{"id":"https://openalex.org/W2064331089","doi":"https://doi.org/10.1186/1752-0509-6-s3-s10","title":"Mathematical modeling of left ventricular dimensional changes in mice during aging","display_name":"Mathematical modeling of left ventricular dimensional changes in mice during aging","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2064331089","doi":"https://doi.org/10.1186/1752-0509-6-s3-s10","mag":"2064331089","pmid":"https://pubmed.ncbi.nlm.nih.gov/23281647"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-6-s3-s10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-s3-s10","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S3-S10","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S3-S10","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105986973","display_name":"Tianyi Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianyi Yang","raw_affiliation_strings":["San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center at San Antonio, TX, USA","Department of Electrical and Computer Engineering, The University of Texas at San Antonio, USA","San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center at San Antonio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center at San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, The University of Texas at San Antonio, USA","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center at San Antonio, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017106083","display_name":"Ying Ann Chiao","orcid":"https://orcid.org/0000-0002-1256-4335"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Ann Chiao","raw_affiliation_strings":["Barshop Institute of Longevity and Aging Studies; Division of Geriatrics, Gerontology and Palliative Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio, USA","Department of Biochemistry, The University of Texas Health Science Center at San Antonio, USA","San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center at San Antonio, USA","Barshop Institute of Longevity and Aging Studies","Division of Geriatrics, Gerontology and Palliative Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barshop Institute of Longevity and Aging Studies; Division of Geriatrics, Gerontology and Palliative Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Biochemistry, The University of Texas Health Science Center at San Antonio, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center at San Antonio, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Barshop Institute of Longevity and Aging Studies","institution_ids":[]},{"raw_affiliation_string":"Division of Geriatrics, Gerontology and Palliative Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091817975","display_name":"Yunji Wang","orcid":"https://orcid.org/0000-0002-2691-8042"},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunji Wang","raw_affiliation_strings":["Department of Electrical and Computer Engineering, The University of Texas at San Antonio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, The University of Texas at San Antonio, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078474229","display_name":"Andrew Voorhees","orcid":"https://orcid.org/0000-0002-8125-8825"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Voorhees","raw_affiliation_strings":["Department of Mechanical Engineering, The University of Texas at San Antonio, USA","San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center at San Antonio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, The University of Texas at San Antonio, USA","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center at San Antonio, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053647070","display_name":"Hai\u2010Chao Han","orcid":"https://orcid.org/0000-0002-3077-5814"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hai-Chao Han","raw_affiliation_strings":["Department of Mechanical Engineering, The University of Texas at San Antonio, USA","San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center at San Antonio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, The University of Texas at San Antonio, USA","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center at San Antonio, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058202537","display_name":"Merry L. Lindsey","orcid":"https://orcid.org/0000-0002-4090-0391"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Merry L Lindsey","raw_affiliation_strings":["Barshop Institute of Longevity and Aging Studies; Division of Geriatrics, Gerontology and Palliative Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio, USA","San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center at San Antonio, USA","Barshop Institute of Longevity and Aging Studies","Division of Geriatrics, Gerontology and Palliative Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barshop Institute of Longevity and Aging Studies; Division of Geriatrics, Gerontology and Palliative Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center at San Antonio, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Barshop Institute of Longevity and Aging Studies","institution_ids":[]},{"raw_affiliation_string":"Division of Geriatrics, Gerontology and Palliative Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046855484","display_name":"Yufang Jin","orcid":"https://orcid.org/0000-0002-9049-9807"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yu-Fang Jin","raw_affiliation_strings":["Department of Electrical and Computer Engineering, The University of Texas at San Antonio, USA","San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center at San Antonio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, The University of Texas at San Antonio, USA","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center at San Antonio, USA","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5046855484"],"corresponding_institution_ids":["https://openalex.org/I165951966","https://openalex.org/I45438204"],"apc_list":null,"apc_paid":null,"fwci":3.9338,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.93511762,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"S3","first_page":"S10","last_page":"S10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9869999885559082,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ventricle","display_name":"Ventricle","score":0.7262259721755981},{"id":"https://openalex.org/keywords/stiffness","display_name":"Stiffness","score":0.6239561438560486},{"id":"https://openalex.org/keywords/isotropy","display_name":"Isotropy","score":0.5196355581283569},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"Extracellular