{"id":"https://openalex.org/W2006985558","doi":"https://doi.org/10.1186/1752-0509-6-51","title":"Inferring biochemical reaction pathways: the case of the gemcitabine pharmacokinetics","display_name":"Inferring biochemical reaction pathways: the case of the gemcitabine pharmacokinetics","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2006985558","doi":"https://doi.org/10.1186/1752-0509-6-51","mag":"2006985558","pmid":"https://pubmed.ncbi.nlm.nih.gov/22640931"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-6-51","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-51","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-51","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-51","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047664773","display_name":"Paola Lecca","orcid":"https://orcid.org/0000-0002-7224-136X"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I2802934434","display_name":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology","ror":"https://ror.org/04kcgyj43","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1290206253","https://openalex.org/I193223587","https://openalex.org/I2802934434","https://openalex.org/I4210164937"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Lecca","raw_affiliation_strings":["The Microsoft Research - University of Trento Centre for Computational and Systems Biology, 38068 Rovereto, Italy. lecca@cosbi.eu","The Microsoft Research\u2013University of Trento Centre for Computational and Systems Biology, Rovereto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology, 38068 Rovereto, Italy. lecca@cosbi.eu","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]},{"raw_affiliation_string":"The Microsoft Research\u2013University of Trento Centre for Computational and Systems Biology, Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077332010","display_name":"Daniele Morpurgo","orcid":null},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I2802934434","display_name":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology","ror":"https://ror.org/04kcgyj43","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1290206253","https://openalex.org/I193223587","https://openalex.org/I2802934434","https://openalex.org/I4210164937"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniele Morpurgo","raw_affiliation_strings":["The Microsoft Research - University of Trento Centre for Computational and Systems Biology, 38068, Rovereto, Italy","The Microsoft Research\u2013University of Trento Centre for Computational and Systems Biology, Rovereto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology, 38068, Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]},{"raw_affiliation_string":"The Microsoft Research\u2013University of Trento Centre for Computational and Systems Biology, Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070726715","display_name":"Gianluca Fantaccini","orcid":null},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I2802934434","display_name":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology","ror":"https://ror.org/04kcgyj43","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1290206253","https://openalex.org/I193223587","https://openalex.org/I2802934434","https://openalex.org/I4210164937"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Fantaccini","raw_affiliation_strings":["The Microsoft Research - University of Trento Centre for Computational and Systems Biology, 38068, Rovereto, Italy","The Microsoft Research\u2013University of Trento Centre for Computational and Systems Biology, Rovereto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology, 38068, Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]},{"raw_affiliation_string":"The Microsoft Research\u2013University of Trento Centre for Computational and Systems Biology, Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061143197","display_name":"Alessandro Casagrande","orcid":"https://orcid.org/0000-0001-6148-2128"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I2802934434","display_name":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology","ror":"https://ror.org/04kcgyj43","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1290206253","https://openalex.org/I193223587","https://openalex.org/I2802934434","https://openalex.org/I4210164937"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Casagrande","raw_affiliation_strings":["Department of Information Engineering and Computer Science, University of Trento, Trento, Italy","The Microsoft Research - University of Trento Centre for Computational and Systems Biology, 38068, Rovereto, Italy","The Microsoft Research - University of Trento Centre for Computational and Systems Biology, Rovereto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering and Computer Science, University of Trento, Trento, Italy","institution_ids":["https://openalex.org/I193223587"]},{"raw_affiliation_string":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology, 38068, Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]},{"raw_affiliation_string":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology, Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028775661","display_name":"Corrado