{"id":"https://openalex.org/W2150071693","doi":"https://doi.org/10.1186/1752-0509-6-72","title":"Integrated pathway modules using time-course metabolic profiles and EST data from Milnesium tardigradum","display_name":"Integrated pathway modules using time-course metabolic profiles and EST data from Milnesium tardigradum","publication_year":2012,"publication_date":"2012-06-19","ids":{"openalex":"https://openalex.org/W2150071693","doi":"https://doi.org/10.1186/1752-0509-6-72","mag":"2150071693","pmid":"https://pubmed.ncbi.nlm.nih.gov/22713133"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-6-72","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-72","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-72","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-72","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043906941","display_name":"Daniela Bei\u00dfer","orcid":"https://orcid.org/0000-0002-0679-6631"},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniela Beisser","raw_affiliation_strings":["Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Am Hubland, W\u00fcrzburg 97074, Germany","Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Am Hubland, W\u00fcrzburg 97074, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037640562","display_name":"Markus A. Grohme","orcid":"https://orcid.org/0000-0002-4250-5600"},"institutions":[{"id":"https://openalex.org/I38517508","display_name":"Technical University of Applied Sciences Wildau","ror":"https://ror.org/00k62pe27","country_code":"DE","type":"education","lineage":["https://openalex.org/I38517508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus A Grohme","raw_affiliation_strings":["Molecular Biotechnology and Functional Genomics, Technical University of Applied Sciences Wildau, Bahnhofstra\u00dfe 1, Wildau, 15745, Germany","Molecular Biotechnology and Functional Genomics, Technical University of Applied Sciences Wildau, Wildau, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biotechnology and Functional Genomics, Technical University of Applied Sciences Wildau, Bahnhofstra\u00dfe 1, Wildau, 15745, Germany","institution_ids":["https://openalex.org/I38517508"]},{"raw_affiliation_string":"Molecular Biotechnology and Functional Genomics, Technical University of Applied Sciences Wildau, Wildau, Germany","institution_ids":["https://openalex.org/I38517508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073438755","display_name":"Joachim Kopka","orcid":"https://orcid.org/0000-0001-9675-4883"},"institutions":[{"id":"https://openalex.org/I4210105972","display_name":"Max Planck Institute of Molecular Plant Physiology","ror":"https://ror.org/01fbde567","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210105972"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim Kopka","raw_affiliation_strings":["Department of Molecular Physiology, Max-Planck-Institute of Molecular Plant Physiology, Potsdam-Golm, Brandenburg, Germany","Department of Molecular Physiology, Max-Planck-Institute of Molecular Plant Physiology, Potsdam-Golm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology, Max-Planck-Institute of Molecular Plant Physiology, Potsdam-Golm, Brandenburg, Germany","institution_ids":["https://openalex.org/I4210105972"]},{"raw_affiliation_string":"Department of Molecular Physiology, Max-Planck-Institute of Molecular Plant Physiology, Potsdam-Golm, Germany","institution_ids":["https://openalex.org/I4210105972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026608305","display_name":"Marcus Frohme","orcid":"https://orcid.org/0000-0001-9063-2682"},"institutions":[{"id":"https://openalex.org/I38517508","display_name":"Technical University of Applied Sciences Wildau","ror":"https://ror.org/00k62pe27","country_code":"DE","type":"education","lineage":["https://openalex.org/I38517508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcus Frohme","raw_affiliation_strings":["Molecular Biotechnology and Functional Genomics, Technical University of Applied Sciences Wildau, Bahnhofstra\u00dfe 1, Wildau, 15745, Germany","Molecular Biotechnology and Functional Genomics, Technical University of Applied Sciences Wildau, Wildau, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biotechnology and Functional Genomics, Technical University of Applied Sciences Wildau, Bahnhofstra\u00dfe 1, Wildau, 15745, Germany","institution_ids":["https://openalex.org/I38517508"]},{"raw_affiliation_string":"Molecular Biotechnology and Functional Genomics, Technical University of Applied Sciences Wildau, Wildau, Germany","institution_ids":["https://openalex.org/I38517508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023293164","display_name":"Ralph O. Schill","orcid":"https://orcid.org/0000-0002-7930-5282"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralph O Schill","raw_affiliation_strings":["Department of Zoology, Biological Institute, University of Stuttgart, Pfaffenwaldring 57, Stuttgart, 70569, Germany","Department of Zoology, Biological Institute, University of Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Biological Institute, University of Stuttgart, Pfaffenwaldring 57, Stuttgart, 70569, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"Department of Zoology, Biological Institute, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009802086","display_name":"Steffen Hengherr","orcid":null},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Hengherr","raw_affiliation_strings":["Department of Zoology, Biological Institute, University of Stuttgart, Pfaffenwaldring 57, Stuttgart, 70569, Germany","Department of