{"id":"https://openalex.org/W2029581384","doi":"https://doi.org/10.1186/1752-0509-6-s3-s19","title":"Potential metabolic mechanism of girls' central precocious puberty: a network analysis on urine metabonomics data","display_name":"Potential metabolic mechanism of girls' central precocious puberty: a network analysis on urine metabonomics data","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2029581384","doi":"https://doi.org/10.1186/1752-0509-6-s3-s19","mag":"2029581384","pmid":"https://pubmed.ncbi.nlm.nih.gov/23282096"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-6-s3-s19","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-s3-s19","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S3-S19","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S3-S19","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101901449","display_name":"Linlin Yang","orcid":"https://orcid.org/0000-0002-2849-700X"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Linlin Yang","raw_affiliation_strings":["School of Life Science and Technology, Tongji University, Shanghai 200092, China","School of Life Science and Technology, Tongji University, Shanghai, 200092, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Tongji University, Shanghai 200092, China","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"School of Life Science and Technology, Tongji University, Shanghai, 200092, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060948898","display_name":"Kailin Tang","orcid":"https://orcid.org/0000-0002-0508-6056"},"institutions":[{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kailin Tang","raw_affiliation_strings":["Shanghai Center for Bioinformation Technology, Shanghai, 200235, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Center for Bioinformation Technology, Shanghai, 200235, China","institution_ids":["https://openalex.org/I4210162648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102899551","display_name":"Ying Qi","orcid":"https://orcid.org/0000-0001-9144-6216"},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Qi","raw_affiliation_strings":["Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041274004","display_name":"Hao Ye","orcid":"https://orcid.org/0000-0002-8630-1458"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Ye","raw_affiliation_strings":["Shanghai Center for Bioinformation Technology, Shanghai, 200235, China","State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, Shanghai, 200237, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Center for Bioinformation Technology, Shanghai, 200235, China","institution_ids":["https://openalex.org/I4210162648"]},{"raw_affiliation_string":"State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, Shanghai, 200237, China","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002118192","display_name":"Wenlian Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210147369","display_name":"Shanghai Institute of Hematology","ror":"https://ror.org/03fz4ce66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210147369"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenlian Chen","raw_affiliation_strings":["State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","institution_ids":["https://openalex.org/I4210147369","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101899036","display_name":"Yongyu Zhang","orcid":"https://orcid.org/0000-0002-0215-9141"},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongyu Zhang","raw_affiliation_strings":["Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103827078","display_name":"Zhiwei Cao","orcid":null},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiwei Cao","raw_affiliation_strings":["Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai, 200021, China","School of Life Science and Technology, Tongji University, Shanghai, 200092, China","Shanghai Center for Bioinformation Technology, Shanghai, 200235, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai, 200021, China","institution_ids":["https://openalex.org/I4210098460"]},{"raw_affiliation_string":"School of Life Science and Technology, Tongji University, Shanghai, 200092, China","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"Shanghai Center for Bioinformation Technology, Shanghai, 200235, China","institution_ids":["https://openalex.org/I4210162648"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5101901449"],"corresponding_institution_ids":["https://openalex.org/I116953780"],"apc_list":null,"apc_paid":null,"fwci":1.0747,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.75622108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"6","issue":"S3","first_page":"S19","last_page":"S19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.501800000667572,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.501800000667572,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.20360000431537628,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urine","display_name":"Urine","score":0.7388936281204224},{"id":"https://openalex.org/keywords/endocrine-system","display_name":"Endocrine system","score":0.6027593612670898},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.5591816902160645},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.4481201171875},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.4430621862411499},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.379932701587677},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.37979185581207275},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3625040650367737},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.35223835706710815},{"id":"https://openalex.org/keywords/physiology","display_name":"Physiology","score":0.33631229400634766},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3062341809272766},{"id":"https://openalex.org/keywords/hormone","display_name":"Hormone","score":0.21568647027015686},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07596087455749512}],"concepts":[{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.7388936281204224},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.6027593612670898},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5591816902160645},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4481201171875},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4430621862411499},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.379932701587677},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37979185581207275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3625040650367737},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35223835706710815},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.33631229400634766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3062341809272766},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.21568647027015686},