Priami","orcid":"https://orcid.org/0000-0002-3261-6235"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I2802934434","display_name":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology","ror":"https://ror.org/04kcgyj43","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1290206253","https://openalex.org/I193223587","https://openalex.org/I2802934434","https://openalex.org/I4210164937"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Corrado Priami","raw_affiliation_strings":["Department of Information Engineering and Computer Science, University of Trento, Trento, Italy","The Microsoft Research - University of Trento Centre for Computational and Systems Biology, 38068, Rovereto, Italy","The Microsoft Research - University of Trento Centre for Computational and Systems Biology, Rovereto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering and Computer Science, University of Trento, Trento, Italy","institution_ids":["https://openalex.org/I193223587"]},{"raw_affiliation_string":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology, 38068, Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]},{"raw_affiliation_string":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology, Rovereto, Italy","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0838,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.8670572,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"51","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.351500004529953,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.351500004529953,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.10459999740123749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.06870000064373016,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.8360782861709595},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6527214646339417},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.49794530868530273},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.48717349767684937},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.472231388092041},{"id":"https://openalex.org/keywords/statistical-inference","display_name":"Statistical inference","score":0.4109654426574707},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3402201235294342},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.32868388295173645},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3216645121574402},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.26651573181152344},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.19865238666534424},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.13001057505607605},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12078574299812317}],"concepts":[{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.8360782861709595},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6527214646339417},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.49794530868530273},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.48717349767684937},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.472231388092041},{"id":"https://openalex.org/C134261354","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical inference","level":2,"score":0.4109654426574707},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3402201235294342},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.32868388295173645},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3216645121574402},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.26651573181152344},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19865238666534424},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.13001057505607605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12078574299812317},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1752-0509-6-51","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-51","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-51","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:22640931","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22640931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:iris.unitn.it:11572/91735","is_oa":true,"landing_page_url":"http://hdl.handle.net/11572/91735","pdf_url":"http://www.biomedcentral.com/1752-0509/6/51/abstract","source":{"id":"https://openalex.org/S4306401913","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Trento)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I193223587","host_organization_name":"University of Trento","host_organization_lineage":["https://openalex.org/I193223587"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:alma.39UBZ_INST:11256533850001241","is_oa":true,"landing_page_url":"https://link.springer.com/article/10.1186/1752-0509-6-51","pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"View","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:arpi.unipi.it:11568/881789","is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/881789","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:a305c2ac288d4bde9004c4038ecb9513","is_oa":false,"landing_page_url":"https://doaj.org/article/a305c2ac288d4bde9004c4038ecb9513","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 6, Iss 1, p 51 (2012)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3536593","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3536593","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-6-51","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-51","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-51","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308943","display_name":"Microsoft Research","ror":"https://ror.org/00d0nc645"},{"id":"https://openalex.org/F4320322275","display_name":"Universit\u00e0 degli Studi di Trento","ror":"https://ror.org/05trd4x28"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2006985558.pdf","grobid_xml":"https://content.openalex.org/works/W2006985558.