant circadian clock and its outputs","publication_year":2013,"publication_date":"2013-03-19","ids":{"openalex":"https://openalex.org/W1991363773","doi":"https://doi.org/10.1186/1752-0509-7-23","mag":"1991363773","pmid":"https://pubmed.ncbi.nlm.nih.gov/23506153"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-7-23","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-23","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-23","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-23","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052905184","display_name":"Alexandra Pokhilko","orcid":"https://orcid.org/0000-0001-6565-6551"},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexandra Pokhilko","raw_affiliation_strings":["School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh, EH9 3JH, UK","School of Biological Sciences, University of Edinburgh, Edinburgh, UK","Institute for Complex Systems and Mathematical Biology, University of Aberdeen, Aberdeen, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh, EH9 3JH, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"School of Biological Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Institute for Complex Systems and Mathematical Biology, University of Aberdeen, Aberdeen, UK","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021715023","display_name":"Paloma M\u00e1s","orcid":"https://orcid.org/0000-0002-3780-8041"},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210158808","display_name":"Center for Research in Agricultural Genomics","ror":"https://ror.org/04tz2h245","country_code":"ES","type":"facility","lineage":["https://openalex.org/I123044942","https://openalex.org/I157913058","https://openalex.org/I4210100913","https://openalex.org/I4210158808","https://openalex.org/I4387153040","https://openalex.org/I4387153040","https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Paloma Mas","raw_affiliation_strings":["Centre for Research in Agricultural Genomics (CRAG), Consortium CSIC-IRTA-UAB-UB, Parc de Recerca UAB, Bellaterra (Cerdanyola del Vall\u00e9s), 08193, Barcelona, Spain","Centre for Research in Agricultural Genomics (CRAG), Consortium CSIC-IRTA-UAB-UB, Parc de Recerca UAB, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Research in Agricultural Genomics (CRAG), Consortium CSIC-IRTA-UAB-UB, Parc de Recerca UAB, Bellaterra (Cerdanyola del Vall\u00e9s), 08193, Barcelona, Spain","institution_ids":["https://openalex.org/I4210158808"]},{"raw_affiliation_string":"Centre for Research in Agricultural Genomics (CRAG), Consortium CSIC-IRTA-UAB-UB, Parc de Recerca UAB, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079005978","display_name":"Andrew J. Millar","orcid":"https://orcid.org/0000-0003-1756-3654"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Andrew J Millar","raw_affiliation_strings":["School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh, EH9 3JH, UK","SynthSys, University of Edinburgh, C.H. Waddington Building, Mayfield Road, Edinburgh, EH9 3JD, UK","SynthSys, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh, EH9 3JH, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"SynthSys, University of Edinburgh, C.H. Waddington Building, Mayfield Road, Edinburgh, EH9 3JD, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"SynthSys, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5079005978"],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":null,"apc_paid":null,"fwci":20.676,"has_fulltext":true,"cited_by_count":131,"citation_normalized_percentile":{"value":0.99447868,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"7","issue":"1","first_page":"23","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.9699000120162964,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.9699000120162964,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-clock","display_name":"Circadian clock","score":0.7920074462890625},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7527683973312378},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6786749362945557},{"id":"https://openalex.org/keywords/oscillating-gene","display_name":"Oscillating gene","score":0.5472455024719238},{"id":"https://openalex.org/keywords/clock","display_name":"CLOCK","score":0.5357683300971985},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"Circadian rhythm","score":0.47875919938087463},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.47060948610305786},{"id":"https://openalex.org/keywords/master-clock","display_name":"Master clock","score":0.4463987946510315},{"id":"https://openalex.org/keywords/cryptochrome","display_name":"Cryptochrome","score":0.44433024525642395},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3106578588485718},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2618122398853302},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.2596774697303772},{"id":"https://openalex.org/keywords/clock-signal","display_name":"Clock signal","score":0.1943213939666748},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.07029074430465698}],"concepts":[{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.7920074462890625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7527683973312378},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6786749362945557},{"id":"https://openalex.org/C125168821","wikidata":"https://www.wikidata.org/wiki/Q7106408","display_name":"Oscillating