{"id":"https://openalex.org/W2064412842","doi":"https://doi.org/10.1186/1752-0509-6-41","title":"A network perspective on metabolic inconsistency","display_name":"A network perspective on metabolic inconsistency","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2064412842","doi":"https://doi.org/10.1186/1752-0509-6-41","mag":"2064412842","pmid":"https://pubmed.ncbi.nlm.nih.gov/22583819"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-6-41","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-41","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-41","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-41","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003812348","display_name":"Nikolaus Sonnenschein","orcid":"https://orcid.org/0000-0002-7581-4936"},"institutions":[{"id":"https://openalex.org/I193619901","display_name":"Constructor University","ror":"https://ror.org/02yrs2n53","country_code":"DE","type":"education","lineage":["https://openalex.org/I193619901"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Nikolaus Sonnenschein","raw_affiliation_strings":["School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany. niko.sonnenschein@gmail.com","School of Engineering & Science, Jacobs University Bremen, Bremen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany. niko.sonnenschein@gmail.com","institution_ids":["https://openalex.org/I193619901"]},{"raw_affiliation_string":"School of Engineering & Science, Jacobs University Bremen, Bremen, Germany","institution_ids":["https://openalex.org/I193619901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101597356","display_name":"Jos\u00e9 Felipe Golib Dzib","orcid":"https://orcid.org/0000-0002-6383-135X"},"institutions":[{"id":"https://openalex.org/I84909340","display_name":"Institut des Hautes \u00c9tudes Scientifiques","ror":"https://ror.org/05d5m2r55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I84909340"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Golib Dzib","raw_affiliation_strings":["Institut des Hautes \u00c9tudes Scientifiques \u2014 Centre National de la Recherche Scientifique, Bures-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Hautes \u00c9tudes Scientifiques \u2014 Centre National de la Recherche Scientifique, Bures-sur-Yvette, France","institution_ids":["https://openalex.org/I84909340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068924391","display_name":"Annick Lesne","orcid":"https://orcid.org/0000-0002-6647-612X"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210140797","display_name":"Laboratoire de Physique Th\u00e9orique de la Mati\u00e8re Condens\u00e9e","ror":"https://ror.org/04zaaa143","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I39804081","https://openalex.org/I4210098836","https://openalex.org/I4210140797"]},{"id":"https://openalex.org/I84909340","display_name":"Institut des Hautes \u00c9tudes Scientifiques","ror":"https://ror.org/05d5m2r55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I84909340"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Annick Lesne","raw_affiliation_strings":["Institut des Hautes \u00c9tudes Scientifiques \u2014 Centre National de la Recherche Scientifique, Bures-sur-Yvette, France","LPTMC CNRS UMR 7600, Universit\u00e9 Pierre et Marie Curie-Paris 6, 4 place Jussieu75252 Paris Cedex 05, France","LPTMC CNRS UMR 7600, Universit\u00e9 Pierre et Marie Curie-Paris 6, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Hautes \u00c9tudes Scientifiques \u2014 Centre National de la Recherche Scientifique, Bures-sur-Yvette, France","institution_ids":["https://openalex.org/I84909340"]},{"raw_affiliation_string":"LPTMC CNRS UMR 7600, Universit\u00e9 Pierre et Marie Curie-Paris 6, 4 place Jussieu75252 Paris Cedex 05, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I1294671590","https://openalex.org/I4210140797"]},{"raw_affiliation_string":"LPTMC CNRS UMR 7600, Universit\u00e9 Pierre et Marie Curie-Paris 6, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210140797","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031990643","display_name":"Sebastian Eilebrecht","orcid":"https://orcid.org/0000-0002-8111-950X"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013"]},{"id":"https://openalex.org/I4210119150","display_name":"Institut de Recherche Vaccinale","ror":"https://ror.org/02f9r3321","country_code":"FR","type":"facility","lineage":["https://openalex.org/I197681013","https://openalex.org/I4210116296","https://openalex.org/I4210119150"]},{"id":"https://openalex.org/I4210159433","display_name":"Institut Mondor de Recherche