{"id":"https://openalex.org/W2115559271","doi":"https://doi.org/10.1186/1752-0509-6-55","title":"Yeast 5 \u2013 an expanded reconstruction of the Saccharomyces cerevisiae metabolic network","display_name":"Yeast 5 \u2013 an expanded reconstruction of the Saccharomyces cerevisiae metabolic network","publication_year":2012,"publication_date":"2012-06-04","ids":{"openalex":"https://openalex.org/W2115559271","doi":"https://doi.org/10.1186/1752-0509-6-55","mag":"2115559271","pmid":"https://pubmed.ncbi.nlm.nih.gov/22663945"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-6-55","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-55","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-55","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-55","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022865164","display_name":"Ben Heavner","orcid":"https://orcid.org/0000-0003-2898-9044"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin D Heavner","raw_affiliation_strings":["Department of Biological & Environmental Engineering, Cornell University, Ithaca, NY 14853, USA","Department of Biological & Environmental Engineering Cornell University Ithaca NY 14853 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological & Environmental Engineering, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Biological & Environmental Engineering Cornell University Ithaca NY 14853 USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084775701","display_name":"Kieran Smallbone","orcid":"https://orcid.org/0000-0003-2815-7045"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kieran Smallbone","raw_affiliation_strings":["Manchester Centre for Integrative Systems Biology, University of Manchester, Manchester, M1 7DN, UK","Manchester Centre for Integrative Systems Biology, University of Manchester Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Manchester Centre for Integrative Systems Biology, University of Manchester, Manchester, M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Manchester Centre for Integrative Systems Biology, University of Manchester Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067466835","display_name":"Brandon Barker","orcid":"https://orcid.org/0000-0001-5732-9550"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon Barker","raw_affiliation_strings":["Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY, 14853, USA","Department of Biological Statistics and Computational Biology, Cornell University,  Ithaca, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY, 14853, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Biological Statistics and Computational Biology, Cornell University,  Ithaca, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058635802","display_name":"Pedro Mendes","orcid":"https://orcid.org/0000-0001-6507-9168"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pedro Mendes","raw_affiliation_strings":["School of Computer Science, University of Manchester, Manchester, M13 9PL, UK","Sch. of Comput. Sci., Univ. of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, University of Manchester, Manchester, M13 9PL, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Sch. of Comput. Sci., Univ. of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103410799","display_name":"Larry P. Walker","orcid":null},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Larry P Walker","raw_affiliation_strings":["Department of Biological & Environmental Engineering, Cornell University, Ithaca, NY, 14853, USA","Department of Biological and Environmental Engineering Cornell University Ithaca USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological & Environmental Engineering, Cornell University, Ithaca, NY, 14853, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Biological and Environmental Engineering Cornell University Ithaca USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103410799"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":8.9613,"has_fulltext":true,"cited_by_count":144,"citation_normalized_percentile":{"value":0.98725599,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"6","issue":"1","first_page":"55","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9686999917030334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9686999917030334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8171771764755249},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.7696586847305298},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5778334140777588},{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.5413603186607361},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47383981943130493},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.441