gene","level":5,"score":0.5472455024719238},{"id":"https://openalex.org/C184738001","wikidata":"https://www.wikidata.org/wiki/Q14908739","display_name":"CLOCK","level":4,"score":0.5357683300971985},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.47875919938087463},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.47060948610305786},{"id":"https://openalex.org/C65595194","wikidata":"https://www.wikidata.org/wiki/Q1000863","display_name":"Master clock","level":4,"score":0.4463987946510315},{"id":"https://openalex.org/C144543706","wikidata":"https://www.wikidata.org/wiki/Q85754737","display_name":"Cryptochrome","level":4,"score":0.44433024525642395},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3106578588485718},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2618122398853302},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2596774697303772},{"id":"https://openalex.org/C137059387","wikidata":"https://www.wikidata.org/wiki/Q426882","display_name":"Clock signal","level":3,"score":0.1943213939666748},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07029074430465698},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C134652429","wikidata":"https://www.wikidata.org/wiki/Q1052698","display_name":"Jitter","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000040","descriptor_name":"Abscisic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000040","descriptor_name":"Abscisic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000040","descriptor_name":"Abscisic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000040","descriptor_name":"Abscisic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054046","descriptor_name":"Plant Stomata","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054046","descriptor_name":"Plant Stomata","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054046","descriptor_name":"Plant Stomata","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054046","descriptor_name":"Plant Stomata","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1752-0509-7-23","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-23","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-23","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:23506153","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23506153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pure.ed.ac.uk:publications/329dd434-32ab-43ae-9798-5f7ee4c4b11c","is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/329dd434-32ab-43ae-9798-5f7ee4c4b11c","pdf_url":"http://hdl.handle.net/20.500.11820/329dd434-32ab-43ae-9798-5f7ee4c4b11c","source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pokhilko, A, Mas, P & Millar, A J 2013, 'Modelling the widespread effects of TOC1 signalling on the plant circadian clock and its outputs', BMC Systems Biology, vol. 7, no. 1, 23. https://doi.org/10.1186/1752-0509-7-23","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pure.ed.ac.uk:publications/329dd434-32ab-43ae-9798-5f7ee4c4b11c","is_oa":true,"landing_page_url":null,"pdf_url":"http://hdl.handle.net/20.500.11820/329dd434-32ab-43ae-9798-5f7ee4c4b11c","source":{"id":"https://openalex.org/S4406922455","display_name":"Edinburgh Research Explorer","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:digital.csic.es:10261/73185","is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/73185","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Art\u00edculo"},{"id":"pmh:oai:europepmc.org:2617049","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3614443","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3614443","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3614443","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-7-23","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-7-23","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-7-23","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4399999976158142,"display_name":"Life below water","id":"https://metadata.un.org/sdg/14"}],"awards":[{"id":"https://openalex.org/G1614786199","display_name":"Linking the clock to metabolism","funder_award_id":"245143","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2080879326","display_name":null,"funder_award_id":"D019621","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2160003213","display_name":null,"funder_award_id":"BB/D019621/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G922893353","display_name":"Centre for Systems Biology at Edinburgh","funder_award_id":"BB/D019621/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320310214","display_name":"Fundaci\u00f3n Ram\u00f3n Areces","ror":"https://ror.org/04ra91131"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1991363773.pdf","grobid_xml":"https://content.openalex.org/works/W1991363773.