matrix","score":0.4964452385902405},{"id":"https://openalex.org/keywords/diastole","display_name":"Diastole","score":0.48919227719306946},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.48532217741012573},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4169559180736542},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3962912857532501},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3786803185939789},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.3721387982368469},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.28230419754981995},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2526998221874237},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2012840211391449},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.11013928055763245},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.10782581567764282}],"concepts":[{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.7262259721755981},{"id":"https://openalex.org/C2779372316","wikidata":"https://www.wikidata.org/wiki/Q569057","display_name":"Stiffness","level":2,"score":0.6239561438560486},{"id":"https://openalex.org/C184050105","wikidata":"https://www.wikidata.org/wiki/Q273163","display_name":"Isotropy","level":2,"score":0.5196355581283569},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4964452385902405},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.48919227719306946},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.48532217741012573},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4169559180736542},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3962912857532501},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3786803185939789},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.3721387982368469},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28230419754981995},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2526998221874237},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2012840211391449},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11013928055763245},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.10782581567764282},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-6-s3-s10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-s3-s10","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S3-S10","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:23281647","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23281647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:0043c53d483043b3a46611db677483bf","is_oa":false,"landing_page_url":"https://doaj.org/article/0043c53d483043b3a46611db677483bf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 6, Iss Suppl 3, p S10 (2012)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3524011","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3524011","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-6-s3-s10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-s3-s10","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S3-S10","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.46000000834465027,"display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G1330698378","display_name":null,"funder_award_id":"HL75360","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1336385654","display_name":null,"funder_award_id":"N01-HV-00244","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1824644288","display_name":null,"funder_award_id":"0644646","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3630046279","display_name":null,"funder_award_id":"SC2HL101430","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5340568625","display_name":null,"funder_award_id":"0644646","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5822735789","display_name":null,"funder_award_id":"HHSN268201000036C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6195923504","display_name":null,"funder_award_id":"1R03EB009496","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6671297155","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G752354275","display_name":null,"funder_award_id":"N01-HV-00244","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8245670873","display_name":null,"funder_award_id":"NIH R01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8288036582","display_name":null,"funder_award_id":"NIH R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309319","display_name":"Max and Minnie Tomerlin Voelcker Fund","ror":"https://ror.org/00951b249"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2064331089.pdf","grobid_xml":"https://content.openalex.org/works/W2064331089.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W104311351","https://openalex.org/W1506298186","https://openalex.org/W1577665082","https://openalex.org/W1965976126","https://openalex.org/W1970516435","https://openalex.org/W1981294092","https://openalex.org/W1984815851","https://openalex.org/W1985084134","https://openalex.org/W1990681110","https://openalex.org/W1997802108","https://openalex.org/W2028705213","https://openalex.org/W2040792697","https://openalex.org/W2045209036","https://openalex.org/W2050872632","https://openalex.org/W2055410241","https://openalex.org/W2094197268","https://openalex.org/W2094612016","https://openalex.org/W2096155049","https://openalex.org/W2104905716","https://openalex.org/W2119906179","https://openalex.org/W2125088647","https://openalex.org/W2131087908","https://openalex.org/W2140737741","https://openalex.org/W2140799084","https://openalex.org/W2151339600","https://openalex.org/W2163156588","https://openalex.org/W2163876034","https://openalex.org/W2167510007","https://openalex.org/W2170066676","https://openalex.org/W2414618041","https://openalex.org/W2483171196","https://openalex.org/W2492870763","https://openalex.org/W2593366827"],"related_works":["https://openalex.org/W2794789911","https://openalex.org/W4298134547","https://openalex.org/W2122976425","https://openalex.org/W2088773039","https://openalex.org/W2028697747","https://openalex.org/W4382753160","https://openalex.org/W2284229495","https://openalex.org/W4320084277","https://openalex.org/W3033827510","https://openalex.org/W2049998042"],"abstract_inverted_index":{"Cardiac":[0],"aging":[1,68,202],"is":[2,13,33],"characterized":[3],"by":[4,70],"diastolic":[5,24],"dysfunction":[6],"of":[7,40,48,95,103,132,147,159,173,200],"the":[8,23,38,46,111,133,139,142,153,156,170,174,181,205],"left":[9],"ventricle":[10],"(LV),":[11],"which":[12],"due":[14],"in":[15,67],"part":[16],"to":[17,37,59,101,119,212],"increased":[18],"LV":[19,41,61,80,84,160,175,213],"wall":[20,42,64,82,113],"stiffness.":[21,43],"In":[22,191],"phase,":[25],"myocytes":[26],"are":[27],"relaxed":[28],"and":[29,63,74,86,115,122,164,177,184,208],"extracellular":[30],"matrix":[31],"(ECM)":[32],"a":[34,56,196],"critical":[35],"determinant":[36],"changes":[39,66],"To":[44],"evaluate":[45],"effects":[47],"ECM":[49],"composition":[50],"on":[51,138],"cardiac":[52,201],"aging,":[53],"we":[54,193],"developed":[55],"mathematical":[57,149,198],"model":[58,107,150,154,199],"predict":[60],"dimension":[62],"stiffness":[65],"mice":[69,94],"integrating":[71],"mechanical":[72],"laws":[73],"our":[75,188],"experimental":[76,167,189],"results.":[77,168,190],"We":[78],"measured":[79],"dimension,":[81],"thickness,":[83],"mass,":[85],"collagen":[87],"content":[88],"for":[89],"wild":[90],"type":[91],"(WT)":[92],"C57/BL6J":[93],"ages":[96],"ranging":[97],"from":[98,141],"7.3":[99],"months":[100],"those":[102],"34.0":[104],"months.":[105],"The":[106,129],"was":[108],"established":[109],"using":[110],"thick":[112],"theory":[114,207],"stretch-induced":[116,209],"tissue":[117,210],"growth":[118,211],"an":[120],"isotropic":[121],"homogeneous":[123],"elastic":[124],"composite":[125],"with":[126,162,215],"mixed":[127],"constituents.":[128],"initial":[130],"conditions":[131],"simulation":[134],"were":[135],"set":[136],"based":[137],"data":[140],"young":[143],"mice.":[144],"Matlab":[145],"simulations":[146],"this":[148],"demonstrated":[151,180],"that":[152,203],"captured":[155],"major":[157],"features":[158],"remodeling":[161,214],"age":[163],"closely":[165],"approximated":[166],"Specifically,":[169],"temporal":[171],"progression":[172],"interior":[176],"exterior":[178],"dimensions":[179],"same":[182],"trend":[183],"order-of-magnitude":[185],"change":[186],"as":[187],"conclusion,":[192],"present":[194],"here":[195],"validated":[197],"applies":[204],"thick-wall":[206],"age.":[216]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}