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07596087455749512},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011629","descriptor_name":"Puberty, Precocious","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011629","descriptor_name":"Puberty, Precocious","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011629","descriptor_name":"Puberty, Precocious","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011629","descriptor_name":"Puberty, Precocious","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011629","descriptor_name":"Puberty, Precocious","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D011629","descriptor_name":"Puberty, Precocious","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D011629","descriptor_name":"Puberty, Precocious","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D011629","descriptor_name":"Puberty, Precocious","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-6-s3-s19","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-s3-s19","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S3-S19","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:23282096","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23282096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:9f15308df4724faab350493eb4d6b808","is_oa":false,"landing_page_url":"https://doaj.org/article/9f15308df4724faab350493eb4d6b808","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 6, Iss Suppl 3, p S19 (2012)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3524310","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3524310","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-6-s3-s19","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-s3-s19","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S3-S19","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7599999904632568}],"awards":[{"id":"https://openalex.org/G7090351897","display_name":null,"funder_award_id":"31171272","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2029581384.pdf","grobid_xml":"https://content.openalex.org/works/W2029581384.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W99296762","https://openalex.org/W103751348","https://openalex.org/W260396355","https://openalex.org/W309163783","https://openalex.org/W1690046598","https://openalex.org/W1884137499","https://openalex.org/W1968439746","https://openalex.org/W1971639265","https://openalex.org/W1987536633","https://openalex.org/W1987711524","https://openalex.org/W1995051707","https://openalex.org/W2003938647","https://openalex.org/W2010713665","https://openalex.org/W2011348557","https://openalex.org/W2017987256","https://openalex.org/W2032113920","https://openalex.org/W2036734202","https://openalex.org/W2040683679","https://openalex.org/W2043793319","https://openalex.org/W2048602284","https://openalex.org/W2049725427","https://openalex.org/W2065603506","https://openalex.org/W2076470995","https://openalex.org/W2078085488","https://openalex.org/W2080859170","https://openalex.org/W2100168610","https://openalex.org/W2109278577","https://openalex.org/W2110375707","https://openalex.org/W2126591541","https://openalex.org/W2127169206","https://openalex.org/W2130466489","https://openalex.org/W2156849151","https://openalex.org/W2159482845","https://openalex.org/W2159585030","https://openalex.org/W2163410580","https://openalex.org/W2166711199","https://openalex.org/W2168408572","https://openalex.org/W3146956997","https://openalex.org/W4246613822","https://openalex.org/W4249095702","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2027850379","https://openalex.org/W4205289363","https://openalex.org/W2364973402","https://openalex.org/W2088962229","https://openalex.org/W2014991083","https://openalex.org/W3169423050","https://openalex.org/W2068260376","https://openalex.org/W2064445380","https://openalex.org/W2031825920","https://openalex.org/W4214899539"],"abstract_inverted_index":{"BACKGROUND:":[0],"Central":[1],"precocious":[2],"puberty":[3,189],"(CPP)":[4],"is":[5,48],"a":[6,45,55,71,132,234,249,268],"common":[7],"pediatric":[8],"endocrine":[9],"disease":[10],"caused":[11],"by":[12,92,197,240],"early":[13,186],"activation":[14,187],"of":[15,58,74,123,146,174,188,207,225,251],"hypothalamic-putuitary-gonadal":[16],"(HPG)":[17],"axis,":[18],"yet":[19],"the":[20,41,59,65,101,142,162,172,185,205],"exact":[21],"mechanism":[22],"was":[23,36,148,220],"poorly":[24],"understood.":[25],"Although":[26],"there":[27],"were":[28,90,98,113],"some":[29],"proofs":[30],"that":[31,108,222],"an":[32,264],"altered":[33],"metabolic":[34,144,214],"profile":[35],"involved":[37],"in":[38,50,100,161,190],"CPP,":[39],"interpreting":[40],"biological":[42,60],"implications":[43],"at":[44,267],"systematic":[46,56,269],"level":[47],"still":[49],"pressing":[51],"need.":[52],"To":[53],"gain":[54],"understanding":[57],"implications,":[61],"this":[62,78],"paper":[63],"analyzed":[64],"CPP":[66,84,109,124,136,147,191],"differential":[67,80,110,125,154],"urine":[68,81,111,126,155,198,208],"metabolites":[69,82,112,127,130],"from":[70],"network":[72,105,145],"point":[73],"view.":[75],"RESULTS:":[76],"In":[77],"study,":[79],"between":[83,135],"girls":[85,192],"and":[86,128,138,176,244],"age-matched":[87],"normal":[88],"ones":[89],"identified":[91],"LC-MS.":[93],"Their":[94],"basic":[95],"topological":[96],"parameters":[97],"calculated":[99],"background":[102],"network.":[103],"The":[104,201],"decomposition":[106],"suggested":[107],"most":[114],"relevant":[115],"to":[116,184,210,258,262],"amino":[117,167,226,230],"acid":[118,168],"metabolism.":[119],"Further":[120],"proximity":[121],"analysis":[122,253,261],"neuro-endocrine":[129,139],"showed":[131],"close":[133,235],"relationship":[134],"metabolism":[137,169,224],"system.":[140],"Then":[141],"core":[143,163],"successfully":[149],"constructed":[150],"among":[151],"all":[152],"these":[153],"metabolites.":[156],"As":[157],"can":[158],"be":[159,195,256],"demonstrated":[160,204],"network,":[164],"abnormal":[165,223],"aromatic":[166,229],"might":[170,232],"influence":[171],"activity":[173],"HPG":[175,242],"hypothalamic":[177],"pituitary":[178],"adrenal":[179],"(HPA)":[180],"axis.":[181,247],"Several":[182],"adjustments":[183],"could":[193,254],"also":[194,255],"revealed":[196,221],"metabonomics.":[199],"CONCLUSIONS:":[200],"present":[202],"article":[203],"ability":[206],"metabonomics":[209,260],"provide":[211,263],"several":[212],"potential":[213],"clues":[215],"for":[216],"CPP's":[217,238],"mechanism.":[218],"It":[219],"acid,":[227,231],"especially":[228],"have":[233],"correlation":[236],"with":[237],"pathogenesis":[239],"activating":[241],"axis":[243],"suppressing":[245],"HPA":[246],"Such":[248],"method":[250],"network-based":[252],"applied":[257],"other":[259],"overall":[265],"perspective":[266],"level.":[270]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}