{"id":"https://openalex.org/W2004351228","doi":"https://doi.org/10.1186/1752-0509-6-7","title":"Evolvability of feed-forward loop architecture biases its abundance in transcription networks","display_name":"Evolvability of feed-forward loop architecture biases its abundance in transcription networks","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2004351228","doi":"https://doi.org/10.1186/1752-0509-6-7","mag":"2004351228","pmid":"https://pubmed.ncbi.nlm.nih.gov/22260237"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-6-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-7","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-7","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073288820","display_name":"Stefanie Widder","orcid":"https://orcid.org/0000-0003-0733-5666"},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I2801864671","display_name":"Barcelona Biomedical Research Park","ror":"https://ror.org/05sajct49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801864671"]},{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]}],"countries":["AT","ES"],"is_corresponding":true,"raw_author_name":"Stefanie Widder","raw_affiliation_strings":["Department for Computational Systems Biology, University of Vienna, Althanstr, 14, A-1090 Vienna, Austria. stefanie.widder@univie.ac.at","Department for Computational Systems Biology, University of Vienna, Vienna, Austria","Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Computational Systems Biology, University of Vienna, Althanstr, 14, A-1090 Vienna, Austria. stefanie.widder@univie.ac.at","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Department for Computational Systems Biology, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Barcelona, Spain","institution_ids":["https://openalex.org/I2801864671","https://openalex.org/I11932220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046878011","display_name":"Ricard V. Sol\u00e9","orcid":"https://orcid.org/0000-0001-6974-1008"},"institutions":[{"id":"https://openalex.org/I2801864671","display_name":"Barcelona Biomedical Research Park","ror":"https://ror.org/05sajct49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801864671"]},{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"funder","lineage":["https://openalex.org/I1308548392"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Ricard Sol\u00e9","raw_affiliation_strings":["Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Dr. Aiguader 88, 08003, Barcelona, Spain","Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM, 87501, USA","Santa Fe Institute, , USA","Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Dr. Aiguader 88, 08003, Barcelona, Spain","institution_ids":["https://openalex.org/I2801864671","https://openalex.org/I11932220"]},{"raw_affiliation_string":"Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM, 87501, USA","institution_ids":["https://openalex.org/I1308548392"]},{"raw_affiliation_string":"Santa Fe Institute, , USA","institution_ids":["https://openalex.org/I1308548392"]},{"raw_affiliation_string":"Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Barcelona, Spain","institution_ids":["https://openalex.org/I2801864671","https://openalex.org/I11932220"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080642556","display_name":"Javier Mac\u00eda","orcid":"https://orcid.org/0000-0002-6705-5554"},"institutions":[{"id":"https://openalex.org/I2801864671","display_name":"Barcelona Biomedical Research Park","ror":"https://ror.org/05sajct49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801864671"]},{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Mac\u00eda","raw_affiliation_strings":["Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Dr. Aiguader 88, 08003, Barcelona, Spain","Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Dr. Aiguader 88, 08003, Barcelona, Spain","institution_ids":["https://openalex.org/I2801864671","https://openalex.org/I11932220"]},{"raw_affiliation_string":"Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB), Barcelona, Spain","institution_ids":["https://openalex.org/I2801864671","https://openalex.org/I11932220"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073288820"],"corresponding_institution_ids":["https://openalex.org/I11932220","https://openalex.org/I129774422","https://openalex.org/I2801864671"],"apc_list":null,"apc_paid":null,"fwci":1.6124,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.82361666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"6","issue":"1","first_page":"7","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.90420001745224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.90420001745224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.07180000096559525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/evolvability","display_name":"Evolvability","score":0.8486318588256836},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5691219568252563},{"id":"https://openalex.org/keywords/motif","display_name":"Motif (music)","score":0.5210113525390625},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5190787315368652},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.47070619463920593},{"id":"https://openalex.org/keywords/kurtosis","display_name":"Kurtosis","score":0.46535807847976685},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.4495096802711487},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38301122188568115},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3189952075481415},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2936926484107971},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1411999762058258},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1373043954372406},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.12224262952804565},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.09425416588783264}],"concepts":[{"id":"https://openalex.org/C176147130","wikidata":"https://www.wikidata.org/wiki/Q909622","display_name":"Evolvability","level":2,"score":0.8486318588256836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5691219568252563},{"id":"https://openalex.org/C32276052","wikidata":"https://www.wikidata.org/wiki/Q908349","display_name":"Motif (music)","level":2,"score":0.5210113525390625},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5190787315368652},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.47070619463920593},{"id":"https://openalex.org/C166963901","wikidata":"https://www.wikidata.org/wiki/Q287251","display_name":"Kurtosis","level":2,"score":0.46535807847976685},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4495096802711487},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38301122188568115},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3189952075481415},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2936926484107971},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1411999762058258},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1373043954372406},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.12224262952804565},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09425416588783264},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016008","descriptor_name":"Statistical Distributions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016008","descriptor_name":"Statistical Distributions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016008","descriptor_name":"Statistical Distributions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-6-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-7","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-7","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:22260237","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22260237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:repositori.upf.edu:10230/23290","is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/23290","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:85184537f9434e759d34e97c658c168b","is_oa":false,"landing_page_url":"https://doaj.org/article/85184537f9434e759d34e97c658c168b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 6, Iss 1, p 7 (2012)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3349539","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3349539","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-6-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-7","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-7","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","score":0.7699999809265137,"id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306183","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19"},{"id":"https://openalex.org/F4320312777","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35"},{"id":"https://openalex.org/F4320321691","display_name":"Universit\u00e4t Wien","ror":"https://ror.org/03prydq77"},{"id":"https://openalex.org/F4320323816","display_name":"Fundaci\u00f3n Bot\u00edn","ror":"https://ror.org/03zefme93"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004351228.pdf","grobid_xml":"https://content.openalex.org/works/W2004351228.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1637936532","https://openalex.org/W1808967201","https://openalex.org/W1966638085","https://openalex.org/W1971985527","https://openalex.org/W1983682811","https://openalex.org/W1987815409","https://openalex.org/W1995875735","https://openalex.org/W1998435329","https://openalex.org/W2038012561","https://openalex.org/W2040177850","https://openalex.org/W2045645277","https://openalex.org/W2049797028","https://openalex.org/W2059044327","https://openalex.org/W2061425021","https://openalex.org/W2064483836","https://openalex.org/W2071495240","https://openalex.org/W2102243804","https://openalex.org/W2105557836","https://openalex.org/W2108350807","https://openalex.org/W2109110326","https://openalex.org/W2109339694","https://openalex.org/W2110699703","https://openalex.org/W2117056464","https://openalex.org/W2122980078","https://openalex.org/W2126074998","https://openalex.org/W2130130653","https://openalex.org/W2140497888","https://openalex.org/W2141327539","https://openalex.org/W2153624566","https://openalex.org/W2162884852","https://openalex.org/W2768658530","https://openalex.org/W3099251374","https://openalex.org/W4229578634","https://openalex.org/W4241088457"],"related_works":["https://openalex.org/W1977516605","https://openalex.org/W1972737244","https://openalex.org/W2979422531","https://openalex.org/W2999329173","https://openalex.org/W4284705248","https://openalex.org/W2000745141","https://openalex.org/W1681307731","https://openalex.org/W3123897949","https://openalex.org/W2900384991","https://openalex.org/W2042702935"],"abstract_inverted_index":{"BACKGROUND:":[0],"Transcription":[1],"networks":[2,56],"define":[3],"the":[4,7,24,46,85,90,94,103,115,123,133,141,145,155,161,172,207,215,220,224,228],"core":[5],"of":[6,10,48,74,80,89,117,135,144,163,171,191,194,198,219],"regulatory":[8,55],"machinery":[9],"cellular":[11],"life":[12],"and":[13,20,36,112,152,201],"are":[14,65],"largely":[15],"responsible":[16],"for":[17,109,132],"information":[18],"processing":[19],"decision":[21],"making.":[22],"At":[23],"small":[25],"scale,":[26],"interaction":[27],"motifs":[28,52,146],"have":[29,41],"been":[30,42],"characterized":[31],"based":[32],"on":[33],"their":[34,164],"abundance":[35,47,125,156,169,229],"some":[37,61],"seemingly":[38],"general":[39],"patterns":[40],"described.":[43],"In":[44],"particular,":[45],"different":[49],"feed-forward":[50,91,173],"loop":[51,92,174],"in":[53,97,150,189],"gene":[54],"displays":[57],"systematic":[58],"biases":[59],"towards":[60],"particular":[62],"topologies,":[63],"which":[64],"much":[66],"more":[67],"common":[68],"than":[69],"others.":[70],"The":[71,167],"causative":[72],"process":[73],"this":[75],"pattern":[76,157,170],"is":[77,128,158,184,203,212],"still":[78],"matter":[79],"debate.":[81],"RESULTS:":[82],"We":[83,101],"analyzed":[84],"entire":[86],"motif-function":[87],"landscape":[88],"using":[93],"formalism":[95],"developed":[96],"a":[98,129,196],"previous":[99],"work.":[100],"evaluated":[102],"probabilities":[104],"to":[105,186,206],"implement":[106],"possible":[107,199],"functions":[108,200],"each":[110,187],"motif":[111,188,221],"found":[113],"that":[114,154],"kurtosis":[116],"these":[118],"distributions":[119],"correlate":[120],"well":[121],"with":[122],"natural":[124,168],"pattern.":[126,230],"Kurtosis":[127],"standard":[130],"measure":[131],"peakedness":[134],"probability":[136],"distributions.":[137],"Furthermore,":[138],"we":[139],"examined":[140],"functional":[142],"robustness":[143],"facing":[147],"mutational":[148],"pressure":[149],"silico":[151],"observed":[153],"biased":[159],"by":[160],"degree":[162],"evolvability.":[165,209],"CONCLUSIONS:":[166],"can":[175],"be":[176],"reconstructed":[177],"concerning":[178],"its":[179,192],"intrinsic":[180],"plasticity.":[181],"Intrinsic":[182],"plasticity":[183],"associated":[185],"terms":[190],"capacity":[193],"implementing":[195],"repertoire":[197],"it":[202],"directly":[204],"linked":[205],"motif's":[208],"Since":[210],"evolvability":[211],"defined":[213],"as":[214],"potential":[216],"phenotypic":[217],"variation":[218],"upon":[222],"mutation,":[223],"link":[225],"plausibly":[226],"explains":[227]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}