Biom\u00e9dicale","ror":"https://ror.org/04qe59j94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I17606148","https://openalex.org/I197681013","https://openalex.org/I197681013","https://openalex.org/I4210159433"]},{"id":"https://openalex.org/I84909340","display_name":"Institut des Hautes \u00c9tudes Scientifiques","ror":"https://ror.org/05d5m2r55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I84909340"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sebastian Eilebrecht","raw_affiliation_strings":["Institut des Hautes \u00c9tudes Scientifiques \u2014 Centre National de la Recherche Scientifique, Bures-sur-Yvette, France","Vaccine Research Institute, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Hautes \u00c9tudes Scientifiques \u2014 Centre National de la Recherche Scientifique, Bures-sur-Yvette, France","institution_ids":["https://openalex.org/I84909340"]},{"raw_affiliation_string":"Vaccine Research Institute, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I4210159433","https://openalex.org/I154526488","https://openalex.org/I4210119150","https://openalex.org/I197681013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017494730","display_name":"Sheerazed Boulkroun","orcid":"https://orcid.org/0000-0002-8796-7534"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210131199","display_name":"Paris Cardiovascular Research Center","ror":"https://ror.org/03gvnh520","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sheerazed Boulkroun","raw_affiliation_strings":["INSERM, U970, Paris Cardiovascular Research Center, Paris, France","INSERM U970, Paris Cardiovascular Research Center, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U970, Paris Cardiovascular Research Center, Paris, France","institution_ids":["https://openalex.org/I4210131199","https://openalex.org/I154526488"]},{"raw_affiliation_string":"INSERM U970, Paris Cardiovascular Research Center, Paris, France","institution_ids":["https://openalex.org/I4210131199","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018749828","display_name":"Maria\u2010Christina Zennaro","orcid":"https://orcid.org/0000-0001-5449-9191"},"institutions":[{"id":"https://openalex.org/I110736937","display_name":"D\u00e9l\u00e9gation Paris 5","ror":"https://ror.org/02e0y6e06","country_code":"FR","type":"government","lineage":["https://openalex.org/I110736937","https://openalex.org/I154526488"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210131199","display_name":"Paris Cardiovascular Research Center","ror":"https://ror.org/03gvnh520","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210131199"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maria-Christina Zennaro","raw_affiliation_strings":["INSERM, U970, Paris Cardiovascular Research Center, Paris, France","University Paris Descartes, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U970, Paris Cardiovascular Research Center, Paris, France","institution_ids":["https://openalex.org/I4210131199","https://openalex.org/I154526488"]},{"raw_affiliation_string":"University Paris Descartes, Paris, France","institution_ids":["https://openalex.org/I110736937","https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054769886","display_name":"Arndt Benecke","orcid":"https://orcid.org/0000-0002-7121-823X"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I197681013","display_name":"Universit\u00e9 Paris-Est Cr\u00e9teil","ror":"https://ror.org/05ggc9x40","country_code":"FR","type":"education","lineage":["https://openalex.org/I197681013"]},{"id":"https://openalex.org/I4210119150","display_name":"Institut de Recherche Vaccinale","ror":"https://ror.org/02f9r3321","country_code":"FR","type":"facility","lineage":["https://openalex.org/I197681013","https://openalex.org/I4210116296","https://openalex.org/I4210119150"]},{"id":"https://openalex.org/I4210159433","display_name":"Institut Mondor de Recherche Biom\u00e9dicale","ror":"https://ror.org/04qe59j94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I17606148","https://openalex.org/I197681013","https://openalex.org/I197681013","https://openalex.org/I4210159433"]},{"id":"https://openalex.org/I84909340","display_name":"Institut des Hautes \u00c9tudes Scientifiques","ror":"https://ror.org/05d5m2r55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I84909340"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Arndt Benecke","raw_affiliation_strings":["Institut des Hautes \u00c9tudes Scientifiques \u2014 Centre National de la Recherche Scientifique, Bures-sur-Yvette, France","Vaccine Research Institute, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Hautes \u00c9tudes Scientifiques \u2014 Centre National de la Recherche Scientifique, Bures-sur-Yvette, France","institution_ids":["https://openalex.org/I84909340"]},{"raw_affiliation_string":"Vaccine