{"id":"https://openalex.org/W2072971818","doi":"https://doi.org/10.1186/1752-0509-6-34","title":"Revisiting the variation of clustering coefficient of biological networks suggests new modular structure","display_name":"Revisiting the variation of clustering coefficient of biological networks suggests new modular structure","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2072971818","doi":"https://doi.org/10.1186/1752-0509-6-34","mag":"2072971818","pmid":"https://pubmed.ncbi.nlm.nih.gov/22548803"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-6-34","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-34","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-34","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-34","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034472419","display_name":"Dapeng Hao","orcid":"https://orcid.org/0000-0002-9043-371X"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dapeng Hao","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. dapenghao@hotmail.com","College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. dapenghao@hotmail.com","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022232798","display_name":"Cong Ren","orcid":"https://orcid.org/0000-0003-1981-439X"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210132813","display_name":"Second Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/03s8txj32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cong Ren","raw_affiliation_strings":["The Second Department of Orthopedics, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China","The Second Department of Orthopedics, the Second Affiliated Hospital of Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Orthopedics, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"]},{"raw_affiliation_string":"The Second Department of Orthopedics, the Second Affiliated Hospital of Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064777784","display_name":"Chuanxing Li","orcid":"https://orcid.org/0000-0003-2189-5010"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chuanxing Li","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034472419","https://openalex.org/A5064777784"],"corresponding_institution_ids":["https://openalex.org/I156144747"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":1.107,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.75959401,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"1","first_page":"34","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7093999981880188,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7093999981880188,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13362","display_name":"Slime Mold and Myxomycetes Research","score":0.05510000139474869,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modularity","display_name":"Modularity (biology)","score":0.8714017868041992},{"id":"https://openalex.org/keywords/clustering-coefficient","display_name":"Clustering coefficient","score":0.851004958152771},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.7414499521255493},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.7106910347938538},{"id":"https://openalex.org/keywords/hierarchical-clustering","display_name":"Hierarchical clustering","score":0.6455601453781128},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6115090847015381},{"id":"https://openalex.org/keywords/variation","display_name":"Variation (astronomy)","score":0.6065428256988525},{"id":"https://openalex.org/keywords/hierarchical-network-model","display_name":"Hierarchical network model","score":0.6034504175186157},{"id":"https://openalex.org/keywords/node","display_name":"Node (physics)","score":0.6029265522956848},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.587364673614502},{"id":"https://openalex.org/keywords/complex-network","display_name":"Complex network","score":0.5409407019615173},{"id":"https://openalex.org/keywords/signature","display_name":"Signature (topology)","score":0.45161911845207214},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.37128400802612305},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.36498111486434937},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3095566928386688},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23467564582824707},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.21667265892028809},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.16968154907226562},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.14159062504768372},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.12120106816291809}],"concepts":[{"id":"https://openalex.org/C2779478453","wikidata":"https://www.wikidata.org/wiki/Q6889748","display_name":"Modularity (biology)","level":2,"score":0.8714017868041992},{"id":"https://openalex.org/C22047676","wikidata":"https://www.wikidata.org/wiki/Q898680","display_name":"Clustering coefficient","level":3,"score":0.851004958152771},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.7414499521255493},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.7106910347938538},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.6455601453781128},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6115090847015381},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.6065428256988525},{"id":"https://openalex.org/C64900535","wikidata":"https://www.wikidata.org/wiki/Q5753111","display_name":"Hierarchical network model","level":3,"score":0.6034504175186157},{"id":"https://openalex.org/C62611344","wikidata":"https://www.wikidata.org/wiki/Q1062658","display_name":"Node (physics)","level":2,"score":0.6029265522956848},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.587364673614502},{"id":"https://openalex.org/C34947359","wikidata":"https://www.wikidata.org/wiki/Q665189","display_name":"Complex