{"id":"https://openalex.org/W1979254666","doi":"https://doi.org/10.1186/1752-0509-6-s3-s14","title":"Genetic studies of complex human diseases: Characterizing SNP-disease associations using Bayesian networks","display_name":"Genetic studies of complex human diseases: Characterizing SNP-disease associations using Bayesian networks","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W1979254666","doi":"https://doi.org/10.1186/1752-0509-6-s3-s14","mag":"1979254666","pmid":"https://pubmed.ncbi.nlm.nih.gov/23281790"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-6-s3-s14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-s3-s14","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S3-S14","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S3-S14","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091275779","display_name":"Bing Han","orcid":"https://orcid.org/0000-0002-7299-2753"},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bing Han","raw_affiliation_strings":["Bioinformatics and Computational Life-Sciences Laboratory, ITTC, Department of Electrical Engineering and Computer Science, University of Kansas, 1520 West 15th Street, Lawrence, KS 66045, USA","University of Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Computational Life-Sciences Laboratory, ITTC, Department of Electrical Engineering and Computer Science, University of Kansas, 1520 West 15th Street, Lawrence, KS 66045, USA","institution_ids":["https://openalex.org/I146416000"]},{"raw_affiliation_string":"University of Kansas","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083809431","display_name":"Xue-wen Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xue-wen Chen","raw_affiliation_strings":["Department of Computer Science Wayne State University Detroit, MI, 48202","Department of Computer Science , Wayne State University, Detroit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science Wayne State University Detroit, MI, 48202","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Department of Computer Science , Wayne State University, Detroit","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021941687","display_name":"Zohreh Talebizadeh","orcid":"https://orcid.org/0000-0002-8964-4763"},"institutions":[{"id":"https://openalex.org/I1328594524","display_name":"Children's Mercy Hospital","ror":"https://ror.org/04zfmcq84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328594524"]},{"id":"https://openalex.org/I4210124720","display_name":"Mercy Hospital","ror":"https://ror.org/02sxmkm79","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210113060","https://openalex.org/I4210124720"]},{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zohreh Talebizadeh","raw_affiliation_strings":["Children's Mercy Hospital and University of Missouri-Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO, 64108, USA","Children\u2019s Mercy Hospital and University of Missouri-Kansas City School of Medicine, Kansas City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Mercy Hospital and University of Missouri-Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO, 64108, USA","institution_ids":["https://openalex.org/I1328594524","https://openalex.org/I4210124720","https://openalex.org/I75421653"]},{"raw_affiliation_string":"Children\u2019s Mercy Hospital and University of Missouri-Kansas City School of Medicine, Kansas City, USA","institution_ids":["https://openalex.org/I75421653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084072550","display_name":"Hua Xu","orcid":"https://orcid.org/0000-0002-5274-4672"},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Xu","raw_affiliation_strings":["School of Biomedical Informatics The University of Texas Health Science Center at Houston Houston, TX, 77030","School of Biomedical Informatics The University of Texas Health Science Center at Houston Houston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Informatics The University of Texas Health Science Center at Houston Houston, TX, 77030","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"School of Biomedical Informatics The University of Texas Health Science Center at Houston Houston,","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5083809431"],"corresponding_institution_ids":["https://openalex.org/I185443292"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":2.2637,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.87874067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"S3","first_page":"S14","last_page":"S14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.28859999775886536,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.28859999775886536,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.22660000622272491,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.06340000033378601,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.7323324680328369},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6974145174026489},{"id":"https://openalex.org/keywords/markov-chain-monte-carlo","display_name":"Markov