{"id":"https://openalex.org/W2041130480","doi":"https://doi.org/10.1186/1752-0509-6-151","title":"Similar temperature dependencies of glycolytic enzymes: an evolutionary adaptation to temperature dynamics?","display_name":"Similar temperature dependencies of glycolytic enzymes: an evolutionary adaptation to temperature dynamics?","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2041130480","doi":"https://doi.org/10.1186/1752-0509-6-151","mag":"2041130480","pmid":"https://pubmed.ncbi.nlm.nih.gov/23216813"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-6-151","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-151","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/1752-0509-6-151","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/1752-0509-6-151","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111728492","display_name":"AnaLuisa B Cruz","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129165","display_name":"General Electric (Netherlands)","ror":"https://ror.org/03q3a0475","country_code":"NL","type":"company","lineage":["https://openalex.org/I1332737386","https://openalex.org/I4210129165"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"AnaLuisa B Cruz","raw_affiliation_strings":["Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands","institution_ids":["https://openalex.org/I4210129165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084758216","display_name":"Marit Hebly","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129165","display_name":"General Electric (Netherlands)","ror":"https://ror.org/03q3a0475","country_code":"NL","type":"company","lineage":["https://openalex.org/I1332737386","https://openalex.org/I4210129165"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marit Hebly","raw_affiliation_strings":["Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands","institution_ids":["https://openalex.org/I4210129165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028525348","display_name":"Giang-Huong Duong","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129165","display_name":"General Electric (Netherlands)","ror":"https://ror.org/03q3a0475","country_code":"NL","type":"company","lineage":["https://openalex.org/I1332737386","https://openalex.org/I4210129165"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Giang-Huong Duong","raw_affiliation_strings":["Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands","institution_ids":["https://openalex.org/I4210129165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081992425","display_name":"A. Wahl","orcid":"https://orcid.org/0000-0003-2120-1859"},"institutions":[{"id":"https://openalex.org/I4210129165","display_name":"General Electric (Netherlands)","ror":"https://ror.org/03q3a0475","country_code":"NL","type":"company","lineage":["https://openalex.org/I1332737386","https://openalex.org/I4210129165"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sebastian A Wahl","raw_affiliation_strings":["Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands","institution_ids":["https://openalex.org/I4210129165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087000945","display_name":"Jack T. Pronk","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129165","display_name":"General Electric (Netherlands)","ror":"https://ror.org/03q3a0475","country_code":"NL","type":"company","lineage":["https://openalex.org/I1332737386","https://openalex.org/I4210129165"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jack T Pronk","raw_affiliation_strings":["Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands","institution_ids":["https://openalex.org/I4210129165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090214575","display_name":"Joseph J. Heijnen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129165","display_name":"General Electric (Netherlands)","ror":"https://ror.org/03q3a0475","country_code":"NL","type":"company","lineage":["https://openalex.org/I1332737386","https://openalex.org/I4210129165"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joseph J Heijnen","raw_affiliation_strings":["Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands","institution_ids":["https://openalex.org/I4210129165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066968633","display_name":"Pascale Daran\u2010Lapujade","orcid":"https://orcid.org/0000-0002-4097-7831"},"institutions":[{"id":"https://openalex.org/I4210129165","display_name":"General Electric (Netherlands)","ror":"https://ror.org/03q3a0475","country_code":"NL","type":"company","lineage":["https://openalex.org/I1332737386","https://openalex.org/I4210129165"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pascale Daran-Lapujade","raw_affiliation_strings":["Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands","institution_ids":["https://openalex.org/I4210129165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015782458","display_name":"Walter M. van Gulik","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129165","display_name":"General Electric (Netherlands)","ror":"https://ror.org/03q3a0475","country_code":"NL","type":"company","lineage":["https://openalex.org/I1332737386","https://openalex.org/I4210129165"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Walter M van Gulik","raw_affiliation_strings":["Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Delft University of Technology and Kluyver Centre for Genomics of Industrial Fermentation, Julianalaan 67, Delft, 2628 BC, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Netherlands Consortium for Systems Biology, PO Box 94215, Amsterdam, 1090 GE, The Netherlands","institution_ids":["https://openalex.org/I4210129165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015782458"],"corresponding_institution_ids":["https://openalex.org/I4210129165","https://openalex.org/I98358874"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.9823,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.73434132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"6","issue":"1","first_page":"151","last_page":"151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.6766999959945679,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.6766999959945679,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.10520000010728836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0544000007212162,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemostat","display_name":"Chemostat","score":0.7549850344657898},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.6649043560028076},{"id":"https://openalex.org/keywords/glycolysis","display_name":"Glycolysis","score":0.6399877071380615},{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.5596339106559753},{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.5061432719230652},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.49467918276786804},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.491269052028656},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4440719485282898},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4392741918563843},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.42832937836647034},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.42666101455688477},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.4128195643424988},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.4105469584465027},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.40304291248321533},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.35430586338043213},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.18213525414466858},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13633155822753906},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.08043527603149414}],"concepts":[{"id":"https://openalex.org/C125111812","wikidata":"https://www.wikidata.org/wiki/Q902311","display_name":"Chemostat","level":3,"score":0.7549850344657898},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6649043560028076},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.6399877071380615},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5596339106559753},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5061432719230652},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49467918276786804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.491269052028656},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4440719485282898},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4392741918563843},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.42832937836647034},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.42666101455688477},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.4128195643424988},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.4105469584465027},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.40304291248321533},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35430586338043213},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.18213525414466858},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13633155822753906},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.08043527603149414},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1752-0509-6-151","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-151","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/1752-0509-6-151","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:23216813","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23216813","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:91f4c5af72c0488a8bb5bc839dcd25b9","is_oa":false,"landing_page_url":"https://doaj.org/article/91f4c5af72c0488a8bb5bc839dcd25b9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 6, Iss 1, p 151 (2012)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2737153","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3554419","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3554419","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3554419","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:tudelft.nl:uuid:75361b4a-7d5e-4ba2-a9ea-a1abb639c478","is_oa":true,"landing_page_url":"http://resolver.tudelft.nl/uuid:75361b4a-7d5e-4ba2-a9ea-a1abb639c478","pdf_url":null,"source":{"id":"https://openalex.org/S4306400906","display_name":"Research Repository (Delft University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/244207","is_oa":true,"landing_page_url":"http://www.dspace.cam.ac.uk/handle/1810/244207","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-6-151","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-6-151","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/1752-0509-6-151","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.5600000023841858,"display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2041130480.pdf","grobid_xml":"https://content.openalex.org/works/W2041130480.