Zoology, Biological Institute, University of Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Biological Institute, University of Stuttgart, Pfaffenwaldring 57, Stuttgart, 70569, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"Department of Zoology, Biological Institute, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086202312","display_name":"Thomas Dandekar","orcid":"https://orcid.org/0000-0003-1886-7625"},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Dandekar","raw_affiliation_strings":["Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Am Hubland, W\u00fcrzburg, 97074, Germany","Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Am Hubland, W\u00fcrzburg, 97074, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029642674","display_name":"Gunnar W. Klau","orcid":"https://orcid.org/0000-0002-6340-0090"},"institutions":[{"id":"https://openalex.org/I1341640284","display_name":"Centrum Wiskunde & Informatica","ror":"https://ror.org/00x7ekv49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1341640284","https://openalex.org/I2800991832","https://openalex.org/I4405262988"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gunnar W Klau","raw_affiliation_strings":["Life Sciences group, CWI, Science Park 123, Amsterdam, 1098, XG, the Netherlands","Netherlands Institute for Systems Biology, Amsterdam, the Netherlands","Life Sciences group, CWI, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences group, CWI, Science Park 123, Amsterdam, 1098, XG, the Netherlands","institution_ids":["https://openalex.org/I1341640284"]},{"raw_affiliation_string":"Netherlands Institute for Systems Biology, Amsterdam, the Netherlands","institution_ids":[]},{"raw_affiliation_string":"Life Sciences group, CWI, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I1341640284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070610653","display_name":"Marcus Dittrich","orcid":"https://orcid.org/0000-0002-7726-5491"},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Marcus Dittrich","raw_affiliation_strings":["Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Am Hubland, W\u00fcrzburg, 97074, Germany","Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Am Hubland, W\u00fcrzburg, 97074, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078146941","display_name":"Tobias M\u00fcller","orcid":"https://orcid.org/0000-0003-3035-7070"},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Tobias M\u00fcller","raw_affiliation_strings":["Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Am Hubland, W\u00fcrzburg, 97074, Germany","Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, Am Hubland, W\u00fcrzburg, 97074, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Department of Bioinformatics, Biocenter, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5070610653","https://openalex.org/A5078146941"],"corresponding_institution_ids":["https://openalex.org/I25974101"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":1309,"currency":"EUR","value_usd":1411},"fwci":3.2003,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.91550996,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"72","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13679","display_name":"Tardigrade Biology and Ecology","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13679","display_name":"Tardigrade Biology and Ecology","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12180","display_name":"Polar Research and Ecology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12561","display_name":"bioluminescence and chemiluminescence research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.6215391159057617},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.5694430470466614},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5564097166061401},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5477015376091003},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.5424994826316833},{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.5371658802032471},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.5248986482620239},{"id":"https://openalex.org/keywords/tardigrade","display_name":"Tardigrade","score":0.496284544467926},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.2970418334007263},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.252864271402359},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2474249303340912},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15325477719306946}],"concepts":[{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.6215391159057617},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5694430470466614},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5564097166061401},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5477015376091003},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5424994826316833},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5371658802032471},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.5248986482620239},{"id":"https://openalex.org/C2777895711","wikidata":"https://www.wikidata.org/wiki/Q5194","display_name":"Tardigrade","level":2,"score":0.496284544467926},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2970418334007263},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.252864271402359},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2474249303340912},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15325477719306946},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020224","descriptor_name":"Expressed Sequence Tags","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020224","descriptor_name":"Expressed