{"id":"https://openalex.org/W1974327174","doi":"https://doi.org/10.1186/1752-0509-6-2","title":"Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control","display_name":"Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control","publication_year":2012,"publication_date":"2012-01-06","ids":{"openalex":"https://openalex.org/W1974327174","doi":"https://doi.org/10.1186/1752-0509-6-2","mag":"1974327174","pmid":"https://pubmed.ncbi.nlm.nih.gov/22225989"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-6-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066734010","display_name":"Kevin M. D\u2019Auria","orcid":null},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kevin M D'Auria","raw_affiliation_strings":["Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA","Dept. of Biomedical Engineering, University of Virginia, Charlottesville, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Dept. of Biomedical Engineering, University of Virginia, Charlottesville, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103560300","display_name":"Gina M. Donato","orcid":null},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gina M Donato","raw_affiliation_strings":["Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA","Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, USA"],"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083575795","display_name":"Mary C. Gray","orcid":"https://orcid.org/0000-0003-4441-5905"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary C Gray","raw_affiliation_strings":["Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA","Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, USA"],"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058436904","display_name":"Glynis L. Kolling","orcid":"https://orcid.org/0000-0001-8871-8129"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glynis L Kolling","raw_affiliation_strings":["Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA","Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, USA"],"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084842107","display_name":"Cirle A. Warren","orcid":"https://orcid.org/0000-0002-4417-0445"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cirle A Warren","raw_affiliation_strings":["Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA","Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, USA"],"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027892694","display_name":"Lauren M Cave","orcid":null},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren M Cave","raw_affiliation_strings":["Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA","Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, USA"],"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108491010","display_name":"Michael D. Solga","orcid":"https://orcid.org/0009-0002-9148-2836"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D Solga","raw_affiliation_strings":["Department of Microbiology, University of Virginia, Charlottesville, Virginia, 22908, USA","Department of Microbiology University of Virginia, Charlottesville, USA"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Virginia, Charlottesville, Virginia, 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Microbiology University of Virginia, Charlottesville, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041629116","display_name":"Joanne Lannigan","orcid":"https://orcid.org/0000-0002-3981-8681"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne A Lannigan","raw_affiliation_strings":["Department of Microbiology, University of Virginia, Charlottesville, Virginia, 22908, USA","Department of Microbiology University of Virginia, Charlottesville, USA"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Virginia, Charlottesville, Virginia, 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Microbiology University of Virginia, Charlottesville, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000119406","display_name":"Jason A. Papin","orcid":"https://orcid.org/0000-0002-2769-5805"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason A Papin","raw_affiliation_strings":["Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, 22908, USA","Dept. of Biomedical Engineering, University of Virginia, Charlottesville, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Dept. of Biomedical Engineering, University of Virginia, Charlottesville, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085490758","display_name":"Erik L. Hewlett","orcid":"https://orcid.org/0000-0002-3833-6349"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik L Hewlett","raw_affiliation_strings":["Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA","Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, USA"],"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5066734010"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":null,"apc_paid":null,"fwci":1.2855,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.77720056,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"2","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9801999926567078,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.9261000156402588,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7787799835205078},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.7248924970626831},{"id":"https://openalex.org/keywords/clostridium-difficile-toxin-a","display_name":"Clostridium difficile toxin A","score":0.6887503862380981},{"id":"https://openalex.org/keywords/clostridium-difficile","display_name":"Clostridium difficile","score":0.5652745962142944},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.5486012101173401},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.52665776014328},{"id":"https://openalex.org/keywords/clostridium-difficile-toxin-b","display_name":"Clostridium difficile toxin