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W70082989","https://openalex.org/W196358094","https://openalex.org/W399385914","https://openalex.org/W568941435","https://openalex.org/W1559247622","https://openalex.org/W1638100349","https://openalex.org/W1767531733","https://openalex.org/W1775749144","https://openalex.org/W1873506857","https://openalex.org/W1984044253","https://openalex.org/W1991547334","https://openalex.org/W1992888813","https://openalex.org/W1993141629","https://openalex.org/W1997707564","https://openalex.org/W2007378834","https://openalex.org/W2008913755","https://openalex.org/W2026481834","https://openalex.org/W2031180754","https://openalex.org/W2034354682","https://openalex.org/W2039609168","https://openalex.org/W2041889981","https://openalex.org/W2044036506","https://openalex.org/W2044348714","https://openalex.org/W2048317717","https://openalex.org/W2054664724","https://openalex.org/W2055160697","https://openalex.org/W2061411038","https://openalex.org/W2065566468","https://openalex.org/W2072106875","https://openalex.org/W2072529816","https://openalex.org/W2077724722","https://openalex.org/W2077798236","https://openalex.org/W2096336948","https://openalex.org/W2108089570","https://openalex.org/W2110154943","https://openalex.org/W2115994034","https://openalex.org/W2118655754","https://openalex.org/W2120187999","https://openalex.org/W2121891865","https://openalex.org/W2138088677","https://openalex.org/W2140375832","https://openalex.org/W2159687660","https://openalex.org/W2159687706","https://openalex.org/W2161301111","https://openalex.org/W2162719167","https://openalex.org/W2165762336","https://openalex.org/W2166699835","https://openalex.org/W2169756968","https://openalex.org/W2267560786","https://openalex.org/W2482371382","https://openalex.org/W3145097052","https://openalex.org/W4255480110"],"related_works":["https://openalex.org/W1608758340","https://openalex.org/W2123404724","https://openalex.org/W1505019344","https://openalex.org/W4237795480","https://openalex.org/W47420346","https://openalex.org/W2143478158","https://openalex.org/W2025026414","https://openalex.org/W2102268782","https://openalex.org/W2042789668","https://openalex.org/W2064253281"],"abstract_inverted_index":{"BACKGROUND:":[0],"Temperature":[1],"strongly":[2],"affects":[3],"microbial":[4,25],"growth,":[5],"and":[6,28,50,62,72,87],"many":[7],"microorganisms":[8],"have":[9],"to":[10,67,135,153,157],"deal":[11],"with":[12,113,118],"temperature":[13,26,39,48,70,75,104,140,149,158],"fluctuations":[14],"in":[15,35,116,163],"their":[16],"natural":[17],"environment.":[18],"To":[19],"understand":[20],"regulation":[21],"strategies":[22],"that":[23,96,105],"underlie":[24],"responses":[27],"adaptation,":[29],"we":[30],"studied":[31],"glycolytic":[32,85,131],"pathway":[33],"kinetics":[34],"Saccharomyces":[36,42],"cerevisiae":[37,43],"during":[38],"changes.":[40],"RESULTS:":[41],"was":[44],"grown":[45],"under":[46],"different":[47,60],"regimes":[49],"glucose":[51,89],"availability":[52,101],"conditions.":[53],"These":[54],"included":[55],"glucose-excess":[56],"batch":[57],"cultures":[58],"at":[59],"temperatures":[61],"glucose-limited":[63],"chemostat":[64],"cultures,":[65],"subjected":[66],"fast":[68],"linear":[69],"shifts":[71],"circadian":[73],"sinoidal":[74],"cycles.":[76],"An":[77],"observed":[78],"temperature-independent":[79],"relation":[80],"between":[81],"intracellular":[82,107,167],"levels":[83],"of":[84,122,129,166,177],"metabolites":[86],"residual":[88],"concentration":[90],"for":[91,174],"all":[92,130],"experimental":[93],"conditions":[94],"revealed":[95],"it":[97],"is":[98],"the":[99,126,137,172],"substrate":[100],"rather":[102],"than":[103],"determines":[106],"metabolite":[108,168],"profiles.":[109],"This":[110],"observation":[111],"corresponded":[112],"predictions":[114],"generated":[115],"silico":[117],"a":[119],"kinetic":[120],"model":[121],"yeast":[123],"glycolysis,":[124],"when":[125],"catalytic":[127],"capacities":[128],"enzymes":[132],"were":[133],"set":[134],"share":[136],"same":[138],"normalized":[139],"dependency.":[141],"CONCLUSIONS:":[142],"From":[143],"an":[144],"evolutionary":[145],"perspective,":[146],"such":[147],"similar":[148],"dependencies":[150],"allow":[151],"cells":[152],"adapt":[154],"more":[155],"rapidly":[156],"changes,":[159],"because":[160],"they":[161],"result":[162],"minimal":[164],"perturbations":[165],"levels,":[169],"thus":[170],"circumventing":[171],"need":[173],"extensive":[175],"modification":[176],"enzyme":[178],"levels.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}
