{"id":"https://openalex.org/W2068320203","doi":"https://doi.org/10.1186/1752-0509-6-s1-s5","title":"The drug cocktail network","display_name":"The drug cocktail network","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2068320203","doi":"https://doi.org/10.1186/1752-0509-6-s1-s5","mag":"2068320203","pmid":"https://pubmed.ncbi.nlm.nih.gov/23046711"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-6-s1-s5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-s1-s5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S1-S5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S1-S5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064726881","display_name":"Kejia Xu","orcid":"https://orcid.org/0009-0001-1659-4363"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I4210150558","display_name":"Shanghai Research Institute of Materials","ror":"https://ror.org/04sbx8232","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210150558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke-Jia Xu","raw_affiliation_strings":["Institute of Systems Biology, Shanghai University, Shanghai, China. zhaoxingming@gmail.com","Institute of Systems Biology, Shanghai University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Systems Biology, Shanghai University, Shanghai, China. zhaoxingming@gmail.com","institution_ids":["https://openalex.org/I4210150558"]},{"raw_affiliation_string":"Institute of Systems Biology, Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012709797","display_name":"Jiangning Song","orcid":"https://orcid.org/0000-0001-8031-9086"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210139473","display_name":"Tianjin Institute of Industrial Biotechnology","ror":"https://ror.org/042pyga86","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210139473"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","CN"],"is_corresponding":false,"raw_author_name":"Jiangning Song","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Medicine, Monash University, Melbourne, VIC 3800, Australia","National Engineering Laboratory for Industrial Enzymes and Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China","National Engineering Laboratory for Industrial Enzymes and Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China","Department of Biochemistry and Molecular Biology, Faculty of Medicine, Monash University, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, Monash University, Melbourne, VIC 3800, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"National Engineering Laboratory for Industrial Enzymes and Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210139473"]},{"raw_affiliation_string":"National Engineering Laboratory for Industrial Enzymes and Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210139473"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, Monash University, Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049435754","display_name":"Xing\u2010Ming Zhao","orcid":"https://orcid.org/0000-0002-4531-3970"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xing-Ming Zhao","raw_affiliation_strings":["Institute of Systems Biology, Shanghai University, Shanghai, 200444, China","Institute of Systems Biology, Shanghai University, Shanghai\u00a0, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Systems Biology, Shanghai University, Shanghai, 200444, China","institution_ids":["https://openalex.org/I113940042"]},{"raw_affiliation_string":"Institute of Systems Biology, Shanghai University, Shanghai\u00a0, China","institution_ids":["https://openalex.org/I113940042"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5049435754"],"corresponding_institution_ids":["https://openalex.org/I113940042"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":3.5583,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.93003851,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"6","issue":"S1","first_page":"S5","last_page":"S5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9632999897003174,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9632999897003174,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6025524735450745},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5373806953430176},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.495206743478775},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3382570743560791}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6025524735450745},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5373806953430176},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.495206743478775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3382570743560791}],"mesh":[{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-6-s1-s5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-s1-s5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S1-S5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:23046711","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23046711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:9b34dd9b415b428d98acc02a4b3162a2","is_oa":false,"landing_page_url":"https://doaj.org/article/9b34dd9b415b428d98acc02a4b3162a2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 6, Iss Suppl 1, p S5 (2012)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2408522","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3403482","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-6-s1-s5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-s1-s5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-S1-S5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3440752333","display_name":null,"funder_award_id":"91130032","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G3491903578","display_name":"\u57fa\u4e8e\u591a\u6e90\u6570\u636e\u6574\u5408\u7684\u836f\u7269\u7ec4\u5408\u9884\u6d4b\u65b9\u6cd5\u7814\u7a76","funder_award_id":"61103075","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G505025389","display_name":null,"funder_award_id":"61103075","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G5737903045","display_name":null,"funder_award_id":"91130032","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"},{"id":"https://openalex.org/F4320327803","display_name":"Shanghai Rising-Star Program","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2068320203.pdf","grobid_xml":"https://content.openalex.org/works/W2068320203.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1916504364","https://openalex.org/W1965482421","https://openalex.org/W1980482640","https://openalex.org/W1997533142","https://openalex.org/W2008598398","https://openalex.org/W2009313526","https://openalex.org/W2010601590","https://openalex.org/W2020738281","https://openalex.org/W2022192839","https://openalex.org/W2024302667","https://openalex.org/W2027155618","https://openalex.org/W2031506666","https://openalex.org/W2038465199","https://openalex.org/W2044025814","https://openalex.org/W2049792735","https://openalex.org/W2050343160","https://openalex.org/W2056354857","https://openalex.org/W2070775961","https://openalex.org/W2098161468","https://openalex.org/W2103736926","https://openalex.org/W2105536900","https://openalex.org/W2107046691","https://openalex.org/W2109322740","https://openalex.org/W2110095004","https://openalex.org/W2113613985","https://openalex.org/W2119617160","https://openalex.org/W2122082921","https://openalex.org/W2123519683","https://openalex.org/W2137959503","https://openalex.org/W2138275182","https://openalex.org/W2138427043","https://openalex.org/W2140595402","https://openalex.org/W2141053481","https://openalex.org/W2146384083","https://openalex.org/W2148606196","https://openalex.org/W2149754404","https://openalex.org/W2149908785","https://openalex.org/W2156737316","https://openalex.org/W2158698691","https://openalex.org/W2160261947","https://openalex.org/W2163480486","https://openalex.org/W2165863045","https://openalex.org/W2171692650","https://openalex.org/W2404828650","https://openalex.org/W2412802950"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W5284979","https://openalex.org/W4245853730"],"abstract_inverted_index":{"BACKGROUND:":[0],"Combination":[1,72,120],"of":[2,24,37,132,156,162,182,195],"different":[3],"agents":[4,89],"is":[5],"widely":[6],"used":[7],"in":[8,90,172],"clinic":[9],"to":[10,33,47,80,95,122,190],"combat":[11],"complex":[12],"diseases":[13],"with":[14],"improved":[15],"therapy":[16],"and":[17,75,101,186],"reduced":[18],"side":[19],"effects.":[20],"However,":[21],"the":[22,34,63,70,88,129,133,139,145,150,159,179,192],"identification":[23],"effective":[25,65,92,183],"drug":[26,66,82,125,134,141,168,184,197],"combinations":[27,39,67,126,185],"remains":[28],"a":[29,57,77,113],"challenging":[30],"task":[31],"due":[32],"huge":[35],"number":[36],"possible":[38,124],"among":[40],"candidate":[41],"drugs":[42],"that":[43,87],"makes":[44],"it":[45],"impractical":[46],"screen":[48],"putative":[49],"combinations.":[50,83,198],"RESULTS:":[51],"In":[52],"this":[53,173],"work,":[54],"we":[55,110],"construct":[56],"'drug":[58],"cocktail":[59,135,169],"network'":[60],"using":[61],"all":[62],"known":[64,140],"extracted":[68],"from":[69],"Drug":[71],"Database":[73],"(DCDB),":[74],"propose":[76],"network-based":[78],"approach":[79,115],"investigate":[81],"Our":[84],"results":[85],"show":[86],"an":[91],"combination":[93],"tend":[94],"have":[96],"more":[97,103],"similar":[98],"therapeutic":[99],"effects":[100],"share":[102],"interaction":[104],"partners.":[105],"Based":[106],"on":[107,138],"our":[108,163],"observations,":[109],"further":[111],"develop":[112],"statistical":[114],"termed":[116],"as":[117],"DCPred":[118,143],"(Drug":[119],"Predictor)":[121],"predict":[123],"by":[127],"exploiting":[128],"topological":[130],"features":[131],"network.":[136],"Validating":[137],"combinations,":[142],"achieves":[144],"overall":[146],"AUC":[147],"(Area":[148],"Under":[149],"receiver":[151],"operating":[152],"characteristic":[153],"Curve)":[154],"score":[155],"0.92,":[157],"indicating":[158],"predictive":[160],"power":[161],"proposed":[164],"approach.":[165],"CONCLUSIONS:":[166],"The":[167],"network":[170],"constructed":[171],"work":[174],"provides":[175],"useful":[176],"insights":[177],"into":[178],"underlying":[180],"rules":[181],"offer":[187],"important":[188],"clues":[189],"accelerate":[191],"future":[193],"discovery":[194],"new":[196]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4}],"updated_date":"2026-07-25T09:21:30.201066","created_date":"2025-10-10T00:00:00"}