chain Monte Carlo","score":0.5688347816467285},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5410448908805847},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.5172567963600159},{"id":"https://openalex.org/keywords/bayesian-network","display_name":"Bayesian network","score":0.5152692794799805},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.504165768623352},{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.46254250407218933},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.4599245488643646},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.38261958956718445},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19496360421180725},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12362739443778992}],"concepts":[{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.7323324680328369},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6974145174026489},{"id":"https://openalex.org/C111350023","wikidata":"https://www.wikidata.org/wiki/Q1191869","display_name":"Markov chain Monte Carlo","level":3,"score":0.5688347816467285},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5410448908805847},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.5172567963600159},{"id":"https://openalex.org/C33724603","wikidata":"https://www.wikidata.org/wiki/Q812540","display_name":"Bayesian network","level":2,"score":0.5152692794799805},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.504165768623352},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.46254250407218933},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.4599245488643646},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.38261958956718445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19496360421180725},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12362739443778992},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-6-s3-s14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-s3-s14","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S3-S14","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:23281790","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23281790","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3524021","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3524021","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.wayne.edu:biomedcentral-1013","is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/biomedcentral/14","pdf_url":null,"source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Associated BioMed Central Scholarship","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:752fcbe6b1804c21959666138bd9a16d","is_oa":false,"landing_page_url":"https://doaj.org/article/752fcbe6b1804c21959666138bd9a16d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 6, Iss Suppl 3, p S14 (2012)","raw_type":"article"},{"id":"pmh:oai:kuscholarworks.ku.edu:1808/12832","is_oa":true,"landing_page_url":"http://hdl.handle.net/1808/12832","pdf_url":null,"source":{"id":"https://openalex.org/S4377196285","display_name":"KU ScholarWorks (University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-6-s3-s14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-s3-s14","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S3-S14","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2854726526","display_name":"CAREER: Machine Learning Approaches for Genome-wide Biological Network Inference","funder_award_id":"0644366","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1979254666.pdf","grobid_xml":"https://content.openalex.org/works/W1979254666.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W73784630","https://openalex.org/W143237373","https://openalex.org/W1480376833","https://openalex.org/W1493217831","https://openalex.org/W1500895378","https://openalex.org/W1517637854","https://openalex.org/W1524326598","https://openalex.org/W1546962148","https://openalex.org/W1554944419","https://openalex.org/W1604572656","https://openalex.org/W1967395566","https://openalex.org/W1968908999","https://openalex.org/W1976407234","https://openalex.org/W1980175560","https://openalex.org/W1980309199","https://openalex.org/W1980771638","https://openalex.org/W1993663642","https://openalex.org/W2008352401","https://openalex.org/W2008906462","https://openalex.org/W2009435671","https://openalex.org/W2013374740","https