Research Institute, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I4210159433","https://openalex.org/I154526488","https://openalex.org/I4210119150","https://openalex.org/I197681013"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084385844","display_name":"Marc\u2010Thorsten H\u00fctt","orcid":"https://orcid.org/0000-0003-2221-423X"},"institutions":[{"id":"https://openalex.org/I193619901","display_name":"Constructor University","ror":"https://ror.org/02yrs2n53","country_code":"DE","type":"education","lineage":["https://openalex.org/I193619901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marc-Thorsten H\u00fctt","raw_affiliation_strings":["School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, 28759, Bremen, Germany","School of Engineering & Science, Jacobs University Bremen, Bremen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, 28759, Bremen, Germany","institution_ids":["https://openalex.org/I193619901"]},{"raw_affiliation_string":"School of Engineering & Science, Jacobs University Bremen, Bremen, Germany","institution_ids":["https://openalex.org/I193619901"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5003812348"],"corresponding_institution_ids":["https://openalex.org/I193619901"],"apc_list":null,"apc_paid":null,"fwci":0.6621,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.68182237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"6","issue":"1","first_page":"41","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.477400004863739,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.477400004863739,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.12530000507831573,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.12060000002384186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.7400819063186646},{"id":"https://openalex.org/keywords/perspective","display_name":"Perspective (graphical)","score":0.6352007985115051},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48898279666900635},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47722604870796204},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.45364806056022644},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3783070147037506},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.15661248564720154}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.7400819063186646},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.6352007985115051},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48898279666900635},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47722604870796204},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.45364806056022644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3783070147037506},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.15661248564720154}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000272","descriptor_name":"Adipates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000272","descriptor_name":"Adipates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000272","descriptor_name":"Adipates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-6-41","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-41","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-41","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:22583819","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22583819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.863.9281","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.863.9281","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.hal.inserm.fr/inserm-00793168/document/","raw_type":"text"},{"id":"pmh:oai:HAL:inserm-00793168v1","is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-00793168","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, 2012, 6 (1), pp.41. &#x27E8;10.1186/1752-0509-6-41&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:2586728","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3579709","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3579709","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3579709","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-6-41","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-41","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-41","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","score":0.5299999713897705,"display_name":"Partnerships for the goals"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320328633","display_name":"Jacobs University","ror":"https://ror.org/02yrs2n53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2064412842.pdf","grobid_xml":"https://content.openalex.org/works/W2064412842.