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1604304060","https://openalex.org/W1660761394","https://openalex.org/W2004037030","https://openalex.org/W2011265440","https://openalex.org/W2013198399","https://openalex.org/W2015950073","https://openalex.org/W2020311756","https://openalex.org/W2024952216","https://openalex.org/W2035159078","https://openalex.org/W2046879305","https://openalex.org/W2055437699","https://openalex.org/W2055531437","https://openalex.org/W2059746610","https://openalex.org/W2086068316","https://openalex.org/W2087087285","https://openalex.org/W2092547196","https://openalex.org/W2107062718","https://openalex.org/W2110682165","https://openalex.org/W2112183540","https://openalex.org/W2113878162","https://openalex.org/W2114900530","https://openalex.org/W2123471722","https://openalex.org/W2133282072","https://openalex.org/W2135007181","https://openalex.org/W2135518907","https://openalex.org/W2141148584","https://openalex.org/W2150998297","https://openalex.org/W2154518257","https://openalex.org/W2156444576","https://openalex.org/W2158706468","https://openalex.org/W2159868152","https://openalex.org/W2164965140","https://openalex.org/W4235377647"],"related_works":["https://openalex.org/W2390348595","https://openalex.org/W2145024015","https://openalex.org/W2084887961","https://openalex.org/W2135658843","https://openalex.org/W2583671727","https://openalex.org/W2140241157","https://openalex.org/W2071679532","https://openalex.org/W2276119694","https://openalex.org/W2493982139","https://openalex.org/W2105185711"],"abstract_inverted_index":{"BACKGROUND:":[0],"24-hour":[1],"biological":[2],"clocks":[3],"are":[4],"intimately":[5],"connected":[6],"to":[7,97,157,243,270,282,308,319],"the":[8,14,33,37,53,62,86,89,108,131,136,147,152,159,162,171,175,187,191,198,214,217,225,245,256,260,264,271,287,298,314,339,342,347],"cellular":[9],"signalling":[10,106,179,240],"network,":[11],"which":[12,114,336],"complicates":[13],"analysis":[15],"of":[16,32,48,61,83,88,149,161,190,200,238,247,259,290,297,330,341,349],"clock":[17,54,90,137,163,176,193,202,300],"mechanisms.":[18],"The":[19,208,294],"transcriptional":[20],"regulator":[21],"TOC1":[22,45,84,94,127,229,284,331],"(TIMING":[23],"OF":[24],"CAB":[25],"EXPRESSION":[26],"1)":[27],"is":[28,77,115],"a":[29,100,274,327],"founding":[30],"component":[31],"gene":[34,194],"circuit":[35,195,301],"in":[36,99,151,228],"plant":[38,109,192],"circadian":[39,250,299],"clock.":[40],"Recent":[41],"results":[42,325],"show":[43],"that":[44,104],"suppresses":[46],"transcription":[47,64],"multiple":[49,201,310],"target":[50],"genes":[51,203],"within":[52],"circuit,":[55],"far":[56],"beyond":[57],"its":[58,92,165],"previously-described":[59],"regulation":[60],"morning":[63],"factors":[65],"LHY":[66],"(LATE":[67],"ELONGATED":[68],"HYPOCOTYL)":[69],"and":[70,91,129,164,177,221,231,249,277,302,316,321,345],"CCA1":[71],"(CIRCADIAN":[72],"CLOCK":[73],"ASSOCIATED":[74],"1).":[75],"It":[76],"unclear":[78],"how":[79],"this":[80],"pervasive":[81],"effect":[82],"affects":[85,338],"dynamics":[87,160],"outputs.":[93],"also":[95],"appears":[96],"function":[98],"nested":[101],"feedback":[102],"loop":[103],"includes":[105],"by":[107,117,143,196,204],"hormone":[110],"Abscisic":[111],"Acid":[112],"(ABA),":[113],"upregulated":[116],"abiotic":[118],"stresses,":[119],"such":[120,145],"as":[121,146,273,332],"drought.":[122],"ABA":[123,239,248,253],"treatments":[124],"both":[125,337],"alter":[126],"levels":[128,254],"affect":[130],"clock's":[132,218,226],"timing":[133,222,315],"behaviour.":[134],"Conversely,":[135],"rhythmically":[138],"modulates":[139,346],"physiological":[140],"processes":[141],"induced":[142],"ABA,":[144],"closing":[148],"stomata":[150],"leaf":[153],"epidermis.":[154],"In":[155],"order":[156],"understand":[158],"outputs":[166],"under":[167],"changing":[168],"environmental":[169,304,322,334],"conditions,":[170],"reciprocal":[172],"interactions":[173,246],"between":[174],"other":[178],"pathways":[180],"must":[181],"be":[182],"integrated.":[183],"RESULTS:":[184],"We":[185],"extended":[186],"mathematical":[188],"model":[189,210,296],"incorporating":[197],"repression":[199],"TOC1,":[205],"observed":[206],"experimentally.":[207],"revised":[209],"more":[211],"accurately":[212],"matches":[213],"data":[215],"on":[216,286,313],"molecular":[219],"profiles":[220],"behaviour,":[223],"explaining":[224],"responses":[227,318],"over-expression":[230],"toc1":[232],"mutant":[233],"plants.":[234],"A":[235],"simplified":[236],"representation":[237],"allowed":[241,281,306],"us":[242,307],"investigate":[244],"pathways.":[251],"Increased":[252],"lengthen":[255],"free-running":[257],"period":[258],"clock,":[261],"consistent":[262],"with":[263],"experimental":[265,311],"data.":[266],"Adding":[267],"stomatal":[268,291,317],"closure":[269],"model,":[272],"key":[275],"ABA-":[276],"clock-regulated":[278],"downstream":[279,350],"process":[280],"describe":[283],"effects":[285],"rhythmic":[288],"gating":[289],"closure.":[292],"CONCLUSIONS:":[293],"integrated":[295],"ABA-regulated":[303],"sensing":[305],"explain":[309],"observations":[312],"genetic":[320],"perturbations.":[323],"These":[324],"crystallise":[326],"new":[328],"role":[329],"an":[333],"sensor,":[335],"pace":[340],"central":[343],"oscillator":[344],"kinetics":[348],"processes.":[351]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}