://openalex.org/W2017079501","https://openalex.org/W2017867103","https://openalex.org/W2032999356","https://openalex.org/W2035386168","https://openalex.org/W2041170649","https://openalex.org/W2052182252","https://openalex.org/W2057765075","https://openalex.org/W2063575312","https://openalex.org/W2066669827","https://openalex.org/W2093805274","https://openalex.org/W2098038934","https://openalex.org/W2099900459","https://openalex.org/W2101350555","https://openalex.org/W2113784410","https://openalex.org/W2113979998","https://openalex.org/W2120450109","https://openalex.org/W2122189635","https://openalex.org/W2122863289","https://openalex.org/W2128016314","https://openalex.org/W2132137212","https://openalex.org/W2142390772","https://openalex.org/W2142635246","https://openalex.org/W2143891888","https://openalex.org/W2144601878","https://openalex.org/W2154572047","https://openalex.org/W2159985326","https://openalex.org/W2161630867","https://openalex.org/W2161642932","https://openalex.org/W2161791121","https://openalex.org/W2168175751","https://openalex.org/W2170112109","https://openalex.org/W2317800347","https://openalex.org/W2403155714","https://openalex.org/W2498005307","https://openalex.org/W2608799023","https://openalex.org/W3149745985","https://openalex.org/W4302423442"],"related_works":["https://openalex.org/W1547817677","https://openalex.org/W2615678788","https://openalex.org/W2023460495","https://openalex.org/W2109954095","https://openalex.org/W1967902778","https://openalex.org/W3083099115","https://openalex.org/W1981509636","https://openalex.org/W3139253026","https://openalex.org/W3035525216","https://openalex.org/W2140249224"],"abstract_inverted_index":{"BACKGROUND:":[0],"Detecting":[1],"epistatic":[2,26,72,87,129,156,170],"interactions":[3,130,171],"plays":[4],"a":[5,45,77,149,162,181,190,212],"significant":[6],"role":[7],"in":[8,71,117],"improving":[9],"pathogenesis,":[10],"prevention,":[11],"diagnosis,":[12],"and":[13,51,60,98,121,123,179,253],"treatment":[14],"of":[15,38,48,68,119,189,211,225,246],"complex":[16],"human":[17],"diseases.":[18],"Applying":[19],"machine":[20],"learning":[21,82],"or":[22,133],"statistical":[23],"methods":[24,70,116],"to":[25,53,85,94,142,154,185,204,219,229],"interaction":[27,73],"detection":[28],"will":[29],"encounter":[30],"some":[31,113,230],"common":[32],"problems,":[33],"e.g.,":[34],"very":[35],"limited":[36],"number":[37,47],"samples,":[39],"an":[40],"extremely":[41],"high":[42],"search":[43],"space,":[44],"large":[46],"false":[49],"positives,":[50],"ways":[52],"measure":[54],"the":[55,61,66,91,174,187,209,221,226,243],"association":[56,234],"between":[57],"disease":[58,101,144],"markers":[59],"phenotype.":[62],"RESULTS:":[63],"To":[64,199],"address":[65],"problems":[67],"computational":[69],"detection,":[74],"we":[75,160,207],"propose":[76,148,208],"score-based":[78],"Bayesian":[79,150,192],"network":[80,193],"structure":[81,188],"method,":[83,152],"EpiBN,":[84,153,159],"detect":[86,155],"interactions.":[88,157],"We":[89,147],"apply":[90,180],"proposed":[92,227],"method":[93,111,139,202,218,228],"both":[95],"simulated":[96],"datasets":[97,236],"three":[99],"real":[100,143,205,231],"datasets.":[102],"Experimental":[103],"results":[104],"on":[105],"simulation":[106],"data":[107],"show":[108],"that":[109],"our":[110,138,201],"outperforms":[112],"other":[114],"commonly-used":[115],"terms":[118],"power":[120],"sample-efficiency,":[122],"is":[124,140],"especially":[125],"suitable":[126],"for":[127],"detecting":[128],"with":[131],"weak":[132],"no":[134],"marginal":[135],"effects.":[136],"Furthermore,":[137],"scalable":[141,203],"data.":[145],"CONCLUSIONS:":[146],"network-based":[151],"In":[158],"develop":[161],"new":[163],"scoring":[164],"function,":[165],"which":[166],"can":[167],"reflect":[168],"higher-order":[169],"by":[172],"estimating":[173],"model":[175],"complexity":[176],"from":[177],"data,":[178,206],"fast":[182],"Branch-and-Bound":[183],"algorithm":[184],"learn":[186],"two-layer":[191],"containing":[194],"only":[195],"one":[196],"target":[197],"node.":[198],"make":[200],"use":[210],"Markov":[213],"chain":[214],"Monte":[215],"Carlo":[216],"(MCMC)":[217],"perform":[220],"screening":[222],"process.":[223],"Applications":[224],"GWAS":[232],"(genome-wide":[233],"studies)":[235],"may":[237],"provide":[238],"helpful":[239],"insights":[240],"into":[241],"understanding":[242],"genetic":[244],"basis":[245],"Age-related":[247],"Macular":[248],"Degeneration,":[249],"late-onset":[250],"Alzheimer's":[251],"disease,":[252],"autism.":[254]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-23T07:36:19.812096","created_date":"2025-10-10T00:00:00"}