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1966286251","https://openalex.org/W1975385846","https://openalex.org/W1978996317","https://openalex.org/W1986586503","https://openalex.org/W1986730103","https://openalex.org/W1996529795","https://openalex.org/W2001168187","https://openalex.org/W2012991302","https://openalex.org/W2016170962","https://openalex.org/W2025795724","https://openalex.org/W2046577147","https://openalex.org/W2048214825","https://openalex.org/W2070489671","https://openalex.org/W2075283200","https://openalex.org/W2075862542","https://openalex.org/W2094397891","https://openalex.org/W2096194986","https://openalex.org/W2098450614","https://openalex.org/W2103950919","https://openalex.org/W2104108767","https://openalex.org/W2123144543","https://openalex.org/W2126175129","https://openalex.org/W2136060005","https://openalex.org/W2141360045","https://openalex.org/W2143861551","https://openalex.org/W2150908245","https://openalex.org/W2153373497","https://openalex.org/W2154061034","https://openalex.org/W2162666840","https://openalex.org/W4252016380"],"related_works":["https://openalex.org/W2133150343","https://openalex.org/W2072067873","https://openalex.org/W5284979","https://openalex.org/W2047632644","https://openalex.org/W2031492751","https://openalex.org/W3033588432","https://openalex.org/W2147102947","https://openalex.org/W2075919068","https://openalex.org/W1989168955","https://openalex.org/W235738631"],"abstract_inverted_index":{"BACKGROUND:":[0],"Integrating":[1],"gene":[2,48,71,80,120],"expression":[3,40,49,81,121,234],"profiles":[4,190],"and":[5,42,62,83,95,119,262,276],"metabolic":[6,29,117,176,229,244,260,279],"pathways":[7],"under":[8],"different":[9],"experimental":[10],"conditions":[11],"is":[12],"essential":[13],"for":[14,58,145],"understanding":[15,69],"the":[16,52,77,106,136,140,146,157,165,168,175,180,210,232,257,274],"coherence":[17,78],"of":[18,22,28,37,47,54,63,70,79,86,114,139,183,191,202,259,278],"these":[19],"two":[20,107,227],"layers":[21],"cellular":[23,60],"organization.":[24],"The":[25,237],"network":[26,94,127,248],"character":[27],"systems":[30,261],"can":[31,122,241,281],"be":[32,123,282],"instrumental":[33],"in":[34,174,209,231],"developing":[35],"concepts":[36],"agreement":[38],"between":[39,105,116,256],"data":[41,50,211,221],"pathways.":[43],"A":[44],"network-driven":[45,185],"interpretation":[46],"has":[51],"potential":[53,182],"suggesting":[55],"novel":[56,286],"classifiers":[57],"pathological":[59],"states":[61,230],"contributing":[64],"to":[65,155],"a":[66,84,101,111,126,200,247,254],"general":[67],"theoretical":[68],"regulation.":[72],"RESULTS:":[73],"Here,":[74],"we":[75,134,152,225,267],"analyze":[76],"patterns":[82],"reconstruction":[85],"human":[87],"metabolism,":[88],"using":[89,284],"consistency":[90],"scores":[91],"obtained":[92,198,283],"from":[93,125,167,199,246],"constraint-based":[96],"analysis":[97],"methods.":[98],"We":[99,178,206],"find":[100],"surprisingly":[102],"strong":[103],"correlation":[104],"measures,":[108],"demonstrating":[109],"that":[110,160,171,195,212],"substantial":[112],"part":[113],"inconsistencies":[115,245],"processes":[118],"understood":[124],"perspective":[128],"alone.":[129],"Prompted":[130],"by":[131,187,218],"this":[132,150,285],"finding,":[133],"investigate":[135],"topological":[137],"context":[138],"individual":[141],"biochemical":[142],"reactions":[143],"responsible":[144],"observed":[147],"inconsistencies.":[148],"On":[149],"basis,":[151],"are":[153],"able":[154],"separate":[156],"differential":[158],"contributions":[159,170],"bear":[161],"physiological":[162],"information":[163],"about":[164],"system,":[166],"unspecific":[169],"unravel":[172,207],"gaps":[173],"reconstruction.":[177],"demonstrate":[179,268],"biological":[181],"our":[184],"approach":[186],"analyzing":[188],"transcriptome":[189],"aldosterone":[192],"producing":[193],"adenomas":[194],"have":[196,215],"been":[197,216],"cohort":[201],"Primary":[203],"Aldosteronism":[204],"patients.":[205],"systematics":[208],"could":[213],"not":[214],"resolved":[217],"conventional":[219],"microarray":[220],"analysis.":[222],"In":[223],"particular,":[224],"discover":[226],"distinct":[228],"adenoma":[233],"patterns.":[235],"CONCLUSIONS:":[236],"methodology":[238],"presented":[239],"here":[240],"help":[242],"understand":[243],"perspective.":[249],"It":[250],"thus":[251],"serves":[252],"as":[253],"mediator":[255],"topology":[258],"their":[263],"dynamical":[264],"function.":[265],"Finally,":[266],"how":[269],"physiologically":[270],"relevant":[271],"insights":[272],"into":[273],"structure":[275],"dynamics":[277],"networks":[280],"approach.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}