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W28414123","https://openalex.org/W1480376833","https://openalex.org/W1546727052","https://openalex.org/W1554944419","https://openalex.org/W1601975155","https://openalex.org/W1964386634","https://openalex.org/W1977255056","https://openalex.org/W1981054279","https://openalex.org/W1997577150","https://openalex.org/W2011677145","https://openalex.org/W2015796769","https://openalex.org/W2026612931","https://openalex.org/W2027328359","https://openalex.org/W2032324498","https://openalex.org/W2033591223","https://openalex.org/W2040704490","https://openalex.org/W2043508111","https://openalex.org/W2044259495","https://openalex.org/W2060033626","https://openalex.org/W2061901927","https://openalex.org/W2061911199","https://openalex.org/W2067752346","https://openalex.org/W2083691092","https://openalex.org/W2105129830","https://openalex.org/W2112492416","https://openalex.org/W2113330225","https://openalex.org/W2113973513","https://openalex.org/W2125914984","https://openalex.org/W2127979111","https://openalex.org/W2128151805","https://openalex.org/W2131810611","https://openalex.org/W2134208894","https://openalex.org/W2149325066","https://openalex.org/W2152740075","https://openalex.org/W2154090392","https://openalex.org/W2164193797","https://openalex.org/W2169371330","https://openalex.org/W2171074980","https://openalex.org/W3175318380"],"related_works":["https://openalex.org/W2055243143","https://openalex.org/W2062195135","https://openalex.org/W4321636575","https://openalex.org/W1986418932","https://openalex.org/W137830373","https://openalex.org/W3000984192","https://openalex.org/W2103073163","https://openalex.org/W4286952477","https://openalex.org/W4321348134","https://openalex.org/W4387929287"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,149,231,250,329],"representation":[2],"of":[3,13,17,23,45,54,63,71,90,100,106,117,120,130,137,151,163,172,187,191,207,228,242,245,255,257,261,275,285,291,319,322,336],"a":[4,8,98,107,131,178,272,292,295,297],"biochemical":[5,211],"system":[6],"as":[7,314],"network":[9,70,95,119,133,152,195,260],"is":[10,82,97,158,252,309],"the":[11,18,21,32,43,58,61,68,72,87,94,104,110,115,118,128,135,138,161,170,173,185,188,192,210,225,229,238,243,253,258,262,283,286,302,316,320,323,333,337],"precursor":[12],"any":[14],"mathematical":[15,28,101],"model":[16,108,274,304],"processes":[19],"driving":[20],"dynamics":[22],"that":[24],"system.":[25],"Pharmacokinetics":[26],"uses":[27],"models":[29,47],"to":[30,114,169,184,204,223,233,271,332],"describe":[31],"interactions":[33],"between":[34],"drug,":[35],"and":[36,39,41,75,140,176,197,247,289,326,343],"drug":[37,49,55,73,139,293,325],"metabolites":[38,142,279],"targets":[40],"through":[42],"simulation":[44],"these":[46],"predicts":[48],"levels":[50],"and/or":[51],"dynamic":[52],"behaviors":[53],"entities":[56,74],"in":[57,86,155,306],"body.":[59],"Therefore,":[60],"development":[62],"computational":[64],"techniques":[65],"for":[66],"inferring":[67],"interaction":[69,174],"its":[76,141,248,327],"kinetic":[77,189],"parameters":[78,190],"from":[79,109,134,213,278],"observational":[80],"data":[81,112],"raising":[83],"great":[84],"interest":[85],"scientific":[88],"community":[89],"pharmacologists.":[91],"In":[92,122,300],"fact,":[93,301],"inference":[96,129,153,166,196,221,235,268,277,303],"set":[99,254],"procedures":[102],"deducing":[103],"structure":[105],"experimental":[111,216,239],"associated":[113],"nodes":[116],"interactions.":[121],"this":[123,156,307],"paper,":[124],"we":[125],"deal":[126],"with":[127,167,182,294],"pharmacokinetic":[132],"concentrations":[136],"observed":[143],"at":[144,209],"discrete":[145],"time":[146,240,280,317],"points.":[147],"RESULTS:":[148],"method":[150,222],"presented":[154,305],"paper":[157,308],"inspired":[159],"by":[160],"theory":[162],"time-lagged":[164],"correlation":[165,266],"regard":[168,183],"deduction":[171],"network,":[175],"on":[177],"maximum":[179],"likelihood":[180],"approach":[181],"estimation":[186,199],"network.":[193],"Both":[194],"parameter":[198,276],"have":[200],"been":[201],"designed":[202],"specifically":[203],"identify":[205],"systems":[206],"biotransformations,":[208],"level,":[212],"noisy":[214],"time-resolved":[215],"data.":[217],"We":[218],"use":[219],"our":[220,234],"deduce":[224],"metabolic":[226,259],"pathway":[227],"gemcitabine.":[230,263],"inputs":[232],"algorithm":[236],"are":[237],"series":[241,281,318],"concentration":[244],"gemcitabine":[246,338],"metabolites.":[249,328],"output":[251],"reactions":[256],"CONCLUSIONS:":[264],"Time-lagged":[265],"based":[267],"pairs":[269],"up":[270],"probabilistic":[273],"allows":[282],"identification":[284],"microscopic":[287],"pharmacokinetics":[288],"pharmacodynamics":[290],"minimal":[296],"priori":[298],"knowledge.":[299],"completely":[310],"unsupervised.":[311],"It":[312],"takes":[313],"input":[315],"concetrations":[321],"parent":[324],"method,":[330],"applied":[331],"case":[334],"study":[335],"pharmacokinetics,":[339],"shows":[340],"good":[341],"accuracy":[342],"sensitivity.":[344]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}