network","level":2,"score":0.5409407019615173},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.45161911845207214},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37128400802612305},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.36498111486434937},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3095566928386688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23467564582824707},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21667265892028809},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.16968154907226562},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.14159062504768372},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12120106816291809},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-6-34","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-34","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-34","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:22548803","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22548803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2463423","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3465239","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3741f34b79d1436caa803761fd685d44","is_oa":false,"landing_page_url":"https://doaj.org/article/3741f34b79d1436caa803761fd685d44","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 6, Iss 1, p 34 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-6-34","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-34","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-34","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7200000286102295,"id":"https://metadata.un.org/sdg/16","display_name":"Peace, Justice and strong institutions"}],"awards":[{"id":"https://openalex.org/G2599479890","display_name":"\u75be\u75c5\u76f8\u5173SNP\u4f4d\u70b9\u6316\u6398\u4e0eSNP\u529f\u80fd\u6ce8\u91ca\u7cfb\u7edf\u7684\u7814\u7a76","funder_award_id":"30600367","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320312270","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072971818.pdf","grobid_xml":"https://content.openalex.org/works/W2072971818.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1438382185","https://openalex.org/W1546324274","https://openalex.org/W1644749979","https://openalex.org/W1656674553","https://openalex.org/W1971421925","https://openalex.org/W1983202741","https://openalex.org/W1987224493","https://openalex.org/W1995089961","https://openalex.org/W2008620264","https://openalex.org/W2011357608","https://openalex.org/W2016621483","https://openalex.org/W2018045523","https://openalex.org/W2018049970","https://openalex.org/W2033193852","https://openalex.org/W2040956707","https://openalex.org/W2043004358","https://openalex.org/W2047693963","https://openalex.org/W2082340690","https://openalex.org/W2097888056","https://openalex.org/W2103453943","https://openalex.org/W2124354935","https://openalex.org/W2130687290","https://openalex.org/W2144885342","https://openalex.org/W2156737316","https://openalex.org/W2157082398","https://openalex.org/W2160058983","https://openalex.org/W2161605580","https://openalex.org/W2163056825","https://openalex.org/W2163480486","https://openalex.org/W2163485494","https://openalex.org/W2399279838","https://openalex.org/W2763420538","https://openalex.org/W3103786587","https://openalex.org/W4256140420"],"related_works":["https://openalex.org/W2161231129","https://openalex.org/W3135338679","https://openalex.org/W2390492032","https://openalex.org/W1724817857","https://openalex.org/W2361239511","https://openalex.org/W1615899219","https://openalex.org/W4387930971","https://openalex.org/W2097005420","https://openalex.org/W2357702059","https://openalex.org/W2072971818"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1,13],"central":[2],"idea":[3],"in":[4,62,142],"biology":[5],"is":[6,52,83,103,124,219],"the":[7,19,63,96,105,120,125,128,147,155,175,179,200,214,233,248,252],"hierarchical":[8,20,59,101,244],"organization":[9,22],"of":[10,23,34,48,65,74,80,90,100,107,114,122,131,149,159,163,178,181,206,216,235,243,255],"cellular":[11],"processes.":[12],"commonly":[14,97],"used":[15,55,98],"method":[16],"to":[17,57,227,240,250],"identify":[18,58],"modular":[21],"network":[24,115,226],"relies":[25],"on":[26],"detecting":[27],"a":[28,69,88,111,132,135,225],"global":[29],"signature":[30,76,99],"known":[31],"as":[32,196,238],"variation":[33,162,180,215],"clustering":[35,129,164,182,201,217],"coefficient":[36,130,202,218],"(so-called":[37],"modularity":[38,102,148],"scaling).":[39],"Although":[40],"several":[41],"studies":[42],"have":[43,211],"suggested":[44],"other":[45],"possible":[46],"origins":[47],"this":[49,75],"signature,":[50],"it":[51],"still":[53],"widely":[54],"nowadays":[56],"modularity,":[60,245],"especially":[61],"analysis":[64],"biological":[66,81,91,150,188,256],"networks.":[67,144],"Therefore,":[68],"further":[70],"and":[71,93,161,184,246],"systematical":[72],"investigation":[73],"for":[77,170,187,224],"different":[78,112],"types":[79],"networks":[82,92,189],"necessary.":[84],"RESULTS:":[85],"We":[86,117,166],"analyzed":[87],"variety":[89],"found":[94,185],"that":[95,119,127,186,213],"actually":[104],"reflection":[106],"spoke-like":[108,236],"topology,":[109],"suggesting":[110],"view":[113],"architecture.":[116],"proved":[118],"existence":[121,234],"super-hubs":[123],"origin":[126,177],"node":[133],"follows":[134],"particular":[136],"scaling":[137],"law":[138],"with":[139],"degree":[140],"k":[141],"metabolic":[143],"To":[145],"study":[146],"networks,":[151],"we":[152,210],"systematically":[153],"investigated":[154],"relationship":[156],"between":[157,172,193],"repulsion":[158,171],"hubs":[160,173],"coefficient.":[165],"provided":[167],"direct":[168],"evidences":[169],"being":[174],"underlying":[176],"coefficient,":[183],"having":[190],"no":[191],"anti-correlation":[192],"hubs,":[194],"such":[195],"gene":[197],"co-expression":[198],"network,":[199],"doesn't":[203],"show":[204],"dependence":[205],"degree.":[207],"CONCLUSIONS:":[208],"Here":[209],"shown":[212],"neither":[220],"sufficient":[221],"nor":[222],"exclusive":[223],"be":[228],"hierarchical.":[229],"Our":[230],"results":[231],"suggest":[232,247],"modules":[237],"opposed":[239],"\"deterministic":[241],"model\"":[242],"need":[249],"reconsider":[251],"organizational":[253],"principle":[254],"hierarchy.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