976398229599},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3282371163368225},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.28657758235931396}],"concepts":[{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.8171771764755249},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.7696586847305298},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5778334140777588},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5413603186607361},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47383981943130493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.441976398229599},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3282371163368225},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28657758235931396}],"mesh":[{"descriptor_ui":"D003299","descriptor_name":"Cooperative Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003299","descriptor_name":"Cooperative Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003299","descriptor_name":"Cooperative Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/1752-0509-6-55","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-55","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-55","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:22663945","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22663945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:eprints.maths.manchester.ac.uk.MIMS.EPrints:1822","is_oa":false,"landing_page_url":"http://eprints.maths.manchester.ac.uk/1822/1/heavner12.pdf","pdf_url":"http://eprints.maths.manchester.ac.uk/1822/1/heavner12.pdf","source":{"id":"https://openalex.org/S4306400452","display_name":"MIMS EPrints (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.maths.manchester.ac.uk.MIMS.EPrints:1859","is_oa":false,"landing_page_url":"http://eprints.maths.manchester.ac.uk/1859/1/heavner12.pdf","pdf_url":"http://eprints.maths.manchester.ac.uk/1859/1/heavner12.pdf","source":{"id":"https://openalex.org/S4306400452","display_name":"MIMS EPrints (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pure.atira.dk:publications/b440b834-b82e-4e3d-8eca-3332deb3a685","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/b440b834-b82e-4e3d-8eca-3332deb3a685","pdf_url":"http://www.biomedcentral.com/1752-0509/6/55","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heavner, B D, Smallbone, K, Barker, B, Mendes, P & Walker, L P 2012, 'Yeast 5 - an expanded reconstruction of the Saccharomyces cerevisiae metabolic network', BMC Systems Biology, vol. 6, 55. https://doi.org/10.1186/1752-0509-6-55","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:2418743","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3413506","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.259.7728","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.259.7728","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://eprints.ma.man.ac.uk/1859/01/covered/MIMS_ep2012_51.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-6-55","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-55","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-55","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2225772532","display_name":null,"funder_award_id":"BB/C008219/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2285713050","display_name":null,"funder_award_id":"BBC0082191","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8105896295","display_name":null,"funder_award_id":"201142","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2115559271.pdf","grobid_xml":"https://content.openalex.org/works/W2115559271.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1502953167","https://openalex.org/W1513592816","https://openalex.org/W1797657318","https://openalex.org/W1857179438","https://openalex.org/W1967711052","https://openalex.org/W1984954439","https://openalex.org/W1990234437","https://openalex.org/W1992306474","https://openalex.org/W1994134392","https://openalex.org/W1996529795","https://openalex.org/W2008609077","https://openalex.org/W2015946597","https://openalex.org/W2016283094","https://openalex.org/W2030776070","https://openalex.org/W2033377040","https://openalex.org/W2036070421","https://openalex.org/W2047632644","https://openalex.org/W2048214825","https://openalex.org/W2054719673","https://openalex.org/W2056365020","https://openalex.org/W2056455864","https://openalex.org/W2060595118","https://openalex.org/W2065181342","https://openalex.org/W2073881372","https://openalex.org/W2080461503","https://openalex.org/W2085993965","https://openalex.org/W2092838569","https://openalex.org/W2096245011","https://openalex.org/W2102944388","https://openalex.org/W2103328552","https://openalex.org/W2106104636","https://openalex.org/W2120