B","score":0.5103709101676941},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.5041762590408325},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.49497169256210327},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.46217742562294006},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4284765124320984},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4278918206691742},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.33238130807876587},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.32931023836135864}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7787799835205078},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7248924970626831},{"id":"https://openalex.org/C97505648","wikidata":"https://www.wikidata.org/wiki/Q5135488","display_name":"Clostridium difficile toxin A","level":4,"score":0.6887503862380981},{"id":"https://openalex.org/C2994496256","wikidata":"https://www.wikidata.org/wiki/Q27031090","display_name":"Clostridium difficile","level":3,"score":0.5652745962142944},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5486012101173401},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.52665776014328},{"id":"https://openalex.org/C134193097","wikidata":"https://www.wikidata.org/wiki/Q5135489","display_name":"Clostridium difficile toxin B","level":5,"score":0.5103709101676941},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5041762590408325},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.49497169256210327},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46217742562294006},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4284765124320984},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4278918206691742},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.33238130807876587},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32931023836135864},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002432","descriptor_name":"Cecum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002432","descriptor_name":"Cecum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002432","descriptor_name":"Cecum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-6-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:22225989","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22225989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:5b85288f9f334deaa63f5d2447750921","is_oa":true,"landing_page_url":"https://doaj.org/article/5b85288f9f334deaa63f5d2447750921","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 6, Iss 1, p 2 (2012)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3266197","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3266197","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-6-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-6-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5799999833106995,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G4281104693","display_name":null,"funder_award_id":"U54 AI057168","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5797893022","display_name":null,"funder_award_id":"T32 AI007046","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6894279922","display_name":null,"funder_award_id":"AI007046","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G897121438","display_name":null,"funder_award_id":"AI057168","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320310536","display_name":"University of Virginia","ror":"https://ror.org/0153tk833"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1974327174.pdf","grobid_xml":"https://content.openalex.org/works/W1974327174.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1533335653","https://openalex.org/W1546952499","https://openalex.org/W1659833910","https://openalex.org/W1973614663","https://openalex.org/W1976491510","https://openalex.org/W1985221982","https://openalex.org/W1994474958","https://openalex.org/W2003370562","https://openalex.org/W2004885660","https://openalex.org/W2010324176","https://openalex.org/W2013723843","https://openalex.org/W2017965065","https://openalex.org/W2018235550","https://openalex.org/W2025024815","https://openalex.org/W2038696352","https://openalex.org/W2040684206","https://openalex.org/W2048881283","https://openalex.org/W2058092689","https://openalex.org/W2060232711","https://openalex.org/W2063224638","https://openalex.org/W2066515650","https://openalex.org/W2069011026","https://openalex.org/W2071408032","https://openalex.org/W2075515543","https://openalex.org/W2077038301","https://openalex.org/W2081098333","https://openalex.org/W2082205311","https://openalex.org/W2085129546","https://openalex.org/W2091256286","https://openalex.org/W2096939566","https://openalex.org/W2100085137","https://openalex.org/W2109905546","https://openalex.org/W2120024428","https://openalex.org/W2120470510","https://openalex.org/W2123366827","https://openalex.org/W2127067932","https://openalex.org/W2132910118","https://openalex.org/W2140539199","https://openalex.org/W2145749026","https://openalex.org/W2149660599","https://openalex.org/W2156616178","https://openalex.org/W2157216937","https://openalex.org/W2158670112","https://openalex.org/W2160939594","https://openalex.org/W2161266187","https://openalex.org/W2163160984","https://openalex.org/W2163423623","https://openalex.org/W2166148711","https://openalex.org/W2167398352","https://openalex.org/W2418279095"],"related_works":["https://openalex.org/W4293204701","https://openalex.org/W3039408246","https://openalex.org/W2001386076","https://openalex.org/W2120670749","https://openalex.org/W2154165794","https://openalex.org/W2805990579","https://openalex.org/W2033598802","https://openalex.org/W2899000927","https://openalex.org/W3122904679","https://openalex.org/W2001116525"],"abstract_inverted_index":{"This":[0],"study":[1],"shows":[2],"a":[3,7],"successful":[4],"example":[5],"of":[6,35,41,49],"workflow":[8],"deriving":[9],"novel":[10],"biological":[11],"insight":[12],"from":[13],"transcriptome-wide":[14],"gene":[15],"expression.":[16],"Importantly,":[17],"we":[18],"do":[19],"not":[20],"find":[21],"any":[22],"significant":[23],"difference":[24],"between":[25],"TcdA":[26],"and":[27,44],"TcdB":[28],"besides":[29],"potency":[30],"or":[31],"kinetics.":[32],"The":[33],"role":[34],"each":[36],"toxin":[37],"in":[38,51],"the":[39,52],"inhibition":[40],"cell":[42],"growth":[43],"proliferation,":[45],"an":[46],"important":[47],"function":[48],"cells":[50],"intestinal":[53],"epithelium,":[54],"is":[55],"characterized.":[56]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