Sequence Tags","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020224","descriptor_name":"Expressed Sequence Tags","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058467","descriptor_name":"Tardigrada","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058467","descriptor_name":"Tardigrada","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058467","descriptor_name":"Tardigrada","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058467","descriptor_name":"Tardigrada","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058467","descriptor_name":"Tardigrada","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058467","descriptor_name":"Tardigrada","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058467","descriptor_name":"Tardigrada","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D058467","descriptor_name":"Tardigrada","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D058467","descriptor_name":"Tardigrada","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1186/1752-0509-6-72","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-72","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-72","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:22713133","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22713133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:research.vu.nl:openaire_cris_publications/d7fbd1cb-61ed-4283-9d8f-cfc4fc9d9582","is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/d7fbd1cb-61ed-4283-9d8f-cfc4fc9d9582","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Beisser, D, Grohme, M, Kopka, J, Frohme, M, Schill, R O, Hengherr, S, Dandekar, T, Klau, G W, Dittrich, M & M\u00fcller, T 2012, 'Integrated pathway modules using time-course metabolic profiles and EST data from Milnesium tardigradum', BMC Systems Biology, vol. 6, no. 72. https://doi.org/10.1186/1752-0509-6-72","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:cwi.nl:20842","is_oa":true,"landing_page_url":"https://ir.cwi.nl/pub/20842/Fulltext","pdf_url":"https://link.springer.com/content/pdf/10.1186/1752-0509-6-72.pdf","source":{"id":"https://openalex.org/S7407055335","display_name":"Centrum Wiskunde & Informatica (CWI), the national research institute for mathematics and computer science in the Netherlands","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology vol. 6 no. 72","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:cwi:oai:cwi.nl:20842","is_oa":true,"landing_page_url":"https://ir.cwi.nl/pub/20842","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, 6(72)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dare.ubvu.vu.nl:1871/40625","is_oa":false,"landing_page_url":"http://hdl.handle.net/1871/40625","pdf_url":null,"source":{"id":"https://openalex.org/S4306400546","display_name":"Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"6","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:europepmc.org:2537017","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3534414","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:kobv.de-opus4-th-wildau:614","is_oa":true,"landing_page_url":"https://opus4.kobv.de/opus4-th-wildau/frontdoor/index/index/docId/614","pdf_url":null,"source":{"id":"https://openalex.org/S4306400195","display_name":"TH Wildau (Technical University of Applied Sciences Wildau)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I38517508","host_organization_name":"Technical University of Applied Sciences Wildau","host_organization_lineage":["https://openalex.org/I38517508"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, 6, 72, S. 13","raw_type":"article"},{"id":"pmh:oai:opus.bibliothek.uni-wuerzburg.de:6482","is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-75241","pdf_url":null,"source":{"id":"https://openalex.org/S4306401635","display_name":"Online Publication Service of W\u00fcrzburg University (W\u00fcrzburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I25974101","host_organization_name":"University of W\u00fcrzburg","host_organization_lineage":["https://openalex.org/I25974101"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3534414","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3534414","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:pure.mpg.de:item_1814620","is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0014-2041-C","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-6-72","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-72","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-72","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Clean water and sanitation","score":0.6899999976158142,"id":"https://metadata.un.org/sdg/6"}],"awards":[{"id":"https://openalex.org/G1227171063","display_name":null,"funder_award_id":"0313838A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2150071693.pdf","grobid_xml":"https://content.openalex.org/works/W2150071693.