428260","https://openalex.org/W2126175129","https://openalex.org/W2128572161","https://openalex.org/W2129536243","https://openalex.org/W2132757418","https://openalex.org/W2133510724","https://openalex.org/W2133522799","https://openalex.org/W2133809942","https://openalex.org/W2137128504","https://openalex.org/W2140948740","https://openalex.org/W2147472054","https://openalex.org/W2150908245","https://openalex.org/W2154109757","https://openalex.org/W2155331065","https://openalex.org/W2162471251","https://openalex.org/W2171437346","https://openalex.org/W2189459442","https://openalex.org/W2505356828","https://openalex.org/W3215028400"],"related_works":["https://openalex.org/W4315558101","https://openalex.org/W261727187","https://openalex.org/W4240624121","https://openalex.org/W3200271510","https://openalex.org/W2028107853","https://openalex.org/W1982584572","https://openalex.org/W4232406862","https://openalex.org/W2397070560","https://openalex.org/W5284979","https://openalex.org/W4245853730"],"abstract_inverted_index":{"BACKGROUND:":[0],"Efforts":[1],"to":[2,15,55,71,194,201,317],"improve":[3],"the":[4,8,17,33,56,114,119,132,151,163,196,222,250,258,277,280,285,319],"computational":[5,251],"reconstruction":[6,29,75,135,252,283],"of":[7,69,85,95,153,156,165,224,253,261],"Saccharomyces":[9],"cerevisiae":[10],"biochemical":[11,80,105,115],"reaction":[12],"network":[13],"and":[14,79,107,130,136,158,161,179,200,210,242,248,256,273,284,289,297,301,326],"refine":[16],"stoichiometrically":[18,35,137,226,263,286],"constrained":[19,36,138,227,264,287],"metabolic":[20,40,229,266,282],"models":[21,90,230,274],"that":[22],"can":[23],"be":[24],"derived":[25],"from":[26,104,270],"such":[27,206],"a":[28,67,73,93,144,184,262],"have":[30,51,190],"continued":[31],"since":[32],"first":[34],"yeast":[37,228,254,265,281],"genome":[38],"scale":[39],"model":[41,154,204],"was":[42,142],"published":[43,91],"in":[44,118,124],"2003.":[45],"Continuing":[46],"this":[47,147,313],"ongoing":[48],"process,":[49],"we":[50,189,315],"constructed":[52],"an":[53,171,217],"update":[54,148,169],"Yeast":[57,60,63,111,245],"Consensus":[58,64],"Reconstruction,":[59],"5.":[61],"The":[62],"Reconstruction":[65],"is":[66],"product":[68],"efforts":[70],"forge":[72],"community-based":[74],"emphasizing":[76,276],"standards":[77,174],"compliance":[78],"accuracy":[81,152,199,260],"via":[82],"evidence-based":[83],"selection":[84],"reactions.":[86],"It":[87,268],"draws":[88],"upon":[89],"by":[92,275],"variety":[94],"independent":[96,218],"research":[97],"groups":[98],"as":[99,101,207,237,293,304],"well":[100],"information":[102],"obtained":[103],"databases":[106],"primary":[108,145],"literature.":[109],"RESULTS:":[110],"5":[112,246,300],"refines":[113,249],"reactions":[116,122],"included":[117,236],"reconstruction,":[120],"particularly":[121],"involved":[123],"sphingolipid":[125],"metabolism;":[126],"updates":[127],"gene-reaction":[128],"annotations;":[129],"emphasizes":[131],"distinction":[133,278],"between":[134,279],"model.":[139,267],"Although":[140],"it":[141],"not":[143],"goal,":[146],"also":[149],"improves":[150,257],"prediction":[155],"viability":[157],"auxotrophy":[159],"phenotypes":[160],"increases":[162],"number":[164],"epistatic":[166],"interactions.":[167],"This":[168],"maintains":[170],"emphasis":[172],"on":[173],"compliance,":[175],"unambiguous":[176],"metabolite":[177],"naming,":[178],"computer-readable":[180],"annotations":[181],"available":[182,292],"through":[183],"structured":[185],"document":[186],"format.":[187],"Additionally,":[188],"developed":[191],"MATLAB":[192],"scripts":[193],"evaluate":[195],"model's":[197],"predictive":[198,259],"demonstrate":[202],"basic":[203],"applications":[205],"simulating":[208],"aerobic":[209],"anaerobic":[211],"growth.":[212],"These":[213],"scripts,":[214],"which":[215],"provide":[216],"tool":[219],"for":[220],"evaluating":[221],"performance":[223],"various":[225],"using":[231],"flux":[232],"balance":[233],"analysis,":[234],"are":[235],"Additional":[238,294,298],"files":[239],"1,":[240],"2":[241],"3.":[243],"CONCLUSIONS:":[244],"expands":[247],"metabolism":[255],"differs":[269],"previous":[271],"reconstructions":[272],"model,":[288],"makes":[290],"both":[291],"file":[295,299],"4":[296],"at":[302],"http://yeast.sf.net/":[303],"separate":[305],"systems":[306],"biology":[307],"markup":[308],"language":[309],"(SBML)":[310],"files.":[311],"Through":[312],"separation,":[314],"intend":[316],"make":[318],"modeling":[320],"process":[321],"more":[322],"accessible,":[323],"explicit,":[324],"transparent,":[325],"reproducible.":[327]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":8}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}