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W145473912","https://openalex.org/W229097380","https://openalex.org/W1548566755","https://openalex.org/W1549912426","https://openalex.org/W1577950817","https://openalex.org/W1601296974","https://openalex.org/W1876024155","https://openalex.org/W1952732372","https://openalex.org/W1971411881","https://openalex.org/W1974948854","https://openalex.org/W1981428755","https://openalex.org/W1998281337","https://openalex.org/W1999817835","https://openalex.org/W2003652380","https://openalex.org/W2013191289","https://openalex.org/W2017578869","https://openalex.org/W2019706321","https://openalex.org/W2028097346","https://openalex.org/W2028561804","https://openalex.org/W2031136928","https://openalex.org/W2050241533","https://openalex.org/W2051198735","https://openalex.org/W2066581808","https://openalex.org/W2075627332","https://openalex.org/W2093960934","https://openalex.org/W2098824895","https://openalex.org/W2100625056","https://openalex.org/W2101196698","https://openalex.org/W2103017472","https://openalex.org/W2103795997","https://openalex.org/W2104843251","https://openalex.org/W2112811019","https://openalex.org/W2116967350","https://openalex.org/W2117310472","https://openalex.org/W2119366102","https://openalex.org/W2119923823","https://openalex.org/W2121016876","https://openalex.org/W2128572161","https://openalex.org/W2130147841","https://openalex.org/W2133579817","https://openalex.org/W2138255346","https://openalex.org/W2140954822","https://openalex.org/W2141577802","https://openalex.org/W2143891630","https://openalex.org/W2148533374","https://openalex.org/W2154061034","https://openalex.org/W2156125289","https://openalex.org/W2159482845","https://openalex.org/W2160697532","https://openalex.org/W2163250554","https://openalex.org/W2165879750","https://openalex.org/W2168617775","https://openalex.org/W2171662214","https://openalex.org/W2174357777","https://openalex.org/W4241202476","https://openalex.org/W4285719527","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W3084209502","https://openalex.org/W1988419672","https://openalex.org/W2799517538","https://openalex.org/W4288069755","https://openalex.org/W1854805732","https://openalex.org/W1969539025","https://openalex.org/W2063475537","https://openalex.org/W2341681417","https://openalex.org/W1961707331","https://openalex.org/W3180007124"],"abstract_inverted_index":{"BACKGROUND:":[0],"Tardigrades":[1,35],"are":[2,36,46,92,178,193],"multicellular":[3],"organisms,":[4],"resistant":[5],"to":[6,26,29,39,68,110,143,180,196,327],"extreme":[7,122],"environmental":[8],"changes":[9,112,217,234],"such":[10,43,269],"as":[11,162,270,284],"heat,":[12],"drought,":[13],"radiation":[14],"and":[15,32,45,75,100,116,152,170,224,238,254,267,273,279,286,302,304,315,332],"freezing.":[16],"They":[17],"outlast":[18],"these":[19],"conditions":[20],"in":[21,82,113,218,230,235,335],"an":[22,163],"inactive":[23,101],"form":[24],"(tun)":[25],"escape":[27],"damage":[28,44],"cellular":[30,280],"structures":[31],"cell":[33],"death.":[34],"apparently":[37],"able":[38],"prevent":[40],"or":[41],"repair":[42],"therefore":[47],"a":[48,83,133,157,186,210,249,336],"crucial":[49],"model":[50],"organism":[51],"for":[52,120,137,222],"stress":[53],"tolerance.":[54],"Cultures":[55],"of":[56,105,140,146,215,248,264,276],"the":[57,65,76,98,138,150,182,201,242,246,259,262,274,319],"tardigrade":[58,114],"Milnesium":[59],"tardigradum":[60],"were":[61,80],"dehydrated":[62],"by":[63,86],"removing":[64],"surrounding":[66],"water":[67],"induce":[69],"tun":[70,260],"formation.":[71],"During":[72],"this":[73,106,129,205],"process":[74],"subsequent":[77],"rehydration,":[78],"metabolites":[79,266,299],"measured":[81],"time":[84],"series":[85],"GC-MS.":[87],"Additionally":[88],"expressed":[89],"sequence":[90],"tags":[91],"available,":[93,318],"especially":[94],"libraries":[95],"generated":[96],"from":[97,200,282],"active":[99],"state.":[102],"The":[103,191,226,292],"aim":[104],"integrated":[107,321],"analysis":[108,139],"is":[109,228,325],"trace":[111],"metabolism":[115,251],"identify":[117,144,209],"pathways":[118],"responsible":[119],"their":[121],"resistance":[123],"against":[124],"physical":[125],"stress.":[126],"RESULTS:":[127],"In":[128],"study":[130],"we":[131,208],"propose":[132],"novel":[134],"integrative":[135],"approach":[136,324],"metabolic":[141,153,159,219,311],"networks":[142],"modules":[145],"joint":[147],"shifts":[148],"on":[149,198],"transcriptomic":[151],"levels.":[154],"We":[155],"derive":[156],"tardigrade-specific":[158],"network":[160,183,323],"represented":[161],"undirected":[164],"graph":[165],"with":[166],"3,658":[167],"nodes":[168,184],"(metabolites)":[169],"4,378":[171],"edges":[172,192],"(reactions).":[173],"Time":[174],"course":[175],"metabolite":[176,236,322],"profiles":[177],"used":[179],"score":[181],"showing":[185,232],"significant":[187,233],"change":[188],"over":[189],"time.":[190],"scored":[194],"according":[195],"information":[197],"enzymes":[199],"EST":[202],"data.":[203],"Using":[204],"combined":[206,337],"information,":[207],"key":[211],"subnetwork":[212],"(functional":[213],"module)":[214],"concerted":[216],"pathways,":[220],"specific":[221],"de-":[223],"rehydration.":[225,290],"module":[227,294],"enriched":[229],"reactions":[231,303],"levels":[237],"enzyme":[239],"abundance":[240],"during":[241,258,289],"transition.":[243],"It":[244],"resembles":[245],"cessation":[247],"measurable":[250],"(e.g.":[252,300],"glycolysis":[253],"amino":[255,277],"acid":[256],"anabolism)":[257],"formation,":[261],"production":[263],"storage":[265],"bioprotectants,":[268],"DNA":[271],"stabilizers,":[272],"generation":[275],"acids":[278],"components":[281],"monosaccharides":[283],"carbon":[285],"energy":[287],"source":[288],"CONCLUSIONS:":[291],"functional":[293],"identifies":[295],"relationships":[296],"among":[297],"changed":[298],"spermidine)":[301],"provides":[305],"first":[306],"insights":[307],"into":[308],"important":[309],"altered":[310],"pathways.":[312],"With":[313],"sparse":[314],"diverse":[316],"data":[317,331],"presented":[320],"suitable":[326],"integrate":[328],"all":[329],"existing":[330],"analyse":[333],"it":[334],"manner.":[338]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}
